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6291464 |
Aminopiperazine derivatives
This invention relates to new aminopiperazine derivatives having the potentiation of the cholinergic activity, etc., and represented by general formula [I]. ##STR1## wherein R 1 is lower alkyl,...
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6248788 |
Therapeutic method with capsaicin and capasicin analogs
Application of capsaicin (or a capsaicin analog) in a concentration from about 5% to about 10% by weight has been discovered to be an extremely effective therapy for treating neuropathic pain. In...
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6225329 |
Modulators of protein tyrosine phosphatases (PTPases)
The present invention provides novel compounds of Formula 1, compositions containing these compounds, methods of their use, and methods of their manufacture, where such compounds are...
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6184252 |
2-amino-1,3-alkanediol compositions for inducing/stimulating hair growth and/or retarding hair loss
Topically applicable hair growth-/hair loss-affecting cosmetic/pharmaceutical compositions for treating mammalian subjects with hair or scalp disorders, comprise an effective amount of at least one...
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6174918 |
Naphthoquinone antitumor compound and method
The invention provides 1,4-naphthoquinone compounds and a method for inhibiting tumor cell growth in a subject by administering such compounds. The compounds are represented by the structures:...
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6143755 |
Pharmaceutical methods of treatment with ACAT inhibitors and HMG-CoA reductase inhibitors
The present invention is a combination of an ACAT inhibitor, for example, sulfamic acid, [[2,4,6-tris(1-methylethyl)phenyl]acetyl]-, 2,6-bis(1-methylethyl) phenyl ester, and an HMG-CoA-reductase...
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6140356 |
Opthalmic pharmaceutical compositions comprising a nitrone compound and methods for treating ocular inflammation using such compositions
Ophthalmic pharmaceutical compositions containing a pharmaceutically acceptable ophthalmic carrier and an inflammation-treating amount of a nitrone compound are disclosed. Also disclosed are...
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6140370 |
Stabilized alkyd based compositions containing halopropynl compounds
This invention pertains to the protection of nonaqueous compositions containing a transition metal from microbial spoilage using a stabilized antimicrobial composition comprising a halopropynyl...
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6124309 |
Method and pharmaceutical composition for regulating lipid concentration
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6117872 |
Enhancement of exercise performance by augmenting endogenous nitric oxide production or activity
NO precursors are administered at elevated levels in addition to the diet of the individual to enhance exercise performance. Particularly, L-arginine and L-lysine by enhancing endothelial NO...
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6114382 |
Methods for treating inflammatory bowel disease
The present invention provides novel compositions and methods relating to the treatment of Inflammatory Bowel Disease ("IBD"), most notably, Ulcerative Colitis, Crohn's Disease, Colitis and...
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6103768 |
Fatty acid based compositions and methods for the control of plant infections and pests
The invention described here concerns the unique utility of fatty acids and their derivatives to eradicate existing fungal and bacterial infections in plants. Also, described herein are combination...
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6090854 |
Aryloxyanilides and related compounds
There is provided novel aryloxyanilides and related compounds of the formula ##STR1## wherein R 1 is --OR, --CO 2 R, or halogen with R being C 1 -4 alkyl; R 2 is R, cyclopropyl, C 2 -4...
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6028112 |
Spirocyclopropyl fluorenes as melatonergic agents
There is provided novel spirocyclopropyl fluorene derivatives having the general Formula I ##STR1## wherein R, R 1 and X are as defined herein which are useful as melatonergic agents.
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6008252 |
Method for increasing muscle mass in a mammal
The present invention is based in part upon the discovery that the use of pyruvate in enteral formulations, in combination with anaerobic exercise produces a synergistic effect in increasing the...
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5990173 |
2,3,5-trimethyl-4-hydroxyanilide derivatives, preparation thereof and therapeutical use thereof
Novel 2,3,5-trimethyl-4-hydroxyanilide derivatives of general formula I, wherein, e.g., R 1 is phenyl, R 2 is H, R 3 is C 12 H 25 , and A is a sulphur atom, are disclosed. A method for...
