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4906385 |
Method for controlling macroinvertebrates
A method of controlling the fouling potential of macroinvertebrates, such as mollusks, in aqueous systems which comprises adding to the system an effective controlling amount of a water-soluble...
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4855325 |
Treatment of mammals suffering from damage to the central nervous system
A method and compositions, for treating an animal with an injured spinal cord, causing loss to sensory function and motor control, to regain such function and control. The method comprises the...
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4851441 |
Antiviral guanidine derivatives compositions and their methods of use
This invention relates to antiviral organic guanidine derivatives compositions; a process of producing the antiviral compositions; and a method for inhibiting viruses utilizing the compositions....
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4812449 |
In situ active compound assembly
Differences in microenvironments associated with various cells and other conditions in this environment are used to advantage in effecting the in situ construction of biologically active agents at...
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4745132 |
Biocidal compositions and use thereof employing a synergistic mixture of n-alkyldimethyl benzyl ammonium halide and n-dodecylguanidine
Bactericidal composition and method for inhibiting and controlling the growth of the capsulated, facultative bacterium, Klebsiella pneumoniae, are disclosed. The composition comprises an amount,...
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4731383 |
Aminoguanidine compounds, their compositions and pharmaceutical uses
The invention relates to new aminoguanidine derivatives of the general formula (I), ##STR1## wherein R 1 , R 2 and R 3 each represent hydrogen or halogen atom, C 1 -4 alkyl, nitro,...
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4680300 |
Anti-inflammatory guanidines
A compound having the formula ##STR1## where Ar=naphthyl, biphenyl, or quinolinyl; X=oxygen or NH; Y=2 to 8; R 1 =phenyl, substituted phenyl, hydrogen, lower alkyl; and R 2 is the...
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4661503 |
Synergistic biocide of dodecyl guanidine hydrochloride and a mixture of 5-chloro-2-methyl-4-isothiazolin-3-one
A synergistic biocide blend of dodecyl guanidine hydrochloride with a mixture of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one.
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4656180 |
Diamine derivatives and pharmaceutical preparations containing these compounds
Diamine derivatives corresponding to the general formula I R 1 R 2 N--(CH 2 ) m --Q--A--NH--R--NH--B--Q'--(CH 2 ) n NR 3 R 4 (I) which have a highly selective action on histamine-H 2 ...
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4656034 |
Absorption enhancing agents
The absorption of a scavenger of oxygen free radicals generated at the time of reperfusion or the absorption of an agent preventing the cytotoxic effects on healthy cells in a mammal. e.g....
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4602041 |
Benzylideneamino- and phenylacetylguanidines and their pharmaceutical uses
Compounds of formula (I): ##STR1## or a salt or acyl derivative thereof; wherein Y is either --CHN or ##STR2## R 1 is hydroxy, halogen, (C 1 -4) alkyl, or (C 1 -4)alkoxy, R 2 is a...
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4543352 |
Naphthalene aminoalkylene ethers and thioethers, and their pharmaceutical uses
A class of naphthalene aminoalkylene ether and thioether compounds exhibiting pharmacological activity including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising...
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4451463 |
Alcohol derivatives
This invention relates to alcohol derivatives which are histamine H-2 antagonists and which inhibit gastric acid secretion. According to the invention there is provided a guanidine derivative of...
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4427685 |
Cycloalkylamino derivatives and their use in the treatment of peptic ulcers and the like
Compounds of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein: a is 1 to 3; b is 0 to 2; c is 2 to 4; d is 1 to 5; X is sulphur, oxygen or --CH 2 --; Y is...
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4393077 |
1-Methylene-1-phenylguanidine compounds
Compounds having the formula: ##STR1## wherein X 1 , X 2 , R, R 1 , R 2 and R 3 are as set forth hereinafter, their preparation and uses as ganglionic blocking agents are disclosed.
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4380550 |
Guanfacine in treating opiate addiction
This invention provides a new opiate withdrawal use of an guanidine derivative and novel pharmaceutical compositions for such use.
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4366164 |
Amine derivatives
The invention provides compounds of general formula ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof, in which Y and Z, which may be the same or different, each...
