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7368605 |
Variously substituted derivatives of guanidine, and their use as medicines with anti-diabetes and/or anti-obesity activity
Formula (I) compounds
are described where the groups are as identified in the text, and their use as medicines, particularly as anti-diabetes, serum glucose-lowering and anti-obesity agents....
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7351743 |
Therapeutic guanidines
The present invention provides therapeutically useful substituted guanidines, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such guanidines.
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7335639 |
IGF-1 composition and its use
A highly concentrated, low salt-containing, biologically active syrup form of IGF-I or variant thereof and methods for its preparation are provided. This novel syrup form of IGF-I has an IGF-I...
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7322369 |
Methods of detaching microorganisms from, or of inhibiting microbial attachment to, animal or poultry carcasses or seafood or parts thereof
Methods of detaching microorganisms (e.g., bacteria) from, or of inhibiting microbial (e.g., bacterial) attachment to, animal or poultry carcasses or seafood or parts thereof, wherein the method...
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7262222 |
Synergistic mixtures of o-phenylphenol and other nitrogen and aldehyde microbiocides
Ortho phenylphenol or its sodium salt is shown to form synergistic antimicrobial mixtures with nitrogen and aldehyde-containing microbiocides.
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7262168 |
Compositions providing for increased IGF-I solubility
Novel IGF-I compositions are described. The compositions include a solubilizing compound comprising a guanidinium group that provides for IGF-I compositions in which IGF-I is highly soluble at pHs...
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7229961 |
Compositions and methods for enhancing drug delivery across and into ocular tissues
This invention provides compositions and methods for enhancing delivery of drugs and other agents across epithelial tissues, including into and across ocular tissues and the like. The compositions...
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7208521 |
Selective inhibitors of the urokinase plasminogen activator
The present invention relates to novel selective inhibitors of the urokinase plasminogene activator (uPA, EC3,4.21.31) of the aryl guanidine type.
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7199159 |
Use of biguanide derivatives for making a medicine having a wound healing effect
The present invention relates to the use of biguanide derivatives of general formula I below:
in which:
the groups R1 and R2 represent, independently of each other, a hydrogen atom, a C...
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7153887 |
Use of 15-deoxyspergualin for the treatment of ANCA associated vasculitis
The invention describes the use of deoxyspergualin (DSG) or an analogue thereof for the preparation of a medicament for the treatment of and/or prophylaxis against hyperreactive inflammatory...
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7153881 |
Compounds acting as melanocortin receptor ligands
The present invention provides novel compounds and use of compounds of general formula (I) as ligands to the melanocortin receptors and/or for treatment of disorders in the melanocortin system:...
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7115665 |
Inhibitors of endo-exonuclease activity for treating cancer
The present invention relates to the treatment of cancer with compounds that inhibit the activity of endo-exonuclease. Endo-exonuclease has been shown to be necessary for the repair of damaged DNA....
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7074834 |
Long acting, reversible veterinary sedative and analgesic and method of use
A veterinary composition comprising a guanidine derivative, e.g., guanabenz or guanabenz acetate is provided which produces a rapid acting and long lasting sedative and analgesic effect in a...
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7067485 |
IGF-I composition and its use
A highly concentrated, low salt-containing, biologically active syrup form of IGF-I or variant thereof and methods for its preparation are provided. This novel syrup form of IGF-I has an IGF-I...
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7008545 |
Synergistic biocidal mixtures
Synergistic mixtures of biocides and their use to control the growth of microorganisms in aqueous systems are disclosed. The method of using the synergistic mixtures entails adding an effective...
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6987129 |
Compounds and methods for the treatment of urogenital disorders
The present invention provides methods for treating a variety of urogenital disorders, such as, for example, vaginismus, dyspareunia, vulvodynia (including vulvar vestibulitis), interstitial...
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6951842 |
Compositions providing for increased IGF-I solubility
Novel IGF-I compositions are described. The compositions include a solubilizing compound comprising a guanidinium group that provides for IGF-I compositions in which IGF-I is highly soluble at pHs...
