Patents in Class 514/615

Matches 1 - 50 out of 102

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Match	Document	Document Title
1	7563928	Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone...
2	7544838	Ligands for estrogen related receptors and methods for synthesis of said ligands Estrogen-Related Receptor (ERR) modulating compounds and methods for synthesis of said compounds are described.
3	7507767	Cannabinoid receptor ligands There are disclosed compounds of the formula a prodrug thereof, or a pharmaceutically acceptable salt, solvate or stereoisomer of the compound or of said prodrug; which exhibit...
4	7485752	Diacylglycerol acyltransferase inhibitors Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds,...
5	7405239	Acylhydrazone derivatives and the use thereof in the inhibition, regulation and/or modulation of kinase signal transduction The invention relates to acylhydrazone derivatives of formula (I), which are SGK inhibitors and can be used for the treatment of diseases and afflictions associated with SGK, such as diabetes,...
6	7399788	N-deacetylthiocolchicine derivatives, their use and pharmaceutical formulations containing them Disclosed is a series of N-deacetylthiocolchicine derivatives of formula (I) in which: the linker is a bivalent straight or branched C 1 -C 8 alkyl residue, C 3 -C 8 cycloalkyl, a phenylene or...
7	7368473	Paclitaxel enhancer compounds One embodiment of the present invention is a compound represented by the Structural Formula (I): Y is a covalent bond of a substituted or unsubstituted straight chained hydrocarbyl group. In...
8	7288572	Active substance combinations having insecticidal and acaricidal properties The present invention relates to novel insecticidally and acaricidally active compound combinations of N 2 -[1,1-dimethyl-2-(methylsulphonyl)ethyl]-3-iodo-N 1...
9	7241797	Method of increasing milk production The invention relates generally to the use of pharmaceutical compositions to increase milk production alone or in combination with certain biological active ingredients. Specifically, the method...
10	7176241	Compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents The present invention relates to novel compounds that can be used as antiinflammatory, immunomodulatory and antiproliferatory agents. In particular the invention refers to new compounds which...
11	7173063	Topoisomerase poisons for the treatment of proliferative disorders Methods for the treatment of a proliferative disorder are provided in which a subject in need of such treatment is administered an effective amount of a compound selected from: compounds of formula...
12	7169816	4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors Phenylamino benzhydroxamic acid derivatives of the formula where R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are hydrogen or substituent groups such as alkyl, and where R 7 is hydrogen or an...
13	7163703	Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds The invention relates to the use of arsenic compounds to treat a variety of neoplastic diseases. The present invention encompasses the administration to a mammal of arsenic in the form of a salt,...
14	7132116	Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds The invention relates to the use of arsenic compounds to treat a variety of neoplastic diseases. The present invention encompasses the administration to a mammal of arsenic in the form of a salt,...
15	7081473	Agent for preventing/ameliorating obesity comprising methylidene hydrizide compound as active ingredient The present invention provides a low-molecular inhibitor of GIP functions and, further, an agent for preventing/ameliorating obesity based on inhibition of GIP functions, which comprises, as an...
16	7001759	Compositions and methods for delivery of genetic material Methods of introducing genetic material into cells of an individual and compositions and kits for practicing the same are disclosed. The methods comprise the steps of contacting cells of an...
17	6887863	Hydrazide and alkoxyamide angiogenesis inhibitors Compounds having the formula are methionine aminopeptidase type 2 (MetAP2) inhibitors and are useful for inhibiting angiogenesis. Also disclosed are MetAP2-inhibiting compositions and methods...
18	6861448	NAD synthetase inhibitors and uses thereof Disclosed are compounds that inhibit the microbial NAD synthetase enzyme. For example, disclosed are compounds of the formula Ar 1 —X—Ar 2 —Y—L—Z—Q, wherein Q is Q 1 Ar 3 or Ar 3 Q 1 ;...
