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7601870 |
Substituted aniline derivatives
The present invention relates to aniline derivatives of the general formula I or salts thereof, described therein, and their use.
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7592371 |
External preparation
It is an object of the present invention to provide an external preparation having enhanced transdermal penetration of a mast cell degranulation inhibitor. It is also an object of the present...
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7459428 |
Method of regulating glucose metabolism, and reagents related thereto
One aspect of the present invention relates to a method for treating Type II diabetes in an animal, comprising conjointly administering to the animal metformin and an inhibitor of...
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7432302 |
Composition containing polyamine transport inhibitor and use thereof
Proliferative cutaneous disease states or conditions are treated by administering a polyamine transport inhibitor
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7419972 |
2-substituted estra-1,3,5(10)-trien-17-ones as inhibitors of 17β-hydroxy steroid dehydrogenase type 1
The invention relates to new 2-substituted estra-1,3,5(10)-trien-17-ones of formula I
as well as their pharmaceutically acceptable salts, their methods of manufacture and use as medicaments for...
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7414039 |
Interstitial therapy for immediate symptom relief and chronic therapy in interstitial cystitis
The present invention relates to a disorder of the lower urinary tract, and in particular, reducing the symptoms (including treatment) of interstitial cystitis in vivo. In a preferred embodiment,...
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7402601 |
Pharmaceuticals for the treatment of rejection reactions in organ transplantations
The use of compound 1 and/or 2 of the formulae
and of physiologically tolerable salts of compound 2 for the treatment of rejection reactions of the organ recipient to the transplanted organ is...
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7354954 |
Use of GABA agonists for treatment of spastic disorders, convulsions, and epilepsy
According to the subject invention, there is disclosed a method for treating a patient/subject having a spastic disorder, a convulsive disorder, pain or epilepsy which includes administering to the...
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7345096 |
Use of norepinephrine reuptake modulators for preventing and treating vasomotor symptoms
The present invention relates to the use of compounds and composition of compounds that modulate norepinephrine levels for the prevention and treatment of vasomotor symptoms, such as hot flush,...
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7316815 |
Polyamino acid derivatives and use thereof in compositions for treating keratin fibers
The invention concerns the use in a cosmetic composition of at least a poly-aminoacid of general formula (I) in which X is —O—, —S— or —NR 3 ; R 1 represents in particular a hydrogen...
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7273887 |
Topical anesthetic formulation
The topical anesthetic formulation of the present invention is typically a solution that preferably includes lidocaine, USP as the active anesthetic ingredient with benzyl alcohol and isopropyl...
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7241812 |
Methods and compositions for modulating sphingosine-1-phosphate (S1P) receptor activity
The present invention relates to compounds which modulate the activity of the S1P1 receptor, the use of these compounds for treating conditions associated with signaling through the S1P1 receptor,...
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7208528 |
Polyamine analogues as therapeutic and diagnostic agents
Novel inhibitors of polyamine transport having inhibition constants two orders of magnitude lower than those of known compounds are disclosed. These polyamine analogues are useful pharmaceutical...
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7071232 |
Small molecules that increase the conversion of food to body weight gain
The present invention relates to peptide-like compounds, e.g. aminocarboxylic acid amide derivatives, and to methods of using same in the field of general health care, for example, to improve...
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7045549 |
Treatment of symptoms associated with irritable bowel syndrome
Methods are provided for use in treating humans suffering from irritable bowel syndrome. In the subject methods, an effective amount of a nerve-acting agent, e.g., lidocaine, topiramate, mexiletine...
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6933320 |
Combination comprising combretastatin and anticancer agents
An antitumor combination comprising a stilbene derivative and an anticancer compound selected from the group consisting of taxanes, alkylating agents, antimetabolites, vinca alkaloids, platinum...
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RE38761 |
Styryl compounds which inhibit EGF receptor protein tyrosine kinase
A method of inhibiting cell proliferation in a patient suffering from such disorder comprising administering to said patient an effective amount of a composition comprising, in admixture with a...