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6927218 |
Aryl N-cyanoguanidines and methods related thereto
Compounds, compositions and methods treating arthritic disorders such as osteoarthritis or rheumatoid arthritis, and for treating other diseases associated with altered mitochondrial function, such...
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6908628 |
Disinfectant and antiseptic composition
Wide spectrum disinfecting and antiseptic composition for use in the fields of human medicine, veterinary science and industry, characterized because it includes: Hydrogen peroxide, lactic acid...
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6906076 |
Compounds and methods of use to treat infectious diseases
The present invention concerns alkyl aryl carbonyl compounds that possess anti-infective activity. The compounds of the invention can be used to target specific nuclear localization signal, thereby...
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6890957 |
Liquid formulation of metformin
The present invention is directed to a liquid formulation of metformin or its pharmaceutically acceptable salts thereof. The liquid pharmaceutical composition comprises a therapeutically effective...
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6878748 |
Fluorinated cycloalkyl-derivatized benzoylguanidines, process for their preparation, their uses as medicament, and medicament containing them
Fluorinated cycloalkyl-derivatized benzoylguanidines of formula I
are suitable as antiarrhythmic medicaments with a cardioprotective component for infarction prophylaxis and infarction...
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6875759 |
Substituted guanidines and the use thereof
A method for the treatment of cancer and pain in an animal subject is disclosed, comprising administering to said animal in need of such treatment an effective amount of a compound of formula I:
...
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6872751 |
Composition and method for augmenting or restoring the production of fetal protein in patient in need thereof
The present invention relates to methods for prevention and/or treatment of diseases or conditions caused by deficiency in the adult isoform of a given protein wherein said method comprises...
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6787569 |
Therapeutic guanidines
The present invention provides therapeutically useful substituted guanidines, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such guanidines.
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6784178 |
Pharmacotherapy for vascular dysfunction associated with deficient nitric oxide bioactivity
A patient with a disorder involving endothelial dysfunction associated with deficient nitric oxide bioactivity, e.g., coronary artery disease, atherosclerosis, hypertension, diabetes or...
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6770678 |
Lyophilisates having improved reconstitutability
The present invention relates to lyophilisates having an improved dissolution rate which can be reconstituted in a particle-free manner, which is achieved by re-warming the solutions already drawn...
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6767892 |
Compositions providing for increased IGF-I solubility
Novel IGF-I compositions are described. The compositions include a solubilizing compound comprising a guanidinium group that provides for IGF-I compositions in which IGF-I is highly soluble at pHs...
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6759434 |
Anti-infective compositions, methods and systems for treating disordered tissue
The present invention relates to the treatment of disordered epithelial tissues such as cold sores and other complications resulting from disorders such as herpes, and the like. The invention...
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6747062 |
Regulation of wound healing by nitric oxide
The present invention provides methods and compositions for promoting healing of damaged tissue that result in an increased level of nitric oxide in the vicinity of the damaged tissue. Also...
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6737077 |
Proteinaceous animal chew with dentally therapeutic cation
This invention relates to chewable objects for animals which contain, as a dentally therapeutic ingredient, one or more cationic substances. The inventive therapeutic animal chews are of sufficient...
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6726899 |
Calcified tissue facing preparation containing antimicrobial agent
The present invention provides a calcified tissue facing preparation characterized by having a polymerizable resin, and an antimicrobial agent of the formula: where R 1 is a hydrocarbon radical...
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6706754 |
Reversed amidines and methods of using for treating, preventing, or inhibiting leishmaniasis
Methods for treating, preventing or inhibiting leishmaniasis in a subject comprising administering to the subject a therapeutically effective amount of at least one compound having the structural...
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6706290 |
Methods for eradication of nanobacteria
Nanobacteria contribute to pathological calcification in the human and animal body, including diseases such as kidney stones, salivary gland stones, dental pulp stones and atherosclerosis. The...
