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8956604 Conjugates comprising an N-oxime bond and associated methods  
Conjugates comprising a N-oxime bond are disclosed. In one embodiment, a suitable conjugate is represented by the following Formula (I): wherein R′ is derived from a compound comprising at least...
8912214 Use of Chk2 kinase inhibitors for cancer treatment  
Described herein are Chk2-inhibitor compounds and derivatives thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions thereof.
8877784 TRPA1 antagonists  
Compounds of formula (I) wherein R1, R2, R3, and Y are defined in the description are TRPA1 antagonists. Compositions comprising such compounds and methods for treating conditions and disorders...
8846719 Isoxazolo-pyridine derivatives  
The present invention is concerned with isoxazole-pyridine derivatives of formula I wherein X, R1 to R6 are as described herein. The compounds are active on the GABA A α5 receptor binding site and...
8841300 Treatment for Parkinson's disease—combination high dose serotonergic synaptic reuptake inhibitor with phosphodiesterase inhibitor  
A new treatment methodology and pharmacological composition for the treatment and remission of Parkinson's Disease and other neurological diseases are provided. The medication and treatment are...
8772345 Oximes for treatment of peripheral and central nervous system exposure to acetyl cholinesterase inhibitors  
The present invention relates to non-charged oxime compounds which are acetyl cholinesterase (AChE) reactivators of inhibited AChE and which protect against organophosphate poisoning both...
8758788 Fungicidally active compound combinations  
Active compound mixtures comprising ipconazole and at least one further fungicidally active compound are highly suitable for protecting industrial materials against colonization and destruction by...
8759350 Carbostyril derivatives and serotonin reuptake inhibitors for treatment of mood disorders  
The pharmaceutical composition of the present invention comprises (1) a carbostyril derivative and (2) a serotonin reuptake inhibitor in a pharmaceutically acceptable carrier. The carbostyril...
8722669 Compounds and methods of treating ocular disorders  
A method of treating an ocular disorder in a subject associated with aberrant all-trans-retinal clearance in the retina, the method comprising administering to the subject a therapeutically...
8633249 Adjuvant chemotherapy for anaplastic gliomas  
The present invention involves the use of 2,4-disulfonyl phenyl tert-butyl nitrone (2,4-ds-PBN) in the treatment and prevention of gliomas. The 2,4-ds-PBN may be used alone or combined with other...
8536157 Non-steroidal compounds  
The present invention relates to non-steroidal compounds useful in the treatment of inflammatory conditions and pharmaceutical compositions comprising them. A representative example of these...
8536120 Ghrelin/growth hormone releasing peptide/growth hormone secretatogue receptor antagonists and uses thereof  
The present invention provides novel compounds that have been demonstrated to be modulators of the ghrelin receptor (growth hormone secretagogue receptor, GHS-R1a and subtypes, iso forms and...
8492441 Dosage regimen of an S1P receptor agonist  
S1P receptor modulators or agonists are administered following a dosage regimen whereby during the initial days of treatment the daily dosage is lower than the standard daily dosage.
8475850 Methods and compositions for heavy metal detoxification  
Compositions and methods for enhancing heavy metal detoxification are described. The compositions and methods described provide enhanced activity of key detoxification systems including that the...
8440671 Compositions comprising a phoshodiesterase-5 inhibitor and their use in methods of treatment  
The invention relates generally to novel pharmaceutical methods for the treatment of various conditions. Compositions comprising: at least one phosphodiesterase-5-inhibitor in combination with one...
8420595 Methods for treating acute acoustic trauma  
The current invention provides methods and compositions for treating sensorineural hearing loss including but not limited to acute acoustic trauma (AAT). The composition includes compounds which...
8338488 Use of at least one oxime derivative of 3,5-seco-4-nor-cholestane as antioxidants  
The invention relates to the use of at least one oxime derivative of 3,5-seco-4-norcholestane as antioxidants in the cosmetics and food fields, and as antioxidant preservatives that can be used,...