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6900203 |
Optically active fluorinated vasoconstrictors, methods for making them, and anesthetic formulations comprising them
(R)-6F-phenylephrine, essentially free of (S)-6F-phenylephrine, and an anesthetic formulation comprising (R)-6F-epinephrin or (R)-6F-phenylephrine and having improved stability compared to...
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6897209 |
Labelled factor XIIIa substrates
A complex of a radiometal or paramagnetic metal ion with a metal chelating agent such as a diaminedioxime has attached thereto a substituent of formula (Y) m -A-NHR) k can function as a substrate...
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6894078 |
Alcohol based topical anesthetic formulation and method
A method for applying a topical anesthetic to an area of skin comprising the steps of a) incorporating an anesthetic in a lipophilic base into a volatile solvent, to form a homogeneous solution; b)...
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6881756 |
Method for treating skin disorders
The present invention relates to a method for reducing inflammation in the skin and/or treating inflammatory skin disorders, pain, or pruritis by topically applying a composition comprising totarol...
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6855668 |
Methods and products for inhibiting growth of fungal pathogens on turfgrass
Methods and products for inhibiting growth of fungus and fungal disease on a plant. Methods comprise contacting at least a portion of a plant or plant seed together with a fungicidal composition...
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6835388 |
Medicament against dysmenorrhoea and premenstrual syndrome
A local anesthetic is used for the manufacture of a medicament for use against dysmenorrhoea and premenstrual syndrome and for increasing fertility. A pharmaceutical composition may also be used...
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6825203 |
Topical anesthetic/opioid formulations and uses thereof
Many chemical and pharmaceutical compositions are known to produce antinociceptive effects that are helpful in relieving pain and inflammation. Both opioids and local anesthetics serve an important...
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6762174 |
Low molecular weight compounds administered together with anti-cancer agents to prevent or treat cancer and pharmaceutical compositions thereof
The present invention relates to peptide-like compounds, e.g. aminocarboxylic acid amide derivatives, and to methods of using same to stimulate cells of the immune system, bone marrow and other...
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6734204 |
Serotonin potentiation by oleamide analogs
Analogs related to oleamide are employed for potentiating the 5-HT 2A and 5-HT 1A responses to serotonin (5-HT). With respect to the potentiation of the 5-HT 2A receptor response, it is...
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6730329 |
Zinc containing compositions for anti-viral use
One aspect of the invention relates to anti-viral composition containing at least one zinc compound and at least one phenolic antioxidant (and optionally other ingredients such as at least one...
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6716411 |
Method for finding nucleotide synthesis inhibitors having fewer side effects
The invention relates to a method for finding nucleotide synthesis inhibitors which have a better therapeutic window. An efficacious dose of a nucleotide synthesis inhibitor is administered to a...
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6685953 |
External preparation compositions
The present invention relates to a dermatologic preparation containing a diamide derivative represented by the following formula (1): (wherein, R 1 represents a linear or branched hydrocarbon...
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6677376 |
Non-peptidic cyclophilin binding compounds and their use
The invention relates to non-peptidic compounds that possess bioactive properties, such as the ability to protect neuronal cells from otherwise lethal treatments or the ability to promote the...
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6620852 |
Topical anesthetic
The present invention is directed to an improved flowable anesthetic composition that does not need to be applied by an applicator. The anesthetic composition of the present invention may be...
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6589992 |
Inhibiting collagen-induced platelet aggregation
The present invention describes a therapeutic method useful for treating or preventing a condition of platelet aggregation in a subject including administering to the subject a pharmaceutically...
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6576679 |
Hydrogel
A hydrogel formed by adding an anion having a molecular weight of 90 or more to an aqueous dispersion of a cationic amphiphile comprising a linear or branched alkyl group having 10 or less carbon...
