|
Match
|
Document |
Document Title |
|
|
8168614 |
Boron-containing small molecules as anti-inflammatory agents
Methods of treating anti-inflammatory conditions through the use of boron-containing small molecules are disclosed.
|
|
|
8106031 |
Hydrolytically-resistant boron-containing therapeutics and methods of use
Compositions and methods of use of boron derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by fungi, yeast, bacteria...
|
|
|
8101588 |
Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith
Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and...
|
|
|
8058262 |
Proteasome inhibitors and methods of using the same
The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and...
|
|
|
8039451 |
Boron-containing small molecules
This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to...
|
|
|
8039450 |
Boron-containing small molecules as anti-inflammatory agents
Compounds and methods of treating anti-inflammatory conditions are disclosed.
|
|
|
7989486 |
Use of diindolylmethane-related indoles for the treatment and prevention of respiratory syncytial virus associated conditions
The present invention includes compositions and methods for the treatment and prevention of conditions associated with Respiratory Syncytial Virus (RSV) infection. RSV-associated conditions include...
|
|
|
7947663 |
Inhibitors of fatty acid amide hydrolase
The present invention provide compounds, and pharmaceutical compositions thereof, encompassed by the formulae (I), (II) or (III). The present invention also provides methods for treating an FAAH...
|
|
|
7932239 |
Methods of and compositions for reducing neuronal cell death
Methods and compositions involving a class of boron-protected phenylphosphine agents having increased cell permeability and having improved chemical stability for treating or for preventing...
|
|
|
7915236 |
Proteasome inhibitors and methods of using the same
The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and...
|
|
|
7910090 |
Non-irritating compositions
The present invention provides a base composition that allows for the formulation of non-irritating cosmetic and/or dermatological compositions. The base composition includes one or more of...
|
|
|
7858598 |
Reagents for detection of hypochlorous acid
Provided herein are compounds or hypochlorous acid probes which can be used as reagents for measuring, detecting and/or screening, directly or indirectly, hypochlorous acid or hypochlorite....
|
|
|
7825104 |
Methods and compositions for treating fungal infections
Phenylboronic acid and water soluble derivatives thereof and related boronic acid compounds are used for treating fungal and bacterial infections.
|
|
|
7816344 |
Boron-containing small molecules
This invention provides, among other things, novel oxaboroles which are monosubstituted at the 3-, 6-, or 7-position, or disubstituted at the 3-/6- or 3-/7- positions, which are useful for treating...
|
|
|
7816343 |
Wood preservative composition
A wood preservative composition comprising a mixture of a fungicide which is a combination of a boric acid ester, which is soluble in an organic solvent and has a sterically hindered di-alcohol or...
|
|
|
7767657 |
Boron-containing small molecules
This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to...
|
|
|
7731787 |
Stabilization of triphenylboron-pyridine
A method for stabilizing triphenylboron-pyridine (TPBP) in a solvent-based anti-fouling coating, such as a marine anti-fouling coating, by adding to the coating about 0.04 to about 0.40% wt., based...
|
|
|
7727964 |
Peptidomimetic inhibitors of post-proline cleaving enzymes
The present invention relates to inhibitors of post-proline cleaving enzymes, such as inhibitors of dipeptidyl peptidase IV, as well as pharmaceutical compositions thereof, and methods for using...
|
|
|
7671078 |
Isothiourea derivatives of imadazo[2,1-b]Thiazoles and 5,6-dihydro derivatives thereof useful as CXCR4 chemokine receptor inhibitors
The invention relates to isothiourea derivatives of formula I: wherein R1 is a residue of one of the following structures: where the variables are as defined in the claims of the invention, as well...
|
|
|
7652000 |
Boron-containing compounds and methods of use
Methods of treating and/or preventing surface infections, such as acne, in an animal, such as a human being, using antibiotics incorporating borinic acid complexes, especially picolinic acid...
|
|
|
7625939 |
Cyclopropyl-fused pyrrolidine derivatives as dipeptidyl peptidase IV inhibitors
The present invention relates to DP IV-inhibitors of formula (1) for the treatment and/or prophylaxis of diseases of mammals including cancer and tumors, metastasis and tumor colonization; and...
|
|
|
7582621 |
Boron-containing small molecules
This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to...
|
|
|
7572606 |
Biosyntheses of salinosporamide A and its analogs and related methods of making salinosporamide A and its analogs
Disclosed are methods of modulating biosynthesis of Salinosporamide A and its analogs, which are useful in treating cancer, inflammatory conditions, and/or infectious disease. The methods involve,...
|
|
|
7531526 |
Boronic ester and acid compounds, synthesis and uses
Disclosed herein is a method for reducing the rate of degradation of proteins in an animal, comprising contacting cells of the animal with certain boronic ester and acid compounds. Also disclosed...
|
|
|
7514469 |
Formulation of a mixture of Free-B-ring flavonoids and flavans as a therapeutic agent
The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compounds—Free-B-ring flavonoids and flavans—for use in the prevention and tre...
|
|
|
7485626 |
Combinations of enzyme inhibitor-containing preparations and the use thereof
The invention comprises a process wherein the DNA synthesis and, thus, the proliferation of mononuclear cells (MNZ) and of T cells as well is inhibited by the simultaneous and combined inhibition...
|
|
|
7476404 |
Composition for treatment of bone loss
The composition set forth provides for the treatment of bone loss and osteoporosis. The formulation combines Vitamin D; Calcium Citrate Malate; Potassium Citrate; Magnesium; Boron and Vitamin K....
