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7291647 Guanylhydrazone compounds, compositions, methods of making and using  
The present invention relates to compounds having the formula: salts thereof; compositions comprising one or more of the compounds and/or salts thereof; methods of using; and methods of...
6936637 Prevention of apoptosis in non-cancerous cells  
Treatment of normal, non-cancerous, animal cells with an agent that depletes polyamines within the cells results in an inhibition of apoptosis when the cells are exposed to an inducer of apoptosis....
6849662 Therapeutic uses for nitric oxide inhibitors  
The present invention is based on the discovery that nitric oxide (NO) is an important growth regulator in an intact developing organism. In particular, the present invention relates to a method of...
6831061 Apicidin-derivatives, their synthetic methods and anti-tumor compositions containing them  
A substituted apicidin derivative, a method of synthesis therefore, and an anti-tumor composition comprising the same are disclosed. The substituent of the derivative is preferably semicarbazone,...
6747062 Regulation of wound healing by nitric oxide  
The present invention provides methods and compositions for promoting healing of damaged tissue that result in an increased level of nitric oxide in the vicinity of the damaged tissue. Also...
6689813 Process for the preparation of pharmaceutical compositions possessing neurogenic or non-neurogenic anti-inflammatory as well as analgetic effects  
The invention relates to the use of peptide amides of formula (I) and phenylamino-oxoacetic acid derivatives of formula (II) as well as the salts of the above compounds as active substances for...
6673777 Guanylhydrazones useful for treating diseases associated with T cell activation  
There is disclosed a method for treating diseases and disorders involving T cell activation and HIV-infection, using the p38 mitogen activated protein kinase (MAPK) signaling pathway as a target...
6605447 Methods and means of detecting nitric oxide synthase  
Methods for identifying and monitoring increased or decreased levels of inducible nitric oxide synthase in biological samples are provided. A collection device for detecting inducible nitric oxide...
6444706 Guanidine derivatives, processes for preparing them and their use as pharmaceutical compositions  
The invention concerns new guanidine derivatives of formula (I), methods of preparing them and their use in drugs containing such compounds.
6433019 Neurotrophic factor secretion promoters  
The present invention relates to a neurotrophic factor secretagogue, in particular, to a BDNF (brain-derived neurotrophic factor) secretagogue, which comprises as an active ingredient an NO donor....
6410598 Compositions and methods for advanced glycosylation endproduct-mediated modulation of amyloidosis  
The present invention relates generally to the non-enzymatic glycosylation of amyloidogenic proteins and the consequent formation of advanced glycosylation endproducts (AGEs). It has been found...
6339082 Tricyclic compounds, preparation method and said method intermediates, application as medicines and pharmaceutical compositions containing same  
A compound selected from the group consisting of a compound of the formula wherein the substituents are defined as set forth in the specification and its salts with non-toxic pharmaceutically...
6284798 Guanidine derivatives, methods of preparing them and their use as drugs  
The invention concerns new guanidine derivatives of formula (I), methods of preparing them and their use in drugs containing compounds, of formula (I), wherein ##STR1## wherein x is --NH--NH--CH 2 ...
6248787 Guanylhydrazones and their use to treat inflammatory conditions  
This invention concerns new methods and compositions that are useful in preventing and ameliorating cachexia, the clinical syndrome of poor nutritional status and bodily wasting associated with...
6133320 Treatment of osteoporosis and metabolic bone disorders with nitric oxide substrate and/or donors  
Primary and secondary osteoporosis in a female or a male mammal is treated by administering thereto a nitric oxide synthase substrate, a nitric oxide donor or both, optionally; in further...
6114392 Agmatine, and polyaminoguanidine-bound heterocyclic compounds for neurotrauma and neurodegenerative diseases  
The invention relates to the use of agmatine, in the treatment of acute neurotrauma (such as stroke) and degenerative disorders of the central and peripheral nervous system (such as dementia). The...
5965529 Treatment of preeclampsia and preterm labor with combination of progestational agent and a nitric oxide synthase substrate and/or donor  
Preeclampsia and preterm labor in a pregnant female mammal are treated by administering thereto a combination of a progestin and a nitric oxide synthase substrate, a nitric oxide donor or both,...
