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6503950 |
Triple drug therapy for the treatment of narcotic and alcohol withdrawal symptoms
A triple drug, pharmaceutical kit, composition, and method of treatment containing a combination of effective amounts of at least one anxiolytic agent, at least one centrally acting alpha...
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6498194 |
Fungicidal mixtures
The invention relates to a novel fungicidal composition comprising a fungicidally acceptable carrier and/or surface active agent together with, and synergistically effective amounts of (a) at...
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6469059 |
Fungicidal composition and method for disease control of paddy-rice plants
A fungicidal composition for paddy-rice plants has as active ingredients N-(1-cyano-1,2-dimethylpropyl)-2-(2,4-dichlorophenoxy)propan
amide in combination with one or more compounds selected from...
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6462052 |
Synergistic fungicide and/or bactericide composition
The invention concerns a synergistic fungicide and/or bactericide composition comprising dodine and a derivative of the anilino-pyrimidine family. The invention also concerns a preventive or...
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6448291 |
Fungicidal active compound combinations
There are described new active compound combinations of a compound of the formula (I) with known fungicidal active compounds, and their use for combating phytopathogenic fungi.
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6444706 |
Guanidine derivatives, processes for preparing them and their use as pharmaceutical compositions
The invention concerns new guanidine derivatives of formula (I), methods of preparing them and their use in drugs containing such compounds.
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6436999 |
Diacyl-substituted guanidines, a process for their preparation, their use as medicine or diagnostic aid, and medicine containing them
Diacyl-substituted guanidines of the formula I are described where X( 1 ) and X( 2 ) are as defined herein. The compounds are suitable for use as antiarrhythmic pharmaceuticals possessing a...
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6433019 |
Neurotrophic factor secretion promoters
The present invention relates to a neurotrophic factor secretagogue, in particular, to a BDNF (brain-derived neurotrophic factor) secretagogue, which comprises as an active ingredient an NO donor....
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6423750 |
Systems for delivering anti-infective compositions to treat disordered tissue such as cold sores
The present invention relates to the treatment of disordered epithelial tissues such as cold sores and other complications resulting from disorders such as herpes, and the like. The invention...
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6423748 |
Amido polybiguanides and the use thereof as antimicrobial agents
Amido polybiguanides and their use as antimicrobial agents in pharmaceutical compositions are disclosed. A method of synthesis of amido polybiguanides is also disclosed. The amido polybiguanides...
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6423705 |
Combination therapy
The invention provdes methods of reducing tissue damage resulting from ischemia which comprise administering to a mammal in need of such reduction an effective amount of a combination, or a...
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6420431 |
Methods for treating disordered tissue through agitated delivery of anti-infective compositions
The present invention relates to the treatment of disordered epithelial tissues such as cold sores and other complications resulting from disorders such as herpes, and the like. The invention...
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6420430 |
Use of inhibitors of the sodium-hydrogen exchanger for preparing a medicament for preventing age-related disorders, and for prolonging life
Inhibitors of the cellular sodium-hydrogen exchanger are employed for preparing a medicament for preventing age-related functional disorders and dysfuntional changes of organs of the body and for...
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6417184 |
Triple drug therapy for the treatment and prevention of acute or chronic pain
A triple drug therapy, pharmaceutical kit, composition, and method of treatment regimen utilized as a combination of effective amounts of an anxiolytic agent, centrally acting alpha antiadrenergic...
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6417159 |
Method of enhancing effect of a neurotrophin with analogues of p75NTR367-379.
The present invention provides methods and compositions for enhancing the effect of a neurotrophin on a cell expressing a neurotrophin receptor. The effect is preferably neurotrophin-mediated...
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6414032 |
Anti-infective compositions for treating disordered tissue such as cold sores
The present invention relates to the treatment of disordered epithelial tissues such as cold sores and other complications resulting from disorders such as herpes, and the like. The invention...
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6413962 |
Guanidino compounds effective as anesthetics
The compositions are aromatic, gaunidino group containing compounds used for inducing anesthesia and reducing core temperatures in mammals.
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6410599 |
Antiseptic compositions suitable for application to human tissue
The present invention relates to an antiseptic composition for treating a human infected with a virus, a bacteria or a fungus, for example, disordered epithelial tissues such as cold sores and...
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6410598 |
Compositions and methods for advanced glycosylation endproduct-mediated modulation of amyloidosis
The present invention relates generally to the non-enzymatic glycosylation of amyloidogenic proteins and the consequent formation of advanced glycosylation endproducts (AGEs). It has been found...
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6395189 |
Method for the control of biofilms
A process is provided for both removing and controlling biofilms present in industrial cooling and process waters. The process provides a composition which includes the reaction products of an...
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6376534 |
Compounds useful in pain management
Compounds of general formula I are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts, pharmaceutical compositions comprising the novel...
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6342522 |
Microbiocidal compositions
A microbiocidal composition including a first component comprises a guanidine compound, a second component which comprises either prochloraz, propiconazole or iodocarb, wherein the weight ratio of...
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6339082 |
Tricyclic compounds, preparation method and said method intermediates, application as medicines and pharmaceutical compositions containing same
A compound selected from the group consisting of a compound of the formula wherein the substituents are defined as set forth in the specification and its salts with non-toxic pharmaceutically...
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6329353 |
Clear personal care formulations containing quaternary ammonium compounds and other nitrogen-containing compounds
A composition formulated from a primary anionic surfactant; optionally a secondary surfactant and/or a resin; and a nitrogen-containing compound of the structural formula: ##STR1## wherein R is...
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6297253 |
Compounds and methods of use to treat infectious diseases
The present invention concerns alkyl aryl carbonyl compounds that possess anti-infective activity. The compounds of the invention can be used to target specific nuclear localization signal, thereby...
