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7622505 |
Association between agomelatine and a noradrenaline reuptake inhibitor, and pharmaceutical compositions containing it
Association comprising agomelatine, or N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide, in association with a noradrenaline reuptake inhibitor agent. Medicinal products containing the same which are...
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7608737 |
Naphthyl(ethyl)acetamides
This disclosure relates to novel melatonin analogues or naphthyl(ethyl)acetamides, their derivatives, pharmaceutically acceptable salts, solvates, and hydrates thereof. This disclosure also...
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7589237 |
Treatment of CNS disorders with trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine
Treatment of CNS disorders with (1R,4S)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine; and (1S,4R)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine is disclosed....
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7579379 |
CETP activity inhibitors
The present invention provides a CETP activity inhibitor comprising as an active ingredient a compound represented by the formula (I):
wherein R represents a straight chain or branched alkyl...
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7553646 |
Microbial sulfoxidation and amidation of benzhdrylsulfanyl carboxylic acids and uses thereof
The present invention provides novel methods for the synthesis of racemic and enantiomers of modafinil via microbial oxidation-amidation transformation. The methods include the successive...
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7544717 |
2-amino- and 2-thio- substituted 1,3-diaminopropanes
Disclosed are compounds of the formula:
where variables Q, Z, X, R 15 , R 2 , R 3 , and R c are defined herein. Compounds disclosed herein are inhibitors of the beta-secretase enzyme and are...
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7511175 |
Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
The present invention relates to compounds which are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of...
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7482378 |
Physiological cooling compositions
The present invention provides, in one aspect, a physiological cooling composition comprising at least one cyclohexane carboxamide, at least one acyclic carboxamide, and at least one stereoisomer...
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7462741 |
Naphthalene compounds
A compound selected from those of formula (I):
Medicinal products containing the same which are useful in the treatment of disorders of the melatoninergic system.
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7439393 |
Phenethanolamine derivatives for treatment of respiratory diseases
The invention relates to 4-{(1R)-2-[(6-{2-[(2,6-dichlorobenzyl)oxy]ethoxy}hexyl)amino
]-1-hydroxyethyl}-2-(hydroxymethyl)phenol; and salts and solvates thereof, including those which are...
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7378448 |
Diphenylether amide derivatives as opioid receptor antagonists
A compound of the formula (I) wherein the variables X 1 , X 2 , B, D, R 1 to R 7 including R 3′ , p, y, q, and z, are as defined or a pharmaceutically acceptable salt, solvate, enantiomer,...
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7342018 |
Urokinase inhibitors and uses thereof
The invention relates to the use of derivatives of 3-amidinophenylalanine as urokinase inhibitors for treating malignant tumors and the formation of metastases.
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7291295 |
Method for precipitating finely divided solid particles
A method for precipitation of finely divided solid particles comprising
a) Dissolving a compound C in a fluid A to provide a solution A; b) Thermostatization of said solution A to a temperature...
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7256204 |
Amine compounds, their production and use
A compound of the formula:
wherein Ar is an aromatic ring assembly group which may be substituted or a fused aromatic group which may be substituted; X is (i) a bond, (ii) —S—, —SO— or...
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7244767 |
N-acylvanillinamide derivatives capable of activating peripheral cannabinoid receptors
The present invention relates to the use of N-acylvanillinamide derivatives capable of activating the peripheral receptor CB1 of cannabinoids. In particular, the present invention relates to the...
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7179489 |
Process for preparing a pharmaceutical composition containing an active ingredient and a micronised carrier/diluent
The invention relates to a stable pharmaceutical composition useful in the treatment of respiratory disorders such as asthma, rhinitis and chronic obstructive pulmonary disease (COPD) and a novel...
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7115605 |
Peptide deformylase inhibitors
PDF inhibitors and novel methods for their use are provided.
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7034015 |
Aminobenzoephenones
The invention relates to a novel class of aminobenzophenones derivatives, to pharmaceutical preparations comprising said compounds, to dosage units of such preparations, to methods of treating...
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RE39072 |
2-aminopropane-1,3-diol compounds, medicinal use thereof, and intermediates in synthesizing the same
The present invention relates to a compound of the general formula
wherein R 1 , R 2 , R 3 and R 4 are each a hydrogen or an acyl, a pharmaceutically acceptable acid addition salt thereof or...
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6933320 |
Combination comprising combretastatin and anticancer agents
An antitumor combination comprising a stilbene derivative and an anticancer compound selected from the group consisting of taxanes, alkylating agents, antimetabolites, vinca alkaloids, platinum...
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6814953 |
Bronchodilating compositions and methods
Bronchodilating compositions and methods are provided. The compositions are intended for administration as a nebulized aerosol. In certain embodiments, the compositions contain formoterol, or a...
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6656453 |
Medicaments
This invention relates to aerosol formulations of use for the administration of medicaments by inhalation. More particularly, the invention relates to a pharmaceutical aerosol formulation which...
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6642243 |
Migraine medicine and method for treating same
This invention is a safe and effective composition and method for treating acute migraine attacks using pseudoephedrine, acetaminophen, and other agents in an orally administrated form to alleviate...
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6617351 |
Amide, carbamate, and urea derivatives
The present invention provides certain amide, carbamate and urea derivatives useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of...
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6602903 |
Substituted heterocyclic compounds
The invention relates to compounds of formula (I): and medicinal products containing the same are useful in treating or in preventing melatoninergic disorders.
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6537524 |
Combinations of formoterol and a tiotropium salt
A medicament containing, separately or together, (A) formoterol or a pharmaceutically acceptable salt thereof or a solvate of formoterol or said salt and (B) a tiotropium salt of a pharmaceutically...
