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8168827 |
Amide derivative
Amide derivatives represented by the formula (I): wherein: A is a cycloalkyl group, an aryl group or a heteroaryl group; X is a nitrogen atom or CR17; Y is —NRa-, —(CRbRb′)m-, and the like; m is 0 ...
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8153693 |
Compounds for the selective treatment of the intestinal immuno-inflammatory component of the celiac disease
The present invention relates to amino-salicylic-aminophenyl compounds for use in the treatment of the inflammatory component of celiac disease. These compounds act by blocking the cytokines...
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8129431 |
Aqueous liquid preparation containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid
An aqueous liquid preparation of the present invention containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid or its pharmacologically acceptable salt or a hydrate thereof, an alkyl aryl polyether...
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8093295 |
Formulations of suberoylanilide hydroxamic acid and methods for producing the same
The present invention provides a pharmaceutical composition or crystalline composition with a specific dissolution profile, which comprises suberoylanilide hydroxamic acid or a pharmaceutically...
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8088828 |
Treating benign prostate hyperplasia with SARMS
This invention provides a method of treating, preventing, suppressing, inhibiting or reducing the incidence of benign prostate hyperplasia in a male subject, by administering to the subject a...
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8071575 |
Methods and compounds for the targeted delivery of agents to bone for interaction therewith
Bone targeted compounds and methods are provided. Compounds can include a Bone Targeting Portion (RT), having an affinity for bone; a Bone Active Portion (RA) for interacting with and affecting...
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8044078 |
Amino-alkyl amide derivatives as CCR3 receptor ligands
The invention relates to a compound of the general formula (I), as defined herein which is useful for the treatment of a pathology in a patient wherein a CCR3 receptor plays a role in the...
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8021687 |
Modified release compositions of milnacipran
A milnacipran formulation that provides delayed and extended release of milnacipran has been developed. The formulation comprises milnacipran or a salt thereof; an extended release excipient, and a...
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8017630 |
Cyclohexylacetic acid compounds
Novel cyclohexylacetic acid compounds corresponding to formula I: processes for the production thereof, pharmaceutical compositions containing these compounds, methods of producing pharmaceutical...
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8008348 |
Treating muscle wasting with selective androgen receptor modulators
This invention provides: 1) a method of treating a subject suffering from a muscle wasting disorder; 2) a method of preventing a muscle wasting disorder in a subject; 3) a method of treating,...
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7981937 |
Stable dispersion of DBNPA in viscosified brine
A dispersion of 2,2-dibromo-3-nitrilopropionamide (“DBNPA”) particles in a restrictedly viscosified concentrated brine solution effectively negates gelling of the brine solution because the nat...
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7973079 |
Methods and compounds for treating retinol-related diseases
Compounds that reduce serum retinol levels are used to treat ophthalmic conditions associated with the overproduction of waste products that accumulate during the course of the visual cycle. We...
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7960436 |
Substituted arylamino-1,2,3,4-tetrahydro naphthalenes and-2,3-dihydro-1H-indenes as potassium channel modulators
This invention provides compounds of formula I where Ar1 is a 5- to 10-member mono- or bicyclic aromatic group, optionally substituted; where the —NR3R4 group is situated ortho to the NHC(═X) gro...
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7956093 |
Substituted amides, their preparation and use
An amide of the formula I and its tautomeric forms, possible enantiomeric and diastereomeric forms, E and Z forms, and possible physiologically tolerated salts.
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7901701 |
Methods for producing dried pesticide compositions
Disclosed are compositions and methods related to powder and granular emulsifiable concentrate pesticide formulations. As disclosed, emulsions from non-aqueous based liquid or solvent soluble...
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7888393 |
Transdermal compositions
The present invention is directed to transdermal compositions and the uses thereof. These compositions include at least one of the following components: a C1-C6 dialkyl, C12-C30 dialkyl quaternary...
