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7208528 |
Polyamine analogues as therapeutic and diagnostic agents
Novel inhibitors of polyamine transport having inhibition constants two orders of magnitude lower than those of known compounds are disclosed. These polyamine analogues are useful pharmaceutical...
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7173063 |
Topoisomerase poisons for the treatment of proliferative disorders
Methods for the treatment of a proliferative disorder are provided in which a subject in need of such treatment is administered an effective amount of a compound selected from: compounds of formula...
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7160887 |
Aromatic amine derivatives, their production and use
Compounds of a formula:
wherein Ring A represents an optionally-substituted aromatic ring; Ring B represents an optionally-substituted cyclic hydrocarbon group; Z represents an...
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7157078 |
Devices and methods for eliminating termite colonies
This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing
a) a termiticide selected...
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7153887 |
Use of 15-deoxyspergualin for the treatment of ANCA associated vasculitis
The invention describes the use of deoxyspergualin (DSG) or an analogue thereof for the preparation of a medicament for the treatment of and/or prophylaxis against hyperreactive inflammatory...
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7148223 |
4′-thio-L-xylo furanosyl nucleosides, precursors thereof, preparation and use thereof
Compounds represented by the formula 1:
A is selected from the group consisting of
wherein each R individually is H or acyl, Y is X, N 3 , NH 2 , monoalkylamino, or dialkylamino; Z is...
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7148257 |
Methods of treating mesothelioma with suberoylanilide hydroxamic acid
Methods for treating mesothelioma comprising administering the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) are disclosed.
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7135499 |
Active substance combinations having insecticidal and acaricidal properties
The present invention relates to novel insecticidally and acaricidally active compound combinations of N 2 -[1,1-dimethyl-2-(methylsulphonyl)ethyl]-3-iodo-N 1...
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7132455 |
Phthalamide derivatives
This invention relates to novel phthalamide derivatives of formula (I)
wherein R 1 , R 2 , R 3 , R 4 , and R 5 have the meanings given in the disclosure, to processes for their...
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7119105 |
Methods for treating neurodegenerative disorders using aspartyl protease inhibitors
The present invention relates to () non-peptide aspartyl protease inhibitors; (ii) methods for modulating the processing of an amyloid precursor protein (APP); (iii) methods for modulating the...
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7112612 |
N-alkylated GABA compounds, processes for their preparation and their use as medicaments
The present invention relates to N-alkylated GABA (Gamma-aminobutyric acid) compounds, to processes for their preparation, to their use in therapy and to pharmaceutical compositions containing...
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7105507 |
Cyclohexane derivatives and their use as therapeutic agents
The present invention relates compounds of formula (I), wherein ring A is a phenyl or pyridyl ring; X represents a linker selected from the group consisting of formulae: (a), (b), (c), (d), and...
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7098247 |
Arylene-carboxylic acid (2-amino-phenyl)-amide derivatives
The present invention describes compounds of the general formula I
as well as processes for their manufacture, pharmaceutical compositions containing them and methods for using these compounds...
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7091247 |
Biphenyl compound
A novel biphenyl compound having GPR 14 antagonistic activity. It is a compound represented by the formula (I):
wherein R 1 represents hydrogen, etc.; X represents 1 to 12 spacers; A...
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7071232 |
Small molecules that increase the conversion of food to body weight gain
The present invention relates to peptide-like compounds, e.g. aminocarboxylic acid amide derivatives, and to methods of using same in the field of general health care, for example, to improve...
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7071235 |
Latent reactive blood compatible agents
A reagent and related method for use in passivating a biomaterial surface, the reagent including a latent reactive group and a bifunctional aliphatic acid (e.g., fatty acid), in combination with a...
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7049328 |
Use for deferiprone
A method of treating iron induced cardiac disease in a patient with iron overload, such as in thalassemia or the like comprising administering to the patient a therapeutically effective amount of...
