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7618651 |
Pharmaceutical compositions for drug delivery and methods of treating or preventing conditions using same
The present invention relates to pharmaceutical compositions in the form of a gel for controlled- or sustained-release of a pharmaceutically active agent and to methods for treating or preventing...
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7598232 |
Amino-substituted (E)-2,6-dialkoxystyryl 4-substituted-benzylsulfones for treating proliferative disorders
Compounds useful as antiproliferative agents, including, for example, anticancer agents, are provided according to formula (I); wherein: X, X 1 , X 2 , R a , R 1 , R 2 ,R 3 , R 4 , R 5 , R 6 , R 7...
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7595344 |
Sulphones which modulate the action of gamma secretase
Disclosed are sulphones which modulate the action of gamma-secretase. The compounds are useful in the treatment or prevention of Alzheimer's disease.
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7553646 |
Microbial sulfoxidation and amidation of benzhdrylsulfanyl carboxylic acids and uses thereof
The present invention provides novel methods for the synthesis of racemic and enantiomers of modafinil via microbial oxidation-amidation transformation. The methods include the successive...
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7528172 |
Compositions and methods for improving recovery after general anesthesia
Compositions and methods for improving recovery following general anesthesia are provided. The composition comprises an effective dose of modafinil. Modafinil has been shown to reduce the symptoms...
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7511175 |
Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
The present invention relates to compounds which are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of...
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7449493 |
Diamines as modulators of chemokine receptor activity
The present application describes modulators of MCP-1 of formula (I):
or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma, multiple sclerosis,...
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7446225 |
Pentafluorosulfanylphenyl-substituted benzoylguanidines, method for the production thereof, their use as a medicament or diagnostic agent, and a medicament containing these compounds
The invention relates to pentafluorosulfanylphenyl-substituted benzoylguanidines of the formula I:
and a process for preparing a compound of the formula I and/or the pharmaceutically acceptable...
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7405323 |
Modafinil polymorphic forms
Modafinil polymorphic forms of modafinil racemate, methods of preparation thereof, pharmaceutical compositions and methods of therapeutic treatment involving modafinil polymorphic forms.
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7375138 |
Pentafluorosulfanylbenzoylguanidines, processes for their preparation, their use as medicaments or diagnostic aids, and medicaments comprising them
Pentafluorosulfanylbenzoylguanidines of the formula I and II
in which R1 to R4 have the meanings stated in the claims, are suitable as antiarrhythmic medicaments with a cardioprotective...
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7361653 |
Pest control agent composition and method of using the same
The present invention relates to a composition for noxious organisms-controlling agent having a synergistic effect and a method for using said composition, which comprises, as active ingredients...
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7319112 |
Non-halogenated antibacterial agents and processes for making same
The present invention provides antibacterial compounds, antibacterial compositions, bacteria-reducing methods, bacteria-reduced substrates/articles made by the methods that employ an antibacterial...
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7304094 |
Cyclohexyl sulphones
Novel sulphones of formula I are disclosed:
The compounds modulate the processing of amyloid precursor protein by gamma-secretase, and hence are useful in the treatment or prevention of...
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7253210 |
Methylene-bridged selective androgen receptor modulators and methods of use thereof
This invention provides a class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). Several of the...
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7141555 |
Modafinil compound and cyclodextrin mixtures
Mixtures of a modafinil compound with a cyclodextrin, methods for their use, and compositions thereof are disclosed, along with complexes comprising a modafinil compound and a cyclodextrin which...
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7132456 |
MCH receptor antagonists
The present invention relates to a melanin concentrating hormone antagonist compound of Formula I: (I) wherein Ar 1 , Ar 2 , Ar 3 , L 1 , L 2 and Q areas defined, or a pharmaceutically acceptable...
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7132455 |
Phthalamide derivatives
This invention relates to novel phthalamide derivatives of formula (I)
wherein R 1 , R 2 , R 3 , R 4 , and R 5 have the meanings given in the disclosure, to processes for their...