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6669951 |
Compositions and methods for enhancing drug delivery across and into epithelial tissues
This invention provides compositions and methods for enhancing delivery of drugs and other agents across epithelial tissues, including the skin, gastrointestinal tract, pulmonary epithelium, ocular...
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6656967 |
Fungicidal phenylimidate derivatives
The invention provides fungicidal compounds of formula I and salts thereof: wherein the various radicals and substituents are as defined in the description, fungicidal compositions containing...
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6632840 |
Monoacyl-substituted guanidines, a process for their preparation, their use as a medicament or diagnostic aid, and pharmaceutical compositions containing them
Monoacyl-substituted guanidines of formula III, or a salt or acid thereof, and their use as medicine or diagnostic aid: in which X(2) is
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6617356 |
Gel system for oral and topical administration of water insoluble and/or water intolerant drugs and supplements
Suspensions, emulsions or dispersions of therapeutically active agents which are water insoluble or water intolerant such as nutritional supplements, herbal products, drugs, bacteria, yeast,...
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6599943 |
Use of hydroxyguanidines
The invention features pharmaceutical compositions that include hydroxyguanidines. The compositions can be used, for example, for treating or preventing ischemic diseases, hypoxia,or arrhythmias.
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6593292 |
Compositions and methods for enhancing drug delivery across and into epithelial tissues
This invention provides compositions and methods for enhancing delivery of drugs and other agents across epithelial tissues, including the skin, gastrointestinal tract, pulmonary epithelium, and...
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6565894 |
Healthcare formulations comprising imidazole and hydrogen peroxide
An ophthalmic solution comprising: 0.01 to 5 weight percent imidazole: 0.01 to 30 weight percent hydrogen peroxide and the balance water which can further comprisie 0.01 to 2 weight percent of a...
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6562821 |
Aryl-N-cyanoguanidines and methods related thereto
Compounds, compositions and methods treating arthritic disorders such as osteoarthritis or rheumatoid arthritis, and for treating other diseases associated with altered mitochondrial function, such...
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6559187 |
Liquid formulation of metformin
The present invention is directed to a liquid formulation of metformin or its pharmaceutically acceptable salts thereof. The liquid pharmaceutical composition comprises a therapeutically effective...
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6559186 |
Compositions and methods of treatment of sympathetically maintained pain
Sympathetically maintained pain is treated topically by administering to the site where sympathetically maintained pain is present an α-1-adrenergic antagonist, α-2-adrenergic agonist, or other...
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6525034 |
Clear personal care formulations containing quaternary ammonium compounds and other nitrogen-containing compounds
A composition formulated from a primary anionic surfactant; optionally a secondary surfactant and/or a resin; and a nitrogen-containing compound of the structural formula: wherein R is a...
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6521591 |
Pharmaceutical composition for muscular anabolism
A pharmaceutical composition suitable for enhancing muscular anabolism contains, per daily dose, at least 5 mg of anabolic initiators comprising anabolic growth factors, at least 0.12 g of protein...
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6518309 |
Microbiocidal properties of poy-substituted guanidinium salts
This patent discloses the use of poly-substituted isothiouronium salts (T1 where R 1 , R 2 , R 3 , R 4 =hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, aryl, heteroaryl, etc. and X − =Cl −...
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6517852 |
Disinfection method
In order to disinfect objects at low temperatures, which can lie well below 0 ° C., said objects are treated with a hydroalcoholic solution containing an active microbicidal chlorhexidine...
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6509022 |
Composition for use in personal care comprising organic acid salts of polymeric biguanidines
Cosmetic composition for use in personal care applications comprising a carrier and a polymeric biguanide, characterised in that the polymeric biguanide is in the form of its salt with an organic...
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6503951 |
Use of creatine and/or creatine derivatives for treating typical disorders in women
The invention relates to the use of creatine and/or creatine derivatives for treating typical disorders in women, for example PMS or dysmenorrhea, which involves the prophylactic of therapeutic...
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