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7618988 |
Use of substituted aminomethyl chromans
Compounds of formula I in which R has a meaning as indicated in claim 1 , or one of their optical isomers or pharmaceutically acceptable salts, used for the treatment of extrapyramidal movement...
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7618966 |
Abnormal Cannabidiols as agents for lowering intraocular pressure
The present invention provides a method of treating glaucoma or ocular hypertension which comprises applying to the eye of a person in need thereof an amount sufficient to treat glaucoma or ocular...
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7589056 |
Agent for the prevention and treatment of sexually transmitted diseases-I
Use of a polylysine, polyamidoamine or polypropylenimine dendrimer having naphthyl disulphonate terminal groups as a topically applied agent in prophylaxis or treatment of sexually transmitted...
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7579507 |
Polymorphic crystal of 4′-{2-[ (1S, 2R)—2- hydroxy-2- (4-hydroxyphenyl)-1-methylethylamino]ethoxy} - 3 - isopropyl-3′, 5′ -dimethylbiphenyl- 4 - carboxylic acid hydrochloride
Crystals of a salt of 4′-{2-[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl
amino]ethoxy}-3-isopropyl-3′,5′-dimethylbiphenyl-4-carbo
xylic acid. The α type, β type and γ type crystals...
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7572774 |
Methods for treating glutamate cytotoxicity with beta-naphthoquinone compounds
The present invention relates to the use of beta-naphthoquinone derivatives, and salts thereof, for the prevention and/or the treatment of glutamate cytotoxicity. It further relates to the use of...
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7553834 |
Method for the targeted treatment of depression
A method for determining the appropriate medication for a patient suffering from depression. A patient will take a questionnaire wherein the patient answers a number of questions with scaled...
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7538127 |
Medicinal compounds
A compound of formula (I) or a salt, solvate, or physiologically functional derivative thereof, wherein: m is an integer of from 2 to 8; n is an integer of from 2 to 5; with the proviso that m+n is...
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7524886 |
L-(−)-moprolol L-(+)-tartrate
L-(−)-moprolol L-(+)-tartrate salt (2:1), method for preparing it and pharmaceutical composition comprising it.
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7521480 |
Aryl ureido benzoic acid derivatives and their use
This invention relates to novel aryl ureido benzoic acid derivatives useful as selective and non-competitive antagonists of the ionotropic GluR5 receptor. Due to their biological activity, the aryl...
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7507767 |
Cannabinoid receptor ligands
There are disclosed compounds of the formula
a prodrug thereof, or a pharmaceutically acceptable salt, solvate or stereoisomer of the compound or of said prodrug; which exhibit...
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7482489 |
Enantiomerically pure (R)-albuterol dibenzoyltartrate and protected analogs thereof
Provided are processes for the preparation of (R)-SLB.D-DBTA salt and levalbuterol hydrochloride. Also provided are levalbuterol hydrochloride degradation products and processes for preparing them....
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7427639 |
β2-adrenergic receptor agonists
Disclosed are multibinding compounds which are β2 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also...
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7425580 |
(Diaryl-methyl)-malononitriles and their use as estrogen receptor ligands
The present invention concerns compounds of formula:
where R 1 , R 2 , R 3 and R 4 are defined in the specification.
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7425579 |
Methods for inhibiting activity of polyamine transporters
A method for inhibiting the activity of a natural polyamine transporter comprising the step of contacting the transporter with an inhibitorily effective amount of a compound of formula (I) or (II):...
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7425578 |
Immunoregulatory compounds and derivatives and methods of treating diseases therewith
Compounds are disclosed having the structure of Formula I:
where R 1 , R 3 , and R 4 are independently hydrogen or C 1 to C 4 alkyl, and R 2 is:
where R 5 is selected from the group...
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7423185 |
Amino alcohol derivatives, pharmaceutical compositions containing the same, and use thereof
The present invention provides compounds represented by general formula (I):
or pharmaceutical acceptable salts thereof, wherein R 1 and R 2 are each hydrogen or lower alkyl; R 3 , R 4 , R 5 ...
