Matches 101 - 150 out of 277 < 1 2 3 4 5 6 >
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5985917 Mercapto and seleno derivatives as inhibitors of nitric oxide synthase  
This invention is directed to a pharmacologically acceptable composition for inhibiting nitric oxide synthase in a mammal, which includes a mercapto or seleno derivative and a pharmaceutically...
5972940 Arginine analogues having nitric oxide synthase inhibitor activity  
A compound selected from the group consisting of a compound of the formula wherein A is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms and --NO 2 , E is --O-- or a...
5965529 Treatment of preeclampsia and preterm labor with combination of progestational agent and a nitric oxide synthase substrate and/or donor  
Preeclampsia and preterm labor in a pregnant female mammal are treated by administering thereto a combination of a progestin and a nitric oxide synthase substrate, a nitric oxide donor or both,...
5952385 Mercapto derivatives as inhibitors of nitric oxide synthase  
This invention is directed to a pharmacologically acceptable composition for inhibiting nitric oxide synthase in a mammal, which includes a mercapto derivative and a pharmaceutically acceptable...
5945455 Amine and amidine containing compounds as weight reducing agents  
Use of amine and amidine containing compounds of formula (I) such as galegine and related substituted amine and amidine containing compounds as agents for reducing weight in mammals, pharmaceutical...
5939078 Wrinkle-care product  
A wrinkle-care product, an aging-preventive cosmetic and a skin cosmetic each comprising a guanidine derivative of formula (I) or an acid addition salt thereof: ##STR1## wherein R1 represents a...
5929120 Guainidino, formamidino, amino and related compounds for inhibiting osteoclast-mediated bone resorption  
Compounds of the following general structure X--Y--Z-Aryl-A--B, ##STR1## which inhibit osteoclast mediated bone resorption.
5929055 Therapeutic method for management of diabetes mellitus  
A method for treating diabetes in a mammal by moderately controlling blood glucose concentration in the mammal together with administering to the mammal an amount of a tetracycline compound...
5922769 Glibenclamide-metformin combination for the treatment of diabetes mellitus of type II  
Non-insulin dependent diabetes mellitus in cases of secondary failure is treated with a combination of glibenclamide and metformin.
5922693 Cleaning compositions containing biostatic agent  
The present invention relates to an aqueous cleaning composition containing (a) 1 to 10 weight % of at least one surfactant selected from the group consisting of anionic surfactants and...
5886040 Creatine pyruvate salt with enhanced palatability  
An organic salt formed between creatine and pyruvic acid and their attendant salts and analogs, is water soluble and possesses improved palatability. The creatine is in a chemical form which...
5883133 Substituted cinnamic acid guanidides, a process for their preparation, their use as medicaments or diagnostic agents and medicaments comprising them  
Compounds of the formula I ##STR1## are described in which at least one of the substituents R(1), R(2), R(3), R(4) and R(5) is a nitrogen-containing heterocyclic radical. They are outstanding...
5869531 Fluoroalkyl substituted benzoylguanidines  
Disclosed are 4-(2'-trifluoromethylethyl)benzoylguanidine and 3-methylsulfonyl-4-(2'-trifluoromethylethyl)benzoylguanidine . Also disclosed are pharmaceutical compositions and the use of the...
5869073 Antimicrobial liquid compositions and methods for using them  
A liquid composition for applying a non-leachable antimicrobial coating on a surface. The liquid composition consists of a solution, dispersion or suspension of a biguanide polymer reacted with a...
5869534 Glycosylation of lipids and lipid-containing particles, and diagnostic and therapeutic methods and materials derived therefrom  
The in vivo oxidation of lipids and lipid-containing molecules has been discovered to be initiated by the concurrent reaction of such lipid materials with reducing sugars such as glucose, advanced...
5856344 Sulfonylamino-substituted benzoylguanidines, a process for their preparation, their use as a medicament or diagnostic aid, and medicament containing them  
Benzoylguanidines of the formula I ##STR1## in which R(1) to R(6) have the meanings stated in the claims, are antiarrhythmic pharmaceuticals which have excellent activity and a cardioprotective...
5854290 Use of guanfacine in the treatment of behavioral disorders  
Disclosed is a method of treating disorders which have prominent symptoms of behavioral disinhibition (e.g., Attention-Deficit Hyperactivity Disorder, Conduct Disorder, Oppositional Defiant...
