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8183296 Pesticide phenyloxy substituted phenylamidine derivatives  
The present invention relates to 2,5-di-substituted-4-phenyloxy-substituted-phenyl-amidine derivatives of formula (I) in which the substituents are as in the description, their process of...
8183414 N-(1-phenyl-2-arylethyl)-4,5-dihydro-2H-pyrrol-5-amine compounds as subtype selective modulators of ALPHA2B or ALPHA2B and ALPHA2C adrenoceptors  
The present invention provides compounds which are N-(1-phenyl-2-arylethyl)-4,5-dihydro-2H-pyrrol-5-amine compounds and are subtype selective modulators of alpha 2B or alpha 2B and alpha 2C...
8119640 Hedgehog pathway antagonists methods of use  
The present disclosure provides for compounds, pharmaceutical preparations, kits and methods for the inhibition of the Hh pathway and the alleviation of cancer and developmental disorders...
8008352 Pentafluorosulfanylbenzoylguanidines, processes for their preparation, their use as medicaments or diagnostic aids, and medicaments comprising them  
Pentafluorosulfanylbenzoylguanidines, of the formula I and II in which R1 to R4 have the meanings stated in the claims, are suitable as antiarrhythmic medicaments with a cardioprotective component...
7947741 Use and administration of bacterial efflux pump inhibitors  
This invention provides for efflux pump inhibitors to be co-administered with antimicrobial agents for the treatment of infections caused by drug resistant pathogens, novel efflux pump inhibitors,...
7928137 Meta-benzamidine derivatives as serine protease inhibitors  
Compounds of formula I in which R1, R2, R3, each X, L, Y, Cy, Lp, D and n have the meanings as set out in the specification, and corresponding compounds in which the unsubstituted or substituted...
7592374 Insecticidal nitromethylene compounds  
A composition of matter is disclosed that comprises a compound of the formula: wherein R1 is selected from the group consisting of unsubstituted and substituted biphenyl moieties, unsubstituted and...
7488757 Invisible antimicrobial glove and hand antiseptic  
An alcohol based hand surgical scrub, which includes cationic anti-microbial agent preservatives, cationic polymer film-forming agents and a skin emollient, and provides a long term residual,...
7262223 Amidine derivatives for treating amyloidosis  
The present invention relates to the use of amidine compounds in the treatment of amyloid-related diseases. In particular, the invention relates to a method of treating or preventing an...
7220781 Meta-benzamidine derivatives as serine protease inhibitors  
Compounds of formula I in which R1, R2, R3, each X, L, Y, Cy, Lp, D and n have the meanings as set out in the specification, and corresponding compounds in which the unsubstituted or substituted...
7157078 Devices and methods for eliminating termite colonies  
This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing a) a termiticide selected such...
7078400 20-HETE synthase inhibitor  
The present invention relates to an inhibitor for production of 20-hydroxyeicosatetraenoic acid, comprising, as an effective ingredient, specific hydroxyformamidine derivatives or...
6936597 Prodrugs of anticancer agents employing substituted aromatic acids  
Polymeric prodrugs of the formula: wherein B is selected from the group consisting of OH, leaving groups, residues of amine-containing moieties and a residues of hydroxyl-containing moieties;Y1 is...
6921752 Use of LTB4 antagonists in veterinary medicine  
The invention relates to the use of LTB4 antagonists for preparing a pharmaceutical composition for the treatment or prevention of respiratory diseases in companion and domesticated animals.
6906076 Compounds and methods of use to treat infectious diseases  
The present invention concerns alkyl aryl carbonyl compounds that possess anti-infective activity. The compounds of the invention can be used to target specific nuclear localization signal, thereby...
6864254 Inhibitor for 20-hete-yielding enzyme  
An inhibitor for 20-hydroxyeicosatetraenoic acid production which comprises as the active ingredient a specific hydroxyformamidine derivative or a pharmacologically acceptable salt thereof. It is...
6852761 Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade  
The invention relates to polycyclic aryl and heteroaryl substituted benzene compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for...
