|
Match
|
Document |
Document Title |
|
|
5547984 |
N-Acetonyl-substituted-amides
Certain N-acetonyl-substituted-amides of the formula: ##STR1## wherein A is a heterocycle, a phenylalkyl, a phenylalkoxy, naphthyl, cycloalkyl, alkoxyalkyl, alkyl, haloalkyl or alkenyl group; X, Y...
|
|
|
5532278 |
Methods and compositions for treating urinary incontinence using optically pure (S)-oxybutynin
A method for treating urinary incontinence while avoiding concomitant liability of adverse effects associated with racemic oxybutynin is disclosed. The method comprises administering a...
|
|
|
5514683 |
Bicyclo 2,2,2!octane derivatives
The compounds of the formula I ##STR1## and their pharmaceutical acceptable salts, which are defined herein, are ligands for cholecystokinin and/or gastrin receptors.
|
|
|
5514676 |
Amino-benzoic acids and derivatives, and methods of use
The present invention relates to compounds, compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises an agent...
|
|
|
5506257 |
Aminocyclohexylamides for antiarrhythmic and anaesthetic uses
The present invention provides methods for blocking sodium channels in cardiac or neuronal tissue using aminocyclohexylamides. This invention also provides kits including aminocyclohexylamides and...
|
|
|
5504115 |
Inhibitors of farnesyl protein transferase
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to...
|
|
|
5502061 |
Peptidyl substituted benzamides and naphthamies
The present invention provides HIV protease inhibitors, pharmaceutical formulations containing those compounds and methods of treating and/or preventing HIV infection and/or AIDS.
|
|
|
5496857 |
Whitefly insecticide
A specially formulated environmental insecticide is provided which effectively controls whiteflies and other insects but is safe to humans, farm animals, pets, crops, and fish. The cost-effective...
|
|
|
5492917 |
Endothelin antagonists incorporating a cyclobutane
Novel compounds of the general structural formula I: ##STR1## have endothelin antagonist activity and are therefore useful in treating cardiovascular disorders, such as hypertension, pulmonary...
|
|
|
5482942 |
(3,4-dioxocyclobuten-1-yl)chromene, indene, and dihydronaphthalenone derivatives as smooth muscle relaxants
This invention relates to novel 4-(3,4-dioxocyclobuten-1-yl)chromenes and dihydronaphthalenones and 3-(3,4-dioxocyclobuten-1-yl)indenes and salts thereof having smooth muscle relaxing activity, to...
|
|
|
5478835 |
Tricyclic compounds and intermediates thereof
Disclosed is a tricyclic compound represented by the formula (I): ##STR1## wherein each of R 1 , R 2 , R 3 and R 4 independently represents hydrogen, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio,...
|
|
|
5476944 |
Derivatives of cyclic phenolic thioethers
The present invention relates to derivatives of cyclic phenolic thioethers of the formula: ##STR1## and the pharmaceutically acceptable salts thereof, which are inhibitors or stimulators of...
|
|
|
5476874 |
New HIV protease inhibitors
Oligopeptide analogs containing sulfonamide, urea or carbamate linkages in the backbone are described. These compounds are useful in the inhibition of HIV protease, the prevention or treatment of...
|
|
|
5476849 |
Methods for glycosylation inhibition using amino-benzoic acids and derivatives
The present invention relates to compounds, compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises an agent...
|
|
|
5475034 |
Topically administrable compositions containing 3-benzoylphenylacetic acid derivatives for treatment of ophthalmic inflammatory disorders
Novel ester and amide derivatives of 3-benzoylphenylacetic acid are disclosed. The use of these novel derivatives and certain known derivatives in topically administrable compositions for the...
|
|
|
5472983 |
Benzamide-containing pharmaceutical compositions
A group of benzamide compounds are disclosed that are formed into pharmaceutical compositions for oral or intravenous administration to patients suffering from neurodegenerative conditions...
|
|
|
5470878 |
Cell signaling inhibitors
Therapeutic compounds have the formula: (X)j-(non-cyclic core moiety), j being an integer from one to three, the core moiety is non-cyclic and X is a racemic mixture, R or S enantiomer, solvate,...
|
|
|
5466712 |
Substituted n-aryl-1,2-diaminocyclobutene-3,4-diones
The compound of the formula (I) or a pharmaceutically acceptable salt thereof, are smooth muscle relaxants ##STR1##
|
|
|
5464870 |
Methods of inhibiting development of leukoplakia with fenretinide
This invention relates to methods of inhibiting development of leukoplakia or malignant lesions in a patient comprising the step of administering an effective leukoplakia or malignant lesion...
