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7572833 |
Drug composition comprising dipeptidyl aldehyde derivative
The present invention provides a preparation containing a compound of the formula (I)
wherein R 1 is an alkyl group having 1 to 4 carbon atoms or an optionally substituted aryl group having 6...
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7566739 |
Substituted N-sulfonylaminophenylethyl-2-phenoxyacetamide compounds as VR1 receptor antagonists
This invention provides compounds of the formula (I) useful for the treatment of disease conditions caused by over activation of Vr1 receptors such as pain or the like in mammals as well as...
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7560459 |
Substituted sulfamate anticonvulsant derivatives
The present invention is directed to novel compounds of the formula (I)
wherein X, R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as described in the specification, processes for the preparation of...
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7544717 |
2-amino- and 2-thio- substituted 1,3-diaminopropanes
Disclosed are compounds of the formula:
where variables Q, Z, X, R 15 , R 2 , R 3 , and R c are defined herein. Compounds disclosed herein are inhibitors of the beta-secretase enzyme and are...
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7528170 |
Sulfonamide derivatives for the treatment of diseases
The invention relates to compounds of formula (1)
and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives....
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7479508 |
Nimesulide containing topical pharmaceutical compositions
This invention relates to compositions of nimesulide for topical application.
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7453010 |
Phenylcyclohexylpropanolamine derivatives, preparation and therapeutic application thereof
The invention relates to compounds of general formula (I):
where R 1 represents H or a (C 1 -C 4 )alkyl, —CO(C 1 -C 4 )alkyl, (C 1 -C 4 )alkylphenyl or —CO-phenyl group, said phenyl...
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7417169 |
Amino alcohol derivatives, medicinal composition containing the same, and use of these
The present invention provides compounds represented by general formula (I):
a prodrug thereof, or pharmaceutical acceptable salts thereof, wherein R 1 is hydrogen or lower alkyl; each of R2...
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7375136 |
pH-dependent NMDA receptor antagonists
NMDA receptor blockers, including pH-sensitive NMDA receptor blockers, are provided as neuroprotective drugs that are useful in stroke, traumatic brain injury, epilepsy, and other neurologic events...
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7375120 |
Peptide deformylase inhibitors
Novel PDF inhibitors and novel methods for their use are provided.
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7321001 |
Asthma and allergic inflammation modulators
Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related diseases and conditions. In particular, the invention provides...
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7291620 |
N-alkyl phenylcarboxamide beta-secretase inhibitors for the treatment of Alzheimer's disease
The present invention is directed to compounds which are inhibitors of the beta-secretase enzyme and which are useful in the treatment or prevention of diseases in which the beta-secretase enzyme...
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7196119 |
Development of new selective estrogen receptor modulators
The present disclosure concerns a new class of selective estrogen receptor modulators (SERMs). The disclosure also includes the identification of a previously unknown membrane associated estrogen...
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7186755 |
Nimesulide gel systems for topical use
The present invention relates to nimesulide topical formulations comprising a carboxyvinylpolymer neutralized as a gel-forming agent or a polyacrylamide-isoparaffin and a solvent selected from the...
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7141609 |
α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
α- and β-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
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7105569 |
Fungicidal active compound combinations
New active compound combinations of valinamide derivatives of the formula (I)
in which
R 1 and R 2 has the meaning given in the description,
with known fungicidal active substances,...
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7037941 |
Alpha-and Beta-amino acid hydroxyethylamino sulfamic acid derivatives useful as retroviral protease inhibitors
Certain Alpha- and Beta-amino acid hydroxyethylamino sulfamic acid derivatives represented by the following formula are useful as retroviral protease inhibitors:
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7034045 |
Monofluoroalkyl derivatives
The present invention provides certain monofluoroalkyl derivatives useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of conditions,...
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7030160 |
Propanolaminotetralines, preparation thereof and compositions containing same
The invention relates to phenoxypropanolamines, to pharmaceutical compositions containing them, to processes for preparing them, and to the method of use thereof in the treatment of diseases that...
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7011854 |
Method for treating a mammal by administration of a compound having the ability to release CO, compounds having the ability to release CO and pharmaceutical compositions thereof
Several classes of in vivo carbon monoxide-releasing compounds are useful for the treatment and/or prevention of diseases, such as chronic inflammatory, e.g., rheumatoid arthritis, and of diseases...
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6998423 |
Prevention of loss and restoration of bone mass by certain prostaglandin agonists
Prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such prostaglandin agonists. The...
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6982097 |
Biocidal compositions and methods of using same
This invention relates to biocidal compositions and methods of using same. Also provided is a process for the manufacturing of a biocidal composition in the form of a tablet and a method of using...
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6919369 |
Serine protease inhibitors
Compounds having the structure shown below are useful to inhibit serine protease enzymes, such as TF/factor VIIa, factor Xa, thrombin and kallikrein. These compounds may be used in methods of...
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6916852 |
Method for regulation of microvascular tone
Methods and kits for regulating arterial microvascular tone in which a COX-2 inhibitor and a cannabinoid receptor agonist are co-administered to a subject.
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6911476 |
Sulfonamide derivatives
The present invention provides certain sulfonamide derivatives useful for potentiating glutamate receptor function in a patient and therefore, useful for treating a wide variety of conditions, such...
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6908947 |
Sulfonamide-substituted fused 7-membered ring compounds, their use as a medicament, and pharmaceutical preparations comprising them
The present invention relates to compounds of formula I,
in which X1, X2, X3, X4, Y1, Y2, Y3, Y4, R(3), R(4) and R(5) have the meanings mentioned in the specification, their preparation and...
