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6946486 |
Quaternary ammonium compounds
The invention features quaternary ammonium compounds of formula I, described herein, and their use in treating asthma, chronic obstructive pulmonary disorder, allergic rhinitis, and infectious...
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6933320 |
Combination comprising combretastatin and anticancer agents
An antitumor combination comprising a stilbene derivative and an anticancer compound selected from the group consisting of taxanes, alkylating agents, antimetabolites, vinca alkaloids, platinum...
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6933321 |
Antiandrogenic biphenyls
Biphenyl derivatives are disclosed for use in the treatment of androgen-dependent diseases, such as prostate cancer, benign prostatic hyperplasia, precocious puberty, polycystic ovarian syndrome,...
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6923990 |
Stabilized silver-ion amine complex compositions and methods
The present invention relates to new silver-ion super-complex compositions. More particularly, the present invention describes silver-ion super-complex compositions comprising a silver-thiosulfate...
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6919092 |
Method for the management of incontinence
A composition and a dosage form are disclosed comprising oxybutynin alone/or accompanied by another drug indicated for therapy. A method is disclosed for administering oxybutynin alone/or...
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6919336 |
Hallogenated aminobenzophenones and aminobenzoylpyridines as inhibitors of IL-1 and TNF
Compounds of formula I and pharmaceutically-acceptable and -cleavable esters thereof and acid addition salts thereof wherein the symbols are as defined are MAP kinase inhibitors, useful...
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6914079 |
Polyamine analogs that activate antizyme frameshifting
Novel polyamines, their synthesis and use in pharmacological, cosmetic or agricultural applications are provided. The polyamines induce antizyme production which in turn down regulates both the...
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6911477 |
Muscarinic receptor agonists
This invention relates to a novel class of partial or full muscarinic receptor agonists intermediates for their preparation, and pharmaceutical compositions and methods of use for the treatment or...
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6903114 |
Derivatives of naphthalene with COMT inhibiting activity
Compounds of formula (I′), wherein A, R 1 to R 3 and t are as defined in the disclosure, exhibit COMT enzyme inhibiting activity so that they are useful as COMT inhibitors.
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6900245 |
Pharmaceutical composition comprising crystalline sibutramine methanesulfonate hemihydrate
The present invention relates to a pharmaceutical composition for treating or preventing obesity, comprising novel crystalline sibutramine methanesulfonate hemihydrate of formula (I). The...
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6900244 |
Anilino liver X-receptor modulators
The present invention is directed to selective LXR modulators, small molecule compounds corresponding to Formula I and is further directed to a process of treating a condition in a mammal that is...
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6890959 |
Aminomethyl-phenyl-cyclohexanone derivatives
Aminomethyl-phenyl-cyclohexanone derivatives of formula I or Ia,
their diastereomers, enantiomers and salts formed with a physiologically tolerated acid. Also disclosed are processes for...
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6887904 |
Substituted arylcycloalkanes, compositions containing them and use thereof
Substituted arylcycloalkanes, compositions containing them and use thereof. The present invention relates especially to substituted arylcycloalkanes with therapeutic activity, which may be used...
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6887871 |
Use of phenylheteroakylamine derivatives
There is disclosed the use of a compound of formula (I) wherein R 1 , R 2 , X, Y, V, W and Z are as defined in the specification, and pharmaceutically acceptable salts, enantiomers or racemates...
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6867237 |
DNA encoding apoptosis-induced eucaryotic initiation factor-5A and deoxyhypusine synthase and a method for controlling apoptosis in animals and humans
Genes encoding an apoptosis-induced eukaryotic initiation Factor-5A (eIF-5A) and an apoptosis-induced deoxyhypusine synthase (DHS), whose expressions are induced by the onset of apoptosis, are...
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6828345 |
O-substituted 6-methyltramadol derivatives
The invention relates to O-substituted 6-methyl-tramadol derivatives, to methods for producing them, to medicaments containing these compounds, to the use of O-substituted 6-methyl-tramadol...
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6818656 |
Method and composition for treatment of irritable bowel disease
A method and composition for treating irritable bowel syndrome in a subject in need of such treatment, utilizing an amount of a polyamine having the formula: 1) R—NH—(CH 2 ) a —NH—(CH 2 )...
