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6114382 |
Methods for treating inflammatory bowel disease
The present invention provides novel compositions and methods relating to the treatment of Inflammatory Bowel Disease ("IBD"), most notably, Ulcerative Colitis, Crohn's Disease, Colitis and...
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6096784 |
Inhibitors of oleamide hydrolase
Inhibitors of oleamide hydrolase, responsible for the hydrolysis of an endogenous sleep-inducing lipid (1, cis-9-octadecenamide) were designed and synthesized. The most potent inhibitors possess an...
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6083987 |
Phenylenediamine derivative, radical scavenger, brain-infarction depressant, and brain-edema depressant
A phenylenediamine derivative or a salt thereof in accordance with the present invention is expressed by the following formula 1: ##STR1## wherein A represents a group expressed by --CO--, --CH 2 ...
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6075023 |
Method for combatting fish mycoses and one-celled ectoparasites
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6037361 |
Fluorinated butyric acids and their derivatives as inhibitors of matrix metalloproteinases
Fluorinated butyric acid compounds and derivatives are described as well as acid methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix...
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6028110 |
Succinyl hydroxamic acid, N-formyl-N-hydroxy amino carboxylic acid and succinic acid amide derivatives as metalloprotease inhibitors
A pharmaceutical or veterinary composition comprising a compound of formula I ##STR1## wherein X is a --CO 2 H group and R 1 , R 2 , R 3 , R 4 , R 5 are as defined in the specification, or a...
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6017906 |
Polyamine conjugates for treatment of infection
The present invention relates to methods of preventing or treating an infection or disease caused by an infectious agent. The present invention also relates to the augmentation of the efficacy of...
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6013673 |
Naphthyloxy acetic acid derivatives
A naphthyloxyacetic acid derivative of the formula (I) ##STR1## wherein R 1 is H, alkyl, alkylene-(--COOR 10 , --OH, --CONR 4 R 5 , --CONR 6 -alkylene-OH, --NR 4 R 5 , -cyano or -tetrazolyl); A...
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6004992 |
Aminocarboxylic acid fluorobutenyl esters
The present invention relates to novel fluorobutenyl aminocarboxylates of the formula (I) R--CO--O--CH 2 --CH 2 --CXCF 2 (I) in which X represents hydrogen or halogen and R...
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5994270 |
Fungicides for the control of take-all disease of plants
Plant disease caused by soil-borne fungus Gaeumannonyces graminis (Gg) is controlled by applying to the seed or the soil a fungicide which has the following general formula: ##STR1##
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5994405 |
Agent for contact lenses
An agent for contact lenses, comprising chloroacetamide. According to the present invention, chloroacetamide, which is the bacteriocidal component to be contained, is scarcely adsorbed not only to...
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5990170 |
Therapeutic use of mono and bicarboxylic acid amides active at the peripheral cannabinoid receptor
The following description concerns a therapeutic method for the treatment of diseases connected with the modulation of the cannabinoid peripheral receptor, comprising administering amidic...
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5985926 |
Method for inhibiting intracellular viral replication
There is disclosed a method of preventing or delaying the occurrence of acquired immunodeficiency syndrome (AIDS) in human immunodeficiency virus (HIV) seropositive humans by administering an...
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5985910 |
3- [4- (2- Phenyl-Indole-1-ylmethyl) Phenyl]- Acrylamides as estrogenic agents
The present invention relates to new 3-[4-(2-Phenyl-Indole-1-ylmethyl)-Phenyl]-Acrylamide compounds which are useful as estrogenic agents, as well as pharmaceutical compositions and methods of...
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5981580 |
Fatty acid analogs and prodrugs
Novel derivatives of fatty acid analogs that have from one to three heteroatoms in the fatty acid moiety which can be oxygen, sulfur or nitrogen, are disclosed in which the carboxy-terminus has...
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5976516 |
Hair cosmetic compositions
Described is a hair cosmetic composition comprising an amide compound having a melting point of 0 to 50° C. The hair cosmetic composition according to the present invention can impart the hair...
