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7605289 |
Benzamide derivatives and uses related thereto
Benzamide derivatives of formula I and II, and pharmaceutically acceptable salts, solvates, stereoisomers, and prodrugs thereof, and pharmaceutical compositions comprising the same, are described...
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7605164 |
Compositions and methods for treating heart failure
Certain substituted benzamide derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including...
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7601868 |
Amine derivative
The present invention provides a compound represented by the formula
or salts thereof, wherein, Ar 1 , Ar, R, R 1 , R 2 , Ra 1 , Ra 2 , Ra 3 , Ra 4 and Y have meanings described in the...
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7595343 |
Inhibitors of histone deacetylase
The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides...
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7589094 |
N- (3-amino-2-hydroxy-propyl) substituted alkylamide compounds
Disclosed are compounds of the formula (I):
useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in...
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7582663 |
Biaromatic compounds which activate PPARγ type receptors and cosmetic/pharmaceutical compositions comprised thereof
Novel biaromatic compounds having the structural formula (I) below:
are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine (in dermatology,...
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7557143 |
Thyroid receptor ligands
Thyroid receptor ligands are provided which have the general formula I
wherein:
R1 is
R2 and R3 are the same or different and are hydrogen, halogen, alkyl of 1 to 4...
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7553876 |
Polycationic compounds and uses thereof
Aspects of the present invention relate to compounds and methods useful in modulating angiogenesis and methods of treating or preventing diseases associated with angiogenesis by administering a...
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7553831 |
Compounds to treat Alzheimer's disease
The present invention is disubstituted amines of formula (I)
and disubstituted amines of formula (II)
useful in treating Alzheimer's disease and other similar diseases.
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7547804 |
Compounds, compositions, and methods employing same
Compounds and pharmaceutical compositions containing the same are provided, which are useful in therapeutic treatment or prevention of various diseases.
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7544839 |
Process for the synthesis and crystalline form agomelatine
Process for the industrial synthesis and new crystalline form of the compound of formula (I):
Medicinal products containing the same which are useful in treating disorders of the melatoninergic...
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7531576 |
Biphenyl derivatives
Biphenyl derivatives represented by the following formula (1):
wherein R 1 represents a C 5-7 alkyl group, R 2 represents a substituted or unsubstituted aromatic hydrocarbon, or cycloalkyl...
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7521476 |
Aminoacetonitrile derivatives suitable for controlling parasites
The invention relates to compounds of the general formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 8′ , R 9 , W, a, b and n have the significances given in claim 1 , and...
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7514582 |
2′-substituted 1,1′-biphenyl-2-carboxamides, processes for their preparation, their use as medicaments, and pharmaceutical preparations comprising them
Compounds of the formula I,
in which R(1), R(2), R(3), R(4), R(5), R(6), R(7), R(8), R(30) and R(31) have the meanings indicated in the claims, are very particularly suitable as novel and...
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7511175 |
Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
The present invention relates to compounds which are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of...
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7511077 |
Diamine calcium channel blockers
Aromatic derivatives of aliphatic diamines are effective in ameliorating conditions characterized by unwanted calcium ion channel activity, especially T-type and N-type channels. These conditions...
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7507836 |
Benzamide modulators of metabotropic glutamate receptors
The present invention is directed to compounds which are allosteric modulators of metabotropic glutamate receptors, including the mGluR5 receptor, and which are useful in the treatment or...
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7504422 |
Polyamine compounds
This invention relates to methods for treating retinopathy and repairing tissue damage. The methods include administering to a subject in need thereof an effective amount of one or more compounds...
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7485320 |
Liposome for incorporating large amounts of hydrophobic substances
A liposome formulation for stably incorporating high content of hydrophobic substance is disclosed. The liposome includes two phospholipids with different phase transition temperatures such as...
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7482488 |
Aryl and heteroaryl propene amides, derivatives thereof and therapeutic uses thereof
Compounds useful as antiproliferative agents, radioprotective agents and cytoprotective agents, including, for example, anticancer agents, are provided according to formula I: wherein ring A, ring...
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7476764 |
Phenylcarboxyamides as beta-secretase inhibitors
There is provided a series of novel phenylcarboxyamides of Formula (I)
or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , X and Y as defined herein,...
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7476683 |
Glycinamide derivatives as raf-kinase inhibitors
The present invention relates to glycinamide derivatives of formula (I), the use of the compounds of formula (I) as inhibitors of raf-kinase, the use of the compounds of formula (I) for the...
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7449493 |
Diamines as modulators of chemokine receptor activity
The present application describes modulators of MCP-1 of formula (I):
or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma, multiple sclerosis,...
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7439394 |
Cyclohexyl-1,4-diamine compounds
Novel cyclohexyl-1,4-diamine compounds corresponding to formula I,
processes for the production thereof, pharmaceutical compositions containing these compounds, methods of producing...
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7432289 |
5-Acylamino-1,1′-biphenyl-4-carboxamide derivatives and their use as P38 kinase inhibitors
Compounds of formula (I):
or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
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7425579 |
Methods for inhibiting activity of polyamine transporters
A method for inhibiting the activity of a natural polyamine transporter comprising the step of contacting the transporter with an inhibitorily effective amount of a compound of formula (I) or (II):...