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6548523 |
Process for the preparation of arylethanolamine derivatives having an anti-obesity and anti-diabetic properties
The present invention is a process for the preparation of a compound of Formula (IA) or a pharmaceutically acceptable salt thereof: that includes preparing a diamide of Formula (II) or a...
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6514999 |
Use of an agent for treating the symptoms of Parkinson's disease
With an agent for preparing a medication for treating the symptoms of Parkinson's disease, one obtains more effective treatment of the symptoms of said disease compared to classical treatment by a...
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6506416 |
Virucide composition and sporicide composition
The present invention provides a virucide composition and/or sporicide composition having a high virucidal effect and sporicidal effect and being excellent in safety and workability. That is, the...
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6489119 |
Analgesic screening method and composition
Disclosed is a method of selecting analgesic agents based on their selective ability to block tetrodotoxin-insensitive sodium channels, particularly in comparison to blocking tetrodotoxin-sensitive...
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6436996 |
Modulation of nitric oxide production
A method of treating cells that carry at least one APOE4 allele comprises increasing nitric oxide levels in the cells (e.g., by administering an exogenous source of nitric oxide to the cells) by an...
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6429228 |
Local anesthetic for external use
A local anesthetic for external use is prepared by blending a) an active ingredient selected from lidocaine, prilocaine, and pharmaceutically acceptable salts thereof; b) a percutaneous absorption...
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6426338 |
Therapy for constipation
Compositions comprising colchicine and at least one amino-salicylic acid derivative, preferably olsalazine is used for treatment of prophylaxis of constipation.
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6413961 |
Irrigation solution and method for inhibition of pain and inflammation
A method and solution for perioperatively inhibiting a variety of pain, inflammation, spasm and restenosis processes resulting from cardiovascular or general surgical, therapeutic and diagnostic...
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6391888 |
Topical anesthetics useful for treating cancer
The invention provides methods which are useful for treating diseases (e.g., cancer) where PKCδ is implicated, and modulation (e.g, inhibition) of its activity is desired.
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6365590 |
Compounds, compositions and methods for treating erectile dysfunction
Vasoactive compounds are described for the treatment of erectile dysfunction and impotence. The compounds are reaction products of an anionic or negatively charged vasoactive or erection-inducing...
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6346547 |
N-substituted amino acids, antioxidant pharmaceutical compositions containing n-substituted amino acids and methods for preventing cardiovascular diseases and/or preventing and/or treating antioxidant responsive diseases therewith
Low-toxicity, highly-bioavailable, pharmaceutical antioxidant compositions for preferred oral administration to mammals are provided which have at least one amino acid-based compound of the general...
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6340482 |
Methods for inducing weight loss in a human with materials derived from Citrus varieties
Materials derived from Citrus plants can be administered orally to humans for the purpose of producing or maintaining weight loss as well as improving the person's physical performance and...
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6335356 |
Method of treating a patient by parenteral administration of a lipophilic compound
The present invention features pharmaceutical formulations containing a lipophilic compound such as leflunomide. The lipophilic compound is solubilized in solution containing alcohol and a...
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6297290 |
Composition containing a nerve fiber reactivity modulating compound
The present invention relates to a novel aqueous composition based on a compound modulating the reactivity of nerve fibers. It relates more particularly to a pharmaceutical composition for topical...
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6255334 |
5HT 1 receptor agonists and metoclopramide for the treatment of migraine
The present invention relates to a method of treating migraine in a mammal, including a human, by administering to the mammal a 5HT 1 receptor agonist, and particularly eletriptan, in combination...
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6255285 |
Phenethylamine derivatives
The present invention has as its object providing phenethylamine derivatives that typically function as a motilin receptor antagonist and which are useful as medicines. The invention provides...
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6242494 |
Substituted β-amino acid inhibitors of methionine aminopeptidase-2
A class of substituted b-amino acids are potent inhibitor of methionine aminopeptidase type 2 (MetAP2) and are thus useful in inhibiting angiogenesis and disease conditions which depend upon...
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