5962413 Treatment of uterine contractility disorders with a nitric oxide synthase substrate and/or donor, or a nitric oxide inhibitor  
Dysmenorrhea, disfunctional uterine bleeding, preterm labor and postpartum labor in female mammals are treated by inhibiting uterine contractility by administering thereto a nitric oxide synthase...
5891909 Amidinohydrazones as protease inhibitors  
Amidino and benzamidino compounds, including compounds of the formula: ##STR1## wherein R 1 -R 4 , R 6 -R 9 , Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or...
5869534 Glycosylation of lipids and lipid-containing particles, and diagnostic and therapeutic methods and materials derived therefrom  
The in vivo oxidation of lipids and lipid-containing molecules has been discovered to be initiated by the concurrent reaction of such lipid materials with reducing sugars such as glucose, advanced...
5837737 Hydrazinedicarboximidamide compounds and pharmaceutical composition comprising same  
Modulators of neurotransmitter release including substituted guanidines, N"-aminoguanidines, and N,N'N",N"'-tetrasubstituted hydrazinedicarboximidamides, and pharmaceutical compositions thereof are...
5693673 Process of preparing 2,2'-(1-methyl-1,2-ethanediylidene)bis hydrazine caroximidamide!  
Process for the preparation of 2,2'-(1-methyl 1,2-ethanediylidene)bis hydrazine carboximidamide! by: a) reacting aminoguanidine hydrochloride with methylglyoxal aldehyde or methylglyoxal...
5686495 Substituted hydrazinedicarboximidamides and methods of use thereof  
Modulators of neurotransmitter release including substituted guanidines, N"-aminoguanidines, and N,N'N",N"'-tetrasubstituted hydrazinedicarboximidamides, and pharmaceutical compositions thereof are...
5652269 Substituted hydrazinecarboximidamides and methods of use thereof  
Modulators of neurotransmitter release including substituted guanidines, N"-aminoguanidines, and N,N'N",N"'-tetrasubstituted hydrazinedicarboximidamides, and pharmaceutical compositions thereof are...
5646188 Polyamine derivatives of 1-aminoindan  
A compound of general formula I ##STR1## wherein n is 1 or 2; R 1 and R 2 are each independently hydrogen, hydroxy, substituted or unsubstituted C 1 -4 alkyl, substituted or unsubstituted C 1 -4...
5614557 Method of controlling tumor growth rate  
α-Fluoromethyl- or α-difluoromethylornithine, and certain derivatives thereof, can be used alone or in combination with cytotoxic agents for the treatment of neoplastic diseases.
5514676 Amino-benzoic acids and derivatives, and methods of use  
The present invention relates to compounds, compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises an agent...
5494934 Guanidine compounds  
A compound of formula (I): ##STR1## in which: R 1 represents substituted or unsubstituted phenyl or (C 3 -C 7 ) cycloalkyl, R 2 represents trifluoromethyl or (C 3 -C 4 ) cycloalkyl, A...
5476849 Methods for glycosylation inhibition using amino-benzoic acids and derivatives  
The present invention relates to compounds, compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises an agent...
5451607 Hydrazone derivatives, process for producing same, insecticides and/or acaricides containing same as active ingredient and intermediate compounds thereof  
There are disclosed hydrazone derivatives of the general formula [I]: ##STR1## wherein R 1 is halogen, etc.; R 2 is hydrogen or C 1 -C 6 alkyl, etc.; R 3 is hydrogen or C 1 -C 6 alkyl, etc.;...
5444082 3,9-disubstituted-spiro(5.5)undecanes active on the cardiovascular system, process for their preparation and pharmaceutical composition containing same  
3,9-disubstituted-spiro[5.5]undecanes and ##STR1## wherein, R, Y, A, B and n are defined in the specification, pharmaceutical compositions containing same for the treatment of cardiovascular...
5405871 Benzophenonehydrazones  
Compounds of the formula ##STR1## wherein each of o and p, independently of the other, is 0, 1, 2, 3, 4 or 5, the radicals R 1 being the same or different when o is greater than 1 and the radicals...
5288727 Hydrazone compounds, processes for their production, intermediates useful for their production and pesticidal compositions containing them  
The present invention relates to a hydrazone compound of the formula (I) or its salt, a process for its preparation, an intermediate of the formula (II-5), a pesticidal composition containing said...
5272176 Advanced glycation inhibitors containing amino-benzoic acids and derivatives, and methods of use  
The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises an agent capable of...