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7855229 |
Treating wasting disorders with selective androgen receptor modulators
This invention provides: 1) a method of treating a subject suffering from a muscle wasting disorder; 2) a method of preventing a muscle wasting disorder in a subject; 3) a method of treating,...
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7851509 |
Polymorphs of suberoylanilide hydroxamic acid
The present invention provides methods of selectively inducing terminal differentiation, cell growth arrest and/or apoptosis of neoplastic cells, and/or inhibiting histone deacetylase (HDAC) by...
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7846958 |
Fungicidal use
The use of benzophenones of the formula I in which R is hydrogen or C1-C4-alkyl andHal is fluorine, chlorine or bromine for controlling Pseudocercosporella herpotrichoides in crop plants is described.
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7838557 |
Concentrated X-ray contrast media can act as universal antigens and can inhibit or prevent allergic reactions
The present application is directed to the use of X-ray contrast media that act as universal antigens that are labeled herein as “pseudoantigens.” X-ray contrast media have the potential to exi...
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7816386 |
Cinnamic, phenylpropiolic and phenylpropanoic acid derivatives useful as anti-tumor agents
Cinnamic and phenylpropiolic acid derivatives of formula (I) having antitumour and chemo sensitizing activity are described. Also described are pharmaceutical compositions containing the...
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7795208 |
Methods of using deacetylase inhibitors to promote cell differentiation and regeneration
A method of enhancing progenitor cell differentiation, including enhancing myogenesis, neurogenesis, and hematopoiesis, by contacting a progenitor cell with an effective amount of a deacetylase...
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7741371 |
Selective androgen receptor modulators and methods of use thereof
This invention provides a class of androgen receptor targeting agents (ARTA). The compounds are selective androgen receptor modulators (SARM) useful for, inter-alia, suppressing spermatogenesis,...
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7741323 |
Indene derivatives and process for the preparation thereof
An indene derivative for selectively modulating the activities of peroxisome proliferator activated receptors (PPARs) having the following formula (I): wherein, R1 is C1-6 alkyl, C1-6 alkenyl, or...
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7732491 |
Treatment of breast cancer with a PARP inhibitor alone or in combination with anti-tumor agents
In one aspect, the present invention provides a method of treating breast cancer that is negative for at least one of ER, PR, or HER2, comprising administering to a subject at least one PARP...
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7700626 |
Compositions containing opioid antagonists
Compositions containing opioid antagonists, particularly alvimopan and its active metabolite, with improved solubility and bioavailability for oral or parenteral administration, injectable dosage...
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7622503 |
Selective androgen receptor modulators and methods of use thereof
This invention provides SARM compounds and their use in treating a variety of diseases or conditions in a subject, including, inter-alia, a muscle wasting disease and/or disorder or a bone-related...
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7550510 |
Solid phase synthesis of arylretinamides
A solid phase synthetic method for preparing arylretinamides is provided. The method comprises reacting hexachloroacetone with a solvent-suspended resin-bound triphenylphosphine to provide a...
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7550481 |
Phenylamide and pyridylamide beta-secretase inhibitors for the treatment of Alzheimer's disease
The present invention is directed to phenylamide and pyridylamide derivative compounds of which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which...
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7547728 |
Treating muscle wasting with selective androgen receptor modulators
This invention provides: 1) a method of treating a subject suffering from a muscle wasting disorder; 2) a method of preventing a muscle wasting disorder in a subject; 3) a method of treating,...
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7456221 |
Prodrugs of excitatory amino acids
This invention relates to synthetic excitatory amino acid prodrugs and processes for their preparation. The invention further relates to methods of using, and pharmaceutical compositions...
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7399789 |
Bone targeting compounds for delivering agents to bone for interaction therewith
The present invention relates to compounds of the formula or pharmaceutically acceptable salts thereof, useful for delivering agents having the capacity to diagnose, treat or prevent bone injury or...
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7361653 |
Pest control agent composition and method of using the same
The present invention relates to a composition for noxious organisms-controlling agent having a synergistic effect and a method for using said composition, which comprises, as active ingredients...
