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7135498 |
Nitric oxide donors for inducing neurogenesis
There is provided a method of promoting neurogenesis by administering a therapeutic amount of a nitric oxide donor compound to a patient in need of neurogenesis promotion. Also provided is a...
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6984624 |
Composition containing an iron complexing protein and a precursor of nitrogen monoxide metabolism and/or a chemical donor of nitrogen monoxide and uses thereof
The invention concerns a pharmaceutical composition or a food supplement containing at least an iron complexing protein optionally in the presence of at least an iron salt, and at least a precursor...
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6936639 |
Nitroxyl progenitors in the treatment of heart failure
Administration of an HNO/NO − donating compound, such as Angeli's salt, increases myocardial contractility while concomitantly lowering left ventricular preload in subjects experiencing heart...
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6911478 |
Nitric oxide-releasing amidine- and enamine-derived diazeniumdiolates, compositions and uses thereof and method of making same
The present invention relates to nitric oxide-releasing amidine- and enamine-derived diazeniumdiolates, compositions comprising such compounds, methods of using such compounds and compositions, and...
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6872751 |
Composition and method for augmenting or restoring the production of fetal protein in patient in need thereof
The present invention relates to methods for prevention and/or treatment of diseases or conditions caused by deficiency in the adult isoform of a given protein wherein said method comprises...
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6780849 |
Lipid-based nitric oxide donors
Novel nitric-oxide releasing lipid molecules are provided which comprise a lipid molecule selected from (a) phosphoglycerides, (b) lipids having a sphingosine base as a backbone, (c)...
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6750254 |
Nitric oxide-releasing amidine—and enamine-derived diazeniumdiolates, compositions and uses thereof and method of making same
The present invention relates to nitric oxide-releasing amidine- and enamine-derived diazeniumdiolates, compositions comprising such compounds, methods of using such compounds and compositions, and...
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6656452 |
Use of inhaled NO as anti-inflammatory agent
A method for lessening or preventing non-pulmonary ischemia-reperfusion injury or inflammation in a mammal by identifying a mammal which has ischemia-reperfusion or is at risk for developing...
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6511991 |
Nitric oxide-releasing amidine- and enamine-derived diazeniumdiolates, compositions and uses thereof and method of making same
The present invention relates to nitric oxide-releasing amidine- and enamine-derived diazeniumdiolates, compositions comprising such compounds, methods of using such compounds and compositions, and...
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6482846 |
Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
Nonsteroidal antiinflammatory drugs which have been substituted with a nitrogen monoxide group; compositions comprising (i) a nonsteroidal antiinflammatory drug, which can optionally be substituted...
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6472390 |
Use of therapeutic dosages for nitric oxide donors which do not significantly lower blood pressure or pulmonary artery pressure
Patients with pathologic conditions involving constriction or proliferation of smooth muscle or disease associated with cysteine containing proteins, or who are at risk for such, are administered a...
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6379660 |
Nitric oxide-releasing 1-&lsqb (2-carboxylato)pyrrolidin-1-yl&rsqb diazen-1-ium-1,2-diolates and composition comprising same
A polymeric composition capable of releasing nitric oxide under physiological conditions which includes a biopolymer, such as a peptide, polypeptide, protein, oligonucleotide or nucleic acid, to...
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6323234 |
Methods to treat gastrointestinal lesions and to reduce drug-induced gastrointestinal or renal toxicity
Nonsteroidal antiinflammatory drugs which have been substituted with a nitrogen monoxide group; composition comprising (i) a nonsteroidal antiinflammatory drug, which can optionally be substituted...
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6287601 |
Topical nitric oxide donor compositions
Compositions and methods of the topical treatment of equine laminitis are disclosed. In particular, combinations of a fast acting nitric oxide (NO) donor, a sustained acting NO donor and an NSAID...
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6200558 |
Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
A polymeric composition capable of releasing nitric oxide under physiological conditions which includes a biopolymer, such as a peptide, polypeptide, protein, oligonucleotide or nucleic acid, to...