5852009 Compositions, including pharmaceutical compositions, for inhibiting the advanced glycosylation of proteins, and therapeutic methods based thereon  
The present invention relates to compositions and methods for inhibiting protein aging. Accordingly, a composition is disclosed which comprises an agent or compound capable of inhibiting the...
5849799 Use of deoxyspergualin for preparing a pharmaceutical for treating hyperreactive inflammatory diseases  
Methods are disclosed for treatment of hyperreactive inflammatory diseases of humans and animals comprising administering a pharmaceutically effective amount of deoxyspergualin to a human or an...
5847006 Therapeutic guanidines  
The present invention provides N,N'-diaryl substituted guanidines having therapeutic utility. The compounds of the present invention are represented by the formula: ##STR1## wherein R and R 1 ...
5837738 Method of inhibiting nitric oxide formation  
A method is disclosed for inhibiting nitric oxide formation in a warm blooded mammal afflicted with an acute or chronic inflammatory disease which comprises administering to said mammal an...
5830917 L-N.sup.6 -(1-iminoethyl) lysine derivatives useful as nitric oxide synthase inhibitors  
There is disclosed a novel amino alcohol amine derivatives of L-N 6 -(1-iminoethyl)lysine, pharmaceutical compositions containing these novel compounds, and to their use in therapy, in particular...
5801179 Vasoconstrictive substituted aryloxyalkyl diamines  
The present invention is concerned with compounds having the formula ##STR1## the pharmaceutically acceptable acid addition salts thereof, and the stereochemically isomeric forms thereof, wherein R...
5801200 Methods and materials for the diagnosis and treatment of conditions such as stroke  
The in vivo oxidation of lipids and lipid-containing molecules has been discovered to be initiated by the concurrent reaction of such lipid materials with reducing sugars such as glucose, advanced...
5795917 Enzyme inhibitor acaricides I  
The invention provides novel methods of controlling mite infestations of plants. The novel methods employ the step of applying an effective amount of a compound that can inhibit the proteolytic...
5792769 Guanidino protease inhibitors  
Compounds of the formula: ##STR1## wherein R 1 --R 4 , R 7 --R 8 , R a , R b , R c , Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable...
5780513 Method of inhibiting the release of bioactive IL-1  
A method for the treating an individual afflicted with a disease condition mediated by IL-1 bioactivity is disclosed. The method comprises administering an effective amount of the NOS inhibitor,...
5773469 Diaryl antimicrobial agents  
The invention relates to diaryl antimicrobial compounds of the general formula: ##STR1## where G, E L, J, q, m, X, Ar, W, p, n and A are as described herein, pharmaceutical compositions containing...
5753710 Substituted benzyloxycarbonylguanidines, a process for their preparation, their use as a medicament or diagnostic, and a medicament containing them  
Substituted benzyloxycarbonylguanidines, a process for their preparation, their use as a medicament or diagnostic, and a medicament containing them. There are described compounds of the formula I...
5753715 2-disubstituted cyclohexenyl and cyclohexyl antimicrobial agents  
The invention relates to cyclohexenyl antibacterial compounds of the formula I: ##STR1## and pharmaceutical compositions containing the compounds, methods for their production and use.
5741661 Substituted guanidines and derivatives thereof as modulators of neurotransmitter release and novel methodology for identifying neurotransmitter release blockers  
Modulators of neurotransmitter release including substituted guanidines, N"-aminoguanidines, and N,N'N",N"'-tetrasubstituted hydrazinedicarboximidamides, and pharmaceutical compositions thereof are...
5739142 4-aminobenzoylguanidine derivatives  
4-Aminobenzoylguanidines of the formula I ##STR1## in which A, R 1 , R 2 and R 3 have the meanings given, and the physiologically unobjectionable salts thereof exhibit antiarrhythmic properties...
5733934 Antiarrythmic and cardioprotective substituted indenoylguanidines  
Indenoylguanidines of formula I and formula II, the process for their preparation, their use as medicaments, medicaments containing them, their use as diagnostic agents and medicaments containing...
5733932 Compounds and methods of use to derivatize neighboring lysine residues in proteins under physiological conditions  
The present invention encompasses the use of the compounds of formula as given below to detect certain specific protein structures which are present in nuclear localization sequences ##STR1##...