5262152 Amidrazones and derivatives thereof  
The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging) which contain novel amidrazones and derivatives thereof. Accordingly, a...
5232706 Oral pharmaceutical preparation containing omeprazol  
The preparation comprises a nucleus formed by a mixture of omeprazol or an alkali salt of omeprazol with a first basic compound; the nucleus has two coatings, the first of which is formed by one or...
5177083 Drugs effective against retroviruses  
A method to treat or prevent retroviral infection by administering a novel conjugate is described. Lucifer Yellow and its analogs are conjugated to compounds having carbonyl functional groups for...
5118709 Arylhydrazones and pharmaceutical compositions containing the same  
Compounds of formula I ##STR1## wherein A, X 1 , X 2 , X 3 , X 4 , Y, Z and R 1 to R 6 have the meanings given in the description, have valuable pharmaceutical properties and are effective...
4990514 Non-particulate, non-flowable, non-repellant insecticide-bait composition for the control of cockroaches  
A solid, non-particulate, non-flowable, non-repellant insecticide bait composition for consumer household control of cockroaches, comprises an insecticide compound, a food attractant system, and a...
4977145 Method for preventing or treating depression employing an ace inhibitor  
A method is provided for inhibiting onset of or treating depression by administering an ACE inhibitor, which is (S)-1-[6-amino-2-[[hydroxy-(4-phenylbutyl)phosphenyl]oxy]-1- oxohexyl]-L-pr oline,...
4845103 Non-particulate, non-flowable, non-repellant insecticide-bait composition for the control of cockroaches  
A solid, non-particulate, non-flowable, non-repellant insecticide bait composition for consumer household control of cockroaches, comprises a pentadienone hydrazone insecticide compound, a food...
4665085 Amidines, preparation process and therapeutical application thereof  
Compounds having the formula (I) wherein R 1 and R 2 are a hydrogen atom, an alkyl group or a hydroxy group, or else R 1 and R 2 form together a bivalent ethylene or trimethylene radical; R 3 ...
4661522 Cycloalkane-indene-carboximidamide derivatives  
The present invention is dealing with cycloalkane-indene-carboximidamide derivatives having the general formula: ##STR1## wherein Rx together with either Ry 1 or Ry 2 represent the moiety...
4656034 Absorption enhancing agents  
The absorption of a scavenger of oxygen free radicals generated at the time of reperfusion or the absorption of an agent preventing the cytotoxic effects on healthy cells in a mammal. e.g....
4604396 [(2,3,9,9a-tetrahydro-3-oxo-9a-substituted-1H-fluoren-7-yl)oxy]ethanimida mides and [(2,3,9,9a-tetrahydro-3-oxo-9a-substituted-1H-fluoren-7-yl)oxy]ethanimid ic acid hydrazides, their derivatives and their salts  
The invention relates to novel [(2,3,9,9a-tetrahydro-3-oxo-9a-substituted-1H-fluoren-yl)oxy ]ethanimidamid es and [(2,3,9,9a-tetrahydro-3-oxo-9a-substituted-1H-fluoren-7-yl)o xy]ethanimidic acid...
4598095 Antiviral isothiosemicarbazones  
An antiviral drug contains as its effective component an isothiosemicarbazone represented by the following general formula (I) or an acidic salt thereof: ##STR1## wherein R 1 represents a halogen...
4520031 Method for reducing toxic effects of methyl-glyoxal bis-guanylhydrazone  
A method of treating cancers or advanced malignant disease involving the weekly administration of methyl-glyoxal bis-guanylhydrazone in amounts of 250-1,000 mg/m 2 per week. In particular the...
4499105 Carboxyimidamide derivatives  
The present invention is dealing with compounds of the formula: ##STR1## and pharmaceutically acceptable salts thereof, in which n and m represent the number 1 or 2, X and Y hydrogen, alkyl (1-4...
4496589 Anti-inflammatory, disinfectant and anti-bacterial compound  
(+)-6-methoxy-α-methyl-2-naphthalene acetate of N,N"-bis (4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecan-d iimidoamide, possessing the formula (I) ##STR1## has high bioavailability by...
4426393 Method of protecting useful plants and formulations for use in said method  
There are disclosed arylhydrazo-aldoximes which, as such, as tautomers, and in the form of organic or inorganic salts thereof, are active in preventing and treating infections of useful plants by...
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