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6190704 |
Regulation of wound healing by nitric oxide
The present invention provides methods and compositions for promoting healing of damaged tissue that result in an increased level of nitric oxide in the vicinity of the damaged tissues. Also...
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6147068 |
Lipophilic polyamine esters for the site specific delivery of nitric oxide in pharmaceutical use
A pharmaceutical composition of matter for delivering nitric oxide. The composition is an amine that was reacted with nitric oxide. The composition of matter is lipophilic and insoluble and...
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6121321 |
Substituted methoxy benzylidene indenyl acetic and propionic acids for treating patients with precancerous lesions
Substituted methoxy benzylidene indenyl compounds are useful in the treatment of precancerous lesions and neoplasms.
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6057347 |
Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
Nonsteroidal antiinflammatory drugs which have been substituted with a nitrogen monoxide group; compositions comprising (i) a nonsteroidal antiinflammatory drug, which can optionally be substituted...
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6045827 |
Treatment of equine laminitis
Compositions and methods of the topical treatment of equine laminitis are disclosed. In particular, combinations of a fast acting nitric oxide (NO) donor, a sustained acting NO donor and an NSAID...
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5985301 |
Antibacterial cellulose fiber and production process thereof
A production process of cellulose fiber is characterized in that tertiary amine N-oxide is used as a solvent for pulp, and a silver-based antibacterial agent and optionally magnetized mineral ore...
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5958427 |
Nitric oxide donor compounds and pharmaceutical compositions for pulmonary hypertension and other indications
The invention is directed to nitric oxide (NO) donor compounds and to pharmaceutical compositions containing such nitric oxide (NO) donor compounds, for delivering NO to the apical surface of a...
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5905086 |
Remedy for anxiety neurosis
N-(2-Hydroxyethyl)nicotinamide nitrate or its salt prevents or ameliorates anxiety neurosis or panic disorder, or the following anxiety. This compound or its salt has few side effects and exhibits...
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5840759 |
Use of nitric oxide releasing compounds to protect noncancerous cells from chemotherapeutic agents
The present invention provides a method for sensitizing hypoxic cells in a tumor to radiation, wherein nitric oxide is delivered to target hypoxic cells through the administration of a nitric...
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5837736 |
Nitric oxide-releasing compounds to sensitive cancerous cells to chemotherapeutic agents
The present invention provides a method for sensitizing hypoxic cells in a tumor to radiation, wherein nitric oxide is delivered to target hypoxic cells through the administration of a nitric...
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5814667 |
Use of nitric oxide-releasing compounds as hypoxic cell radiation sensitizers
The present invention provides a method for sensitizing hypoxic cells in a tumor to radiation, wherein nitric oxide is delivered to target hypoxic cells through the administration of a nitric...
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5814666 |
Encapsulated and non-encapsulated nitric oxide generators used as antimicrobial agents
This invention relates to compositions capable of releasing nitric oxide and therapeutic methods of use thereof for the treatment of microorganism-related disease states. The composition comprises...
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5814656 |
Selective prevention of organ injury is sepsis and shock using selective release of nitric oxide vulnerable organs
A method for the treatment of mammalian tissue injured or at risk of injury during sepsis or shock including the administration to a mammal a diazeniumdiolate which releases a therapeutically...
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5789447 |
Nitric oxide releasing compounds as protective agents in ischemia reperfusion injury
The present invention provides a method for treating oxygen free radical induced tissue damage associated with ischemia reperfusion injury, wherein nitric oxide is delivered to target cells/tissues...
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5714511 |
Selective prevention of organ injury in sepsis and shock using selection release of nitric oxide in vulnerable organs
A method for the treatment of mammalian tissue injured or at risk of injury during sepsis or shock including the administration to a mammal a diazeniumdiolate which releases a therapeutically...
