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7588779 |
Pharmaceutical formulation containing a biguanide and an angiotensin antagonist
A pharmaceutical dosage form comprising a controlled release component comprising an antihyperglycemic drug in combination with a second component comprising a angiotensin antagonist is herein...
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7488757 |
Invisible antimicrobial glove and hand antiseptic
An alcohol based hand surgical scrub, which includes cationic anti-microbial agent preservatives, cationic polymer film-forming agents and a skin emollient, and provides a long term residual,...
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7442720 |
Compositions and methods for treating diabetes
The subject invention provides compositions and methods for treating diabetes in patients. In a preferred embodiment, the invention provides compositions methods for treating diabetes and/or...
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7435429 |
Zinc salt compositions for the prevention of dermal and mucosal irritation
The present invention provides for compositions and methods that may offer protection from irritants, as well as antimicrobial protection. Preferred embodiments of the invention include topical...
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7265156 |
Medicinal association of a biguanine and a carrier, for example metformin and arginine
The present invention relates to a compound of formula III,
method of making the same and its use in the treatment of diabetes.
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7256218 |
Biguanide and dihydrotriazine derivatives
Biguanide and dihydrotriazine derivatives, preferably substituted asymmetrical imidodicarbonimidic diamides derived from hydroxylamines, and compositions containing biguanide and dihydrotriazine...
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7208170 |
Powder teat dip germicide, fungicide and skin conditioner
A non-toxic, germicide, fungicide and healing composition and a method of topically applying the composition in powdered form to the skin of domesticated farm animals including dairy cattle are...
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7199159 |
Use of biguanide derivatives for making a medicine having a wound healing effect
The present invention relates to the use of biguanide derivatives of general formula I below:
in which:
the groups R1 and R2 represent, independently of each other, a hydrogen atom, a C...
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7183321 |
Antidiabetic formulation and method
An antidiabetic pharmaceutical formulation is provided, especially adapted for treating Type II diabetes, which includes a combination of metformin and glipizide in a manner to control moisture in...
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7105573 |
Methods and compositions for the treatment of alopecia and other disorders of the pilosebaceous apparatus
Insulin sensitivity increasing substances (ISIS), including but not limited to D-chiro-inositol, thiazolidinedione and derivatives, and biguanides, are useful in the treatment of hair loss and...
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7030163 |
Biocidal composition
A biocidal composition includes, in combination, poly(hexamethylene)biguanide, didecyldimethylammonium chloride a homogenizing agent and a flocculating agent. The biocidal composition is used to...
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7030133 |
Inhibitors of formation of advanced glycation endproducts (AGEs)
The nonenzymatic glycation and crosslinking of proteins is a part of the aging process with the glycation endproducts and crosslinking of long-lived proteins increasing with age. This process is...
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7008545 |
Synergistic biocidal mixtures
Synergistic mixtures of biocides and their use to control the growth of microorganisms in aqueous systems are disclosed. The method of using the synergistic mixtures entails adding an effective...
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7008531 |
Treatment of circulating water systems
The present invention relates to a method of inhibiting the growth of killing algae, bacteria, yeast and/or fungi in a recirculating water system which comprises adding to the water a polymeric...
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6992093 |
Method of inhibiting lipofibroblast to myofibroblast transdifferentiation
Methods of inhibiting lipofibroblast to myofibroblast transdifferentiation in a mammal are disclosed comprising administering a PPAR gamma ligand when said mammal is exposed to a hyperoxic condition.
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6946297 |
System for stabilizing samples
A transport/preservation system has been found which provides safe, effective transport for patient specimens and bodily fluids, and functions as a preservative for biological reagents,...
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6939566 |
Microbicidal formulations and methods to control microorganisms
Microbicidal formulations are described which are preferably ecologically friendly and non-toxic to mammals, and are highly effective against a broad spectrum of detrimental pathogenic...
