Matches 201 - 250 out of 493 < 1 2 3 4 5 6 7 8 9 10 >
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5780509 Compound bearing two, 2,6-diiodophenol-4-YL groups and diagnostic drug for iodine allergy  
A compound bearing at least two 2,6-diiodophenyl-4-yl groups represented by formula (IV), particularly a polymer composed of two to eight iodinated tyrosine molecules condensed with each other....
5773474 Potent inducers of terminal differentiation and method of use thereof  
The invention provides a class of compounds and compositions thereof having the structure: ##STR1## wherein A is: ##STR2## The invention also concerns a method of selectively inducing terminal...
5763474 Substituted N-arylmethylamino derivatives of cyclobutene-3,4-diones  
The compounds of the formula: ##STR1## wherein R 1 is straight chain alkyl, branched chain alkyl cycloalkyl, hydroxyalkyl, fluoroalkyl or polyfluoroalkyl; R 2 and R 3 are, independently,...
5763481 Vinylcarboxylic acid derivatives  
Compounds of the formula ##STR1## wherein R 1 is C 3 -C 8 cycloalkyl, halo-C 3 -C 8 cycloalkyl, C 3 -C 8 cycloalkyl-C 1 -C 6 alkyl, halo-C 3 -C 8 cycloalkyl-C 1 -C 6 alkyl, --Si(R 3 )...
5760087 Glycylanilide derivatives, their preparation and their application in therapy  
The invention relates to new derivatives of glycylanilides having general formula (I), wherein, particularly, R 1 , R 3 , R 4 , R 8 , R 9 represent CH 3 ; R 2 , R 5 , R 6 , R 7 represent H; R 10...
5756549 Alkylaminoalkyl-terminated sulfide/sulfonyl-containing cycloalkyl-alanine amino-diol compounds for treatment of hypertension  
Compounds characterized generally as alkylaminoalkyl-terminated sulfide/sulfonyl-containing cycloalkylalkyl alanine amino-diol derivatives are useful as renin inhibitors for the treatment of...
5753709 N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics  
Certain N-acyl 2-aryl cyclopropylmethylamine derivatives are useful as melatonergic agents.
5753704 Therapeutic compositions comprising unsaturated dioic acids or derivatives thereof  
Disclosed are certain novel polyunsaturated dioic acids having between 8 and 16 carbon atoms (inclusive), excluding those compounds in the group consisting of: 2,5 octadienedioic acid; 1,7...
5753707 Amide derivatives and their use in cosmetic composition  
An amide derivative represented by the following formula (1): ##STR1## wherein R 1 represents a C 1 -40 hydrocarbon; R 2 represents a C 1 -6 alkylene; R 3 represents H, OH or alkoxyl; R 4 ...
5750574 Fluorinated N-arylmethylamino derivatives of cyclobutene-3,4-diones  
A compound of the general formula (I) ##STR1## wherein R 1 is straight chain alkyl, branched chain alkyl, cycloalkyl, hydroxyalkyl, fluoroalkyl or polyfluoroalkyl; R 2 and R 3 are,...
5739167 Desferrioxamine-B salts and their use as orally effective iron chelators  
A salt of formula (I) where X denotes a group of formula (II), Y denotes a group of formula (III) and R denotes the residue of an aliphatic or cycloaliphatic sulphonic acid having at least 3 carbon...
5731350 Substituted benzenedicarboxylic acid diguanides, process for their preparation, their use as a medicament or diagnostic, and medicament containing them  
Benzenedicarboxylic acid diguanides of the formula I ##STR1## in which R(1) to R(5) have the meanings given in the claims, are useful antiarrhythmic pharmaceuticals having a cardioprotective...
5716980 Alcohol or aldehyde derivatives and their use  
The present invention provides a cathepsin L inhibitor containing a compound of the formula: ##STR1## wherein R 1 is a hydrogen atom or an arylalkyl, heterocyclic-alkyl or lower alkyl group which...
5714519 Method for regulating glucose metabolism  
This invention relates to a method for modifying metabolism in a vertebrate animal which entails the administration of pantethine or cysteamine at a predetermined time daily. The method is useful...
5714518 HIV protease inhibitors and methods of making the same  
HIV protease inhibitors, obtainable by chemical synthesis, block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well...
