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6436999 |
Diacyl-substituted guanidines, a process for their preparation, their use as medicine or diagnostic aid, and medicine containing them
Diacyl-substituted guanidines of the formula I are described where X( 1 ) and X( 2 ) are as defined herein. The compounds are suitable for use as antiarrhythmic pharmaceuticals possessing a...
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6433019 |
Neurotrophic factor secretion promoters
The present invention relates to a neurotrophic factor secretagogue, in particular, to a BDNF (brain-derived neurotrophic factor) secretagogue, which comprises as an active ingredient an NO donor....
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6423705 |
Combination therapy
The invention provdes methods of reducing tissue damage resulting from ischemia which comprise administering to a mammal in need of such reduction an effective amount of a combination, or a...
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6423748 |
Amido polybiguanides and the use thereof as antimicrobial agents
Amido polybiguanides and their use as antimicrobial agents in pharmaceutical compositions are disclosed. A method of synthesis of amido polybiguanides is also disclosed. The amido polybiguanides...
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6423750 |
Systems for delivering anti-infective compositions to treat disordered tissue such as cold sores
The present invention relates to the treatment of disordered epithelial tissues such as cold sores and other complications resulting from disorders such as herpes, and the like. The invention...
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6420430 |
Use of inhibitors of the sodium-hydrogen exchanger for preparing a medicament for preventing age-related disorders, and for prolonging life
Inhibitors of the cellular sodium-hydrogen exchanger are employed for preparing a medicament for preventing age-related functional disorders and dysfuntional changes of organs of the body and for...
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6420431 |
Methods for treating disordered tissue through agitated delivery of anti-infective compositions
The present invention relates to the treatment of disordered epithelial tissues such as cold sores and other complications resulting from disorders such as herpes, and the like. The invention...
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6417159 |
Method of enhancing effect of a neurotrophin with analogues of p75NTR367-379.
The present invention provides methods and compositions for enhancing the effect of a neurotrophin on a cell expressing a neurotrophin receptor. The effect is preferably neurotrophin-mediated...
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6417184 |
Triple drug therapy for the treatment and prevention of acute or chronic pain
A triple drug therapy, pharmaceutical kit, composition, and method of treatment regimen utilized as a combination of effective amounts of an anxiolytic agent, centrally acting alpha antiadrenergic...
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6413962 |
Guanidino compounds effective as anesthetics
The compositions are aromatic, gaunidino group containing compounds used for inducing anesthesia and reducing core temperatures in mammals.
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6414032 |
Anti-infective compositions for treating disordered tissue such as cold sores
The present invention relates to the treatment of disordered epithelial tissues such as cold sores and other complications resulting from disorders such as herpes, and the like. The invention...
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6410599 |
Antiseptic compositions suitable for application to human tissue
The present invention relates to an antiseptic composition for treating a human infected with a virus, a bacteria or a fungus, for example, disordered epithelial tissues such as cold sores and...
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6410598 |
Compositions and methods for advanced glycosylation endproduct-mediated modulation of amyloidosis
The present invention relates generally to the non-enzymatic glycosylation of amyloidogenic proteins and the consequent formation of advanced glycosylation endproducts (AGEs). It has been found...
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6395189 |
Method for the control of biofilms
A process is provided for both removing and controlling biofilms present in industrial cooling and process waters. The process provides a composition which includes the reaction products of an...
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6376534 |
Compounds useful in pain management
Compounds of general formula I are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts, pharmaceutical compositions comprising the novel...
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6342522 |
Microbiocidal compositions
A microbiocidal composition including a first component comprises a guanidine compound, a second component which comprises either prochloraz, propiconazole or iodocarb, wherein the weight ratio of...
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6339082 |
Tricyclic compounds, preparation method and said method intermediates, application as medicines and pharmaceutical compositions containing same
A compound selected from the group consisting of a compound of the formula wherein the substituents are defined as set forth in the specification and its salts with non-toxic pharmaceutically...