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6803387 |
Treatment of neuropathic pain or fibromyalgia
A compound of formula I or a pharmaceutically acceptable salt thereof in which R 1 and R 2 are independently H or methyl (for example N,N-dimethyl-1-[1-(4-chlorophenyl)...
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6797728 |
Use of intracellular calcium chelators to increase surfactant secretion in the lungs
Pulmonary surfactant is required in order to reduce surface tension in the lungs so that less effort is needed to reinflate the lungs after exhalation. A number of diseases and conditions exist...
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6797732 |
Pharmaceutical composition comprising entracapone, levodopa, and carbidopa
An oral solid fixed dose composition comprising pharmacologically effective amounts of entacapone, levodopa, and carbidopa, or pharmaceutically acceptable salts or hydrates thereof, and comprising...
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6780891 |
Tramadol analogs and uses thereof
Compounds of formula I are effective in treating disorders modulated by opiate receptor activity and/or monoamine activity. In formula I, R 1 is selected from alkyl, aryl, alkylaryl,...
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6770678 |
Lyophilisates having improved reconstitutability
The present invention relates to lyophilisates having an improved dissolution rate which can be reconstituted in a particle-free manner, which is achieved by re-warming the solutions already drawn...
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6765022 |
Cyclohexylamine derivatives as subtype selective nmda receptor antagonists
Described are cyclobexylamine derivatives of Formula I, Formula II, or Formula III and their pharmaceutically acceptable salts thereof: The compounds are antagonists of NMDA receptor channel...
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6753298 |
Agents for combating Neospora spec
Compositions for controlling diseases caused by protozoans of the genus Neospora, which are characterized in that they comprise one or more active compounds which inhibit the microtubulin system of...
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6746689 |
Intradermal-penetration agents for topical local anesthetic administration
A non-invasive and non-systemic method for administering a local anesthetic. The method comprises topical application of a local anesthetic in combination with an intradermal-penetration agent...
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6747043 |
Alkoxy aryl β2 adrenergic receptor agonists
The invention provides novel β 2 adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat...
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6720003 |
Serotonin reuptake inhibitor formulations
A process for preparing amorphous paroxetine hydrochloride or sertraline hydrochloride is provided, which comprises preparing a solution in which paroxetine hydrochloride or sertraline...
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6710087 |
Methods of treating or preventing neuropathic pain using sibutramine metabolites
Methods of making and using racemic and optically pure metabolites of sibutramine, and pharmaceutically acceptable salts, solvates, and clathrates thereof, are disclosed. Pharmaceutical...
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6696472 |
Substituted N-phenoxy-N-phenyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer...
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6696495 |
Treatment of disorders secondary to organic impairments
A method for treatment of neuropsychiatric symptoms or disorders emanating from primary brain or systemic impairments includes administration of an effective dose of a dopamine, serotonin, and...
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6696484 |
Method and compositions for regulation of 5-alpha reductase activity
Pharmaceutical compositions and methods for treating androgen related disorders. The pharmaceutical compositions may include a 5α-reductase inhibitor, such as natural and synthetic flavanoids,...
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6689815 |
Intratumoral use of dinitrochorobenzene: composition and use of injections including particular applications
Dinitrohalogenated compounds may be utilized by injection in certain clinical situations to provide a possibility of long term control of human malignancy. In some of those settings no other...
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6677381 |
Guaifenesin tannate
The invention pertains to a novel composition comprising guaifenesin tannate and to a method for preparing guaifenesin tannate by reacting guaifenesin with tannic acid at a temperature above the...
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6673788 |
Electrophilic ketones for the treatment of herpesvirus infections
A class of compounds is described which can be used for the treatment of viral infections. Compounds of particular interest are defined by Formula II: wherein each of R 1 , R 2 , and R 3 is...
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6673794 |
Substituted aminomethyl-phenyl-cyclohexane derivatives
A substituted aminomethyl-phenyl-cyclohexane derivative of formula I or Ia, and their a diastereomer, enantiomer, or of a salt formed with a physiologically tolerated acid. Also disclosed are...