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RE40259 |
Alpha-aminoamide derivatives useful as analgesic agents
The present invention relates to novel and known alpha-aminoamide compounds, to a process for their preparation, to pharmaceutical composition containing them and to their use as therapeutic...
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7342028 |
Medical use for tachykinin antagonists
The present invention relates to the use of tachykinin antagonists, including substance P antagonists and other neurokinin antagonists, in the treatment of emesis. Also described are novel...
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7335664 |
Colon cleansing composition and method
A composition and method for cleansing a colon prior to endoscopic procedure. More particularly, a combination of bisacodyl, metoclopramide, sodium, and/or a phosphorus containing composition...
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7326730 |
Aminoadamantane derivatives as therapeutic agents
The present invention provides novel aminoadamantane derivatives, methods of making the derivatives, compositions including the novel aminoadamantane derivatives, and methods for the treatment and...
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7319112 |
Non-halogenated antibacterial agents and processes for making same
The present invention provides antibacterial compounds, antibacterial compositions, bacteria-reducing methods, bacteria-reduced substrates/articles made by the methods that employ an antibacterial...
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7307078 |
Polycyclic compounds which modulate PPARγ type receptors and cosmetic/pharmaceutical compositions comprised thereof
Novel polycyclic compounds having the structural formula (I) below: are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine (in dermatology, and...
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7307071 |
RAF-MEK-ERK pathway inhibitors to treat cancer
Materials and methods for treating certain cancers are described, preferably cancers that result from the up-regulation of the RAF-MEK-ERK pathway, and more preferably chronic myelogenous leukemia,...
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7235588 |
Method for reducing hypertension and heart failure
A method is provided for reducing hypertension and/or heart failure in a mammal. Preferably, the method is used to treat or prevent tissue damage to a human heart. The method includes administering...
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7229963 |
Methods of using deacetylase inhibitors to promote cell differentiation and regeneration
A method of enhancing progenitor cell differentiation, including enhancing myogenesis, neurogenesis, and hematopoiesis, by contacting a progenitor cell with an effective amount of a deacetylase...
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RE39682 |
Farnesyl derivatives and pharmaceutical compositions containing them
Novel farnesyl derivatives which are inhibitors of the prenylated protein methyltransferase enzyme, and useful as anti-cancer drugs, have the following formula: wherein R1represents farnesyl,...
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7208511 |
Microbicidal composition
A microbicidal composition containing: (a) 2-methyl-4-isothiazolin-3-one; and (b) 2,2-dibromo-3-nitrilopropionamide.
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7157078 |
Devices and methods for eliminating termite colonies
This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing a) a termiticide selected such...
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7151117 |
Concentrated X-ray contrast media can act as universal antigens and can inhibit or prevent allergic reactions
The present application is directed to the use of X-ray contrast media that act as universal antigens that are labeled herein as “pseudoantigens.” X-ray contrast media have the potential to exi...
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7147866 |
UV-absorbing lipid vesicles
Highly effective vesicular compositions from UV-absorbing lipids are described in the present invention. Combination of UV-absorbing property and the vesicular delivery system results in higher...
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7129238 |
Mandelic acid derivatives
The invention is concerned with novel mandelic acid derivatives of formula (I) wherein R1 to R10, X and Y are as defined in the description and in the claims, as well as pharmaceutically acceptable...
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7125559 |
Cosmetic or dermatological composition comprising a combination of an elastase inhibitor of the N-acylaminoamide family and at least one myorelaxing agent
Cosmetic or dermatological composition characterized in that it comprises a combination of an elastase inhibitor of the N-acylaminoamide family and at least one myorelaxing agent.
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7084176 |
N-arylphenylacetamide derivatives and medicinal compositions containing the same
N-Arylphenylacetamide derivatives represented by the following formula [I]: (wherein R1 is C1-6 alkoxy, etc.; R2 is hydrogen, —(CH2)m—N(R6)(R7) (m is an integer of from 1 to 4; R6 is hydrogen, C1-...
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