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5972892 |
Topical composition containing a substance P antagonist
The invention relates to a therapeutic composition for topical application containing at least one product with an irritant side effect and a substance P antagonist for reducing or even eliminating...
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5958439 |
Plant protection composition containing one or more water soluble active materials and one or more polyalkoxylated amidoamines
A composition containing, as active ingredient, one or more water soluble plant protection active materials and further containing an effective amount of one or more polyalkoxylated amidoamines of...
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5929119 |
Fungicidal composition
A composition which is suitable for controlling fungal pests, comprising conventional additives and an effective amount of a p-hydroxyaniline derivative of the general formula I ##STR1## where the...
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5925674 |
Cycloalkylcarboxanilides
This invention relates to cycloalkylcarboxanilides of the formula ##STR1## which are used to combat pests.
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5925367 |
Pest control with UV blockers and pheromones
A composition for controlling harmful insects and representatives of the order Acarina, containing as biologically active components a) a substance that modifies the behavior of the pests and b) at...
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5907049 |
Meadowfoam amine oxides
The present invention deals with the composition of matter and the utilization of certain amine oxides of meadowfoam amido propyl dimethyl amine. These materials are useful in personal care...
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5900432 |
Therapeutic N-(4-benzoyl-2-methyl-phenyl)-3,3,3-trifluoro-2-hydroxy-2-methyl-propana mides
Compounds of formula I: ##STR1## wherein, ring C, A--B, R 1 , n, R 2 , and R 3 have any of the meanings given in the specification, and their pharmaceutically acceptable salts are useful in the...
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5889058 |
Peptidyl derivatives
Methods of use for compounds of formula (I) are described wherein R represent a --CONHOH, carboxyl (--CO 2 H) or esterified carboxyl group; R 1 represents a hydrogen atom or an optionally...
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5877220 |
Amide-based oligomeric cationic lipids
The present invention provides amide-based oligomeric cationic lipids. The present invention further provides compositions of these amide-based cationic lipids with anionic macromolecules, methods...
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5874444 |
Poly (ADP-ribose) polymerase inhibitors to treat diseases associated with cellular senescence
Inhibition of the enzyme poly (ADP-ribose) polymerase can delay the onset of senescence and inhibitors of the enzyme can be used to treat diseases caused or exacerbated by cellular senescence.
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5869453 |
Cytotoxic T-cell epitopes
The present invention provides cytotoxic Epstein-Barr virus T-cell epitopes. The epitopes are selected from the group consisting of QAKWRLQTL, RYSIFFDY, HLAAQGMAY, YPLHEQHGM, SVRDRLARL, AVLLHEESM,...
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5861435 |
Method for preventing settlement of aquatic fouling organisms
A method for preventing settlement of aquatic fouling organisms on surface of an aquatic structure without environmental hazard is provided. The method is based upon absolutely novel concept to...
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5859054 |
Leukotriene B4 derivatives, process for their production and their use as pharmaceutical agents
Pharmacologically active leukotriene-B 4 derivatives of general formula I, ##STR1## are described, in which R 1 represents CH 2 OH, CH 3 , CF 3 , COOR 4 , CONR 5 R 6 , or R 2 represents...
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5849728 |
Desquamation compositions
The subject invention relates to desquamation compositions comprising a combination of salicylic acid and certain zwitterionic surfactants. The subject invention further relates to methods of...
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5834517 |
Meadowfoam sulfosuccinates in personal care applications
The present invention deals with a process for cleaning and conditioning hair and skin which comprises the contacting of hair or skin woth an effective concentration of certain novel meadowfoam...
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5830869 |
Thiadiazole amide MMP inhibitors
The present invention provides novel thiadiazole amide derivatives represented by formula I ##STR1## The compounds of the present invention inhibit various enzymes from the matrix metalloproteinase...
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5827891 |
HIV protease inhibtors
HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These...
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5827852 |
Coated pharmaceutical compositions
Pharmaceutical composition suitable for coating comprising a composition for oral administration in unit dosage form wherein said composition has been coated with from about 0.01% to about 10% by...