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7037934 |
Blood lipid ameliorant composition
A blood lipid ameliorating composition containing atorvastatin in combination with an agent selected from the group consisting of a riboflavin derivative, a tocopherol compound, an ascorbic acid...
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7034015 |
Aminobenzoephenones
The invention relates to a novel class of aminobenzophenones derivatives, to pharmaceutical preparations comprising said compounds, to dosage units of such preparations, to methods of treating...
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7001924 |
Inhibitors of RNase P proteins as antibacterial compounds
The present invention features compounds useful for inhibiting RNase P activity. These compounds can be used as therapeutics for treating or preventing a variety of bacterial infections. The...
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6998422 |
Lipid peroxide-lowering compositions
Compositions having excellent blood lipid peroxide lowering activity are provided. In particular, compositions for lowering lipid peroxides in the blood which contain pravastatin together with at...
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6989383 |
Method of treating cancer
The present invention relates to methods of treating cancer using a combination of a compound which is an antineoplastic agent and a compound which is a inhibitor of prenyl-protein transferase,...
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6982078 |
Dimer amidopropyl dimethyl poly-quaternary compounds
The present invention relates to a novel class of polymeric compounds having specific quaternized amine based upon a dimer acid amido amine quaternary compound. Dimer acid is a C-36 diacid having a...
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6960560 |
Iron chelator delivery system
An iron chelator delivery system is disclosed. The system comprises iron chelator and a lipid carrier, e.g., a liposome. Methods for preparing and administering the iron chelator delivery system...
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6951884 |
Fluorobenzamides and uses thereof
The invention relates to fluorobenzamide derivatives of the formula
wherein R 1 , R 2 , R 3 R 4 , R 5 , R 6 and R 7 are as defined herein. =,
The compounds of the invention are selective...
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6936597 |
Prodrugs of anticancer agents employing substituted aromatic acids
Polymeric prodrugs of the formula:
wherein
B is selected from the group consisting of OH, leaving groups, residues of amine-containing moieties and a residues of hydroxyl-containing...
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6919343 |
N-biphenyl(substituted methyl) aminocycloalkane-carboxamide derivatives
N-Biphenyl(substituted methyl)aminocycloalkanecarboxamide derivatives are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and...
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6914061 |
4′-thio-L-xylofuranosyl nucleosides, precursors thereof, preparation and use thereof
Compounds represented by the formula 1:
A is selected from the group consisting of
wherein each R individually is H or acyl, Y is X, N 3 , NH 2 , monoalkylamino, or dialkylamino; Z...
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6903092 |
Naphthamide neurokinin antagonists for use as medicaments
Compounds having the general formula
wherein R 1 , R 2 , R 3 , R 4 , R 5 , X 1 and X 2 are as defined in the specification, methods of using such compounds for the treatment of diseases and...
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6900213 |
Bisaryl derivatives having FSH modulatory activity
The invention relates to bisaryl derivatives of the formula I,
wherein (R,R) is selected from (H,H), O, (H,CH 3 ), (H,OH) and (H,CN); Ar is substituted phenyl
and A is a group of formula II,...
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6887890 |
Compounds exhibiting thrombopoietin-like activities
The compounds of the invention are compounds represented by the following general formula (1):
wherein E represents one selected from the group consisting of a methylidyne group and a nitrilo...
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6838484 |
Formulations comprising selective androgen receptor modulators
The present invention relates to pharmaceutical compositions and formulations comprising a novel class of androgen receptor targeting agents (ARTA) which demonstrate androgenic and anabolic...
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6821965 |
Amidobenzamide derivatives which are useful as cytokine inhibitors
The invention concerns amide derivatives of the Formula (I) wherein R 3 is (1-6C)alkyl or halogeno; Q is aryl or heteroaryl which optionally bears 1, 2, 3 or 4 substituents such as hydroxy,...
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6777387 |
Terminally-branched polymeric linkers containing extension moieties and polymeric conjugates containing the same
The present invention is directed to polymeric prodrug transport forms and methods of making and using the same. In one preferred aspect, the prodrugs are of the formula: wherein G is a...