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6936640 |
Biguanide/quaternary ammonium containing copolymeric biocides and use thereof in pharmaceutical compositions
Biguanide/quaternary ammonium compounds and the use of same as antimicrobial agents in pharmaceutical compositions are described. The biguanide/quaternary ammonium compounds are useful in the...
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6908628 |
Disinfectant and antiseptic composition
Wide spectrum disinfecting and antiseptic composition for use in the fields of human medicine, veterinary science and industry, characterized because it includes: Hydrogen peroxide, lactic acid...
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6894058 |
Use of 3-hydroxy-3-methylgutaryl coenzym a reductase inhibitors for the manufacture of a medicament for the treatment of diabetic neuropathy
The present invention relates to a new use of a statin drug in the improvement of diabetic neuropathy, specifically in improving nerve conduction velocity and nerve blood flow in patients suffering...
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6890957 |
Liquid formulation of metformin
The present invention is directed to a liquid formulation of metformin or its pharmaceutically acceptable salts thereof. The liquid pharmaceutical composition comprises a therapeutically effective...
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6846846 |
Gentle-acting skin disinfectants
Antimicrobial compositions having synergistic combinations of octoxyglycerin and at least one other antimicrobial agent in formulations which are more effective than prior art compositions without...
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6762206 |
Catheter flush solution and method for its use
A solution of the present invention useful for flushing an intravascular catheter includes a pharmacologically acceptable solium salt, a pharmacologically acceptable calcium salt, a...
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6747062 |
Regulation of wound healing by nitric oxide
The present invention provides methods and compositions for promoting healing of damaged tissue that result in an increased level of nitric oxide in the vicinity of the damaged tissue. Also...
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6737077 |
Proteinaceous animal chew with dentally therapeutic cation
This invention relates to chewable objects for animals which contain, as a dentally therapeutic ingredient, one or more cationic substances. The inventive therapeutic animal chews are of sufficient...
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6734197 |
Combination therapy for type II diabetes or Syndrome X
This invention provides methods of using a pharmacological combination of a biguanide agents, such as metformin, and one or more PTPase inhibiting agents and, optionally, one or more sulfonlylurea...
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6726899 |
Calcified tissue facing preparation containing antimicrobial agent
The present invention provides a calcified tissue facing preparation characterized by having a polymerizable resin, and an antimicrobial agent of the formula: where R 1 is a hydrocarbon radical...
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6693094 |
Biguanide and sulfonylurea formulations for the prevention and treatment of insulin resistance and type 2 diabetes mellitus
The invention describes formulations that include either metformin, sulfonylurea or a biguanide-sulfonylurea combination as one active ingredient in addition to specific, other active ingredients....
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6692757 |
Multi-component, safe biocidal complex
A novel composition has been discovered for decontaminating biofilm-contaminated surfaces (the “Biocidal Complex”). The novel composition both kills bacteria and destroys at least a part of the...
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6677358 |
NIDDM regimen
The present invention discloses a regimen for the treatment of type 2 diabetes, in which the endogenous secretion of insulin is stimulated in connection with meals, by administering a short-acting,...
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6653332 |
Combination therapeutic compositions and method of use
The present invention provides pharmaceutical compositions and methods for the treatment of diabetes mellitus using combination therapy. The compositions relate to a compound of Formula I and an...
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6630172 |
Microbicidal composition containing potassium sodium tartrate
Disinfectant formulations are described which are preferably ecologically friendly and non-toxic to mammals and plants, and are highly effective against a broad spectrum of detrimental pathogenic...
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6624198 |
AIDS prophylactic lubricating composition and devices for its use
A prophylactic spermicidal lubricant composition and method for its use in safe sexual relations, including prevention of infection by HIV and other viruses. The composition contains: a) a...
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6617360 |
Medical treatment
A compound of formula I or a pharmaceutically acceptable salt thereof in which R 1 and R 2 are independently H or methyl (for example...
