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5597809 |
Treatment of optic neuritis
Methods of treating optic neuritis comprising administering a protective agent which inhibits glutamate-mediated retinal cell damage to a mammal at risk of developing optic neuritis.
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5589510 |
Method for inhibiting retroviral infection by administering a naphthalenesulfonic acid compound
A method for inhibiting retroviral infection in a subject comprising administering to said subject a therapeutically effective amount of a naphthalenesulfonic acid compound or a pharmaceutically...
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5583089 |
Bicarbonate salt pesticide composition containing a clathrate spreader-sticker ingredient
This invention provides a dry blend pesticide composition which contains a fungicidal bicarbonate salt ingredient, and a spreader-sticker ingredient which is a crystalline clathrate complex of a...
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5578595 |
Cyclopropylacetic acid derivatives
Novel 2-(2,2-difluorocyclopropyl)-acetic acid derivatives of formula I ##STR1## wherein A is oxygen or --NR 1 --, B is C 2 -C 6 alkylene, D is oxygen, sulfur or --O--CH 2 --, E is...
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5567735 |
Therapeutic amides
Amides having formula I: ##STR1## wherein E, X, R 2 and R 3 have the meanings given in the specification, and pharmaceutically acceptable salts and pharmaceutically acceptable in vivo...
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5560910 |
Topical anti-inflammatory composition and method
The present invention comprises compositions and methods that are useful for topically treating inflammation caused by a wide variety of diseases. The compositions comprise an effective amount of a...
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5554653 |
Inhibitors of HIV protease useful for the treatment of AIDS
The present invention provides novel HIV protease inhibitors, pharmaceutical formulations containing those compounds and methods of treating and/or preventing HIV infection and/or AIDS.
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5547984 |
N-Acetonyl-substituted-amides
Certain N-acetonyl-substituted-amides of the formula: ##STR1## wherein A is a heterocycle, a phenylalkyl, a phenylalkoxy, naphthyl, cycloalkyl, alkoxyalkyl, alkyl, haloalkyl or alkenyl group; X, Y...
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5521221 |
Retro-α-retinol (4,14-retro-retinol) derivatives and uses of retro-α-retinol
This invention provides a purified retro-retinoid compound characterized by a molecular mass of about 302 daltons. Also provided by this invention is a method of enhancing the growth of a cell in a...
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5506257 |
Aminocyclohexylamides for antiarrhythmic and anaesthetic uses
The present invention provides methods for blocking sodium channels in cardiac or neuronal tissue using aminocyclohexylamides. This invention also provides kits including aminocyclohexylamides and...
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5482969 |
Certain N(4-benzoyl-2-phenyl)-3- trifluoro-2-hydroxy-propanamide derivatives
Compounds of formula I: ##STR1## wherein, ring C, A-B, R 1 , n, R 2 , and R 3 have any of the meanings given in the specification, and their pharmaceutically acceptable salts are useful in the...
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5470878 |
Cell signaling inhibitors
Therapeutic compounds have the formula: (X)j-(non-cyclic core moiety), j being an integer from one to three, the core moiety is non-cyclic and X is a racemic mixture, R or S enantiomer, solvate,...
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5455273 |
N,N-disubstituted arylcycloalkylamines, the salts thereof, pharmaceutical compositions containing these compounds and the use thereof and processes for preparing them
The invention relates to N,N-disubstituted arylcycloalkylamines of general formula ##STR1## wherein n, m, A, X and R 1 to R 7 are defined as in claim 1, the isomers, isomer mixtures and salts...
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5432148 |
Slow-release ammonium bicarbonate fungicide compositions
This invention provides a fungicide composition which is capable of in situ generation of ammonium bicarbonate when applied to plant foliage in the form of an aqueous dispersion. The constituents...
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5413997 |
Triphenylmethane derivatives
A triphenylmethane derivative represented by the following general formula: ##STR1## exhibits bone absorption inhibiting effects and is useful as a medicament for treating osteoporosis.
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5407960 |
Mercaptocycloacyl aminoacid endopeptidase inhibitors
Mercaptocycloacyl aminoacid inhibitors of endopeptidase of the formula ##STR1## or a pharmaceutically acceptable salt thereof, alone or in combination with an ACE inhibitor or an ANF, in the...