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4339459 |
Guanidinium compounds and their use as microbiocidal agents
Guanidiunium salts of the formula 1 ##STR1## in which R 1 and R 2 are identical or different and denote alkyl, 2-hydroxyalkyl or alkenyl each having from 8 to 18 carbon atoms, or C 8 -C 18 ...
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4333929 |
Carboxamidine derivatives and hypoglycemical use
A compound of formula (II) or a pharmaceutically acceptable acid addition salt thereof ##STR1## wherein R 1 , R 2 , R 3 and R 4 are the same or different and each represents C 1 -6 alkyl; R 5 ...
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4332822 |
Guanidine derivatives
Novel cyanoguanidine derivatives having the formula ##STR1## wherein Ar is a phenyl or pyrrol-1-yl group substituted by one or more substituents selected from halogen, trifluoromethyl, lower alkyl,...
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4321274 |
Substituted 1-(cinnamylideneamino)-3-benzyli-deneaminoguanidines active against Giardia lamblia and Trichomonas vaginalis
Substituted-1-(cinnamylideneamino)-3-benzylideneaminoguanidi
nes, known as effective anti-coccidial agents, are useful as potent anti-giardiasis and anti-trichomoniasis agents.
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4318915 |
Substituted guandines and methods of preparation thereof
A compound of the formula ##STR1## wherein R 1 is chlorine, bromine, or methoxy; and R 2 , R 3 , and R 4 are individually hydrogen or methyl, at least one of R 2 , R 3 , and R 4 being hydrogen;...
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4312886 |
Prevention of gastric ulcers and depression of gastric secretion by administration of guanabenz
Methods for the prevention of ulcer formation and for the depression of gastric secretions by the administration of guanabenz are disclosed.
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4310541 |
Method of treating giardiasis and trichomoniasis
Benzylidene aminoguanidene derivatives, known as effective anti-coccidial agents, are useful as potent anti-giardiasis and anti-trichomoniasis agents.
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4294852 |
Skin treating compositions
The invention relates to a composition for treatment and control of excessively thickened, inflexible and scaly stratum corneum which often fissures into the dermis resulting in foci of bleeding...
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4279911 |
Amine derivatives and pharmaceutical compositions containing them
The invention relates to compounds of the general formula (I) ##STR1## and physiologically acceptable salts, N-oxides, hydrates and bioprecursors thereof, in which Y represents O, S, CHNO...
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4271190 |
Guanidinium salts, processes for their manufacture as well as microbicidal preparations containing these compounds
Guanidinium salts having the formula ##STR1## wherein R 1 and R 2 are linear alkyl residues, X is an anion, and n is 1 or 2, which possess excellent microbicidal properties, particularly...
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4226885 |
Guanylhydrazones and medicaments containing them
New guanylhydrazones of phenoxyacetic acid. These guanylhydrazones, also their physiologically acceptable salts, are characterized by the following general formula I in which R 1 , R 2 , R 3 , R 4...
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4169154 |
Method of treating depression with thiourea derivatives
A method of utilizing thiourea derivatives of the formulas ##STR1## wherein R, R 1 , R 2 , R 3 and X are as hereinafter described, as agents in the treatment of depression, is described.
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4163800 |
Topical composition and treatment of skin lesions therewith
Compositions and process employing guanidine compounds and peroxide compounds for treatment of acne and other skin lesions by topical application.
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4161541 |
Benzhydryl guanidines
Benzhydryl derivatives of guanidine (Formula I) having blood sugar lowering activity; pharmaceutical hypoglycemic compositions thereof and methods of administering same to hyperglycemic individuals.
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4152454 |
Insecticidal compositions comprising N'-aryl-N-methylformamidines and 3-phenoxybenzyl carboxylates
Compositions comprising, in combination, N'-aryl-N-methylformamidines and 3-phenoxybenzyl carboxylates exhibit synergistic insecticidal activity. The novel compositions are exemplified and their...
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4109014 |
Pharmaceutical, compositions containing substituted 4'-hydroxyphenyl guanidines and methods of using same
Novel aromatic guanidine compounds having the formula: ##STR1## wherein: R 1 is hydroxyl, methyl or hydroxymethyl and R 2 is hydrogen or methyl, are found to have biological activity. The...