8318780 Methods of administering pirfenidone therapy  
The present invention relates to methods involving avoiding adverse drug interactions with fluvoxamine and pirfenidone or other moderate to strong inhibitors of CYP enzymes.
8293708 Liquid formulations N-terminal serine of pegylated growth hormone  
Pharmaceutical compositions comprising pegylated growth hormone at pH 7 or below are provided.
8013002 Methods of administering pirfenidone therapy  
The present invention relates to methods involving avoiding adverse drug interactions with fluvoxamine and pirfenidone or other moderate to strong inhibitors of CYP enzymes.
7985774 Use of 3,5-seco-4-nor-cholestane derivatives for obtaining a cytoprotective drug  
The present invention relates to the use of 3,5-seco-4-nor-cholestane derivatives for obtaining a cytoprotective drug, with the exception of a neuroprotective drug, notably a cardioprotective or...
7910610 Methods of administering pirfenidone therapy  
The present invention relates to methods involving avoiding adverse drug interactions with fluvoxamine and pirfenidone or other moderate to strong inhibitors of CYP enzymes.
7816383 Methods of administering pirfenidone therapy  
The present invention relates to methods involving avoiding adverse drug interactions with fluvoxamine and pirfenidone or other moderate to strong inhibitors of CYP enzymes.
7741323 Indene derivatives and process for the preparation thereof  
An indene derivative for selectively modulating the activities of peroxisome proliferator activated receptors (PPARs) having the following formula (I): wherein, R1 is C1-6 alkyl, C1-6 alkenyl, or...
7741352 KCNQ channel modulating compounds and their pharmaceutical use  
This invention relates to novel compounds useful as modulators of the KCNQ channel, to pharmaceutical compositions comprising these compounds, and to methods of treatment herewith.
7727967 Cyanooxime inhibitors of carbonyl reductase and methods of using said inhibitors in treatments involving anthracyclines  
Compositions of matter for treating cancer patients are used to prevent or limit cardiotoxicity during or after treatment with anthracycline drugs, and to prevent or lower resistance to...
7718715 pH-modified latex comprising a synergistic combination of biocides  
A stabilized latex with improved antimicrobial features is disclosed. In preferred embodiments, this latex comprises a mixture of 2-bromo-2-nitro-1,3-propanediol and 4,4-dimethyl-oxazolidine or...
7718704 Immunosuppressant compounds and compositions  
The invention provides a novel class of cyclic oximes of Formula I: wherein A, X, Y, Z, W, R1, R2, R3 and n are as described in the summary of the invention; useful in the treatment or prevention...
7642280 Inhibitors of acyl glucosaminyl inositol amidase and methods of use  
The present invention provides compounds with activity as inhibitors of acyl glucosaminylinositol amidases with amidase activity against S-conjugate amides, particularly mycothiol-derived...
7642291 O-acyloxime derivatives, preparation method thereof, and pharmaceutical composition containing the same for prevention and treatment of cardiovascular disease  
The present invention relates to novel O-acyloxime derivatives, a preparation method thereof and a pharmaceutical composition comprising the same for prevention and treatment of cardiovascular...
7598289 Ketones and reduced ketones as therapeutic agents for the treatment of bone conditions  
The present invention pertains to certain ketones and reduced ketones and derivatives thereof which, inter alia, inhibit osteoclast survival, formation, and/or activity; and/or inhibit bone...
7582622 Steroids having a mixed androgenic and progestagenic profile  
The invention provides 19-nor-D-homosteroids, having a mixed androgenic/progestagenic profile, which are orally active, prevent trabecular bone mineral density (BMD) loss, and which lack liver...
7553834 Method for the targeted treatment of depression  
A method for determining the appropriate medication for a patient suffering from depression. A patient will take a questionnaire wherein the patient answers a number of questions with scaled...