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6906092 |
Method of inhibiting matrix metalloproteinases
The present invention relates to a method of inhibiting matrix metalloproteinases using compounds that are dibenzofuran sulfonamide derivatives having the Formula I
More particularly, the...
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6890942 |
Acyl sulfonamides as inhibitors of HIV integrase
The present invention relates a series of compounds of Formula I
wherein R 1 , R 2 , R 3 , and B are as defined in the specification. The compounds are useful for the inhibition of HIV...
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6887903 |
N-(2-aryl-propionyl)-sulfonamides and pharmaceutical preparations containing them
The compounds of formula 1
wherein R and R 2 are as defined in the disclosure, are useful in the prevention and treatment of tissue damage due to exacerbated recruitment of polymorphonuclear...
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6878721 |
Beta2-adrenoceptor agonists
Compounds of formula
in free or salt or solvate form, where
Ar is a group of formula
Y is carbon or nitrogen and R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , X, n,...
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6849634 |
Potassium channel inhibitors
Compounds useful as potassium channel inhibitors and especially useful for the treatment of cardiac arrhythmias and cell proliferative disorders are described.
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6822001 |
Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents
Combination therapies are provided for the treatment of proliferative disorders which use a pentafluorobenzenesulfonamide of formula I and an antineoplastic agent such as gemcitabine or paclitaxel.
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6730703 |
Dual inhibitors of cholesteryl ester and wax ester synthesis for sebaceous gland disorders
The present invention provides a method of treating sebaceous gland disorders comprising administering to a patient in need of said treatment an effective amount of a compound named...
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6720357 |
Sulfonamide derivatives
The present invention relates to a compound of formula (Ia) or a pharmaceutically acceptable salt thereof which is useful for the treatment of conditions associated with glutamate hypofunction,...
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6713516 |
Sulphonamide derivatives
The present invention relates to the potentiation of glutamate receptor function using certain sulphonamide derivatives. It also relates to novel sulphonamide derivatives, to processes for their...
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6706765 |
Aminoguanidines and alkoxyguanidines as protease inhibitors
Aminoguanidine and alkoxyguanidine compounds, including compounds of the formula: wherein X is O or NR 9 and R 1 -R 4 , R 6 -R 9 , R 11 , R 12 , R a , R b , R c , Y, Z, n and m are set forth in...
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6703425 |
Sulfonamide derivatives
The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof which is useful for the treatment of conditions associated with glutamate hypofunction, such...
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6686388 |
Regulators of the hedgehog pathway, compositions and uses related thereto
The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function...
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6677376 |
Non-peptidic cyclophilin binding compounds and their use
The invention relates to non-peptidic compounds that possess bioactive properties, such as the ability to protect neuronal cells from otherwise lethal treatments or the ability to promote the...
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6660772 |
Use of 2-amino-1-(4-hydroxy-2-methanesulfonamidophenyl)ethanol for treating urinary incontinence
A method of treating urinary incontinence in a patient in need thereof, the method comprising administering to the patient an effective amount of...
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6632826 |
Carbocyclic HIV protease inhibitors
The present invention is concerned with novel HIV protease Inhibitors of formula I as individual isomers, racemates, non-racemic mixtures or mixtures of diastereoisomers; wherein n, R 1 and R 4...
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6627661 |
Use of 5HT-6 antagonists
Methods for treating ADHD, comprising administering 5-HT 6 antagonists to subjects having ADHD, are disclosed.
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6620813 |
Hydroxamate derivatives of non-steroidal anti-inflammatory drugs
In accordance with the present invention, there are provided novel chemical entities which have multiple utilities, e.g., as prodrugs of NSAIDs; as dual inhibitors of cyclooxygenase (COX) and...
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6610747 |
Phenoxybenzylamine derivatives as SSRIs
A compound of general formula (I) wherein R 1 and R 2 are H, C 1 -C 6 alkyl or (CH 2 ) d (C 3 -C 6 cycloalkyl) wherein d=0, 1, 2 or 3; or R 1 and R 2 together with the nitrogen to which they...
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6605641 |
20-HETE antagonists and agonists
20-HETE agonists and antagonists are disclosed along with therapeutic applications. In a preferable form of the invention, the 20-HETE agonists are selected from the group consisting of...
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6589973 |
Preparation of selective cyclooxygenase II inhibitors
A clear, stable novel pharmaceutical preparation of selective cyclooxygenase II inhibitors (COX 2) inhibitors in the parenteral form for the treatment of pain & inflammatory conditions arising...
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6573278 |
Aryl sulfonamides and analogues thereof and their use in the treatment of neurodegenerative diseases
The present invention relates to new aryl ether sulphonamides and analogues, processes for their preparation and their use for the treatment of neurodegenerative disorders, in particular for the...
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6559185 |
Nitromethyl ketone compounds having aldose reduction inhibiting properties and methods for their use
The present invention relates to the compounds of formula: in which R 1 , R 2 , R 3 , E, A, X, Z, p and n are as defined herein. These compounds are aldose reductase inhibitors.
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RE38103 |
5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2
The Compound of Formula I and pharmaceutically acceptable sales thereof in the treatment of cyclooxygenase-2 mediated diseases are disclosed.
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6545053 |
Tricyclic compounds and drug compositions containing same
Compounds having a β-3 adrenaline receptor agonist and are useful as drugs for the treatment and prevention of diabetes, obesity, hyperlipemia, etc., represented by a general formula (I) and salts...
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