Matches 201 - 250 out of 284 < 1 2 3 4 5 6 >
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5079248 Anti-arrhythmic agents  
A series of [N-alkyl-N-(nitro-, alkylsulphonamido, or amino-phenalkyl) amino]-alkyl, alkoxy or alkylthio phenyl derivatives having utility as anti-arrhythmic agents.
5075337 Alpha-deuterated 2-alkylaminoacetamide derivatives having reduced toxicity for treatment of CNS disorders  
Deuterated 2-alkylaminoacetamide compounds are described having the alpha carbon of the alkyl side chain of the compounds substituted by one or two deuterium atoms. These compounds have...
5059620 Aryl substituted aminomethyl benzene derivatives  
The present invention relates to new compounds of the formula ##STR1## wherein X is ##STR2## wherein R 1 is hydrogen, lower alkyl, phenyl, benzyl, cinnamoyl, thiophene, furan, pyrrole, imidazole,...
5047425 Amine derivatives having cardiovascular activity  
Compounds of the formula ##STR1## wherein Ar, R, R 1 , R 2 , R 3 , R 4 , X and n have the meanings mentioned in the description, processes and intermediates for their preparation, pharmaceutical...
5032617 Substituted benzamide radiosensitizers  
A method for sensitizing hypoxic tumor cells to radiation using derivatives of benzamide are disclosed. Some of the compounds useful in the REFERENCE TO GOVERNMENT GRANT OR CONTRACT The invention...
5019395 Compositions with enhanced penetration  
Penetration of various drugs through living membranes is improved by their use in transdermal compositions containing certain penetration-enhancing systems. A new delivery device is also described.
5017619 Phenethanolamine derivatives  
The invention is directed to phenethanolamine derivatives and their pharmaceutically compatible salts, having the formula ##STR1## wherein n is the number 1 or 2; L 1 and L 2 are hydrogen, C 1 -3...
5017618 Labile derivatives of ketone analogs of 3-substituted-1-alkylamino-2-propanols and their use as beta-adrenergic blockers  
Compounds having the formula ##STR1## and their pharmaceutically acceptable acid addition salts, wherein --X-- is --O--, --CH 2 -- or --; Y is O or a derivatized keto group which is...
5002946 Phenylethanolamine analog active compounds for the treatment of gastrointestinal diseases  
Phenylethanolamine analog active compounds, optionally substituted on the phenyl group with an halogen atom or with an alkyl or trifluoromethyl group and substituted on the amino group with a...
4999377 Chemical compounds  
2-(2-Hydroxy-3-phenoxypropylamino)ethylphenoxyacetamide compounds are disclosed as useful in the treatment of obesity and related conditions. Processes for their preparation are described, as are...
4990536 Immunopotentiator and spergualin-related compound therefor  
The present invention provides a use for the preparation of an immunopotentiator of a spergualin-related compound represented by the following general formula [I] or a pharmacologically acceptable...
4990505 Phenethanolamine compounds  
The invention provides compounds of the general formula (I) ##STR1## wherein the substituents are defined in the specification, and physiologically acceptable salts and solvates thereof. The...
4987153 Alkylaminoamide compounds  
Novel alkylaminoamides of the formula ##STR1## wherein R is selected from the group consisting of (a) alkyl of 1 to 8 carbon atoms, (b) cycloalkyl of 3 to 7 carbon atoms optionally substituted with...
4981866 Anticonvulsant agents  
This invention provides certain 4-substituted benzamide derivatives, their pharmaceutical formulations, and their use as anticonvulsant agents.
4954512 Anti-ulcer composition  
An anti-peptic ulcer composition containing, as an active ingredient, a therapeutically effective amount of a compound having the formula (I): ##STR1## wherein A represents H 2 NCH 2 --, ##STR2##...
4933369 Dimethyl tyrosyl amide sulfides, sulfoxides and sulfones  
The present invention relates to new compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof and the enantiomers thereof, wherein R 1 is H, lower alkyl, alkenyl,...
4931470 Antiarrhythmic method  
This invention provides a method of treating or preventing cardiac arrhythmias employing certain 4-amino-N-2,6-(dimethylphenyl)benzamide derivatives.
4885313 3,4-Dihydroxyphenylethylamine derivatives and their use  
Novel 3,4-dihydroxyphenylethylamine derivatives possess dopaminergic activity in animals and are therefore useful in the treatment of iner alia congestive heart failure, renal failure and...