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5977180 |
Anandamide analog compositions and method of treating intraocular hypertension using same
Anandamide analogues useful for the treatment of intraocular hypertension, as well as ophthalmic compositions comprising the same and a cyclodextrin, and methods of use of these compounds to treat...
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5965621 |
Methods and compositions for reducing or maintaining body weight in a mammal
A method for reducing or maintaining the level of adipose tissue formation in a mammal includes the step of administering a pantethine composition to the mammal in an amount and for a period of...
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5958439 |
Plant protection composition containing one or more water soluble active materials and one or more polyalkoxylated amidoamines
A composition containing, as active ingredient, one or more water soluble plant protection active materials and further containing an effective amount of one or more polyalkoxylated amidoamines of...
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5955092 |
Skin care compositions containing an n-substituted fatty acid amide and retinol or retinyl ester
N-substituted fatty acid amides which sufficiently inhibit LRAT or ARAT catalyzed esterification of retinol into inactive retinyl esters, have the same effect on keratinocytes as retinoic acid....
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5952384 |
Method and composition for treating mammalian diseases caused by inflammatory response
A method for treating the disease state in mammals caused by mammalian cells involved in the inflammatory response is disclosed. Mammalian cells participating in the inflammatory response are...
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5932233 |
Cosmetic compositions
Described is a cosmetic composition comprising (A) an amide compound having a melting point of 0 to 50° C. and (B) a hydrophilic surfactant. The cosmetic composition according to the present...
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5932595 |
Matrix metalloprotease inhibitors
The present invention relates to compounds of Formula I: ##STR1## that are matrix metalloprotease inhibitors, pharmaceutical compositions containing them, methods for their use and methods of...
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5932229 |
Oxa diacids and related compounds for treating skin conditions
Described are the use of compounds of Formula (I), depicted below, as active principals for treating skin conditions; compositions containing these compounds; and methods of treating skin...
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5929119 |
Fungicidal composition
A composition which is suitable for controlling fungal pests, comprising conventional additives and an effective amount of a p-hydroxyaniline derivative of the general formula I ##STR1## where the...
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5925681 |
Blooming, disinfectant concentrate compositions
Concentrated aqueous liquid disinfectant compositions which exhibit a blooming effect when diluted in a larger volume of water are provided. The concentrate compositions include non-phenolic...
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5925365 |
Water-in-oil cosmetic emulsions
Described is a water-in-oil type cosmetic emulsion comprising (A) an amide compound having a melting point of 0 to 50° C. and (B) a nonionic surfactant having an HLB smaller than 8. The cosmetic...
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5925678 |
Use of N-acyl derivatives of aminoalcohols in the manufacture of a medicament for practicing neuroprotective action in neuropathological states connected with excitotoxicity
The use of N-acyl derivatives of aminoalcohols with mono- and di-carboxylic acids for the prevention and treatment of diseases connected with hyper and prolonged excitation by excitatory amino...
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5891919 |
Denatonium capsaicinate and methods of producing the same
A new compound, Denatonium Capsaicinate, and a method of producing the same are disclosed. Denatonium Capsaicinate provides an enhanced bitter and/or spicy, pungent flavor and may be used as an...
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5891920 |
Medicinal adjuvants consisting of N-subsitituted-o-toluidine derivatives, and percutaneously absorbable preparations comprising the adjuvants
A drug solubilizer or drug-absorption accelerator of Formula I is disclosed wherein R 1 and R 2 are herein defined ##STR1##
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5880158 |
Propionamide anticonvulsants
The present invention is directed to a compound of the following formula: ##STR1## pharmaceutical compositions containing the same and the use thereof as an anticonvulsant.
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5880160 |
Colchicine derivatives, the use thereof and formulations containing them
The present invention relates to novel colchicine derivatives having antiproliferative, antineoplastic, antiinflammatory and muscle relaxant activities; said derivatives include novel colchine...
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5880159 |
Compositions containing and methods of using 1-aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives
Novel derivatives of 1-aminoindan and their salts are described. Optically active 1-aminoindan derivatives are prepared by reacting a N-benzyl analog of the desired compound with an enantiomer of...