|
|
|
5461075 |
Use of vanilloids for the prevention of lesions due to herpes simplex infections
The present invention provides methods of preventing lesions due to herpes simplex infections in humans and lower animals by treatment with natural and synthetic vanilloid compounds.
|
|
|
5459149 |
Penta-2,4-dienamides and use as pesticides
The present Application discloses pesticidally active compounds of formula (I): Q(CH 2 ) a (O) b Q 1 CR 2 =CR 3 CR 4 =CR 5 CXNR 1 R x or a salt or propesticide thereof, wherein Q is an...
|
|
|
5455273 |
N,N-disubstituted arylcycloalkylamines, the salts thereof, pharmaceutical compositions containing these compounds and the use thereof and processes for preparing them
The invention relates to N,N-disubstituted arylcycloalkylamines of general formula ##STR1## wherein n, m, A, X and R 1 to R 7 are defined as in claim 1, the isomers, isomer mixtures and salts...
|
|
|
5449691 |
3,4-disubstituted anilines-immunomodulating agents
A method for inducing the production of interleukin 2 in a warm blooded animal by administering an effective amount of a compound of the formula (I) ##STR1## wherein Y is ##STR2## NHSO 2 or SO 2 ...
|
|
|
5449692 |
Substituted (arylalkylaminobenzyl) aminopropionamide derivatives and process for their preparation
The invention provides new compounds of formula (I) ##STR1## wherein n is an integer of 1 to 4; each of R and R 1 , which may be the same or different, is hydrogen, halogen, trifluoromethyl or C 1 ...
|
|
|
5446066 |
Substituted (arylalkoxybenzyl)aminopropanamide derivatives and process for their preparation
The invention provides new compounds of formula (I) ##STR1## wherein, subject to a proviso, n is zero or an integer of 1 to 3; each of R and R 1 , which may be the same or different, is hydrogen,...
|
|
|
5434188 |
1-ether and 1-thioether-naphthalene-2-carboxamides as inhibitors of cell adhesion and as inhibitors of the activation of HIV
1-Ether and 1-thioether-naphthalene-2-carboxamides are described, methods of manufacture therefor and their use as agents which inhibit leukocyte adherence to vascular endothelium and, as such, are...
|
|
|
5430060 |
Acetamide derivatives
The invention concerns novel N-phenylacetyl and related acyl derivatives of (4-amino-2,6-dimethylphenylsulphonyl)nitromethane and pharmaceutically acceptable salts thereof which are inhibitors of...
|
|
|
5416118 |
Bicyclic amides as inhibitors of acyl-coenzyme A: cholesterol acyl transferase
Novel bicyclic amides of the formula ##STR1## wherein Ar 1 and Ar 2 are phenyl, R 2 -substituted phenyl, heteroaryl or R 2 -substituted heteroaryl, wherein R 2 is 1 to 3 substituents...
|
|
|
5414017 |
Trifluoromethyl mercaptan and mercaptoacyl derivatives and method of using same
Compounds of the formula ##STR1## wherein m is zero or 1; n is zero, 1 or 2; p is zero or 1 to 6 provided that m and p are not both zero; R 3 is hydrogen, acyl, or benzyl; and R 1 is hydrogen,...
|
|
|
5405873 |
Substituted acetamide derivatives
There are provided substituted acetamide derivatives represented by general formula (I): ##STR1## wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13 , n and Z...
|
|
|
5395853 |
Anti-atherosclerotic diaryl compounds
The present invention is concerned with compounds of formula (I) ##STR1## wherein m is 0 or 1; W is hydrogen, a C 1 -16 straight, branched, or cyclic alkyl group, or a C 2 -16 straight,...
|
|
|
5393785 |
Therapeutic antiestrogens
Novel antiestrogenic compounds are disclosed for use in therapeutic preparations for treatment of estrogen-dependent diseases. The compounds are specified diphenylethane and diphenylethylene...
|
|
|
5393776 |
Tocotrienol analogs in the treatment of hypercholesterolemia and hyperlipidemia
This invention relates to structurally novel acyclic tocotrienol analogs, which are useful for cholesterol/lipid lowering in cases of hypercholesterolemia and hyperlipidemia, and for...