5709846 Iodinated derivatives, their preparation and their use as contrast agents in x-ray radiology  
Polyiodinated derivatives of formula: ##STR1## in which A is a moiety from an aromatic or aliphatic molecule, Za, Zb, Zc and Zd is Tz-Qz-Vz wherein Tz and Vz are O, COND or NDCO, and D is H or C...
5708034 Substituted sulfonimidamides, processes for their preparation, their use as a medicament or diagnostic, and medicament comprising them  
Substituted sulfonimidamides, processes for their preparation, their use as a medicament or diagnostic, and medicament comprising them Sulfonimidamides of the formula I ##STR1## in which at least...
5705529 N-benzoyl amino acid derivatives pharmaceutical compositions containing them and process for preparing same  
The invention relates to novel N-benzoylamino acid derivatives of the general formula (I), ##STR1## wherein R 1 and R 2 , which are the same or different, stand for a hydroxyl group optionally...
5703130 Chalcone retinoids and methods of use of same  
New retinoid compounds, as chalcone retinoids and compositions thereof, are provided which exhibit therapeutic and/or biological activity on cancer or precancer cells, as well as to methods of use...
5693311 Polyiodinated compounds, process for preparing them and diagnostic compositions  
A compound of the following formula II ##STR1## in which R 7 , R 8 , R' 7 , R' 8 , collectively, contain 10-24 hydroxyl groups and are selected, independently, from H, (C 1 -C 10 )alkyl, (C 1 -C...
5686494 Pharmaceutical preparations for ameliorating epigastric functional disorders  
A pharmaceutical preparation for ameliorating nonulcer dyspepsia (NUD) or epigastric dysfunction complaints is provided. The present invention uses an aminobenzamide compound represented by the...
5681820 Guanidinoalkyl glycine β-amino acids useful for inhibiting tumor metastasis  
This invention herein relates to a method of treating a condition mediated by inhibition of α v β 3 integrins and a method of inhibiting tumor metastasis by administering a therapeutically...
5674905 Bicyclooctane and bicycloheptane derivatives  
Compounds of formula (I), wherein A is selected from (a), (b), (c), (d), (e), (f) and B is selected from (g), (h), and (i), wherein W is a carbonyl, sulphonyl or sulphinyl group, and X is a...
5672597 Acetamide derivative  
An acetamide derivative having the general formula (I): ##STR1## or a pharmacologically acceptable salt thereof; a synthetic intermediate of the above-mentioned acetamide derivative; a treating...
5672625 Sulfonic stilbene derivatives in the treatment of viral diseases  
Sulfonic acid stilbenes block the infection of cells by HSV and CMV and these compounds can be used to treat viral infection.
5668178 Arylthio compounds  
Phenylthiols and dithiobisbenzamides are potent antibacterial and antiviral agents.
5656668 Hydroxy alkyl amides of dicarboxylic acids and their use in cosmetic compositions  
A class of pseudoceramide having the formula shown in which: R1 is a hydrocarbon group; R2-R8 are each independently H or CH 3 ; R9 and R10 are each independently H or hydrocarbon group of up to...
5654301 Amino acid derivative anticonvulsant  
The present invention relates to compounds of the formula ##STR1##
5650397 Antioccidial method  
The present invention is directed to anticoccidial methods, animal feed premixes, and animal feeds, employing a specified o-phenylenediamine or benzimidazole. The present invention is also directed...
5646188 Polyamine derivatives of 1-aminoindan  
A compound of general formula I ##STR1## wherein n is 1 or 2; R 1 and R 2 are each independently hydrogen, hydroxy, substituted or unsubstituted C 1 -4 alkyl, substituted or unsubstituted C 1 -4...
5639768 Substituted amidino compounds, their manufacture and methods of treatment  
The invention relates to the compounds of formula (I) wherein the C(NH)--NHR 3 group may be in tautomeric or isomeric form, and pharmaceutically acceptable salts thereof, in which: R 1 is...
5633282 Inhibition of viral infection  
The use of a poly(ADP-ribose) polymerase inhibitor for the treatment of a subject against infection by a virus, in which the viral or proviral DNA integrates into the chromosome or chromosomes...