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6288124 |
Methods of inhibiting undesirable cell growth using an aminoguanidine compound
The present invention provides for the use of aminoguanidines for prophylactic and/or therapeutic treatments of undesirable cell growth, e.g. tumors. The present invention provides methods of using...
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6284797 |
Topical treatment of pain and to promote healing
A topical therapeutic preparation includes capsaicin which is an extract of peppers or chiles and which is a potent local pain killer. The ointment also includes a norepinephrine inhibitor and...
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6268398 |
Compounds and methods for treating mitochondria-associated diseases
Compounds, compositions and methods are disclosed for treating mitochondria-associated diseases, such as cancer, psoriasis, stroke, Alzheimer's Disease and diabetes. The compounds of this invention...
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6251948 |
Tri-and tetra-substituted guanidines and their use as excitatory amino acid antagonists
Tri- and tetra-substituted guanidines which exhibit a high binding affinity to phencyclidine (PCP) receptors and, more preferably, low affinity to the brain sigma receptors. These guanidine...
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6251854 |
N-methyl-d-aspartate receptor channel blockers and method for identifying such
Compounds that provide protection against excitotoxic neuronal damage are selected from the group consisting of Arg-rich oligopeptides and compounds of formula 1: ##STR1## where R 1 is alkyl,...
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6248787 |
Guanylhydrazones and their use to treat inflammatory conditions
This invention concerns new methods and compositions that are useful in preventing and ameliorating cachexia, the clinical syndrome of poor nutritional status and bodily wasting associated with...
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6221907 |
Tricyclic compounds having activity specific for integrins, particularly alphanubeta3 integrins, method for preparing same, intermediates therefor, use of said compounds as drugs, and pharmaceutical compositions containing same
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6211243 |
Methods for treating cold sores with anti-infective compositions
The present invention relates to a method of treated disordered epithelial tissues such as cold sores and other complications resulting from disorders such as herpes, and the like. The inventive...
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6201017 |
Ectoparasite controlling agent for animals
An ectoparasite-controlling agent for animals comprising 0.1 to 20% by weight of the neonocotinoid compounds defined in the specification and 10 to 95% by weight of a glycol or glycol monoalkyl...
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6197098 |
Fast drying biocidal preservative composition
The invention relates to a fast drying biocidal composition having enhanced penetration for the treatment and preservation of wood, leather and similar natural products which comprises: A....
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6190652 |
Volatiles of Japanese honeysuckle flowers as attractants for adult Lepidopteran insects
Compositions of cis-jasmone were found to effectively attract adult Lepidoptera. The cis-jasmone may be used alone or in combination with one or more other volatiles of the Japanese honeysuckle...
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6166087 |
Low dosed 15-deoxyspergualin preparations
15-deoxyspergualin or a pharmaceutically compatible salt thereof is suitable for the preparation of an immunosuppressive, anti-inflammatory or anti-tumoral pharmaceutical, which is effective in a...
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6160021 |
Method for treating epidermal or dermal conditions
A method of treating a subject for an unwanted epidermal or dermal condition comprising administering to the subject, a treatment which modulates the level of nitric oxide (NO) in the skin.
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6156741 |
Therapeutic substituted guanidines
The present invention provides therapeutically useful substituted guanidines of the following Formula: ##STR1## and methods of treatment and pharmaceutical compositions that utilize or comprise one...
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6149822 |
Bio-film control
A process is provided for both removing and controlling biofilms present in industrial cooling and process waters. The process provides a composition which includes the reaction products of an...
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6150419 |
Agmatine as a treatment for neuropathic pain
A treatment and composition for neuropathic pain by administering an effective amount of agmatine.
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6150415 |
Epoxide hydrolase complexes and methods therewith
Biologically stable inhibitors of soluble epoxide hydrolases are provided. The inhibitors can be used, for example, to selectively inhibit epoxide hydrolase in therapeutic applications such as...
