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7592374 |
Insecticidal nitromethylene compounds
A composition of matter is disclosed that comprises a compound of the formula:
wherein
R 1 is selected from the group consisting of unsubstituted and substituted biphenyl moieties,...
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7488757 |
Invisible antimicrobial glove and hand antiseptic
An alcohol based hand surgical scrub, which includes cationic anti-microbial agent preservatives, cationic polymer film-forming agents and a skin emollient, and provides a long term residual,...
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7262223 |
Amidine derivatives for treating amyloidosis
The present invention relates to the use of amidine compounds in the treatment of amyloid-related diseases. In particular, the invention relates to a method of treating or preventing an...
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7220781 |
Meta-benzamidine derivatives as serine protease inhibitors
Compounds of formula I
in which R 1 , R 2 , R 3 , each X, L, Y, Cy, Lp, D and n have the meanings as set out in the specification, and corresponding compounds in which the unsubstituted or...
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7157078 |
Devices and methods for eliminating termite colonies
This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing
a) a termiticide selected...
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7122535 |
Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them
A method of treating pain in a warm-blooded animal comprising administering to anwarm-blooded animal in need thereof an amount of a compound of the formula
wherein the substituents are defined...
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7078400 |
20-HETE synthase inhibitor
The present invention relates to an inhibitor for production of 20-hydroxyeicosatetraenoic acid, comprising, as an effective ingredient, specific hydroxyformamidine derivatives or...
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6936597 |
Prodrugs of anticancer agents employing substituted aromatic acids
Polymeric prodrugs of the formula:
wherein
B is selected from the group consisting of OH, leaving groups, residues of amine-containing moieties and a residues of hydroxyl-containing...
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6921752 |
Use of LTB4 antagonists in veterinary medicine
The invention relates to the use of LTB 4 antagonists for preparing a pharmaceutical composition for the treatment or prevention of respiratory diseases in companion and domesticated animals.
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6906076 |
Compounds and methods of use to treat infectious diseases
The present invention concerns alkyl aryl carbonyl compounds that possess anti-infective activity. The compounds of the invention can be used to target specific nuclear localization signal, thereby...
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6864254 |
Inhibitor for 20-hete-yielding enzyme
An inhibitor for 20-hydroxyeicosatetraenoic acid production which comprises as the active ingredient a specific hydroxyformamidine derivative or a pharmacologically acceptable salt thereof. It is...
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6852761 |
Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade
The invention relates to polycyclic aryl and heteroaryl substituted benzene compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for...
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6825231 |
Substituted norbornylamino derivatives, processes for their preparation, their use as medicaments or diagnostics, and a medicament comprising them
The application discloses substituted norbornylamino derivatives, processes for their preparation, their use as medicaments or diagnostics and a medicament comprising them Substituted...
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6767548 |
Gel inhibited liquid carrier for a biocide containing a carbodiimide and an emulsifier mixture
This invention relates to a biocidal composition resistant to the formation of a gel and to the method for stabilizing a concentrate containing, in addition to the biocide, a carbodiimide, a...
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6740653 |
Shelf life extension of microemulsions containing active aza biocide
This invention relates to the stabilization of o/w microemulsions containing an active aza biocide by addition of an alkaline, water soluble buffering agent in an amount sufficient to adjust the pH...
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6737077 |
Proteinaceous animal chew with dentally therapeutic cation
This invention relates to chewable objects for animals which contain, as a dentally therapeutic ingredient, one or more cationic substances. The inventive therapeutic animal chews are of sufficient...
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6706745 |
Biphenylamidine derivatives
The present invention relates to a biphenylamidine derivative of the general formula (1): or a pharmaceutically acceptable salt thereof, which is a novel compound functioning as a clinically...
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6664295 |
Fungicidal phenylamidine derivatives
The invention provides fungicidal compounds of formula I and salts thereof: wherein the various radicals and substituents are as defined in the description, fungicidal compositions containing...
