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6001880 |
Alkylenediamine derivative, anti-ulcer drug, and antibacterial drug
An alkylenediamine derivative or a salt thereof expressed by the following formula 1: ##STR1## wherein each of R 1 and R 2 represents a lower alkyl group, and W represents a group expressed by...
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5998481 |
Fluoroalkyl/alkenyl-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament containing them
There are described benzoylguanidines of the formula I ##STR1## having the definitions of R(1) to R(4) indicated in the text, and their pharmaceutically tolerable salts. They are obtained by...
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5985926 |
Method for inhibiting intracellular viral replication
There is disclosed a method of preventing or delaying the occurrence of acquired immunodeficiency syndrome (AIDS) in human immunodeficiency virus (HIV) seropositive humans by administering an...
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RE36397 |
Inhibitors of poly(ADP-ribose) synthetase and use thereof to treat NMDA neurotoxicity
Inhibitors of poly(ADP-ribose) synthetase can be used to prevent neurotoxicity mediated through N-methyl-D-aspartate (NMDA) receptors. Poly(ADP-ribose) synthetase inhibitors can be used...
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5985910 |
3- [4- (2- Phenyl-Indole-1-ylmethyl) Phenyl]- Acrylamides as estrogenic agents
The present invention relates to new 3-[4-(2-Phenyl-Indole-1-ylmethyl)-Phenyl]-Acrylamide compounds which are useful as estrogenic agents, as well as pharmaceutical compositions and methods of...
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5972892 |
Topical composition containing a substance P antagonist
The invention relates to a therapeutic composition for topical application containing at least one product with an irritant side effect and a substance P antagonist for reducing or even eliminating...
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5968908 |
Restricted 9-cis retinoids
The invention is novel analogs of 9-cis-retinoic acid which are useful for the treatment and prevention of coronary artery disease and to protect against premature atherosclerosis by increasing HDL...
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5968985 |
Benzoylguanidine derivatives as medicaments
A process for preparing a pharmaceutical composition which comprises admixing a compound of claim 1 or a pharmaceutically acceptable salt thereof with a pharmaceutically acceptable carrier.
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5958439 |
Plant protection composition containing one or more water soluble active materials and one or more polyalkoxylated amidoamines
A composition containing, as active ingredient, one or more water soluble plant protection active materials and further containing an effective amount of one or more polyalkoxylated amidoamines of...
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5948732 |
Herbicidal agent based on DEET and method of using same
A herbicidal agent based on DEET (N,N-diethyl-m-toluamide) and method of using same for killing and controlling undesirable plant growth, such as leafy spurge, without significantly affecting...
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5935985 |
Phenoxyacetic acid derivatives
We proposed a novel compound having an activity of PGI 2 receptor agonist. A phenoxyacetic acid derivative of the formula ##STR1## A is --C(R 1 )N.about.OR 2 , --CH(R)NH--OR 2 , --COE, --SO 2 ...
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5935978 |
Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic- or heteroatom-containing linking group
This invention is directed to the pharmaceutical use of phenyl compounds, which are linked to an aryl moiety by various linkages, for inhibiting tumor necrosis factor. The invention is also...
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5929119 |
Fungicidal composition
A composition which is suitable for controlling fungal pests, comprising conventional additives and an effective amount of a p-hydroxyaniline derivative of the general formula I ##STR1## where the...
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5929113 |
Compositions comprising EMU oil or active fractions thereof and methods of using these compositions as insect repellents
This invention provides a method for repelling biting insects such as mosquitoes, ticks, and biting flies by topically applying to the skin of a subject emu oil, fractions of emu oil obtained by...
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5929114 |
Arylthio compounds
Arylthiol and dithiobisarylamide antibacterial and antiviral agents have the general formula ##STR1## where A is monocyclic or bicyclic aryl which can contain up to 3 heteroatoms selected from O,...
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5925646 |
Heterocyclic aryl-, alkyl- and cycloalkylacetamides
The heterocyclic aryl-, alkyl- and cycloalkylacetamides are prepared by reacting the appropriately substituted acetic acids with amines, if appropriate in complexed form. The heterocyclic aryl-,...