|
|
|
5380755 |
Alkyl and alkylbenzyl ethers of substituted hydroquinones
The present invention provides alkyl and alkylbenzyl ethers of substituted hydroquinones and pharmaceutical compositions containing them. The present invention further provides methods of using...
|
|
|
5373023 |
Tetrahydronaphtalene derivatives, their preparation and pharmaceutical compositions containing them
The invention provides compounds which are tetrahydronaphthalene derivatives of the formula (I) ##STR1## wherein R 1 represents a halogen atom, a cyano group, a nitro group, an unbranched (C 1 -C...
|
|
|
RE34805 |
Benzonaphthalene derivatives and their use in therapeutic and cosmetic compositions
A benzonaphthalene compound has the formula ##STR1## wherein R 1 represents ##STR2## or (ii) --CH 2 OH; R 6 represents ##STR3## or OR 7 wherein R 7 represents hydrogen, alkyl having 1-20...
|
|
|
5362747 |
2-nitroaryl and 2-cyanoaryl compounds as regulators of nitric oxide synthase
2-Nitroaryl or 2-cyanoaryl compounds of the formula ##STR1## pharmaceutical compositions thereof, intermediates useful in the preparation of these compounds, and methods for treating disorders of...
|
|
|
5352701 |
Leukotriene-B.sub.4 antagonist compounds and their use as pharmaceutical agents
1. Leukotriene-B 4 antagonists of formula I ##STR1## are described, in which X is a CH 2 group or an oxygen atom, Y is C 1 -C 4 -alkoxy or --S(O) p --C 1 -C 4 -alkyl, p is 0, 1 or 2 ...
|
|
|
5352703 |
Antitussive and mucus regulating agent, a process for the preparation thereof and pharmaceutical compositions containing it
2-benzoylamino-3,5-dibromo-N-(4-hydroxycyclohexyl)benzylamin
e of formula (I), and pharmaceutically acceptable acid addition salts have antitussive and mucus regulating activities. ##STR1##
|
|
|
5346887 |
Glaucoma treatment
A method and a composition for treating or reducing and/or controlling intraocular pressure comprising administering an effective amount of a renin inhibiting compound of the formula: ##STR1##...
|
|
|
5340827 |
Phenylcarboxamide compounds which have useful pharmaceutical activity
|
|
|
5334607 |
Methods for treating mycoses
Antimycotics containing a compound of the formula ##STR1## where Y is CH--OCH 3 , CH--CH 3 , CH--CH 2 --CH 3 , CH--SCH 3 or N--OCH 3 , and X is oxygen, or X may also be NH if Y...
|
|
|
5331010 |
1-phenylalkanecarboxylic acid derivatives as anticonvulsant and neuroprotective agents
The compounds belong to the class of non-narcotic, non-opiate derivatives the 1-phenylalkanecarboxylic acid basic structure useful as anticonvulsant and neuroprotective agents. The compounds...
|
|
|
5321031 |
1,2-disubstituted ethyl amides as inhibitors of ACAT
Amides of the formula ##STR1## wherein: R 1 is A and R 2 is B; R 1 is B and R 2 is A; or R 1 and R 2 are independently selected from the group B; A is phenyl, substituted phenyl,...
|
|
|
5318994 |
N-[2-(7-lower-alkoxynaphth-1-yl)ethyl]benzamides
Compounds of the formula: ##STR1## in which: A represents ##STR2## R represents linear or branched lower alkyl, R 1 represents hydrogen or linear or branched lower alkyl, and R 2 represents...
|
|
|
5304572 |
N-acetonylbenzamides and their use as fungicides
Novel N-acetonylbenzamides and their use in controlling phytopathogenic fungi.
|
|
|
5294613 |
Method of treating endotoxic shock in mammals
This invention provides benzene derivatives, pharmaceutical formulations of those derivatives, and a method of using the derivatives for the treatment of inflammation in mammals.
|
|
|
5290546 |
Method for thermal vaporization of chemical
The present invention provides a cordless thermal vaporizer of the liquid type wherein the body of the vaporizer has a heater for heating a wick for drawing up a chemical solution from a bottle,...
|
|
|
5280046 |
Method of treating type I diabetes
Provided is a method for treating Type I diabetes in mammals utilizing certain phenol and benzamide compounds.
|
|
|
5272176 |
Advanced glycation inhibitors containing amino-benzoic acids and derivatives, and methods of use
The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises an agent capable of...
|