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7098198 |
Compositions of ezetimibe and methods for the treatment of cholesterol-associated benign and malignant tumors
A method of prevention or treatment of a cholesterol-associated tumor is provided which comprises administering a therapeutically effective amount of an azetidinone-based cholesterol absorption...
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7087647 |
Compositions including modafinil for treatment of attention deficit hyperactivity disorder and multiple sclerosis fatigue
Modafinil is effective in improving symptoms of attention deficit hyperactivity disorder and symptoms of multiple sclerosis fatigue. The administration of modafinil is also shown to activate the...
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7084176 |
N-arylphenylacetamide derivatives and medicinal compositions containing the same
N-Arylphenylacetamide derivatives represented by the following formula [I]:
(wherein R 1 is C 1-6 alkoxy, etc.; R 2 is hydrogen, —(CH 2 ) m —N(R 6 )(R 7 ) (m is an integer of from 1 to...
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6951860 |
Calcium channel blockers
The invention involves the identification of a family of compounds which block calcium channels. The compounds can be formulated in pharmaceutical carriers and administered to subjects. The...
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6946441 |
Inhibition of histone deacetylase as a treatment for cardiac hypertrophy
The present invention provides for methods of treating and preventing cardiac hypertrophy. Class II HDACs, which are known to participate in regulation of chromatin structure and gene expression,...
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6919378 |
Pharmaceutical solutions of modafinil compounds
Pharmaceutical compositions of modafinil compounds, including pharmaceutical, non-aqueous compositions of modafinil compounds in organic solvents and pharmaceutical compositions of a modafinil...
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6849648 |
Phenylene alkyne matrix metalloproteinase inhibitors
A compound of Formula I
or a pharmaceutically acceptable salt thereof, or a tautomer thereof, wherein G 1 , G 2 , and B are as defined in the application, are selective inhibitors of...
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6849120 |
Oxidation method for preparing highly pure modafinil, crystalline forms of modafinil, and methods of preparing the crystalline forms
The present invention provides an improved process for preparing modafinil, whereby it may be isolated in high purity by a single crystallization. The process produces modafinil free of sulphone...
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6844361 |
Pharmaceutical composition comprising a sodium hydrogen exchange inhibitor and an angiotensin converting enzyme inhibitor
This invention is directed to a pharmaceutical composition comprising the sodium-hydrogen exchanger (NHE) inhibitor cariporide and an angiotensin converting enzyme (ACE) inhibitor which exhibits...
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6825236 |
Colchicine derivatives
Certain N-deacetylcolchicine and N-deacetylthiocolchine derivatives are described wherein the 7-N position on the B ring is substituted with the group —C(O)—(CHR 4 ) m —AR, wherein m is an...
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6803386 |
Prostacyclin derivative containing compositions and methods of using the same for the treatment of cancer
The present invention is directed to a pharmaceutical composition containing a cancer-treating effective amount of a class of prostacyclin derivatives, and a pharmaceutically acceptable carrier,...
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6787568 |
Antibiotic/analgesic formulation and a method of making this formulation
A formulation that includes a mixture of at least one antibiotic, at least one analgesic, and at least one solvent is provided. The antibiotic and the analgesic are dissolved in the solvent to form...
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6777442 |
Diphenyl derivatives
The present invention relates to compounds of the general formula (I) in which X represents O, S, SO, SO 2 , CH 2 , CHF, CF 2 or NR 8 , and Z represents a group of the formula in which A...
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6699904 |
PPAR agonists
PPAR alpha activators, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and...
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6646003 |
Method of treating ocular inflammatory and angiogenesis-related disorders of the posterior segment of the eye using an amide derivative of flurbiprofen or ketorolac
The topical use of certain flurbiprofen amide derivatives and ketorolac amide derivatives to treat ophthalmic angiogenesis-related and inflammatory disorders of the posterior segment of the eye is...
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6638976 |
Method of treating neurodegenerative disorders of the retina and optic nerve head
The use of 3-benzolphenylacetic acids and derivatives, including nepafenac, to treat neurodegenerative retinal disorders is disclosed.