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4092432 |
Mixtures having antimicrobial or pesticidal effect
The present invention relates to mixtures of guanidated aliphatic polyamines, or their acid addition salts, having antimicrobial or pesticidal effect. More particularly the invention relates to...
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4051256 |
Guanidine derivatives
Guanidine derivatives of the formula: ##STR1## in which R 1 is a cyclohexyl, adamantyl, bicycloheptanyl, bicycloheptenyl, tricycloheptanyl or tetracyclononanyl radical and R 2 is a phenyl or...
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4046917 |
Method of treating migraine
The invention relates to a new use of 2,6-dichlorophenyl-acetylguanidine as an anti-migraine agent.
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4041160 |
Water-suspendible composition comprising robenidine
There are disclosed water-suspendable compositions comprising a 1,3-bis-[(p-chlorobenzylidene)-amino]-guanidine (called Robenidine) or one of its salts. Said compositions comprise also...
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4027039 |
Method of viral chemoprophylaxis and compounds therefor
It has been found that compounds having a stereochemically unencumbered access to a nitrogen-nitrogen bond have antiviral activity in extremely low dose ranges. Hydrazine, hydrazine derivatives and...
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4013576 |
Contact lens treating composition
An improved contact lens treating composition is provided through the incorporation of an amphoteric surfactant as a detergent. The amphoteric surfactant provides good cleaning properties with no...
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4011342 |
Method and composition for the treatment of hypertension with ortho-disubstituted arylguanidines
The guanidines of formula ##STR1## in which R and R' are each hydrogen or methyl and the pharmaceutically acceptable acid addition salts thereof exhibit hypotensive effects.
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3976787 |
Pharmaceutical guanidine preparations and methods of using same
Pharmaceutical preparations and methods of using the same to treat a host having a condition requiring vasoconstrictive therapy. The preparations comprise a pharmaceutically acceptable carrier and...
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3968211 |
Compositions and methods of use of amidines for anti-arrhythmic purposes
Compounds of the formula below are compounded into pharmaceutical compositions and are useful for treatment of arrhythmic conditions. ##EQU1##
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3968243 |
Substituted guanidine compounds in the treating of arrythmias
N- substituted - guanidines having antifibrillatory activity; non-toxic salts thereof; pharmaceutical compositions thereof; and their use in treating cardiac fibrillations.
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3961056 |
Substituted morpholine guanidines for the treatment of arrhythmic conditions
The pharmaceutical compositions and methods of using these compositions for anti-arrhythmic and diuretic uses are disclosed for the compounds below: ##EQU1##
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3960745 |
Cleansing compositions
The disclosure relates to cleansing compositions containing a soluble salt of chlorhexidine, a polyoxyethylene-polyoxypropylene block co-polymer and an inert diluent or carrier.
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3949089 |
Substituted guanidine compounds as antifibrillatory agents
Acid addition salts of N-p-methylbenzyl-N',N"-dimethylguanidine and of N-p-methoxybenzyl-N',N"-dimethylguanidine. The compounds have antiarrhythmic properties, and are useful specifically as...
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3939272 |
Solubilizing process for oil insoluble pesticides
This invention concerns a process for converting normally oil-insoluble, nitrogen-containing pesticidal compounds to oil-soluble complexes by treatment with alkylated phenols, and to the...
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3932656 |
Article of manufacture for instant release of anti-aggregation and non-thrombogenic agents to biological media
Polymeric materials having at least one exposed surface rendered as a release means for platelet aggregation inhibiting agent by serving as a reservoir for release of aggregation inhibiting...
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3915918 |
Paint composition
This Specification describes the preparation of paint compositions which have fungicidal and often algicidal properties. The paint compositions which can otherwise be conventional contain one of a...
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3911125 |
Method of treating angina pectoris, coronary insufficiency, and preventing myocardial infarction
A method of treating angina pectoris (i.e., suppressing the incidence of angina and relieving the painful symptoms of anginal attacks, treating coronary insufficiency and suppressing the incidence...
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