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7622610 |
Crystalline ACAT inhibitor
The invention is directed to the Form A polymorph of N-benzyl-N′-(2,6-diisopropyl-phenyl)-N-isopropyl-malonamid
e and its use as a therapeutic/cosmetic agent.
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7615230 |
Method for decreasing sebum production
The present invention is directed to the topical application of the malonamide ACAT inhibitors described by Formula I. Other aspects of the invention are directed to topical formulations of these...
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7601876 |
Compounds, compositions and methods for the treatment of amyloid diseases such as systemic AA amyloidosis
Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the...
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7595299 |
Peptides as NS3-serine protease inhibitors of hepatitis C virus
The present invention discloses novel peptide compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses...
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7589089 |
Inhibitors for GlyT-1
The present invention relates to compounds of formula I
wherein
R 1 , R 2 , R 3 , R 4 , and X are as defined herein or to pharmaceutically acceptable acid addition salts thereof, with the...
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7589065 |
Catalysis of the cis/trans-isomerisation of secondary amide peptide compounds
The present invention is based on the finding that the cis/trans isomerisation of secondary amide peptide bonds in oligo- and polypeptides can be catalytically promoted. This catalysis is effected...
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7582782 |
Organic compounds
Disclosed are δ-amino-γ-hydroxy-ω-aryl-alkanoic acid amide compounds of formula (I)
and the salts thereof, having renin-inhibiting properties. Also disclosed are pharmaceutical compositions...
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7572790 |
Biphenyl carboxylic amide p38 kinase inhibitors
Compound of formula (I):
or pharmaceutically acceptable derivatives thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
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7553873 |
Glutamate aggrecanase inhibitors
The present invention relates to modulators of metalloproteinase activity.
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7553831 |
Compounds to treat Alzheimer's disease
The present invention is disubstituted amines of formula (I)
and disubstituted amines of formula (II)
useful in treating Alzheimer's disease and other similar diseases.
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7550509 |
Carisoprodol articles and methods
A method of using carisoprodol comprises informing a user that administration of carisoprodol in the presence of food decreases the C max for carisoprodol compared to administration in the absence...
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7547731 |
Formamide derivatives for the treatment of diseases
The invention relates to compounds of formula (1)
and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives....
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7547728 |
Treating muscle wasting with selective androgen receptor modulators
This invention provides: 1) a method of treating a subject suffering from a muscle wasting disorder; 2) a method of preventing a muscle wasting disorder in a subject; 3) a method of treating,...
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7541495 |
para-alkyl-substituted N-(4-hydroxy-3-methoxy-benzyl)-cinnamamides, pharmaceutical compositions and uses thereof
para-Alkyl-substituted N-(4-hydroxy-3-methoxybenzyl)-cinnamic acid amide compounds, processes for the preparation thereof, pharmaceutical compositions containing these compounds, and the use of...
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7538124 |
Biphenylcarboxamides useful as lipid lowering agents
Biphenylcarboxamide compounds of formula (I)
methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for...
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7534915 |
Non-symmetrical gelling agent
The present invention relates to a novel trisubstituted cyclic thickener or gelator. The present invention further relates to a method for thickening or gelating a solution comprising the use of...
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7531692 |
Derivatives of 1-phenylalkanecarboxylic acids for the treatment of neurodegenerative diseases
The present invention concerns novel derivatives of 1-phenylalkanecarboxylic acids, pharmaceutical compositions thereof, a process for their preparation and their use for the treatment and/or...
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7511077 |
Diamine calcium channel blockers
Aromatic derivatives of aliphatic diamines are effective in ameliorating conditions characterized by unwanted calcium ion channel activity, especially T-type and N-type channels. These conditions...
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7501541 |
Malonamides as orexin antagonists
The present invention relates to compounds of formula I
wherein
Ar 1 , Ar 2 , R, R 1 , R 2 , R 3 and n are as defined herein or to pharmaceutically suitable acid addition salts, optically...
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7488848 |
Alpha ketoamide compounds as cysteine protease inhibitors
The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these...
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7488756 |
Use of non-competitive and selective GluR5 antagonists as glutamate receptor modulating compounds
This invention relates to the use of chemical compounds showing non-competitive and selective GluR5 antagonist or partial agonist activity for treating diseases that are responsive to modulation of...
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7485753 |
Contrast agents
The present invention relates to iodine containing compounds containing a central cyclopropane scaffolding moiety allowing for the arrangement of three iodinated phenyl groups bound thereto. The...
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7485752 |
Diacylglycerol acyltransferase inhibitors
Provided herein are compounds of the formula (I):
as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds,...
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7482487 |
Phenylaminoethanol derivatives as β2 receptor agonists
The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The...
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7479571 |
Generation of combinatorial synthetic libraries and screening for novel proadhesins and nonadhesins
One aspect of the present invention relates to compounds, comprising at least two moieties selected from the group consisting of aryl sulfonates and aryl sulfates. A second aspect of the present...
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7476764 |
Phenylcarboxyamides as beta-secretase inhibitors
There is provided a series of novel phenylcarboxyamides of Formula (I)
or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , X and Y as defined herein,...
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7459585 |
Benzene derivatives and pharmaceutical use thereof
The present invention provides an AP-1 activation inhibitor, NF-kappa B activation inhibitor, inflammatory cytokine production inhibitor, matrix metalloprotease production inhibitor, inflammatory...