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RE38551 |
Anticonvulsant enantiomeric amino acid derivatives
The present invention is directed to a compound in the R configuration about the asymmetric carbon in the following formula: pharmaceutical compositions containing same and the use thereof in...
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6740667 |
Antimicrobial agent
The present invention relates to an antimicrobial agent for preventing, ameliorating and treating diseases attributable to Helicobacter pylori , for example peptic ulcer and gastritis,...
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6734204 |
Serotonin potentiation by oleamide analogs
Analogs related to oleamide are employed for potentiating the 5-HT 2A and 5-HT 1A responses to serotonin (5-HT). With respect to the potentiation of the 5-HT 2A receptor response, it is...
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RE38506 |
Potent inducers of terminal differentiation and methods of use thereof
The present invention provides the compound having the structure: wherein each of R 1 and R 2 are independently the same as or different from each other; when R 1 and R 2 are the same, each...
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6696494 |
α-hydroxyarylbutanamine inhibitors of aspartyl protease
Acylated α-hydroxyarylbutanamines and related sulfonamides, ureas and carbamates that inhibit aspartyl protease are disclosed, as are methods of treating diseases, particularly HIV, using these...
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6696472 |
Substituted N-phenoxy-N-phenyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer...
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6677376 |
Non-peptidic cyclophilin binding compounds and their use
The invention relates to non-peptidic compounds that possess bioactive properties, such as the ability to protect neuronal cells from otherwise lethal treatments or the ability to promote the...
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6673777 |
Guanylhydrazones useful for treating diseases associated with T cell activation
There is disclosed a method for treating diseases and disorders involving T cell activation and HIV-infection, using the p38 mitogen activated protein kinase (MAPK) signaling pathway as a target...
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6670400 |
Phenoxyethylamine derivatives having high affinity for the 5-HT1A receptor, preparation thereof, use thereof as drugs, and pharmaceutical compositions containing said derivatives
Phenoxyethylamine derivatives of general formula (I) having high affinity for the 5-HT 1A receptor, methods for preparing same, pharmaceutical compositions containing said derivatives, and their...
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6632836 |
Carbocyclic potassium channel inhibitors
The present invention relates to a class of carbocyclic compounds of Formula I that are useful as potassium channel inhibitors to treat autoimmune disorders, cardiac arrhythmias, and the like.
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6608067 |
Inhibitors of serine proteases, particularly HCV NS3 protease
The present invention relates to compounds, methods and pharmaceutical compositions for inhibiting proteases, particularly serine proteases, and more particularly HCV NS3 proteases. The compounds,...
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6608061 |
Bisaryl compound and medicament for cancer treatment comprising the same
A medicament for treatment of cancer comprising a compound represented by the following general formula (I) or a physiologically acceptable salt thereof: Ar 1 —S—R 1 —S—Ar 2 wherein R 1 ...
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6605641 |
20-HETE antagonists and agonists
20-HETE agonists and antagonists are disclosed along with therapeutic applications. In a preferable form of the invention, the 20-HETE agonists are selected from the group consisting of...
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6599941 |
Insecticide and insect repellant compositions
A non-toxic, environmentally safe and easily employable insecticide and insect repellent is achieved by providing an aqueous composition incorporating ethanolamine based compounds, either...
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6576628 |
3-aryl-succinamido-hydroxamic acids, methods for producing said acids and medicaments containing the same
The invention relates to inhibitors of matrix metalloproteases, more specifically a 3-aryl-succinamido-hydroxamic acid of formula (I) and its salt, ester and derivative thereof, along with...
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6576642 |
Diamide compounds and compositions containing the same
Compounds having the formula (1): wherein A is a phenyl, naphthyl, dihydronaphthyindeny, pyridyl, indolyl,isoindolyl, quinolyl or isoquinolyl group which are optionally substituted; X is...
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