5728734 Pesticide preparation of aqueous suspension type  
A pesticide preparation of aqueous suspension type which comprises: (a) a 1,1'-iminiodi(octamethylene)diguanidinium tris(alkyl-benzenesulfonate) as an active pesticide ingredient; (b) at...
5726146 Non-steroidal, anabolic dietary supplement and method to increase lean mass without linked increase fat mass  
Dietary supplement formulation which increases lean body mass without concomitant increase of body fat mass, an effect parallel to that seen with usage of synthetic anabolic steroidal compounds but...
5723496 Method for prevention and treatment of harmful effects of intracellular acidosis  
Compounds and a method useful for protection of tissue cells in a mammalian body from irreversible damages due to lactic acidosis caused by oxygen deficiency. The protection is achieved by...
5719187 Compounds having a guanidine structure and pharmaceutical composition containing same  
Guanidine derivatives are provided useful for promoting growth, repair and regeneration of a neuronal axon and for treating neuropathies and myopathies. The compounds have the formula: ##STR1##...
5710181 Inhibition of nitric oxide formation in inflammatory bowel disease  
A method is disclosed for inhibiting nitric oxide formation in a warm blooded mammal afflicted with inflammatory bowel disease which comprises administering to said mammal an effective nitric oxide...
5705531 1,5-disubstituted 7A-methylperhydroinden-3A-ol derivatives, useful in treating cardiovascular disorders, processes for their preparation and pharmaceutical compositions containing the same  
1,5-Disubstituted 5a-methylperhydroinden-3a-ol derivatives of formula (I): ##STR1## where either the symbol - - - - represents a single bond, the group A is in cis configuration with respect...
5700834 Synergistic antimicrobial composition of 1,2-dibromo-2,4-dicyanobutaneand alkylguanidine compounds  
Synergistic antimicrobial combinations comprising 1,2-dibromo-2,4-dicyanobutane and an alkylguanidine compound, preferably dodecylguanidine hydrochloride, are disclosed. Methods for inhibiting...
5696138 Urea derivatives and their use  
A compound having the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein X, Z, Y, A, D, E, F, R 1 , R 2 , R 3 , R 4 , R 11 , R 12 have the meanings set forth in the...
5693672 3,4,5-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic and medicament containing them  
3,4,5-Substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic and medicament containing them Benzoylguanidines of the formula I ##STR1## where R(1) is...
5681861 Aminoguanidines and methods of use of same  
Modulators of neurotransmitter release including substituted guanidines, N"-aminoguanidines, and N,N'N",N'"-tetrasubstituted hydrazinedicarboximidamides, and pharmaceutical compositions thereof are...
5677349 Agmatine for the treatment of neurotrauma and neurodegenerative diseases  
The invention relates to the use of agmatine, in the treatment of acute neurotrauma (such as stroke) and degenerative disorders of the central and peripheral nervous system (such as dementia).
5677345 Synergistic antimicrobial composition of N- (dichlorofluoromethyl)thio!-N',N'-dimethyl-N-phenylsulfamide and alkylguanidine compounds  
Synergistic antimicrobial combinations comprising N- (dichlorofluoromethyl)thio!-N',N'-dimethyl-N-phenylsulfamide and an alkylguanidine compound, preferably dodecylguanidine hydrochloride, are...
5672608 Acenaphthyl substituted guanidines and methods of use thereof  
Modulators of neurotransmitter release including substituted guanidines, N"-aminoguanidines, and N,N'N",N'"-tetrasubstituted hydrazinedicarboximidamides, and pharmaceutical compositions thereof are...
5646188 Polyamine derivatives of 1-aminoindan  
A compound of general formula I ##STR1## wherein n is 1 or 2; R 1 and R 2 are each independently hydrogen, hydroxy, substituted or unsubstituted C 1 -4 alkyl, substituted or unsubstituted C 1 -4...
5646135 Method for controlling coccidiosis  
The present invention relates to an improved method for controlling coccidiosis in poultry which comprises administering to poultry on shuttle medication an additional medication prior to switching...
5637623 Substituted adamantyl guanidines and methods of use there of  
Modulators of neurotransmitter release including substituted guanidines, N"-aminoguanidines, and N,N'N",N"'-tetrasubstituted hydrazinedicarboximidamides, and pharmaceutical compositions thereof are...
Matches 101 - 150 out of 277 < 1 2 3 4 5 6 >