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7423067 |
Diphenyl cyclopentyl amides as cannabinoid-1 receptor inverse agonists
Novel compounds of structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases...
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7414078 |
Oral general anesthetics and metabolitically resistant anticonvulsants
The present invention is directed to novel themisone derivative compounds that have been modified to prevent the formation of the toxic metabolite, 2-phenyl-acrylamide. Compositions comprising such...
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7407989 |
Compounds useful for modulating abnormal cell proliferation
There is described compounds of Formula I, and salts, solvates and hydrates thereof:
wherein: R 1 , R 2 and R 3 are each independently selected from OH, C 1-6 alkyl, OC 1-6 alkyl, OC(O)C 1-6...
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7399776 |
Polyamine compounds for treating chemokine receptor mediated diseases
This invention relates to a method for treating inflammatory diseases or immune diseases, developmental or degenerative diseases, or tissue injuries. The method includes administering to a subject...
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7390836 |
Small molecules used to increase cell death
The invention features methods for increasing cell death. The invention also features compounds used to increase cell death. The invention further features methods for identifying compounds that...
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7388029 |
Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
A method for treating hair loss in mammals uses compositions containing prostaglandin F analogs. The compositions can be applied topically to the skin. The compositions can arrest hair loss,...
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7368478 |
Methods for inhibiting angiogenesis and tumor growth
Angiogenesis, tumor growth, and metalloproteinase 2 (MMP2) interaction with integrin-α v β 3 are inhibited by an inhibitor compound of formula:
wherein G 1 and G 2 are each independently...
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7368462 |
Melanin concentrating hormone antagonists
The present invention relates to compounds capable of serving as moderators of human and mammalian appetite and as such provide a means for reducing body mass and controlling obesity.
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7361653 |
Pest control agent composition and method of using the same
The present invention relates to a composition for noxious organisms-controlling agent having a synergistic effect and a method for using said composition, which comprises, as active ingredients...
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7354943 |
Statine derivatives for the treatment of Alzheimer's disease
The present invention relates to compounds of formula (I):
useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme...
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7332524 |
Adamantyl acetamides as 11-beta hydroxysteroid dehydrogenase inhibitors
the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein n represents an integer being 1 or 2; R 1 and R 2 each independently...
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7326730 |
Aminoadamantane derivatives as therapeutic agents
The present invention provides novel aminoadamantane derivatives, methods of making the derivatives, compositions including the novel aminoadamantane derivatives, and methods for the treatment and...
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7323452 |
Method for the accelerated in vivo removal of ethanol
A method for accelerating the process of removing ethanol from the blood through the use of certain additives that accelerate the metabolic oxidation of ethanol, and others which in addition act as...
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7319112 |
Non-halogenated antibacterial agents and processes for making same
The present invention provides antibacterial compounds, antibacterial compositions, bacteria-reducing methods, bacteria-reduced substrates/articles made by the methods that employ an antibacterial...
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7319096 |
Thyroid hormone receptor antagonists for cardiac and metabolic disorders II
This invention relates to novel compounds which are thyroid receptor ligands, preferably antagonists, and to methods for using such compounds in the treatment of cardiac and metabolic disorders,...
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7312236 |
Substituted (4-aminocyclohexen-1-yl)phenyl and (4-aminocyclohexen-1-yl)pyridinyl compounds as 5-HT1F agonists
The present invention relates to compounds of formula I:
or a pharmaceutically acceptable acid addition salt thereof, where;
X is —C(R 4 )═ or —N═; Ar is phenyl, substituted...
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7291621 |
Substituted biaryl amides C5a receptor modulators
Substituted biaryl amides of Formula I are provided. Such compounds are ligands that may be used to modulate C 5 a receptor activity in vivo or in vitro, and are particularly useful in the...
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7268153 |
N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. These compounds are useful in the enhancement of weakened muscle tone and the treatment...
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7262223 |
Amidine derivatives for treating amyloidosis
The present invention relates to the use of amidine compounds in the treatment of amyloid-related diseases. In particular, the invention relates to a method of treating or preventing an...
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7256192 |
Aromatic diamide derivatives, chemicals for agricultural or horticultural use and usage thereof
The present invention relates to an aromatic diamide derivative represented by the general formula (I):
[A 1 is optionally substituted (C 1 -C 8 )alkylene group, (C 3 -C 8 )alkenylene...
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7253194 |
Compounds and inhibitors of phospholipases
The present invention relates generally to amino acid derivatives and to methods of making the same. In particular, the invention relates to compounds bearing a stereochemical identity, that is,...
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7241811 |
Amide compounds for the potentiation of cholinergic activity
Amide compounds of the formula:
wherein R 1 and R 2 are taken together to form lower alkenylene, etc.,
R 3 is aryl, etc., X is N, etc., Y is a single bond, etc., and Q is
...
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7238711 |
Compounds and methods to inhibit or augment an inflammatory response
Isolated and purified chemokine peptides, variants, and derivatives thereof, as well as chemokine peptide analogs, are provided.
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7230018 |
Substituted propane-1,3-diamine derivatives and the pharmaceutical use thereof
Substituted propane-1,3-diamine derivatives, methods for producing such derivatives, and medicaments and pharmaceutical compositions containing such derivatives useful for the treatment or...
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