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5910512 |
Topical analgesic using water soluble capsaicin
A water-based topical analgesic and method of application wherein the analgesic contains capsicum, capsicum oleoresin and/or capsaicin. This analgesic is applied to the skin to provide relief for...
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5908861 |
Methods for treating inflammation and inflammatory disease using pADPRT inhibitors
The present invention is directed to a method for treating inflammation or inflammatory disease in an animal or mammal, which comprises the steps of administering an effective amount of an pADPRT...
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5900436 |
Substituted indanylidineacetylguanidines, processes for their preparation, their use as medicaments or diagnostics and medicaments containing them
Substituted Indanylidineacetylguanidines, process for their preparation, their use as medicaments or diagnostic and medicaments containing them: Indanylidineacetylguanidines I ##STR1## and their...
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5891916 |
Aromatic hydroxamix acid compounds, their production and use
A compound represented by the formula: ##STR1## wherein Ar 1 and Ar 2 independently represent an optionally substituted aromatic group; Q represents an optionally substituted divalent aliphatic...
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5891918 |
Method for controlling resistant fungi
A method for controlling phytopathogenic fungi is disclosed. The method uses a fungicidal composition which has been found to be effective against strains of fungi which are resistant to...
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5886046 |
Dicarbonyl-containing compounds
This invention relates to chemical compounds that contain adjacent carbonyl groups, which effectively inhibit the biological, chemical, and/or physical properties of enzymes and other...
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5880158 |
Propionamide anticonvulsants
The present invention is directed to a compound of the following formula: ##STR1## pharmaceutical compositions containing the same and the use thereof as an anticonvulsant.
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5880159 |
Compositions containing and methods of using 1-aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives
Novel derivatives of 1-aminoindan and their salts are described. Optically active 1-aminoindan derivatives are prepared by reacting a N-benzyl analog of the desired compound with an enantiomer of...
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5880147 |
Amide derivatives having ACAT inhibitory activity, their preparation and their therapeutic and prohylactic use
Compounds of formula (I): ##STR1## wherein: R 1 is alkyl; R 2a , R 2b , R 2c and R 2d are the same or different and each is hydrogen, optionally substituted alkyl, --(CO)--B 1 (wherein B 1 ...
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5874444 |
Poly (ADP-ribose) polymerase inhibitors to treat diseases associated with cellular senescence
Inhibition of the enzyme poly (ADP-ribose) polymerase can delay the onset of senescence and inhibitors of the enzyme can be used to treat diseases caused or exacerbated by cellular senescence.
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5866610 |
Substituted benzoylguanidines, process for their preparation, their use as a pharmaceutical as inhibitors of the cellular NA+/H+ exchange or as a diagnostic, and pharmaceutical containing them
Substituted benzoylguanidines, process for their preparation, their use as a pharmaceutical or diagnostic, and pharmaceutical containing them. Described are benzoylguanidines of the formula I...
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RE36068 |
Methods for treatment of sundamaged human skin with retinoids
Various effects of photoaging or sundamage of skin including impairment of differentiation of epidermal epithelial cells and loss of collagen fibers, abnormal changes in elastic fibers and...
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5861435 |
Method for preventing settlement of aquatic fouling organisms
A method for preventing settlement of aquatic fouling organisms on surface of an aquatic structure without environmental hazard is provided. The method is based upon absolutely novel concept to...
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5859063 |
Use of certain N-acetonylbenzamides as fungicides
Certain N-acetonylbenzamides exhibit low toxicity to plants are particularly useful for control of fungi, especially Phycomycetes.
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5859017 |
Method for inhibiting mast cell and basophil activation
In a method for treating or preventing allergy or allergic disorders an effective amount of a compound that inhibits intracellular generation of phosphatidic acid and diacylglycerol is...
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5854284 |
Candle for dispersion of insect repellent based on DEET
An insect repellent candle including a liquid containing DEET and a fragrance oil which acts as a carrier for dispersing DEET vapor into the atmosphere upon evaporation of the fragrance oil. The...
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5854290 |
Use of guanfacine in the treatment of behavioral disorders
Disclosed is a method of treating disorders which have prominent symptoms of behavioral disinhibition (e.g., Attention-Deficit Hyperactivity Disorder, Conduct Disorder, Oppositional Defiant...