4880840 Arylethanolhydroxylamines and their use for promoting yield  
4880834 Method for administering ethanolamine derivatives to livestock  
A method for treating livestock to decrease birth mortality rate and to increase post-natal survival rate by administering ethanolamine derivatives is disclosed.
4851446 Immunosuppressing method  
The present invention relates to an immunosuppressing method which comprises administering a spergualin-related compound represented by the following formula ##STR1## (wherein R 1 is --(CH 2 ) 4 ...
4847295 Cycloalkyl-substituted 4-aminophenyl halo derivatives and process for their preparation  
The invention relates to cycloalkyl substituted 4-aminophenyl halo derivatives of formula (I) ##STR1## wherein n is an integer of 1 to 5; A is >CO or --CH 2 -- and B is, independently,...
4847301 Methods of use of α-(aminoalkyl)-arylacetic acid derivatives  
Novel α-aryl-α-(ω-aminoalkyl)-α-[hydroxy(aralkyl and cycloalkyl)]acetic acid derivatives and α-aryl-α-(ω-aminoalkyl)-α[alkanoyloxy(aralkyl and cycloalkyl)]acetic acid derivatives, such as...
4845127 Phenethanolamines, compositions containing the same and method for effecting weight control  
Optically active N-3-(4-substituted phenyl)propyl-β-phenethanolamines are provided as well as pharmaceutical compositions containing such compounds. A method for effecting weight control in obese...
4826876 Chemical compounds having selective thyromimetic activity  
This invention relates to chemical compounds which have selective thyromimetic activity. A compound of this invention is 3,5-dibromo-3'-[6-oxo-3(1H)-pyridazinyl-methyl]-thyronine.
4816486 Amide derivatives and 5-lypoxygenase inhibitors containing the same  
Novel amide derivatives are disclosed. As examples of said amide derivatives are mentioned N-cyclohexyl-N-methyl-(2-(3-(3-methoxy-4-hydroxyphenyl)-2-(p ropenoylamino) -3, 5-dibromobenzyl)amine and...
4803225 Dihydroxy-phenethylamino compounds useful as pharmaceuticals  
There are provided compounds of formula I, ##STR1## and pharmaceutically acceptable derivatives thereof. There are also described the use of the compounds of formula I as pharmaceuticals, methods...
4794111 Dihydropyridine preparations containing β-blockers  
An antihypertensive and antianginal combination comprising (A) 0.1 to 10 parts by weight of an asymmetrical dihydropyridine of the formula ##STR1## in which R 1 and R 5 each independently is...
4767781 Derivatives of beta-amino-gamma-trimethylammonio-butyrate and their production and use  
A compound of the formula: ##STR1## wherein R 1 is hydrogen, alkyl or acyl, R 2 is hydroxy, alkoxy or amino, is useful as an antidiabetic agent.
4735959 Carboxylic acid amides and pharmaceutical compositions containing them  
There are described novel carboxylic acid derivatives of the formula ##STR1## and derivatives of the formula ##STR2## and the addition salts thereof, which exhibit an effect on the intermediary...
4732916 Novel guanidinomethylbenzoic acid derivatives  
A guanidinomethylbenzoic acid derivative represented by the formula ##STR1## or a salt thereof. An antiulcer agent comprising the compounds of the afore-said formula as an effective ingredient is...
4692465 2-phenylethylamine derivatives  
Compounds of formula (I): ##STR1## or a pharmaceutically acceptable salt, ester or amide thereof, wherein: Ar is benzofuran-2-yl, or phenyl optionally substituted by groups R 1 and/or R 2 wherein...
4681898 N-N-disubstituted alkenamides and phenylalkenamides  
Compounds of the formula ##STR1## where n is 0 or 1, R is alkyl, phenyl or R 4 -substituted phenyl, R 2 and R 3 are, independently, alkyl or R 2 and R 3 together with N is ##STR2## m...
4668703 γ-allenyl-γ-aminobutyric acids  
This invention is for γ-allenyl-γ-aminobutyric acid derivatives which are γ-aminobutyric acid transaminase inhibitors.
4661515 Compounds having angiotensin converting enzyme inhibitory activity and diuretic activity  
Novel compounds possessing both angiotensin enzyme inhibitory activity and diuretic activity are disclosed. The compounds are represented by the general formula ##STR1## in which X is ##STR2## in...