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5373023 |
Tetrahydronaphtalene derivatives, their preparation and pharmaceutical compositions containing them
The invention provides compounds which are tetrahydronaphthalene derivatives of the formula (I) ##STR1## wherein R 1 represents a halogen atom, a cyano group, a nitro group, an unbranched (C 1 -C...
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5366967 |
Potentiation of the anti-reactive-antiasthmatic effect of inhaled loop diuretics by inhaled non-steroidal anti-inflammatory drugs
The antireactive-antiasthmatic effect of inhaled loop diuretics is potentiated by the use of a combination of a loop diuretic and a non-steroidal anti-inflammatory drug as an inhalant for combating...
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5338762 |
Water-based microemulsuion formulation of a carbamate ester
A clear, efficacious, aqueous microemulsion of an agriculturally active carbamate ester insecticide.
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5318994 |
N-[2-(7-lower-alkoxynaphth-1-yl)ethyl]benzamides
Compounds of the formula: ##STR1## in which: A represents ##STR2## R represents linear or branched lower alkyl, R 1 represents hydrogen or linear or branched lower alkyl, and R 2 represents...
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5272176 |
Advanced glycation inhibitors containing amino-benzoic acids and derivatives, and methods of use
The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises an agent capable of...
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5264425 |
Glycosaminoglycan salts and pharmaceutical compositions containing them
Salts of glycosaminoglycans (heparin, its fractions or fragments which are supersulfated, dermatan sulfate, heparan sulfate, and modified heparins) with bases of formula (I), ##STR1## wherein R 1 ,...
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5260339 |
4-phenyl-1,3-benzodiazepines and 2-amino-α-phenylphenethylamines for treating convulsions and protecting neurons
Novel 4-phenyl-1,3-benzodiazepines and 2-amino-α-phenylphenethylamines, novel intermediates thereof, and methods of preparing same are described. These benzodiazepines are useful as...
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5254590 |
Acylaminophenol compounds
The invention relates to the compounds of formula (I): ##STR1## in which R represents higher alkyl, 1-(higher alkyl)lower cycloalkyl-1-yl or higher alkenyl comprising one or more double bonds, and...
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5246965 |
Arylethers, their manufacture and methods of treatment
The invention relates to the compounds of the formula ##STR1## wherein the C(NH)--NHR group may be in tautomeric or isomeric form, and pharmaceutically acceptable salts thereof, in which: R...
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5234946 |
Substituted alkylamine derivatives
The substituted alkylamine derivatives represented by formula (I) ##STR1## wherein R 1 represents (a) substituted or unsubstituted C 2 -6 alkenyl group, (b) substituted or unsubstituted C 3 -6...
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5225442 |
Compounds having a naphthalene structure
Compounds of general formula: ##STR1## in which A and R are defined in the description. Medicaments containing the same and useful for the treatment of melatoninergic disorders.
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5217994 |
Method of inhibiting osteoclast-mediated bone resorption by administration of aminoalkyl-substituted phenyl derivatives
Compounds of the general formula ##STR1## and the pharmaceutically acceptable salts thereof wherein n is an integer of from 0 to 6; Y is CH 2 , O, SO 2 , --CONH--, --NHCO--, or ##STR2## R 1 ...
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5192798 |
Lipophilic polyamines useful for treating hypercholesterolemia
This invention relates to novel lipophilic polyamines of formula I, the method of using these compounds to treat hypercholesterolemia, and intermediates thereto. Z 1 --(CH 2 ) n --Y 1 --X 1 ...
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5151446 |
Substituted 2-amidotetralins as melatonin agonists and antagonists
The present invention relates generally to compounds having melatonin receptor activities and in particular to substituted 2-amidotetralin derivatives; to pharmaceutical preparations comprising...
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5145873 |
Specifically substituted cyclopropanecarboxamides and their use for controlling pests
Cyclopropanecarboxyamides of the general formula I ##STR1## Where R 1 is C 1 -C 4 -alkyl, fluorine, chlorine, bromine, C 1 -C 3 -haloalkyl or C 1 -C 3 -haloalkoxy, R 2 is hydrogen,...
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5116877 |
Pharmaceutical use for cinnamamide derivatives
A cinnamamide derivative represented by the formula ##STR1## wherein X is a halogen atom is useful as a muscle relaxant.