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6641800 |
Pressurized aerosol compositions comprising powdered medicament dispersed in hydrofluoroalkane
Pressurized aerosol composition for administration by inhalation comprising a liquefied hydrofluoroalkane, a powdered medicament dispersed therein, and a suspending agent comprising a polymer...
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6635668 |
Imidazoline receptor binding compounds
Pentamidine and analogs thereof have activity as imidazoline receptor binding compounds. A method of binding the imidazoline receptor, comprises contacting a bis-benzene to said imidazoline...
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6576669 |
Use of an LTB4 antagonist for the treatment or prevention of diseases caused by increased expression of mucin genes
Medicaments and pharmaceutical kits comprising an LTB 4 antagonist of formula (I) a tautomer thereof or a pharmaceutically acceptable salt thereof, and methods of treating or preventing cystic...
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6545055 |
Inhibitors of factor Xa
Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating...
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6534546 |
Aniline derivatives possessing an inhibitory effect of nitric oxide synthase
Compounds represented by the general formula (1): (where R 1 is SR 6 or NR 7 R 8 , where R 6 is typically an alkyl group having 1-6 carbon atoms, R 7 is a hydrogen atom, an alkyl group...
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6534543 |
Oxa acids and related compounds for treating skin conditions
The present invention is directed to the use of compounds of Formula (I), as active principals for treating skin conditions and compositions containing these compounds wherein R 4 is (CR 5 R 6...
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6528491 |
Pyranoside derivatives
The present invention relates to new pyranoside derivatives of general formula I, processes for preparing them as well as their use as medicaments:
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6500823 |
Unsaturated hydroximic acid derivatives as per abstract inhibitors
The object of the invention consists of novel unsaturated hydroximic acid derivatives, the process for their preparation and as active substance such as compounds containing pharmaceutical...
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6489365 |
Amidine derivatives, the preparation and use thereof as medicaments with Itb4 antagonistic effect
Compounds of the formula which is explained more fully in the specification, may be prepared by conventional methods and used therapeutically in conventional galenic preparations.
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6479524 |
Substituted aryl and heteroaryl derivatives, their production and their use as medicines
Compounds that prolong thrombin time. Exemplary are: (a) rac-4-{3-[5-ethoxycarbonylmethyl-2-methyl-4-(2-methyl-pyrrol
idinocarbonyl)-phenyl]-propargylamino}benzamidine, (b)...
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6444706 |
Guanidine derivatives, processes for preparing them and their use as pharmaceutical compositions
The invention concerns new guanidine derivatives of formula (I), methods of preparing them and their use in drugs containing such compounds.
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6414020 |
Amidino protease inhibitors
Amidino and benzamidino compounds, including compounds of the formula: wherein R 1 -R 4 , R 6 -R 9 , Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or...
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6340700 |
2-(iminomethyl) amino-phenyl derivatives, preparation, application as medicines and pharmaceutical compositions containing same
A compound of the formula wherein the substituents are defined as in the specification and their pharmaceutically acceptable salts having NOS and ROS activity.
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6333356 |
Compounds for treating skin conditions
The present invention is directed to the use of compounds of Formula (I), as active principals for treating skin conditions and compositions containing these compounds; ##STR1## wherein R 4 is (CR...
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6319944 |
Aryl amidines, compositions containing such compounds and methods of use
Compounds represented by formula I: ##STR1## or a pharmaceutically acceptable salt or hydrate thereof, are disclosed. Pharmaceutical compositions and methods of treatment are also included.
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RE37438 |
Acetamidine derivatives and their use as inhibitors for the nitric oxide synthase
A class of acetamidine derivatives of general formula (I) ##STR1## wherein R 1 is hydrogen, C 1 -6 hydrocarbyl group optionally substituted by halo, halo, nitro, cyano or a group XR 3 wherein X...