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7384983 |
Inhibitor of monoamine uptake
The present invention provides compounds and methods for the inhibition of monoamine uptake in mammals.
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7361690 |
Compositions and methods for the treatment of urinary incontinence
A method for treating increased uninary urgency or urinary incontinence, comprising administering an effective amount of a compound corresponding to formula I
It has been surprisingly...
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7354942 |
Benzylether and benzylamino beta-secretase inhibitors for the treatment of Alzheimer's disease
The present invention is directed to benzylether and benzylamino derivative compounds of formula (I)
which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of...
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7314890 |
Sulfonamides
The present invention provides
wherein R 1 is selected from the group consisting of C 1 -C 10 alkoxy, OH and NR 4 R 5 ;
R 2 is selected from the group consisting of C 1 -C 10 alkyl...
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7226949 |
Compounds of use in the treatment of epilepsy, seizure, and electroconvulsive disorders
The present invention provides pharmaceutical preparations and the uses thereof for preventing and/or treating seizures and other electroconvulsive disorders by administering a pharmaceutically...
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7217696 |
Glycuronamides, glycosides and orthoester glycosides of fluoxetine, analogs and uses thereof
Disclosed are glycosides, orthoester glycosides and glycuronamides of fluoxetine and analogs thereof to treat conditions and diseases such as depression.
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7192983 |
N-protected/N-substituted-beta-amino hydroxy sulfonates
N-protected/N-substituted alpha-amino aldehydes, which are useful as pharmaceuticals and pharmaceutical intermediates, can be stored and shipped in a more stable form as...
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7183322 |
Remedy for hypertension
A therapeutic agent for hypertension, which comprises as an active ingredient a compound capable of inhibiting Na + /Ca 2+ exchanger 1.
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7169770 |
Method of enhancing reproductive performance in sows
The present invention relates to supplementing the diets to sows during the periods of gestation, lactation, and breeding by feeding L-carnitine and chromium. The supplementation enhances pork...
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7163956 |
Substituted fullerene compositions and their use as antioxidants
This patent discloses a substituted fullerenes, compositions comprising the same, and their use as antioxidants. The substituted fullerenes comprise a fullerene core (Cn) and at least one of: (i)...
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7157078 |
Devices and methods for eliminating termite colonies
This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing
a) a termiticide selected...
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7151095 |
Immunoregulatory compounds and derivatives and methods of treating diseases therewith
Compounds are disclosed having the structure of Formula I:
where R 1 , R 3 , and R 4 are independently hydrogen or C 1 to C 4 alkyl, and R 2 is:
where R 5 is selected from the group...
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7148258 |
Combination of a CB1 receptor antagonist and of sibutramine, the pharmaceutical compositions comprising them and their use in the treatment of obesity
The present invention relates to the combination of a CB1 receptor antagonist and of sibutramine, to the pharmaceutical compositions comprising them and to their use in the treatment of obesity.
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7138405 |
Pharmaceutical combinations
Pharmaceutical combinations suitable for treating the lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) in men are described herein. The combinations contain an...
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7135502 |
Colchinol derivatives as vascular damaging agents
The invention relates to the use of compounds of formula (I): wherein X is —C(O)—, —C(S)—, —C═NOH, or —CH(R 7 )— wherein R 7 is hydrogen, hydroxy, C 1-7 alkoxy, —OR 8 or —NR 8...
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7098223 |
Arylsulfanyl and heteroarylsulfanyl derivatives for treating pain
According to the invention there is provided a compound the formula I;
wherein A, X, B, R 1 , R 2 , R 3 and R 4 are as defined in the specification.
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7084171 |
Compounds and therapies for the prevention of vascular and non-vascular pathologies
The invention provides a method of treating a mammal having, or at risk of, an indication associated with a TGF-beta deficiency comprising administering one or more agents that is effective to...