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6509380 |
Method of treating iron overload with acetaminophen
The present invention relates to methods of controlling iron overload in a patient in need thereof. The present invention particularly relates to methods of treating hemochromatosis and other...
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6509369 |
Anti-inflammatory compounds
This invention relates to anti-inflammatory compounds, methods of making such compounds and methods of using such compounds having the following structure:
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6458781 |
Substituted diarylalkyl amides as calcium channel antagonists
The present invention provides compounds that block calcium channels and have the Formula I: The present invention also provides pharmaceutical compositions containing the compounds of Formula I...
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6410597 |
Hydroxyalkyl amide analogs of ceramide
The present invention provides methods for treating disease conditions associated with abnormal cellular proliferation, inflammation and viral infection or proliferation by the administration of...
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6399093 |
Method and composition to treat musculoskeletal disorders
A method and composition for the treatment of musculoskeletal disorders in mammals by the application of a topical composition comprising a permeation enhancing amount of one or more penetration...
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6372800 |
Benzene compound and pharmaceutical use thereof
A benzene compound of the formula wherein each symbol is as defined in the specification; an optically active isomer or salt thereof, a medicinal composition containing the same, and an...
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6294573 |
Reverse hydroxamate inhibitors of matrix metalloproteinases
Compounds having the formula ##STR1## are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase...
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6265445 |
Antiarrhythmic compounds
The present invention relates to novel, antiarrhythmically active phenoxyalkylamine derivatives possessing a double point of attack. More particularly, the present invention relates to new...
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6258852 |
Aryl nitrone therapeutics for the treatment of inflammatory bowel disease
Disclosed are methods for treating or preventing inflammatory bowel disease (IBD) using aryl nitrone compounds. Pharmaceutical compositions containing aryl nitrone compounds which are useful for...
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6235789 |
Benzocycloalkene compounds, their production and use
A compound of the formula ##STR1## wherein R 1 and R 2 are H, a hydrocarbon group or a heterocyclic group, or R 1 and R 2 are combinedly a spiro ring; R 3 is a hydrocarbon group, a substituted...
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6159505 |
Compositions for the treatment of migraine, containing potassium, magnesium and pyridoxine
Compositions for the treatment and prevention of migraine or stress headaches wherein there is supplied a combination of potassium, magnesium and pyridoxine optionally in association with other...
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6150418 |
Active substance concentrate with formoterol, suitable for storage
The present invention relates to a formoterol active substance concentrate suitable for storage, in the form of a solution or suspension for use in inhalers for inhalation or nasal therapy.
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6143789 |
Naphthalene compounds
Compound of formula (I): ##STR1## wherein: T represents alkylene, A and B together form a naphthalene, dihydronaphthalene, or tetrahydronaphthalene group, R represents hydrogen, hydroxy, R'...
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6140372 |
Acyl derivatives of melatonin and of melatoninergic analogues and their use as medicinal products
The invention relates to derivatives of general formula I ##STR1## as defined in the description. The invention also relates to a process for their preparation and to their therapeutic use, in...
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6028112 |
Spirocyclopropyl fluorenes as melatonergic agents
There is provided novel spirocyclopropyl fluorene derivatives having the general Formula I ##STR1## wherein R, R 1 and X are as defined herein which are useful as melatonergic agents.
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6020369 |
Method compositions and apparatus for treating and preventing respiratory viral infections
Respiratory viral infections may be effectively prevented or treated by administering an aerosol spray comprising a polyoxometalate to the lungs.
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6013649 |
Thiol sulfone metalloprotease inhibitors
This invention is directed to proteinase (protease) inhibitors, and more particularly to thiol sulfone inhibitors for matrix metalloproteinase 13(MMP-13), compositions of proteinase inhibitors,...
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5990116 |
Trisubstituted phenyl derivatives
The invention concerns compounds of formula I ##STR1## wherein the substituents have various meanings, and their use in the prevention or treatment of inflammatory and proliferative skin diseases...
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5972916 |
Compositions containing the nonprescription combination of acetaminophen, aspirin and caffeine to alleviate the pain and symptoms of migraine
The invention provides a safe and economical nonprescription combination of acetaminophen, aspirin and caffeine (APAP/ASA/CAF) for use in treating migraine pain and the cluster of symptoms...
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5925332 |
Radioimaging and radiochemotherapy phenolic thioether amines and acyl derivatives thereof for use in diagnosing and treating pigmentation disorders
Compounds useful in radioimaging and radiochemotherapy as it particularly relates to the treatment and location of malignant melanomas and other pigmenting disorders, as well as novel acyl...
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5906832 |
Method for treating epilepsies
A dosage form is disclosed for delivering an antiepileptic drug, which dosage form comprises for maintaining the integrity of the dosage form and of the antiepileptic drug.
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5866611 |
Therapeutic amines
Compounds of formula I, and their pharmaceutically acceptable salts, ##STR1## in which R 1 and R 2 are hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, phenylalkyl or alkenyl; or NR 1 R 2 is a...
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5852055 |
Pharmaceutical compositions comprising paracetamol and L-cysteine or a precursor thereof
An improved process for the production of a pharmaceutical composition comprising p-hydroxyacetanilide and L-cysteine or a compound which is converted thereto in vivo comprises mixing...
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5834514 |
Halomethyl amides as IL-1β protease inhibitors
Disclosed are compounds, compositions and methods for inhibiting interleukin-1β protease activity, the compounds having the formula A described herein.
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