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6288124 |
Methods of inhibiting undesirable cell growth using an aminoguanidine compound
The present invention provides for the use of aminoguanidines for prophylactic and/or therapeutic treatments of undesirable cell growth, e.g. tumors. The present invention provides methods of using...
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6288123 |
Therapeutic guanidines
The present invention provides therapeutically useful substituted guanidines, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such guanidines.
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6284797 |
Topical treatment of pain and to promote healing
A topical therapeutic preparation includes capsaicin which is an extract of peppers or chiles and which is a potent local pain killer. The ointment also includes a norepinephrine inhibitor and...
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RE37330 |
Glibenclamide-metformin combination for the treatment of diabetes mellitus of type II
Non-insulin dependent diabetes mellitus in cases of secondary failure is treated with a combination of glibenclamide and metformin.
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6268398 |
Compounds and methods for treating mitochondria-associated diseases
Compounds, compositions and methods are disclosed for treating mitochondria-associated diseases, such as cancer, psoriasis, stroke, Alzheimer's Disease and diabetes. The compounds of this invention...
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6251948 |
Tri-and tetra-substituted guanidines and their use as excitatory amino acid antagonists
Tri- and tetra-substituted guanidines which exhibit a high binding affinity to phencyclidine (PCP) receptors and, more preferably, low affinity to the brain sigma receptors. These guanidine...
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6251854 |
N-methyl-d-aspartate receptor channel blockers and method for identifying such
Compounds that provide protection against excitotoxic neuronal damage are selected from the group consisting of Arg-rich oligopeptides and compounds of formula 1: ##STR1## where R 1 is alkyl,...
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6248787 |
Guanylhydrazones and their use to treat inflammatory conditions
This invention concerns new methods and compositions that are useful in preventing and ameliorating cachexia, the clinical syndrome of poor nutritional status and bodily wasting associated with...
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6221907 |
Tricyclic compounds having activity specific for integrins, particularly alphanubeta3 integrins, method for preparing same, intermediates therefor, use of said compounds as drugs, and pharmaceutical compositions containing same
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6218426 |
Non-peptide GnRH agents
Non-peptide GnRH agents capable of inhibiting the effect of gonadotropin-releasing hormone are of the following general formula, where X 1 , X 2 , Y, and are defined variables: ##STR1## Such...
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6211243 |
Methods for treating cold sores with anti-infective compositions
The present invention relates to a method of treated disordered epithelial tissues such as cold sores and other complications resulting from disorders such as herpes, and the like. The inventive...
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6204294 |
IL-8 receptor antagonists
This invention relates to novel compounds of Formula (1), pharmaceutical compositions and their use in the treatment of disease states mediated by the chemokine, Interleukins-8 (IL-8).
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6201017 |
Ectoparasite controlling agent for animals
An ectoparasite-controlling agent for animals comprising 0.1 to 20% by weight of the neonocotinoid compounds defined in the specification and 10 to 95% by weight of a glycol or glycol monoalkyl...
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6197098 |
Fast drying biocidal preservative composition
The invention relates to a fast drying biocidal composition having enhanced penetration for the treatment and preservation of wood, leather and similar natural products which comprises: A....
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6190652 |
Volatiles of Japanese honeysuckle flowers as attractants for adult Lepidopteran insects
Compositions of cis-jasmone were found to effectively attract adult Lepidoptera. The cis-jasmone may be used alone or in combination with one or more other volatiles of the Japanese honeysuckle...
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6180676 |
Guanylhydrazones and their use to treat inflammatory conditions
This invention concerns new methods and compositions that are useful in preventing and ameliorating cachexia, the clinical syndrome of poor nutritional status and bodily wasting associated with...
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6174924 |
Therapeutic guanidines
The present invention provides therapeutically useful substituted guanidines, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such guanidines.
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6166087 |
Low dosed 15-deoxyspergualin preparations
15-deoxyspergualin or a pharmaceutically compatible salt thereof is suitable for the preparation of an immunosuppressive, anti-inflammatory or anti-tumoral pharmaceutical, which is effective in a...
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6166058 |
Fungicidal mixtures
Fungicidal mixture comprising, as active components, a 1 ) the oxime ether carboxylate of the formula Ia ##STR1## or a salt or adduct thereof, and/or a 2 ) a carbamate of the formula Ib ##STR2##...
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6160021 |
Method for treating epidermal or dermal conditions
A method of treating a subject for an unwanted epidermal or dermal condition comprising administering to the subject, a treatment which modulates the level of nitric oxide (NO) in the skin.
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6156741 |
Therapeutic substituted guanidines
The present invention provides therapeutically useful substituted guanidines of the following Formula: ##STR1## and methods of treatment and pharmaceutical compositions that utilize or comprise one...
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6153604 |
Therapeutic substituted guanidines
The present invention provides therapeutically useful substituted guanidines of the following Formula: ##STR1## and methods of treatment and pharmaceutical compositions that utilize or comprise one...
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6150419 |
Agmatine as a treatment for neuropathic pain
A treatment and composition for neuropathic pain by administering an effective amount of agmatine.
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6150415 |
Epoxide hydrolase complexes and methods therewith
Biologically stable inhibitors of soluble epoxide hydrolases are provided. The inhibitors can be used, for example, to selectively inhibit epoxide hydrolase in therapeutic applications such as...
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6150382 |
Thio acid derived monocyclic n-heterocyclics as anticoagulants
This invention is directed to monocyclic N-heterocyclics which are substituted by acyclic or cyclic thio derivatives which are useful as anti-coagulants. This invention is also directed to...
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