6825231 Substituted norbornylamino derivatives, processes for their preparation, their use as medicaments or diagnostics, and a medicament comprising them  
The application discloses substituted norbornylamino derivatives, processes for their preparation, their use as medicaments or diagnostics and a medicament comprising them Substituted...
6767548 Gel inhibited liquid carrier for a biocide containing a carbodiimide and an emulsifier mixture  
This invention relates to a biocidal composition resistant to the formation of a gel and to the method for stabilizing a concentrate containing, in addition to the biocide, a carbodiimide, a...
6740653 Shelf life extension of microemulsions containing active aza biocide  
This invention relates to the stabilization of o/w microemulsions containing an active aza biocide by addition of an alkaline, water soluble buffering agent in an amount sufficient to adjust the pH...
6737077 Proteinaceous animal chew with dentally therapeutic cation  
This invention relates to chewable objects for animals which contain, as a dentally therapeutic ingredient, one or more cationic substances. The inventive therapeutic animal chews are of sufficient...
6706745 Biphenylamidine derivatives  
The present invention relates to a biphenylamidine derivative of the general formula (1): or a pharmaceutically acceptable salt thereof, which is a novel compound functioning as a clinically...
6664295 Fungicidal phenylamidine derivatives  
The invention provides fungicidal compounds of formula I and salts thereof: whereinthe various radicals and substituents are as defined in the description,fungicidal compositions containing them...
6641800 Pressurized aerosol compositions comprising powdered medicament dispersed in hydrofluoroalkane  
Pressurized aerosol composition for administration by inhalation comprising a liquefied hydrofluoroalkane, a powdered medicament dispersed therein, and a suspending agent comprising a polymer...
6635668 Imidazoline receptor binding compounds  
Pentamidine and analogs thereof have activity as imidazoline receptor binding compounds. A method of binding the imidazoline receptor, comprises contacting a bis-benzene to said imidazoline...
6576669 Use of an LTB4 antagonist for the treatment or prevention of diseases caused by increased expression of mucin genes  
Medicaments and pharmaceutical kits comprising an LTB4 antagonist of formula (I) a tautomer thereof or a pharmaceutically acceptable salt thereof, and methods of treating or preventing cystic...
6534546 Aniline derivatives possessing an inhibitory effect of nitric oxide synthase  
Compounds represented by the general formula (1):  (where R1 is SR6 or NR7R8, where R6 is typically an alkyl group having 1-6 carbon atoms, R7 is a hydrogen atom, an alkyl group having 1-6 carbon a...
6534543 Oxa acids and related compounds for treating skin conditions  
The present invention is directed to the use of compounds of Formula (I), as active principals for treating skin conditions and compositions containing these compounds wherein R4 is...
6528491 Pyranoside derivatives  
The present invention relates to new pyranoside derivatives of general formula I, processes for preparing them as well as their use as medicaments:
6500823 Unsaturated hydroximic acid derivatives as per abstract inhibitors  
The object of the invention consists of novel unsaturated hydroximic acid derivatives, the process for their preparation and as active substance such as compounds containing pharmaceutical...
6489365 Amidine derivatives, the preparation and use thereof as medicaments with Itb4 antagonistic effect  
Compounds of the formula which is explained more fully in the specification, may be prepared by conventional methods and used therapeutically in conventional galenic preparations.
6479524 Substituted aryl and heteroaryl derivatives, their production and their use as medicines  
Compounds that prolong thrombin time. Exemplary are: (a) rac-4-{3-[5-ethoxycarbonylmethyl-2-methyl-4-(2-methyl-pyrrol idinocarbonyl)-phenyl]-propargylamino}benzamidine,(b)...
6444706 Guanidine derivatives, processes for preparing them and their use as pharmaceutical compositions  
The invention concerns new guanidine derivatives of formula (I), methods of preparing them and their use in drugs containing such compounds.
6414020 Amidino protease inhibitors  
Amidino and benzamidino compounds, including compounds of the formula: wherein R1-R4, R6-R9, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically...