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6638970 |
Substituted alkylene diamine compounds
Novel compounds of the general formula: and pharmaceutically acceptable acid addition salts thereof, wherein the compounds are useful in therapy to protect skeletal muscles against damage...
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6624193 |
Preventive and therapeutic agents for eye diseases
The present invention provides a prophylactic and therapeutic medicament for ophthalmic diseases, especially ophthalmic inflammatory diseases and corneal ulcer, comprising as an active ingredient a...
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6610701 |
Thrombin inhibitors
Compounds of the invention are useful in inhibiting thrombin and treating blood coagulation and cardiovascular disorders and have the following structure: wherein R 3 is hydrogen or halogen,...
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6608061 |
Bisaryl compound and medicament for cancer treatment comprising the same
A medicament for treatment of cancer comprising a compound represented by the following general formula (I) or a physiologically acceptable salt thereof: Ar 1 —S—R 1 —S—Ar 2 wherein R 1 ...
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6566404 |
Treatment of drug-induced sleepiness
Benzhydrylsulphinyl derivatives are used to prevent the sleepiness associated with pain medication. Such derivatives selectively antagonize the hypnogenic effect of anti-pain treatment, such as...
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6552061 |
Amino acid derivatives and anti-inflammatory agents
Provided are an anti-inflammatory agent containing, as an active ingredient, at least one selected from amino acid derivatives represented by formula (I) wherein Ar represents an optionally...
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6538029 |
Methods for treatment of renal cell carcinoma
A method of treating renal cell carcinoma in a mammal with that disease comprising administering to the mammal a physiologically effective amount of an inhibitor of PDE10.
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6528528 |
Thiourea and benzamide compounds, compositions and methods of treating or preventing inflammatory diseases and atherosclerosis
The present invention provides compounds of Formula I shown below. The present invention also provides methods of treating or preventing 3 inflammation or atherosclerosis, and a pharmaceutical...
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6515028 |
Glucamine compounds for treating hepatitis virus infections
N-Substituted glucamine compounds of Formula I are effective in treatment of hepatitis infections, including hepatitis B and hepatitis C. In treating hepatitis infections, the compounds of Formula...
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6506798 |
4-Arylamino, 4-aryloxy, and 4-arylthio diarylamines and derivatives thereof as selective MEK inhibitors
The invention provides compounds of formula (II), wherein Ar, R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and W have the meanings given in the description. They are selective MEK inhibitors.
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6503950 |
Triple drug therapy for the treatment of narcotic and alcohol withdrawal symptoms
A triple drug, pharmaceutical kit, composition, and method of treatment containing a combination of effective amounts of at least one anxiolytic agent, at least one centrally acting alpha...
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6465519 |
Uses of modafinil and its D/L enantiomers
This invention relates to new uses of Modafinil and its D/L enantiomers, particularly the new uses in the pharmaceutical preparation field. This invention provides new uses of Modafinil and its D/L...
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6462089 |
Method for correcting the vigilance disorders associated with myopathies
The present invention relates to the use of modafinil and isomers thereof for correcting psychosocial life disturbances due to vigilance disorders observed during the evolution of myopathies.
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RE37873 |
Phenylacetic acid derivatives, preparation thereof and intermediates therefor, and compositions containing them
Phenylacetic acid derivatives of the formula I
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6455588 |
Compositions including modafinil for treatment of eating disorders and for appetite stimulation
Modafinil is effective in improving symptoms of eating disorders or in stimulating appetite.
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6444705 |
Angiogenesis inhibitors
A method for inhibiting angiogenesis comprising administering to a patient (mammal, such as a human) in need thereof, a pharmaceutically effective amount of an angiogenesis inhibitor containing a...
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6420428 |
Treatment and prevention of hepatic disorders
The present invention provides new methods for the treatment of viral hepatitis C involving the administration of vitamin E and other compounds with antioxidant properties. Treatment with high...
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