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6146622 |
Use of certain anionic amino acid based surfactants to enhance antimicrobial effectiveness of topically administrable pharmaceutical compositions
Anionic amino acid based surfactants are used to enhance antimicrobial effectiveness in topically administrable pharmaceutical compositions containing at least one active ingredient, a cationic...
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6143790 |
L-N.sup.6 -(1-iminoethyl)lysine derivatives useful as nitric oxide synthase inhibitors
There is disclosed a novel amino glycol derivatives of L-N 6 -(1-iminoethyl)lysine, pharmaceutical compositions containing these novel compounds, and to their use in therapy, in particular their...
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6140350 |
Method for controlling ectoparasites
A method for controlling ectoparasites systemically through host animal blood which comprises administering at least one neonocotinoid compound among those defined in the specification to the host...
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6133320 |
Treatment of osteoporosis and metabolic bone disorders with nitric oxide substrate and/or donors
Primary and secondary osteoporosis in a female or a male mammal is treated by administering thereto a nitric oxide synthase substrate, a nitric oxide donor or both, optionally; in further...
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6114392 |
Agmatine, and polyaminoguanidine-bound heterocyclic compounds for neurotrauma and neurodegenerative diseases
The invention relates to the use of agmatine, in the treatment of acute neurotrauma (such as stroke) and degenerative disorders of the central and peripheral nervous system (such as dementia). The...
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6103768 |
Fatty acid based compositions and methods for the control of plant infections and pests
The invention described here concerns the unique utility of fatty acids and their derivatives to eradicate existing fungal and bacterial infections in plants. Also, described herein are combination...
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6093746 |
Therapeutic agents for asthma
An object of the present invention is to provide safe therapeutic agents for asthma inhibiting the delayed type asthmatic reaction in bronchial asthma and having no side effect. The present...
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6093745 |
Methods and composition for treating skin proliferative diseases
Methods and a compositions are provided for treating a skin proliferation disease such as psoriasis to inhibit the proliferation of epidermal cells, particularly keratinocytes and to reduce the...
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6075054 |
Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them
Benzoylguanidines of formula I ##STR1## with R(1) to R(4) as defined in the specification, are suitable as antiarrhythmic pharmaceuticals having a cardioprotective component for infarct prophylaxis...
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6071969 |
Substituted aminoguanidines and methods of use thereof
Modulators of neurotransmitter release including substituted guanidines, N"-aminoguanidines, and N,N'N",N"'-tetrasubstituted hydrazinedicarboximidamides, and pharmaceutical compositions thereof are...
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6063819 |
Neuroprotective poly-guanidino compounds which block presynaptic N and P/Q calcium channels
Neuroprotective drugs are disclosed with at least 3 branches extending outwardly from a center atom or group, each branch having a guanidino group at its terminus. All branches preferably should be...
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6060484 |
Anti-viral method
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6043268 |
Agent for treatment of viral infections
A method for treatment of viral infections which comprises administering to the patients being suffering from said viral infections an effective amount of one or more substances selected from the...
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6034080 |
Use of Maillard reaction inhibitors for the treatment of amyloidosis-based disease
Inhibitors of the Maillard reaction are useful in the treatment or prophylaxis of amyloidosis-based disease, particularly Alzheimer's disease. Particular examples include aminoguanidine and...
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6011059 |
Acyl guanidine sodium/proton exchange inhibitors and method
Acyl guanidines are provided which are sodium/proton exchange (NHE) inhibitors which have the structure ##STR1## wherein n is 1 to 5; X is N or C--R 5 wherein R 5 is H, halo, alkenyl, alkynyl,...
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5990174 |
Aqueous composition
A aqueous medium containing a biguanide, particularly a biguanide oligomer, and having a pH of less than 5. The biguanide oligomer may be a poly(hexamethylene biguanide) having up to 15 repeat...
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