7476673 Disubstituted chalcone oximes as selective agonists of RARγ retinoid receptors  
Compounds of the formula where the variables are as defined in the specification, are useful for preventing or treating emphysema and related pulmonary conditions of mammals and other diseases and...
7473709 11β-benzaldoxime derivatives of D-homooestra-4,9-dien-3-ones  
The present patent application relates to 11β-benzaldoxime derivatives of D-homooestra-4,9-dien-3-ones of formula I: wherein R1 is a hydrogen atom or a C1-C6-alkyl, C1-C6-acyl,...
7414042 Method and composition for selectively inhibiting melanoma  
Compositions and methods are disclosed for treating melanoma wherein a betulinic acid derivative is the active compound in the composition to be administered. The compositions are optionally...
7169817 Bis-aromatic alkanols  
The present invention relates to biphenylyl derivatives, processes for their production, their uses and pharmaceutical compositions containing them. Compounds according to the present invention...
7157491 Aryl-carbaldehyde oxime derivatives and their use as estrogenic agents  
This invention provides estrogen receptor modulators having the structure where R1–R5 are as defined in the specification; or a pharmaceutically acceptable salt thereof.
7138419 Process for manufacturing bulk solutions and a lyophilized pure α-aztreonam lysinate  
A process for manufacturing bulk solutions and lyophilized pure α-aztreonam lysinate for large scale production of an inhalable aztreonam is disclosed, as is a pure α-aztreonam lysinate for...
7101889 Lipase inhibiting composition  
The invention relates to compositions for treating dandruff comprising compounds that are non-polymeric and/or have a weight average molecular weight of less than about 1000. These compounds, when...
7087599 Estrogen receptor modulators  
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen...
7056919 Synergistic combination of fungicides to protect wood and wood-based products and wood treated by such combination as well as methods of making the same  
A wood treatment composition having a synergistic combination of fungicides which may include two or more compounds. These combinations are shown to be especially effective in providing resistance...
7026315 Fungicide mixtures which are based on derivatives of morpholine or piperidine and derivatives oxime ether  
Fungicidal mixtures, comprising as active components a) a morpholine or piperidine derivative I selected from the group of the compounds Ia, Ib, Ic and Id and b) compounds of the formula II in a...
6998419 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing the same  
Disclosed are 3,4,5-trisubstituted aryl nitrone compoundsd and pharmaceutical compositions containing such compounds. The 3,4,5-trisubstituted aryl nitrone compounds have formula (I); where R1–R4...
6949551 Dihalopropene compounds, processes for their preparation, compositions comprising them and their use as pesticides  
Dihalopropene compounds, process for their preparation, compositions comprising them and their use as pesticides What is described are dihalopropene compounds of the formula (I) in which R1 and R2...
6949557 Hydroanthracene based compounds as anticancer agents  
The invention relates to the use of novel anthracene based compounds for the inhibition or prevention of the growth or multiplication of cancer cells, and to therapeutic compositions containing...
6933319 Resorcinol derivatives  
The present invention relates to the use of certain resorcinol derivatives as skin lightening agents.
6831061 Apicidin-derivatives, their synthetic methods and anti-tumor compositions containing them  
A substituted apicidin derivative, a method of synthesis therefore, and an anti-tumor composition comprising the same are disclosed. The substituent of the derivative is preferably semicarbazone,...
6803385 Hydroxyeicosatetraenoic acid analogs and methods of their use in treating dry eye disorders  
Hydroxyeicosatetraenoic acid esters and methods of their use in treating dry eye disorders are disclosed.
6696480 Upregulation of type III endothelial cell nitric oxide synthase by agents that disrupt actin cytoskeletal organization  
A use for agents that disrupt actin cytoskeletal organization is provided. In the instant invention, agents that disrupt actin cytoskeletal organization are found to upregulate endothelial cell...

Matches 1 - 50 out of 229 1 2 3 4 5 >