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5869532 |
Taurine derivatives for use in cleanser compositions
Taurine derivatives represented by the following formula (1) and cleanser compositions containing the same: ##STR1## wherein R is a linear or branched alkyl or alkenyl group having 5 to 21 carbon...
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5851782 |
Inhibitors of ceramidase
The present invention relates, in general, to the bioeffector molecule ceramide and, in particular, to methods of effecting intracellular accumulation of ceramide. The invention further relates to...
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5834521 |
Substituted dibenz (A F)azulenes and methods of preparation
Tetracyclic compounds having the following structure are described: ##STR1## wherein R 1 -R 10 are as defined. The tetracyclic compounds are capable of potent effects on steroid sensitive tissues...
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5834517 |
Meadowfoam sulfosuccinates in personal care applications
The present invention deals with a process for cleaning and conditioning hair and skin which comprises the contacting of hair or skin woth an effective concentration of certain novel meadowfoam...
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5830916 |
Inhibitor of ceramidase
The present invention relates, in general, to the bioeffector molecule ceramide and, in particular, to methods of effecting intracellular accumulation of ceramide. The invention further relates to...
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5814649 |
Preventive and remedy for type 1 allergic diseases
A pharmaceutical composition for prophylaxis or treatment of Type I allergic diseases which comprises as an active ingredient an anilide compound represented by the general formula (I) ##STR1##...
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5814659 |
Topical analgesic composition
The present invention comprises a topical analgesic composition comprising an analgesic agent, an alcohol, a chaotropic agent and an unsaturated fatty acid. The composition is preferably in the...
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5801198 |
Retarding neutrophil infiltration ad morphologic reduction in ischemic bowel tissues
Treating mammals having ischemic bowel with a therapeutic quantity of pyruvate enterally or parenterally will retard neutrophil infiltration and retain morphology during and following the bowel...
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5780512 |
Alkylated (hetero) cyclic compounds
The invention relates to a compounds selected from these of formula (I): ##STR1## in which: R 1 , R 2 , R 3 and A are as defined in the description, and a medicinal product containing the same...
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5780505 |
Substituted N-arylmethylamino derivatives of cyclobutene-3, 4-diones
The compounds of the formula: ##STR1## wherein R 1 is straight chain alkyl, branched chain alkyl, cycloalkyl, hydroxyalkyl, fluoroalkyl or polyfluoroalkyl; R 7 and R 8 are, independently,...
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5770188 |
Glucoxide derivatives for enzyme modification, lipid-coated enzymes, method of producing such enzymes and antifouling paint composition
This invention is related to glucoxide derivatives for enzyme modification of the following general formula (1), to provide a lipid-coated enzyme showing high activity in organic solvents;...
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5763438 |
2-acylaminopropanol compound and medical composition
This invention relates to a 2-acylaminopropanol compound represented by the formula (I): ##STR1## (wherein R 1 represents a phenyl group which may be substituted by 1 to 3 same or different...
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5760085 |
Topical aromatic releasing compositions
The present invention relates to topical aromatic releasing compositions containing one or more volatile aromatic compounds selected from the group consisting of 3-1-menthoxy propane-1,2-diol,...
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5753709 |
N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics
Certain N-acyl 2-aryl cyclopropylmethylamine derivatives are useful as melatonergic agents.
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5736578 |
Ethylamido fluorenes and improved method of making same
Novel substituted fluorene compunds of Formula I are active as melatonergic agents: ##STR1## wherein: X=H, halogen, OH or OZ; Z=C 1 -6 alkyl; --(CH 2 ) m --CF 3 (m=0-2); CD 3 ; or ##STR2##...
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5733560 |
Method of improving retention time of volatile organic chemical coated on a surface
A composition comprising: an organic chemical Which has a chemical group having a dipole moment of at least about 1.5 and a chemical linker composition which is an ethoxylated glycerol type...
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5733935 |
Hydroxylamine derivatives and fungicides containing the same
A hydroxylamine derivatives of formula (I): ##STR1## wherein R represents ##STR2## in which R 1 and R 2 represents alkyl group, alkenyl group, alkynyl group, cycloalkyl group, haloalkyl group,...
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