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5849795 |
Tachykinins antagonists
The present invention refers to tachykinins antagonists of general formula (I) ##STR1## their preparation and pharmaceutical compositions containing them.
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5847005 |
Benzamidoxime derivatives, process production thereof, and agrohorticultural bactericide
The present invention relates to benzamidoxime derivatives represented by the formula I!; ##STR1## wherein R 1 is unsubstituted or substituted C 1 -C 4 alkyl, unsubstituted or substituted C 2 ...
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5840761 |
Alkylbenzoylguanidine derivatives
Alkylbenzoylguanidines of the formula I ##STR1## in which A, R 1 , R 2 and R 3 have the given meanings, and their physiologically harmless salts exhibit antiarrhythmic properties and act as...
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5833742 |
Phenylamides as marine antifouling agents
Disclosed is a method of inhibiting the growth of marine organisms on a marine structure, by applying onto or into the marine structure a phenylamide compound. These compounds may be directly...
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5827891 |
HIV protease inhibtors
HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These...
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5824650 |
Topical composition containing a substance P antagoinst
The invention relates to a therapeutic composition for topical application containing at least one product with an irritant side effect and a substance P antagonist for reducing or even eliminating...
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5811459 |
Ortho substituted aromatic compounds useful as antagonists of the pain enhancing effects of E-type prostaglandins
The invention relates to compounds of the formula (I): ##STR1## wherein A, B and D are various ring systems such as phenyl, R 1 includes carboxy, R 3 is hydrogen or C 1 -4 alkyl and Z is a...
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5807896 |
Arylbenzoylguanidines
Arylbenzoylguanidines of the formula I ##STR1## in which R 1 R 2 , R 3 and Ph have the given meanings herein, and also the physiologically harmless salts thereof, exhibit antiarrhythmic...
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5804599 |
Interleukin-1 production inhibiting compound
Provided is an Interleukin-1 production inhibiting compound represented by formula (I) ##STR1## wherein R denotes 4-methyl-1-pentenyl, 5-methyl-1,3-heptadienyl or 1-methylpentanyl.
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5801181 |
Amino alcohol substituted cyclic compounds
Therapeutic compounds have the formula: (X)j--(core moiety), J being an integer from one to three, the core moiety having at least one, five- to seven-membered ring and X being a racemic mixture,...
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5798354 |
Use of adamantyl-substituted polycyclic acetylene compounds in skin and hair treatment
Novel pharmaceutically/cosmetically-active adamantyl-substituted polycyclic acetylene compounds have the structural formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a)-(f):...
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5783593 |
Inhibitors of squalene synthetase and protein farnesyltransferase
The present invention provides a compound of the formula ##STR1## which inhibit squalene synthetase and cholesterol biosynthesis and are useful in the treatment of e.g., hyperlipidaemia,...
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5780505 |
Substituted N-arylmethylamino derivatives of cyclobutene-3, 4-diones
The compounds of the formula: ##STR1## wherein R 1 is straight chain alkyl, branched chain alkyl, cycloalkyl, hydroxyalkyl, fluoroalkyl or polyfluoroalkyl; R 7 and R 8 are, independently,...
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5767091 |
Analgesic effect enhancing preparations
The present invention provides an analgesic effect enhancing preparation capable of enhancement of the effect of analgesics, the preparation comprising as an active ingredient the following amino...
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5763474 |
Substituted N-arylmethylamino derivatives of cyclobutene-3,4-diones
The compounds of the formula: ##STR1## wherein R 1 is straight chain alkyl, branched chain alkyl cycloalkyl, hydroxyalkyl, fluoroalkyl or polyfluoroalkyl; R 2 and R 3 are, independently,...
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5763493 |
Stabilized pharmaceutical
This application discloses a method of inhibiting degradation of the antidepressant bupropion hydrochloride in a solid pharmaceutical formulation, so that the pharmaceutical formulation will...
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5760085 |
Topical aromatic releasing compositions
The present invention relates to topical aromatic releasing compositions containing one or more volatile aromatic compounds selected from the group consisting of 3-1-menthoxy propane-1,2-diol,...
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