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6610315 |
Topical application of stable hydroalcoholic compositions for maintaining or improving skin conditions, and delivering fragrance to skin
Disclosed is a composition including a lower alcohol and water in a weight ratio of about 35:65 to 100:0, between at least 0.5% and 8.0% by weight thickener system comprised of at least two...
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6586438 |
Antidiabetic formulation and method
A low dose antidiabetic pharmaceutical formulation is provided, especially adapted for treating Type II diabetes in drug naive patients, which includes a combination of metformin (employed in a...
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6565894 |
Healthcare formulations comprising imidazole and hydrogen peroxide
An ophthalmic solution comprising: 0.01 to 5 weight percent imidazole: 0.01 to 30 weight percent hydrogen peroxide and the balance water which can further comprisie 0.01 to 2 weight percent of a...
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6562861 |
Substituted cyclopentane and cyclopentene compounds useful as neuraminidase inhibitors
Compounds I-III wherein U is CH, O, or S; Z is mono- or di-substituted carbon; R is (CH2)nCO2H, (CH2)nSO3H, (CH2)nPO3H2, (CH2)nNO2, CH(SCH3)3, esters; R1 is H, hydroxyalkyl, aminoalkyl,...
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6555519 |
O-glucosylated benzamide SGLT2 inhibitors and method
SGLT2 inhibiting compounds are provided having the formula wherein n is 0, 1 or 2; A is or heteroaryl which may contain 1 to 4 heteroatoms in the ring which may be selected from N, O, S, SO,...
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6517852 |
Disinfection method
In order to disinfect objects at low temperatures, which can lie well below 0 ° C., said objects are treated with a hydroalcoholic solution containing an active microbicidal chlorhexidine...
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6509022 |
Composition for use in personal care comprising organic acid salts of polymeric biguanidines
Cosmetic composition for use in personal care applications comprising a carrier and a polymeric biguanide, characterised in that the polymeric biguanide is in the form of its salt with an organic...
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6503952 |
Triple antimicrobial composition
An antimicrobial composition comprising (i) between 0.025 and 2 percent of an antimicrobial agent selected from the group consisting of chlorhexidine free base, a chlorhexidine salt,...
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6498193 |
Treatment for complications of type 2 diabetes
A method is disclosed of lowering plasma levels of α-dicarbonyl precursors of advanced glycation end-products, such as methylglyoxal, in a patient having type 2 diabetes by administrating...
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6489365 |
Amidine derivatives, the preparation and use thereof as medicaments with Itb4 antagonistic effect
Compounds of the formula which is explained more fully in the specification, may be prepared by conventional methods and used therapeutically in conventional galenic preparations.
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6465521 |
Composition for desorbing bacteria
The invention provides a composition for desorbing bacteria from solid surfaces and from living tissues, which is in the form of a two-phase preparation, and which upon shaking forms a temporary...
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6444706 |
Guanidine derivatives, processes for preparing them and their use as pharmaceutical compositions
The invention concerns new guanidine derivatives of formula (I), methods of preparing them and their use in drugs containing such compounds.
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6440442 |
Hydrophilic polymer blends used for dry cow therapy
The present invention provides a mammalian teat dip composition capable of being used during a mammal's dry period comprising a solution of a film-forming polymer blend comprising a first polymer...
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6423748 |
Amido polybiguanides and the use thereof as antimicrobial agents
Amido polybiguanides and their use as antimicrobial agents in pharmaceutical compositions are disclosed. A method of synthesis of amido polybiguanides is also disclosed. The amido polybiguanides...
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6410594 |
Substituted cyclopentane compounds useful as neuraminidase inhibitors
Compounds represented by formula (I), and pharmaceutically acceptacle salts thereof; and their method of preparation are provided. Compounds of the above formula are influenza virus neuraminidase...
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6403363 |
Method of preservation of vaccines with polybiguanide
A method for preventing or reducing bacterial contamination of a viral vaccine is disclosed. The method comprises adding an effective preserving amount of a polybiguanide-containing preservative...
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