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6300342 |
Antithrombotic phenylalkyl derivatives
Antithrombotic phenylalkyl derivatives of the formula ##STR1## Exemplary compounds are: (a) 1-[3-(4-amidino-phenyl)propionyl]-6-(4-fluoro-phenylsulphona
mido)-1,2,3,4- tetrahydro-quinoline, ...
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6291531 |
LTB4 antagonist, processes for the preparation thereof and its use as a pharmaceutical composition
The present invention relates to a new LTB 4 antagonist, processes for the preparation thereof and its use as a pharmaceutical composition.
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6262106 |
Adamantanecarboximidamide derivatives and their use as NMDA antagonists
##STR1## The compound of the above formula wherein R1-R5 are independently selected from hydrogen, alkyl and aryl and prodrugs thereof; and pharmaceutically acceptable salts thereof; and use of the...
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6156741 |
Therapeutic substituted guanidines
The present invention provides therapeutically useful substituted guanidines of the following Formula: ##STR1## and methods of treatment and pharmaceutical compositions that utilize or comprise one...
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6143790 |
L-N.sup.6 -(1-iminoethyl)lysine derivatives useful as nitric oxide synthase inhibitors
There is disclosed a novel amino glycol derivatives of L-N 6 -(1-iminoethyl)lysine, pharmaceutical compositions containing these novel compounds, and to their use in therapy, in particular their...
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6140350 |
Method for controlling ectoparasites
A method for controlling ectoparasites systemically through host animal blood which comprises administering at least one neonocotinoid compound among those defined in the specification to the host...
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6136833 |
Pharmaceutical formulations and process for their preparation
Provided is a pharmaceutical composition comprising a tablet or capsule containing a pharmacologically effective amount of a pharmaceutical compound, or a pharmaceutically acceptable salt thereof,...
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6127423 |
Phenylamidine derivatives, a process for preparing the same and their use as medicaments
The invention relates to new phenylamidine derivatives, processes for preparing them and their use as pharmaceutical compositions. The phenylamidines according to the invention correspond to the...
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6110944 |
LTA.sub.4, hydrolase inhibitors
The present invention provides compounds having the structure Ar 1 --Q--Ar 2 --O--(CH 2 ) n --Z and pharmaceutically acceptable salts and stereoisomers thereof that are useful in the treatment...
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6048862 |
Benzylamidine derivatives with serotonin receptor binding activity
This invention relates to compounds having serotonin receptor binding activity and to their medical use, particularly in the treatment of CNS conditions such as migraine. Described herein are...
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6030985 |
Amidine derivatives with nitric oxide synthetase activities
The present invention relates to methods and compositions useful for treating and preventing conditions in which inhibition of nitric oxide synthetase is beneficial. These conditions include...
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5981580 |
Fatty acid analogs and prodrugs
Novel derivatives of fatty acid analogs that have from one to three heteroatoms in the fatty acid moiety which can be oxygen, sulfur or nitrogen, are disclosed in which the carboxy-terminus has...
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5942547 |
2-Deoxystreptamine derivatives, pharmaceutical compositions thereof and therapeutic methods using same
This invention provides a compound having the formula: ##STR1## wherein R 1 and R 3 independently are hydrogen, --CHO, --COCH 3 , --COR 7 , --A--Ar--(Q) z , etc.; wherein D is a C 1 -6 linear, C...
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5872138 |
Thrombin inhibitors
A compound which inhibits human thrombin and which has the general structure ##STR1##
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5869067 |
Bi-aromatic compounds and pharmaceutical and cosmetic compositions
The present invention relates to new aromatic compounds, to their preparation and to their use in human and veterinary medicine and in cosmetic compositions.
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5830917 |
L-N.sup.6 -(1-iminoethyl) lysine derivatives useful as nitric oxide synthase inhibitors
There is disclosed a novel amino alcohol amine derivatives of L-N 6 -(1-iminoethyl)lysine, pharmaceutical compositions containing these novel compounds, and to their use in therapy, in particular...
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