19	6809090	Derivatives of N-(iminomethy)amines, their preparation, their use as medicaments and the pharmaceutical compositions containing them N-(imino)amines and their preparation and their use as NO synthase inhibitors and selective or non-selective traps for a reactive oxygen species.
20	6696472	Substituted N-phenoxy-N-phenyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer...
21	6673777	Guanylhydrazones useful for treating diseases associated with T cell activation There is disclosed a method for treating diseases and disorders involving T cell activation and HIV-infection, using the p38 mitogen activated protein kinase (MAPK) signaling pathway as a target...
22	6653321	Naphthylsulfonic acids and related compounds as glucose uptake agonists Methods for treating conditions associated with hyperglycemia, especially Type II diabetes, with novel naphthylsulfonic acids and related compounds. These compounds, as single stereoisomers or...
23	6468982	Genetic immunization Methods of prophylactic and therapeutic immunization of an individual against pathogen infection, diseases associated with hyperproliferative cells and autoimmune diseases are disclosed. The...
24	6436421	Pesticide compositions The present invention relates to pesticide compositions. In particular, the present invention relates to pesticide compositions comprising a pesticide and a redispersible polymer and to a method...
25	6433017	Amphiphilic polyamine compounds In accordance with the present invention, there are provided amphiphilic polyamine compounds and derivatives thereof having the property of promoting transfection of polynucleotides and...
26	6410600	Azine used as fungicides The invention relates to novel azines, to a process for their preparation and to their use as fungicides.
27	6376548	Enhanced propertied pesticides This invention relates to enhanced propertied pesticides which can be used as fungicides, herbicides, insecticides, rodenticides or biocides, compositions comprising enhanced propertied pesticides,...
28	6369111	Substituted oximes The invention relates to novel substituted oximes, to a process for their preparation and to their use as fungicides.
29	6369108	Method for treating COPD A method for treating COPD is disclosed comprising administering compounds of Formula (I) wherein the terms R 1 , R 3 , X, X 2 and Z are herein defined.
30	6348499	Amphiphilic polyamide compounds Amphiphilic polyamide compounds and derivatives thereof having the property of promoting transfection of polynucleotides and polypeptides into cells, and formulations comprising said compounds.
31	6319894	Complexes and combinations of fetuin with therapeutic agents There is disclosed a complex and a combination of the glycosylated polypeptide fetuin and a therapeutically active small molecule compound having a net positive charge at physiological pH. The...
32	6271263	Compositions containing and methods of using 1-aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives Novel derivatives of 1-aminoindan and their salts are described. Optically active 1-aminoindan derivatives are prepared by reacting a N-benzyl analog of the desired compound with an enantiomer of...
33	6248787	Guanylhydrazones and their use to treat inflammatory conditions This invention concerns new methods and compositions that are useful in preventing and ameliorating cachexia, the clinical syndrome of poor nutritional status and bodily wasting associated with...
34	6242494	Substituted β-amino acid inhibitors of methionine aminopeptidase-2 A class of substituted b-amino acids are potent inhibitor of methionine aminopeptidase type 2 (MetAP2) and are thus useful in inhibiting angiogenesis and disease conditions which depend upon...
35	6221915	Pharmaceutical compositions The present invention relates to a pharmaceutical composition comprising a nitrate vasodilator and a compound of formula I: ##STR1##
36	6172108	Hydrazide compounds Compounds of formula (I): R--NH--A--CO--NH--NH--(W) n --Z (I) wherein: n is 0 or 1, W represents --CO-- or S(O) r wherein r is 0, 1 or 2, Z represents a group selected from aryl,...
37	6130248	Tricarboxylic acid-containing oxyalkyl esters and uses thereof This invention relates to compositions for and methods of treating, preventing or ameliorating cancer and other proliferative diseases as well as methods of inducing wound healing, treating...