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5700830 |
Use of nitric oxide-releasing agents for reducing metastasis risk
A method for inhibiting the adherence between cancerous cells and noncancerous structures in a mammal, comprising the administration to the mammal of a nitric oxide-releasing compound containing a...
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5665077 |
Nitric oxide-releasing nitroso compositions and methods and intravascular devices for using them to prevent restenosis
A surface of a foreign body exposed to the flowing blood of a living being which normally would promote the aggregation of platelets in that blood to form a coating firmly affixed to that surface...
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5650447 |
Nitric oxide-releasing polymers to treat restenosis and related disorders
Methods of amelioration, treatment and prevention for restenosis and related disorders are provided. Methods involve the administration of nitric oxide by a nitric oxide delivery means comprising a...
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5650442 |
Use of nitric oxide releasing compounds as hypoxic cell radiation sensitizers
The present invention provides a method for sensitizing hypoxic cells in a tumor to radiation, wherein nitric oxide is delivered to target hypoxic cells through the administration of a nitric...
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5560910 |
Topical anti-inflammatory composition and method
The present invention comprises compositions and methods that are useful for topically treating inflammation caused by a wide variety of diseases. The compositions comprise an effective amount of a...
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5525357 |
Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
A polymeric composition capable of releasing nitric oxide including a polymer and a nitric oxide-releasing N 2 O 2 - functional group bound to the polymer; pharmaceutical compositions including...
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5444093 |
Wood preservatives
Wood preservatives contain a copper salt, a polyamine and a fatty amine and are used for preserving wood from fungi and termites.
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5405919 |
Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders
A polymeric composition capable of releasing nitric oxide including a polymer and a nitric oxide-releasing N 2 O 2 - functional group bound to the polymer; pharmaceutical compositions including...
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5366997 |
Oxygen substituted derivatives of nucleophile-nitric oxide adducts as nitric oxide donor prodrugs
There are disclosed cardiovascularly active compounds possessing antihypertensive properties, and pharmaceutical compositions containing these agents and a method of treating cardiovascular...
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5276029 |
Wood preservative compositions having activity against termites and fungi
Wood preservatives contain a copper salt, a polyamine and a fatty amine and are used for preserving wood from fungi and termites.
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5250550 |
Complexes of nitric oxide with polyamines
There are disclosed novel complexes of nitric oxide and polyamines which are useful in treating cardiovascular disorders, including hypertension. The disclosed compounds release nitric oxide...
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5185376 |
Therapeutic inhibition of platelet aggregation by nucleophile-nitric oxide complexes and derivatives thereof
A method of inhibiting platelet aggregation in vivo with physiologically compatible compounds containing at least one N-oxo-N-nitrosoamine moiety in a molecule thereof, wherein the physiologically...
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5155137 |
Complexes of nitric oxide with polyamines
There are disclosed novel complexes of nitric oxide and polyamines which are useful in treating cardiovascular disorders, including hypertension. The disclosed compounds release nitric oxide...
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5039705 |
Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof
This invention concerns anti-hypertensive compositions and a method of lowering blood pressure in mammals. The active component of the compositions is a compound of the formula: ##STR1## wherein R...
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4954526 |
Stabilized nitric oxide - primary amine complexes useful as cardiovascular agents
A method of treating cardiovascular disorders in a mammal, by administering to said mammal an effective amount of a compound of the formula: [R--N(H)N(NO)O--] y X wherein R is loweralkyl, aryl,...
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4166121 |
Method of controlling the growth of bacteria and fungi
The product prepared by the process consisting of the steps of (a) reacting a nitroalcohol of the formula ##STR1## where R and R 1 can be hydrogen, methyl, ethyl or hydroxymethyl in about a 1:1...
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3495013 |
METHOD OF TREATING CARDIAC ARRHYTHMIAS WITH N - BENZYL N',N" - DIMETHYLGUANIDINE
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3287212 |
Method of repelling chewing insect larvae
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3256147 |
N-nitroso-n-lower alkyl-haloanilines as nematocides
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3250672 |
Nitroguanidine fungicide
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