4652584 Acetylenic phenoxypropanol derivatives and pharmaceutical compositions for the treatment of hypertension  
Phenoxypropanol derivatives having a 2-acetylenic moiety on the phenyl group thereof of the following formula (I): ##STR1## and their use as anti-hypertensives, e.g. in man. Also part of the...
4639468 Derivatives of glycinamide, their preparation and their use  
A glycinamide derivative of the general formula I: ##STR1## wherein: R is a linear or ramified alkyl group C 5 -C 18 , a linear or ramified alkenyl group C 5 , C 6 , C 7 , C 8 , C 9 , C 10 , C 11...
4629737 Secondary amines and use in pharmaceutical compositions  
A compound of formula (I): ##STR1## or a pharmaceutically acceptable salt, ester or amide thereof, in which: W is an optionally substituted phenyl group of the formula ##STR2## wherein R 1 is...
4585796 Novel phenethanolamines  
The tertiary amines of the formula ##STR1## wherein n represents a whole number of 1 to 5; X 1 represents phenyl or phenyl mono-, di- or tri-substituted by R 1 , R 2 and R 3 ; X 2 ...
4564636 Diphenylazomethines and pharmaceutical compositions containing them  
Diphenylazomethines of the formula (I) ##STR1## in which R represents --(CH 2 ) 4 OH, --(CH 2 ) 2 --CHOH--CH 3 , --CH 2 --CHOH--C 2 H 5 , --CH 2 --CHOH--CH 2 --COOH, --CH 2 --CHOH--CH 2 ...
4562201 Aminomethyl benzanilides  
The present invention relates to new compounds of the formula ##STR1## where X is ##STR2## alkylene, or --S-- where R 1 is hydrogen, alkyl, or aryl; W is hydrogen, hydroxy, amino, alkyloxy,...
4562206 Orally effective inotropic compounds  
A method for increasing cardiac contractility in a warm-blooded animal suffering from acutely depressed cardiac contractility which comprises administering to said animal an effective amount of a...
4559361 Naphthalenecarboxamides, their production and use  
Novel compounds of the formula: ##STR1## wherein R is phenyl-C 1 -6 alkyl, and salts thereof, have intraocular pressure depressant action.
4545995 Substituted phenylalkenyl ammonium salts as antiarrhythimc agents  
The novel unsaturated arylalkyl ammonium salts described herein are useful as antiarrhythmic agents. A method of treating arrhythmia by increasing the refractoriness of cardiac tissue is provided,...
4460580 N-Alkylated aminoalcohols and their pharmaceutical compositions useful for the treatment of cardiac insufficiency  
The invention relates to novel N-alkylated aminoalcohols of the formula ##STR1## in which Ar is a radical of aromatic character which is unsubstituted or substituted by hydroxyl, n has the values...
4435425 Fluorinated diaminobutane derivatives  
Fluorinated diaminobutane compounds in vivo are inhibitors of gamma-aminobutyric acid transaminase and have the following formula: ##STR1## wherein: R 1 represents hydrogen, C 1 -C 6 alkyl, or...
4428883 Novel method of administering β-blockers and novel dosage forms containing same  
The invention provides a novel method of administering selected known adrenergic β-receptor blocking agents, such as dichloroisoproterenol, pronethalol, sotalol and alprenolol, which are of use in...
4425360 Pharmacologically active novel O-substituted pyruvic acid oximes  
The present invention provides pyruvic acid oximes of the general formula: ##STR1## wherein R is a hydrogen atom, a C 3 -C 8 cycloalkyl, C 1 -C 6 alkoxy, cinnamyloxy, phenylamino,...
4407816 3-Substituted-2-propenimidamides and method of manufacturing the same  
New derivatives of 3-furyl-, 3-thienyl- and 3-phenyl-2-propenimidamides are disclosed, which are useful as anti-ulcer agents. These new compounds are synthesized by reacting an imino ether derived...
4402975 Aminocarboxylic acids, amino alcohols, or the derivatives thereof, processes for production thereof, and pharmaceutical uses thereof  
A compound represented by the following formula ##STR1## wherein R 1 represents a hydrogen atom, an acyl group or an alkoxycarbonyl group; X 1 represents an alkylene group having 3 to 6 carbon...
Matches 201 - 250 out of 284 < 1 2 3 4 5 6 >