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5116851 |
Pharmaceutical composition and method for treating cardiovascular diseases using substituted anilides and sulfonamides
A novel pharmaceutical composition and method is disclosed for the treatment of cardiovascular diseases, e.g. myocardial ischemia and/or arrhythmia. The method and composition include an effective...
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5102910 |
Pharmaceutical preparation and method of treatment for liver dysfunction
A pharmaceutical composition for the treatment of a liver disorder, comprising as an effective agent against liver dysfunction, a mixture in effective amounts of the components: (a)...
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5071875 |
Substituted 2-amidotetralins as melatonin agonists and antagonists
The present invention relates generally to compounds having melatonin receptor activities and in particular to substituted 2-amidotetralin derivatives; to pharmaceutical preparations comprising...
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5059623 |
Substituted cycloalkyl- and heterocyclyl-carboxanilides
A substituted cycloalkyl- or heterocyclyl-carboxanilide of the formula (I) ##STR1## in which X stands for an unsubstituted or an alkyl-substituted cycloalkyl or an unsubstituted or an...
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5059624 |
Guanidine derivatives having hypotensive activity, composition containing them and process for obtaining them
Guanidine derivatives of the following formulas (1) and (2): ##STR1## wherein: R 1 is hydrogen or optionally substituted cinnamoyl, R 2 is hydrogen, alkyl or alkenyl, with the proviso that R 1...
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5047425 |
Amine derivatives having cardiovascular activity
Compounds of the formula ##STR1## wherein Ar, R, R 1 , R 2 , R 3 , R 4 , X and n have the meanings mentioned in the description, processes and intermediates for their preparation, pharmaceutical...
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5039664 |
Renin inhibitors containing phenylalanyl-histidine replacements
Peptides of the formula: ##STR1## which comprise novel elements replacing the Phe(8)-His(9) sequence in renin-inhibitory peptides based on substrate analogy, which inhibit the substrate-cleaving...
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5010107 |
Method and composition for achieving anticarcinogenic activity
The present invention describes a protocol for achieving a very high degree of anticarcinogenic (or chemopreventive or cancer preventative) activity through the combination of a low suboptimal dose...
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5010104 |
Tricyclic compounds
Novel tricyclic compounds having a TXA 2 -antagonizing activity represented by formul (I): ##STR1## which strongly antagonize an action of thromboxane A 2 and are expected to have preventive and...
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5008291 |
Method and composition for achieving chemotherapeutic activity
The present invention describes a dietary supplement for achieving a very high degree of chemotherapeutic activity through the synergistic combination of a low suboptimal dose of a...
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5001159 |
N-aminobutyl-n-phenylarylamide compounds and their application in therapy
A compound of formula (I) ##STR1## in which: X denotes hydrogen, a halogen, a trifluoromethyl group, a C 1 -C 4 alkyl group or a C 1 -C 4 alkoxy group; R 1 denotes a linear or branched C 2 ...
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4992471 |
Molluscicides
A method and composition for controlling molluscs employs fluorinated carboxanilides.
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4981872 |
Prostaglandin derivatives, their preparation and their therapeutic use
Prostaglandin derivatives having an oxo group at specified positions in the α side chain have a variety of physiological effects, notably a strong anti-ulcer activity accompanied by a limited...
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4980462 |
Antiviral agents
A second-step virus binding receptor is found in nature on the surface of animal and plant cells. This receptor is thought to be needed for virus penetration into target cells. The second-step...
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4962129 |
Treatment of symptoms of neoplastic diseases without treating the diseases themselves
A method for treating the symptoms of a neoplastic disease without treating the disease itself which includes administering by injection an effective amount of a composition which includes the...
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4943307 |
Plant-protective pesticidal composition
The invention relates to a plant-protective solution containing 2.5 to 40 % by weight of one or more water-insoluble plant-protective ingredient(s) 20 to 71.5 % by weight of dimethylformamide...
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4895715 |
Method of treating gynecomastia
A method of treating gynecomastia in noncastrated patients being treated with an antiandrogen for androgen-dependent diseases such as benign prostatic hypertrophy, who are in need of such treating...
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4880839 |
Acyanilide derivatives
An acylanilide of the formula: ##STR1## wherein R 1 or R 2 which may be the same or different, each is an electron-withdrawing substituent, alkylthio or phenylthio or R 1 is hydrogen, alkyl or...
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