38	6124356	Fungicides A fungicidal compound of formula (I): or a stereoisomer thereof, wherein A is CH or N, B is OCH 3 or NHCH 3 , E is --NR 1 --C(CH 3 )N-- or --NC(CH 3 )--NR 1 --, R 1 is H, C 1 -4 alkyl, C...
39	6077869	Aryl phenylhydrazides as selective COX-2 inhibitors for treatment of inflammation This invention relates to the use of compounds of formula I as selective COX-2 inhibitors and antiinflammatory agents: ##STR1## wherein: X and Y are selected from hydrogen, halogen, alkyl, nitro,...
40	6077866	Benzophenone hydrazone derivatives as insecticides Novel benzophenonehydrazone derivatives represented by the formula (I): ##STR1## wherein, R 1 is halogen; R 2 is hydrogen or C 1 -4 alkyl; R 3 is cyano, optically substituted C 1 -4 alkyl, C 2...
41	6075044	Heterocyclic derivatives as inhibitors of purine salvage phosphoribosyltransferases The use of certain heterocyclic derivatives for treating parasitic protozoa infections in mammals, in particular bovine trichomoniasis and giardiasis, is disclosed.
42	6043282	Azinooximethers, processes and intermediate products for manufacturing same, and the uses thereof in combating harmful fungi and pests Azinooxime ethers of the formula I ##STR1## (X=NOCH 3 , CHOCH 3 , CHCH 3 ; Y=O, NZ, where Z=H, alkyl; R 1 =H, alkyl; R 2 =cyano, nitro, trifluoromethyl, halogen, alkyl, alkoxy; m=0, 1, 2, it...
43	6028110	Succinyl hydroxamic acid, N-formyl-N-hydroxy amino carboxylic acid and succinic acid amide derivatives as metalloprotease inhibitors A pharmaceutical or veterinary composition comprising a compound of formula I ##STR1## wherein X is a --CO 2 H group and R 1 , R 2 , R 3 , R 4 , R 5 are as defined in the specification, or a...
44	6005009	Method of inhibiting fibrosis with pyridoxal benzoyl hydrazone and analogs thereof Methods of inhibiting fibrosis comprising administering certain pyridoxal benzoyl hydrazones or analogs thereof are disclosed. Preferred hydrazones are pyridoxal benzoyl hydrazone,...
45	5990171	Hydrazonoacetic acid amides and the use thereof as pesticides The invention concerns hydrazonoacetic acid amides of general formula (I), a process for producing them, and the use of the said amides as pesticides. In the formula shown, the following meanings...
46	5905072	Adjuvants for systemic fungicides, fungicidal compositions which contain them and their use Adjuvants for systemic fungicides in the form of a stable microemulsion comprise water, a mixture of methyl esters of fatty acids obtained by the transesterification of vegetable oils, an anionic...
47	5866610	Substituted benzoylguanidines, process for their preparation, their use as a pharmaceutical as inhibitors of the cellular NA+/H+ exchange or as a diagnostic, and pharmaceutical containing them Substituted benzoylguanidines, process for their preparation, their use as a pharmaceutical or diagnostic, and pharmaceutical containing them. Described are benzoylguanidines of the formula I...
48	5753652	Antiretroviral hydrazine derivatives The invention relates to compounds of formula ##STR1## and salts, pharmaceutical compositions, intermediates and processes of preparation thereof.
49	5733934	Antiarrythmic and cardioprotective substituted indenoylguanidines Indenoylguanidines of formula I and formula II, the process for their preparation, their use as medicaments, medicaments containing them, their use as diagnostic agents and medicaments containing...
50	5691376	Substituted biphenyl derivatives A compound of the following structure: ##STR1## wherein R 8 =H: R 1 =alkyl, cycloalkyl, arylalkyl, aryl; R 2 =cycloalkyl, aryl, C 3 -C 10 alkyl; X,Y=O, S(O) n , NH; Z=CO 2 R 3 ,...

Matches 1 - 50 out of 102

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