|
|
|
7456156 |
Aryl boronic acids for treating obesity
Disclosed is a phenyl boronic acid compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aryl group.Z and Z′ are independently —O—, —NH— or —S—.X is an electron with...
|
|
|
7427608 |
Protection against and treatment of hearing loss
The present invention provides a method for protecting against or treating hearing loss in a subject. This method involves administering an effective amount of a protein tyrosine kinase inhibitor...
|
|
|
7371729 |
Boronic acid salts useful in parenteral formulations
Salts of a peptide boronic acid drug, for example of Cbz-(R)-Phe-(S)-Pro-(R)-Mpg-B(OH)2. The counter-ion to the boronate may be an alkali metal or derived from a strongly basic organic...
|
|
|
7326695 |
Anti-bacterial agents based upon oxoanion binding
Compounds of the structure I: are useful for treating bacterial growth, wherein E is selected from the group consisting of B, P, and S, T1 and T2 are each independently selected from the group...
|
|
|
7288533 |
Topical application for treating toenail fungus
A topical applications is used to treat and prevent the spread of nail infections or onychomycosis caused by bacteria, fungi and other pathogens. The topical application has a composition that...
|
|
|
7282491 |
Prokaryotic proteasomal proteases of Mycobacterium tuberculosis (MTB) as targets for antibiotic therapy
The present invention relates to methods of treating Mycobacterium pathogen infection in a subject that involve: inhibiting proteasomal activity in a pathogen under conditions effective to make the...
|
|
|
7267990 |
Chelation of charged and uncharged molecules with porphyrin-based compounds
Porphyrins containing one or more neutral or negatively-charged, closo- or nido-carborane substituents are useful as chelators. The carbon-carbon bonds linking the boron-containing groups to the...
|
|
|
7241459 |
Polymers containing bioactive glass with antimicrobial effect
The method of protecting a polymeric plastic from attack by bacteria and fungi includes providing bioactive glass particles having a mean particles size preferably less than 2 μm as an additive ...
|
|
|
7229969 |
Combinations of enzyme inhibitors and the use thereof
Combination of inhibitors of dipeptidyl peptidase IV (DP IV) and enzymes having the same substrate specificity (DP IV-analogous enzymatic activity) and inhibitors of alanyl aminopeptidase...
|
|
|
7223745 |
Proteasome inhibitors and methods of using the same
The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and...
|
|
|
7220732 |
Compounds useful as photodynamic therapeutic agents
The present invention relates to compounds of the formula or a salt, metal complex or hydrate or other solvate thereof, wherein: M is a chelating agent;R1, R2, R3, R4, R5 and R6 are independently...
|
|
|
7217701 |
Intracellular calcium concentration increase inhibitors
An intracellular calcium concentration increase inhibitor containing as the active ingredient (1) a boron compound represented by the formula (I). The compound represented by the formula (I)...
|
|
|
7217695 |
***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Peptidomimetic inhibitors of post-proline cleaving enzymes
The present invention relates to inhibitors of post-proline cleaving enzymes, such as inhibitors of dipeptidyl peptidase IV, as well as pharmaceutical compositions thereof, and methods for using...
|
|
|
7183267 |
β-lactamase inhibitors and methods of use thereof
The invention provides novel non-β-lactam inhibitors of β-lactamases. In particular, the invention provides boronic acid-based compounds set forth in the specification. These compounds may be u...
|
|
|
7112572 |
Multivalent metal salts of boronic acids
Salts of a pharmaceutically acceptable divalent metal and an organoboronic acid drug. Examples of such metals are calcium, magnesium and zinc. The organoboronic acid drug may be a boropeptide...
|
|
|
7094771 |
Pharmaceutical composition for boron neutron capture therapy containing triphenylboroxin
A pharmaceutical composition for boron neutron capture therapy (BNCT), and in particular for BNCT on hepatoma is disclosed. The pharmaceutical composition contains a therapeutically effective...
|
|
|
7084133 |
Dicarba-closo-dodecaborane derivatives
A compound represented by the following general formula (I), wherein R1 represents a hydroxy-substituted alkyl group, a hydroxy-substituted alkenyl group, a hydroxy-substituted arylalkyl group...
|
|
|
7037905 |
Pharmaceutical use of boronic acids and esters thereof
Use of compounds to inhibit hormone-sensitive lipase, the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds, method of treatment employing...
|
|
|
6958319 |
Formulation of boronic acid compounds
The present invention provides stable compounds prepared from boronic acid and lyophilized compounds thereof of the formula (1): in which Z1 and Z2 are moieties derived from sugar. The invention...
|
|
|
6933290 |
2-{N-(2-amino-3-(heteroaryl or aryl)propionyl)-aminoacyl}-amino}-alkylboronic acid derivatives
Disclosed are derivatives of 2-{[N-(2-amino-3-(heteroaryl or aryl)propionyl)-aminoacyl]-amino}-alkylboronic acid, processes for the preparation of such compounds, pharmaceutical preparations, and...
|
|
|
6924269 |
Enzyme inhibitors and methods therefor
An enzyme is inhibited by presenting the enzyme with a boron containing structure having a tetrahedral boron atom covalently bound to four ligands. Particularly preferred enzymes include...
|
|
|
6919036 |
Nonaborate compositions and their preparation
A family of borate compounds containing an isolated (finite) nonaborate anion with the structural formula [B9O12(OH)6]3−. Preferred amine nonaborate compounds have a resolved oxide formula of A...
|
|
|
6764692 |
Method to treat laminitis and reduce dietary intake for horses
A method of treating laminitis in a horse is disclosed, comprising administering to the horse a naturally chelated trace mineral composition; promoting healthy skin, hair and hoof tissue. A method...
|