6340700 2-(iminomethyl) amino-phenyl derivatives, preparation, application as medicines and pharmaceutical compositions containing same  
A compound of the formula wherein the substituents are defined as in the specification and their pharmaceutically acceptable salts having NOS and ROS activity.
6333356 Compounds for treating skin conditions  
The present invention is directed to the use of compounds of Formula (I), as active principals for treating skin conditions and compositions containing these compounds; ##STR1##wherein R4 is (CR5...
6319944 Aryl amidines, compositions containing such compounds and methods of use  
Compounds represented by formula I: ##STR1##or a pharmaceutically acceptable salt or hydrate thereof, are disclosed.Pharmaceutical compositions and methods of treatment are also included.
RE37438 Acetamidine derivatives and their use as inhibitors for the nitric oxide synthase  
A class of acetamidine derivatives of general formula (I) ##STR1##wherein R1 is hydrogen, C1-6 hydrocarbyl group optionally substituted by halo, halo, nitro, cyano or a group XR3 wherein X is...
6300342 Antithrombotic phenylalkyl derivatives  
Antithrombotic phenylalkyl derivatives of the formula ##STR1##Exemplary compounds are: (a) 1-[3-(4-amidino-phenyl)propionyl]-6-(4-fluoro-phenylsulphona mido)-1,2,3,4- tetrahydro-quinoline, (b)...
6291531 LTB4 antagonist, processes for the preparation thereof and its use as a pharmaceutical composition  
The present invention relates to a new LTB4 antagonist, processes for the preparation thereof and its use as a pharmaceutical composition.
6262106 Adamantanecarboximidamide derivatives and their use as NMDA antagonists  
##STR1##The compound of the above formula wherein R1-R5 are independently selected from hydrogen, alkyl and aryl and prodrugs thereof; and pharmaceutically acceptable salts thereof; and use of the...
6156741 Therapeutic substituted guanidines  
The present invention provides therapeutically useful substituted guanidines of the following Formula: ##STR1## and methods of treatment and pharmaceutical compositions that utilize or comprise one...
6143790 L-N6 -(1-iminoethyl)lysine derivatives useful as nitric oxide synthase inhibitors  
There is disclosed a novel amino glycol derivatives of L-N6 -(1-iminoethyl)lysine, pharmaceutical compositions containing these novel compounds, and to their use in therapy, in particular their use...
6140350 Method for controlling ectoparasites  
A method for controlling ectoparasites systemically through host animal blood which comprises administering at least one neonocotinoid compound among those defined in the specification to the host...
6136833 Pharmaceutical formulations and process for their preparation  
Provided is a pharmaceutical composition comprising a tablet or capsule containing a pharmacologically effective amount of a pharmaceutical compound, or a pharmaceutically acceptable salt thereof,...
6127423 Phenylamidine derivatives, a process for preparing the same and their use as medicaments  
The invention relates to new phenylamidine derivatives, processes for preparing them and their use as pharmaceutical compositions. The phenylamidines according to the invention correspond to the...
6110944 LTA4, hydrolase inhibitors  
The present invention provides compounds having the structure Ar1 --Q--Ar2 --O--(CH2)n --Zand pharmaceutically acceptable salts and stereoisomers thereof that are useful in the treatment of...
6048862 Benzylamidine derivatives with serotonin receptor binding activity  
This invention relates to compounds having serotonin receptor binding activity and to their medical use, particularly in the treatment of CNS conditions such as migraine. Described herein are...
6030985 Amidine derivatives with nitric oxide synthetase activities  
The present invention relates to methods and compositions useful for treating and preventing conditions in which inhibition of nitric oxide synthetase is beneficial. These conditions include...
5981580 Fatty acid analogs and prodrugs  
Novel derivatives of fatty acid analogs that have from one to three heteroatoms in the fatty acid moiety which can be oxygen, sulfur or nitrogen, are disclosed in which the carboxy-terminus has...
Matches 1 - 50 out of 120 1 2 3 >