5629347 Aromatic compounds, pharmaceutical compositions containing them and their use in therapy  
Compounds of formula (I), and salts and prodrugs thereof, wherein Q is R 9 CR 10 R 11 or CH 2 R 9 CR 10 R 11 where R 9 is H or OH and R 10 and R 11 are optionally substituted phenyl,...
5629343 N-(mercaptoacyl) peptidyl derivatives as antidegenerative agents  
Novel N-(mercaptoacyl)peptidyl compounds are useful as inhibitors of matrix metalloendoproteinases which degrade major components of articular cartilage and basement membranes causing degenerative...
5627210 Branched combinatorial libraries  
Combinatorial libraries comprising compounds of the formula ##STR1## where R 1 , R 2 , and R 3 are each independently groups of the formula --C(O)R, where R is an organic radical; x, y, and...
5597809 Treatment of optic neuritis  
Methods of treating optic neuritis comprising administering a protective agent which inhibits glutamate-mediated retinal cell damage to a mammal at risk of developing optic neuritis.
5595753 Topical formulations and methods for treating hemorrhoidal pain and sphincter and smooth muscle spasm in the gastrointestinal tract  
A topical treatment for hemorrhoidal pain and for spasms of the sphincters and muscles located in the gastrointestinal (GI) tract is disclosed. The topical preparation includes the amino acid...
5580904 Formamido and carboxyamido compounds which can be retained in brain  
According to the present invention, a novel compound group which can pass through blood-brain barrier (BBB) with carrying a drug thereon and stay within brain to release the drug and a well-known...
5552439 Method of treating inflammatory bowel disease  
Provided is a method for treating inflammatory bowel disease in mammals utilizing certain phenol and benzamide compounds.
5550161 Substituted orally effective ION chelators related to deferoxamine  
Compounds are described of the general formula: ##STR1## wherein: R 1 is acyl of the formula --C(=O)-R 5 : R 2 , R 3 , R 4 , R 6 , R 7 and R 8 are each selected from the group consisting of...
5516784 Anti-HIV (AIDS) agents  
Compounds of formula ##STR1## wherein Ar, W, Z, Q, R 1 , U, and T are as set forth herein, are described. These compounds are active as agents against retroviruses and in particular against HIV.
5514677 Hydroxamic acid based collagenase inhibitors  
Compounds of general formula I: ##STR1## wherein: A represents the group --NH 2 , a substituted acyclic amine or a heterocyclic base; have collagenase inhibition activity and are useful in the...
5508275 Lipid-selective antioxidants and their preparation and use  
Lipid-selective antioxidants of the formula I (A) a (L)(X) a , (I), in which A=an antioxidative component, L=a bridging member, X=a lipophilic...
5506267 Thioglycerol derivatives  
A compound of the invention is represented by the formula: ##STR1## wherein R 1 and R 2 are the same or different, an acyl group; R 3 , R 4 , R 6 and R 7 are the same or different, hydrogen or...
5504115 Inhibitors of farnesyl protein transferase  
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to...
5502061 Peptidyl substituted benzamides and naphthamies  
The present invention provides HIV protease inhibitors, pharmaceutical formulations containing those compounds and methods of treating and/or preventing HIV infection and/or AIDS.
5482942 (3,4-dioxocyclobuten-1-yl)chromene, indene, and dihydronaphthalenone derivatives as smooth muscle relaxants  
This invention relates to novel 4-(3,4-dioxocyclobuten-1-yl)chromenes and dihydronaphthalenones and 3-(3,4-dioxocyclobuten-1-yl)indenes and salts thereof having smooth muscle relaxing activity, to...
5480871 Peptoid α-1 adrenergic receptor ligands  
Compounds of the formula: ##STR1## are useful for treating conditions modulated by α 1 -adrenergic receptors.
5478835 Tricyclic compounds and intermediates thereof  
Disclosed is a tricyclic compound represented by the formula (I): ##STR1## wherein each of R 1 , R 2 , R 3 and R 4 independently represents hydrogen, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio,...
5461074 Use of di-propargyl-containing aryl/alkylsulfonyl-terminated alanine amino-diol compounds for treatment of hypertension  
Diseases mediated by plasma renin activity may be treated with a compound characterized generally as a di-propargyl-containing aryl/alkylsulfonyl-terminated amino diol derivative. Compounds of...
Matches 201 - 250 out of 493 < 1 2 3 4 5 6 7 8 9 10 >