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6660774 |
Use of (&plus )-tramadol, O-demethyltramadol or (&plus )-O-demethyl-tramadol, O-desmethyl-N-mono-desmethyl-tramadol or (&plus )- O-desmethyl-N-mono-desmethyltramadol
Method for the treatment of increased urinary urgency or urinary incontinence comprising administering (+)-tramadol, O-demethyltramadol, (+)-O-demethyltramadol,...
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6660737 |
Medicinal uses of hydrazones
Compounds having a structure according to Formula (I): are effective in a method of increasing erythropoietin and vascularization of tissue in a subject in need thereof.
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6642275 |
Formulation for respiratory tract administration
A dosage form for intranasal and/or inhalation administration of an analgesic having low opioid receptor binding activity to a warm blooded animal, that includes a pharmaceutically effective amount...
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6638981 |
Topical compositions and methods for treating pain
Topical compositions and methods for treating pain. The invention provides oil-in-water emulsions comprising an antidepressant; an NMDA-receptor antagonists; a lipophilic component; water; and a...
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6624201 |
HIGH PURITY (1R,2S,4R)-(−)-2-&lsqb (2′-&lcub N,N-DIMETHYLAMINO&rcub -ETHOXY)&rsqb -2-&lsqb PHENYL&rsqb -1,7,7 -TRI-&lsqb METHYL&rsqb -BICYCLO &lsqb 2.2.1&rsqb HEPTANE AND PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF AND A PROCESS FOR THE PREPARATION OF THESE COMPOUNDS AS WELL AS MEDICAMENTS CONTAINING 1 OR MORE OF THESE COMPOUNDS AND THEIR USE
The invention relates to high purity (1R,2S,4R)-(−)-2-[(2′-{N,N-dimethylamino}-ethoxy)]-2-[ph
enyl]-1,7,7-tri-[methyl]-bicyclo[2.2.1]heptane and pharmaceutically acceptable acid addition salts...
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6617361 |
Behavior chemotherapy
A protocol for prevention of Alzheimer's disease onset is described. The protocol involves stimulating the implicit memory, followed by continuing such stimulation in conjunction with psychological...
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6617360 |
Medical treatment
A compound of formula I or a pharmaceutically acceptable salt thereof in which R 1 and R 2 are independently H or methyl (for example...
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6610316 |
Disinfection by particle-bound and insolubilized detergents
A detergent such as nonionic, cationic or anionic detergents and preferably a “sugar detergent” such as octyl-glucopyranoside is rendered insoluble by being bound to an inert substrate. This...
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6605644 |
Analgesic regimen
A regimen for the administration of tramadol for the treatment of analgesia is described. The regimen involves a slower initial titration rate of tramadol which results in a significantly lower...
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6599941 |
Insecticide and insect repellant compositions
A non-toxic, environmentally safe and easily employable insecticide and insect repellent is achieved by providing an aqueous composition incorporating ethanolamine based compounds, either...
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6593373 |
Pharmaceutical compositions of O-desmethyl-N-mono-desmethyl-tramadol
A method of producing pharmaceutical compositions using O-desmethyl-N-mono-desmethyl-tramadol for the treatment of pain and various related indications, pharmaceutical compositions containing...
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6593340 |
Pharmaceutical compositions containing N-propargylphentermine and related analogs to treat neurodegeneration and/or depression
The present invention relates to N-propargylphentermine and its derivatives and the neuroprotective and anti-depressant activity of such compounds as well as therapeutic methods for such compounds.
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6579906 |
Dendrimer biocide-silver nanocomposites: their preparation and applications as potent antimicrobials
A novel cationic dendrimer biocide-silver nanocomposite and methods for its use as a biocide. The biocidal nanocomposites of the present invention are effective against a variety of microbial...
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6576660 |
Methods and compositions for regulation of 5-α-reductase activity
Compounds that inhibit 5-alpha-reductase are provided. The compounds are used to treat prostate cancer, breast cancer, obesity, skin disorders and baldness.
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6569850 |
Treatment of multiple sclerosis (MS) and other demyelinating conditions using lofepramine in combination with L-phenylalanine, tyrosine or tyrptophan and possibly a vitamin B12 compound
Method for treating multiple sclerosis or encephalomyelitis by administering to a patient a combination of a tricyclic antidepressant drug and tyrosine or phenylalanine or both.
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