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5824650 |
Topical composition containing a substance P antagoinst
The invention relates to a therapeutic composition for topical application containing at least one product with an irritant side effect and a substance P antagonist for reducing or even eliminating...
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5783593 |
Inhibitors of squalene synthetase and protein farnesyltransferase
The present invention provides a compound of the formula ##STR1## which inhibit squalene synthetase and cholesterol biosynthesis and are useful in the treatment of e.g., hyperlipidaemia,...
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5760085 |
Topical aromatic releasing compositions
The present invention relates to topical aromatic releasing compositions containing one or more volatile aromatic compounds selected from the group consisting of 3-1-menthoxy propane-1,2-diol,...
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5756547 |
Method for the treatment of preserving organs or tissue for transplantation
Bucillamine and N-2,2-dimethyl-3-mercaptopropionyl)-L-cysteine or related compounds can be used to prevent damage to living tissue from the formation or presence of reactive oxygen species. These...
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5753704 |
Therapeutic compositions comprising unsaturated dioic acids or derivatives thereof
Disclosed are certain novel polyunsaturated dioic acids having between 8 and 16 carbon atoms (inclusive), excluding those compounds in the group consisting of: 2,5 octadienedioic acid; 1,7...
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5750559 |
Potentiation of the antireactive-antiasthmatic effect of inhaled loop diuretics by inhaled non-steroidal anti-inflammatory drugs
The antireactive-antiasthmatic effect of inhaled loop diuretics is potentiated by the use of a combination of a loop diuretic and a non-steroidal anti-inflammatory drug as an inhalant for combating...
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5703129 |
5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of β-amyloid protein production
A series of 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives of Formula I have been synthesized. ##STR1## As inhibitors of the production of β-amyloid protein from β-amyloid precursor...
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5693630 |
Phenylethyl and phenylpropylamines
Compounds of the general formula ##STR1## or pharmaceutically acceptable salts thereof, wherein Z is a saturated or unsaturated 3 to 6 carbon chain, m is 2 or 3, R 1 is a hydrogen atom, or a...
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5684049 |
HIV-inhibiting benzeneacetamide derivatives
A compound for use as a medicine having the formula ##STR1## a pharmaceutically acceptable acid addition salt form or a stereochemically isomeric form thereof, wherein R 1 and R 2 each...
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5672597 |
Acetamide derivative
An acetamide derivative having the general formula (I): ##STR1## or a pharmacologically acceptable salt thereof; a synthetic intermediate of the above-mentioned acetamide derivative; a treating...
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5670545 |
Method for the treatment of ischemic disease and reperfusion injury and the prevention of the adverse effects of reactive oxygen species
Bucillamine and N-2,2-dimethyl-3-mercaptopropionyl)-L-cysteine or related compounds can be used to prevent damage to living tissue from the formation or presence of reactive oxygen species. These...
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5652250 |
N-substituted β-aryl- and β-heteroaryl-α-cyanoacrylamide derivatives and process for their preparation
The present invention relates to new compounds of formula ##STR1## wherein A is a bicyclic ring chosen from naphthalene, tetrahydronaphthalene, quinoline, isoquinoline and indole. B is a R 2 ...
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5652228 |
Topical desquamation compositions
The subject invention relates to desquamation compositions comprising a combination of salicylic acid and certain zwitterionic surfactants. The subject invention further relates to methods of...
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5650397 |
Antioccidial method
The present invention is directed to anticoccidial methods, animal feed premixes, and animal feeds, employing a specified o-phenylenediamine or benzimidazole. The present invention is also directed...
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5622916 |
Substituted 2-cylcohexen-1-yl-amine fungicidal and herbicidal agents
A method of combating pests which comprises applying to such pests or to a pest habitat a pesticidally effective amount of a substituted 2-cyclohexen-1-yl-amine derivative of the formula ##STR1##...
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5607978 |
Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
The present invention provides cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives, substituted in the 1-position with halo, methyl, hydroxyl, nitro, amino, amido, azido, oxime,...
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