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RE39221 |
Composition comprising a tramadol material and acetaminophen and its use
This invention relates to a composition comprising a tramadol material and acetaminophen, and its use. As used herein tramadol refers to various forms of tramadol. The compositions are...
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7074430 |
Controlled release tramadol tramadol formulation
A controlled release preparation for oral administration contains tramadol, or a pharmaceutically acceptable salt thereof, as active ingredient.
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7071234 |
Methods of treating or preventing erectile dysfunction
Methods are disclosed for the treatment and prevention of disorders and conditions including, but are not limited to, erectile dysfunction, affective disorders, weight gain, cerebral functional...
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7056890 |
Combination therapy for effecting weight loss and treating obesity
The present invention features a novel therapy for effecting weight loss which involves treating a subject with a sympathomimetic agent (e.g., phentermine or a phentermine-like drug) in combination...
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7053123 |
Substituted (e)-styryl benzylsulfones for treating proliferative disorders
(E)-Styryl benzylsulfones useful as antiproliferative agents, including, for example, anticancer agents, are provided according to formula I: wherein: R 1 is selected from the group consisting of...
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7037944 |
Combination of a CB1 receptor antagonist and of sibutramine, the pharmaceutical compositions comprising them and their use in the treatment of obesity
The present invention relates to the combination of a CB1 receptor antagonist and of sibutramine, to the pharmaceutical compositions comprising them and to their use in the treatment of obesity.
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7037943 |
Retinal treatment method
A method for treating or preventing retinal pathology or injury. The method locates and secures a retinal stimulating substance in the eye between the internal limiting membrane and the retina,...
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7030162 |
Treatment of migraine headache
The invention is directed to pharmaceutical compositions useful in the treatment of migraine. The compositions contain metoclopramide and one or more NSAIDs in unit dosage form. By selecting NSAIDs...
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7030126 |
Use of polyamine analogs for amyotrophic lateral sclerosis
The present invention provides methods and compositions for modulating polyamine pathway activity as a means for ameliorating neurodegenarative disorders. In particular, for ameliorating the...
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7022739 |
Substituted 1-aminobutan-3-ol compounds
Substituted 1-aminobutane-3-ol compounds, methods for producing them, pharmaceutical compounds containing them, and the use of substituted 1-aminobutane-3-ol compounds for producing pharmaceutical...
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7012099 |
Use of substituted 4-amino-1-phenylbutan-2-ol compounds as medicaments
The invention relates to the use of substituted 4-amino-1-phenylbutan-2-ol compounds in the form of their racemates, enantiomers, diastereomers or corresponding bases or corresponding salts of...
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7008962 |
IL-8 receptor antagonists
This invention relates to the novel use of dianilino squarates in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
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6992106 |
Anti-tumor composition
The present invention provides composition having as active ingredients a stilbene derivative and a platinum coordination compound which is highly efficacious and highly safe for treating tumors,...
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6974838 |
Methods of treating or preventing pain using sibutramine metabolites
Methods of making and using racemic and optically pure metabolites of sibutramine, and pharmaceutically acceptable salts, solvates, and clathrates thereof, are disclosed. Pharmaceutical...
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6974837 |
Compositions comprising sibutramine metabolites in combination with phosphodiesterase inhibitors
Pharmaceutical compositions and dosage forms are disclosed that comprise a racemic or optically pure sibutramine metabolite and a phosphodiesterase inhibitor.
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6946486 |
Quaternary ammonium compounds
The invention features quaternary ammonium compounds of formula I, described herein, and their use in treating asthma, chronic obstructive pulmonary disorder, allergic rhinitis, and infectious...
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6933321 |
Antiandrogenic biphenyls
Biphenyl derivatives are disclosed for use in the treatment of androgen-dependent diseases, such as prostate cancer, benign prostatic hyperplasia, precocious puberty, polycystic ovarian syndrome,...
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