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7453009 |
Hydroxybiphenyl carboxylic acids and derivatives, method for producing the same and their use
Disclosed are novel compound of formula I,
As defined herein and their use as pharmaceutically active compounds for reducing blood glucose, and/or treating one or more of type II diabetes,...
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7449599 |
Phenyl carboxamide compounds useful as beta-secretase inhibitors for the treatment of alzheimer's disease
The present invention is directed to phenyl carboxamide compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase...
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7449493 |
Diamines as modulators of chemokine receptor activity
The present application describes modulators of MCP-1 of formula (I):
or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma, multiple sclerosis,...
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7449453 |
Compositions of ezetimibe and methods for the treatment of cholesterol-associated benign and malignant tumors
A method of prevention or treatment of a cholesterol-associated tumor is provided which comprises administering a therapeutically effective amount of an azetidinone-based cholesterol absorption...
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7432302 |
Composition containing polyamine transport inhibitor and use thereof
Proliferative cutaneous disease states or conditions are treated by administering a polyamine transport inhibitor
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7417023 |
Targeted delivery of bioaffecting compounds for the treatment of cancer
A homogeneous conjugate for targeting and treating diseased cells wherein the conjugate comprises an anti-cancer drug and a targeting protein, wherein said anti-cancer drug is selected from the...
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7381745 |
Ligands for metabotropic glutamate receptors and inhibitors of NAALADase
The present invention relates to novel compounds and formulations thereof which compounds are ligands, e.g., agonists or antagonists, for a metabotropic glutamate receptor or a NAALADase enzyme or...
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7375137 |
Methods of treating cancer with HDAC inhibitors
The present invention provides methods of treating cancers, chemoprevention, selectively inducing terminal differentiation, cell growth arrest and/or apoptosis of neoplastic cells, and/or...
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7338978 |
Insecticidal anthranilamides
This invention provides compounds of Formula 1, their N-oxides and agriculturally suitable salts
wherein
A, B, J, R 1 , R 2 , R 3 and R 4 and n are as defined in the disclosure.
...
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7335673 |
2,3-Diphenylpropionic acid derivatives or their salts, medicines or cell adhesion inhibitors containing the same, and their usage
A 2,3-diphenylpropionic acid derivatives or the salts represented by general formula (1) below; and pharmaceutical compositions and cell adhesion inhibitors comprising the derivatives or the salts...
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7291620 |
N-alkyl phenylcarboxamide beta-secretase inhibitors for the treatment of Alzheimer's disease
The present invention is directed to compounds which are inhibitors of the beta-secretase enzyme and which are useful in the treatment or prevention of diseases in which the beta-secretase enzyme...
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7288572 |
Active substance combinations having insecticidal and acaricidal properties
The present invention relates to novel insecticidally and acaricidally active compound combinations of N 2 -[1,1-dimethyl-2-(methylsulphonyl)ethyl]-3-iodo-N 1...
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7262223 |
Amidine derivatives for treating amyloidosis
The present invention relates to the use of amidine compounds in the treatment of amyloid-related diseases. In particular, the invention relates to a method of treating or preventing an...
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7262208 |
Hydroxypropyl amides for the treatment of Alzheimer's disease
The present invention relates to compounds of formula (I):
useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme...
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7256192 |
Aromatic diamide derivatives, chemicals for agricultural or horticultural use and usage thereof
The present invention relates to an aromatic diamide derivative represented by the general formula (I):
[A 1 is optionally substituted (C 1 -C 8 )alkylene group, (C 3 -C 8 )alkenylene...
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7250415 |
1,1-Disubstitutedcycloalkyl-, glycinamidyl-, sulfonyl-amidino-, and tetrahydropyrimidinyl-containing diaminoalkyl, β-aminoacids, α-aminoacids and derivatives thereof as factor Xa inhibitors
The present application describes 1,1-disubstitutedcycloalkyl-, glycinamidyl-, sulfonyl-amidino-, and tetrahydropyrimidinyl-containing diaminoalkyl, β-aminoacids, α-aminoacids and derivatives...
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7244767 |
N-acylvanillinamide derivatives capable of activating peripheral cannabinoid receptors
The present invention relates to the use of N-acylvanillinamide derivatives capable of activating the peripheral receptor CB1 of cannabinoids. In particular, the present invention relates to the...
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7244765 |
Guanylhydrazone salts, compositions, processes of making and methods of using
The invention relates to pharmaceutically acceptable salts of guanylhydrazone-containing compounds, for example, Semapimod. The invention also relates to pharmaceutically acceptable compositions...
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7238714 |
Aryl or heteroaryl amide compounds
This invention provides a compound of the formula (I):
wherein A represents a phenyl group or the like: B represents an aryl or the like: E represents a 1,4-phenylene group; R 1 and R 2 ...
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7208528 |
Polyamine analogues as therapeutic and diagnostic agents
Novel inhibitors of polyamine transport having inhibition constants two orders of magnitude lower than those of known compounds are disclosed. These polyamine analogues are useful pharmaceutical...
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7173063 |
Topoisomerase poisons for the treatment of proliferative disorders
Methods for the treatment of a proliferative disorder are provided in which a subject in need of such treatment is administered an effective amount of a compound selected from: compounds of formula...
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7160887 |
Aromatic amine derivatives, their production and use
Compounds of a formula:
wherein Ring A represents an optionally-substituted aromatic ring; Ring B represents an optionally-substituted cyclic hydrocarbon group; Z represents an...
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7157078 |
Devices and methods for eliminating termite colonies
This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing
a) a termiticide selected...
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