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7411044 |
Polymerized hemoglobin solutions having reduced amounts of tetramer and method for preparing
A substantially tetramer free hemoglobin solution and a method for producing a substantially tetramer free hemoglobin solution. The method includes polymerizing a solution of hemoglobin, treating...
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7396814 |
Metallopeptide compositions for treatment of sexual dysfunction
Metallopeptide compositions are provided for treatment of sexual dysfunction in mammals, including male sexual dysfunction, such as erectile dysfunction, and female sexual dysfunction. The...
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7384916 |
Methods and compositions for preventing and treating aging or photodamaged skin
Disclosed are methods for treating aging and photodamaged skin employing topical application of compositions which comprise at least one peptide manganese complex. Also disclosed are methods...
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7375080 |
Immobilized lactoferrin (Im-LF) antimicrobial agents and uses thereof
Disclosed is a composition of matter comprising a defined dispersion of lactoferria immobilized on a naturally occuring substrate via the N-terminus region of the lactoferrin. Compositions...
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7371728 |
Prostate-specific antigen probes for optical imaging
This invention provides a novel probe, which contains a prostate peptide substrate. The probe can be used as a prostate diagnostic agent for optical imaging. An 11 amino acid peptide substrate is...
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7371411 |
Methods for production of the oxidized glutathione composite with CIS-diamminedichloroplatinum and pharmaceutical compositions based thereof regulating metabolism, proliferation, differentiation and apoptotic mechanisms for normal and transformed cells
The present invention relates to a composite for the treatment of a variety of medical conditions, the composite comprising an oxidized glutathione-based compound, which has a disulfide bond, and a...
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7351690 |
Knockout identification of target-specific sites in peptides
The invention provides methods for identification and determination of target-specific sites in peptides and proteins, including a method for determining the primary sequence of a secondary...
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7329641 |
Blood substitutes
The functional characteristics of heme proteins can be modified to produce hemoglobins that can be used as blood substitutes in different therapeutic applications. Stable polymers of tetrameric...
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7326775 |
Treatments for contaminant reduction in lactoferrin preparations and lactoferrin-containing compositions
A method of preparing an ultra-cleansed lactoferrin preparation, termed treatment for contaminant reduction (TCR) is provided which includes the steps of treating commercial lactoferrin preparation...
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7323443 |
Lactoferrin in the reduction of pain
The present invention relates to methods of using lactoferrin (LF) to reduce pain in conditions associated with severe or intractable pain by administering a composition of lactoferrin either alone...
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7323442 |
Agents for alleviating symptoms accompanied by inflammation
The present invention provides agents for alleviating symptoms resulting from inflammation, which have an activity to alleviate inflammatory symptoms caused by bacterial infection, particularly...
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7318931 |
Sustained release formulation
A composition comprises a protein, a polyol, and a metal. The protein is stabilized by the polyol and the metal, and is protected from denaturing when in contact with an organic solvent. The polyol...
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7314857 |
Synergistic antimicrobial compositions and methods of inhibiting biofilm formation
A synergistic antimicrobial composition for inhibiting biofilm formation includes an iron-sequestering glycoprotein, a cationic polypeptide and a chelating agent, or an iron-sequestering...
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7309482 |
Long lasting waterproof sunscreen comprising metal oxide and peptide conditioner
The disclosure provides a sunscreen formulation comprising a peptide-based metal oxide sunscreen agent, such as titanium dioxide nanoparticles, and a fluid vehicle.
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7307063 |
Melanocortin metallopeptides for treatment of sexual dysfunction
Metallopeptides are provided for use in treatment of sexual dysfunction in mammals. The metallopeptides are agonists for at least one of melanocortin-3 or melanocortin-4 receptors. The...
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7291592 |
Method for treating patients with massive blood loss
Methods for treating a mammal suffering from massive blood loss comprising administering to the mammal a polymerized hemoglobin solution.
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7282479 |
Hyperthermia agent for malignant tumor comprising cytokine and magnetic fine particles
The present invention discloses a hyperthermia agent for malignant tumor which comprises cytokine or a vector in which a cytokine gene is integrated so that cytokine can express in malignant tumor...
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7267817 |
Method for improving oxygen transport by stored red blood cells
A method of treatment of a patient includes administering to the patient stored red blood cells and a hemoglobin solution. The stored red blood cells and the hemoglobin solution can be administered...
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7265084 |
Glycopegylation methods and proteins/peptides produced by the methods
The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying...
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7244805 |
Bimetallic zinc complex and process of producing polycarbonate using the same as polymerization catalyst
Provided are a bimetallic zinc complex and a method of producing polycarbonate, including polymerizing an epoxy compound and carbon dioxide using the bimetallic zinc complex. The bimetallic zinc...
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7238662 |
Alpha 2HS glycoprotein for treatment of cancer and a method for preparation thereof
This invention characterizes the selective apoptotic activity of specially prepared Alpha 2-HS glycoprotein and fragments thereof. Specifically, Alpha 2-HS glycoprotein which has been overloaded...
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7238661 |
Oral lactoferrin in the treatment of respiratory disorders
The present invention relates to methods of treating an allergic or non-allergic respiratory disorder by administering orally a composition of lactoferrin alone or in combination with metal...
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7235542 |
Diagnosis and treatment of human kidney diseases
Kidney disease is diagnosed by measuring urinary catalytic iron in humans. Progressive kidney disease is treated by administering an iron chelator to humans. In particular, the progression of...
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7232805 |
Cobalamin conjugates for anti-tumor therapy
The present invention provides a cobalamin-drug conjugate suitable for the treatment of tumor related diseases. Cobalamin is indirectly covalently bound to an anti-tumor drug via a cleavable linker...
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7214759 |
Biologically absorbable coatings for implantable devices based on polyesters and methods for fabricating the same
Polymers containing polyesters and, optionally, agents for use with medical articles and methods of fabricating the same are disclosed. The medical article generally comprises an implantable...
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7211560 |
Reduced side-effect hemoglobin compositions
The invention relates to novel hemoglobin compositions, particularly novel recombinant mutant hemoglobin compositions, which eliminate or substantially reduce 1) the creation of heart lesions, 2)...
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7208153 |
Method for the improvement of neuronal regeneration
A method for the improvement of neuronal regeneration by prevention or inhibition of basal membrane formation induced by a lesion of neuronal tissue.
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7205002 |
Method of making, and the use of cytotoxic agents containing elemental selenium
Pharmaceutical compositions containing elemental selenium (Se(0)), Se(0)-carrier conjugates, a chromophore photoproduct, fluorescent conjugates of the chromophore photoproduct and carrier...
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7199099 |
Methanobactin: a copper binding compound having antibiotic and antioxidant activity isolated from methanotrophic bacteria
A means and method for treating bacterial infection, providing antioxidant activity, and chelating copper using a copper binding compound produced by methanotrophic bacteria is described. The...
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7186695 |
Treatment of arthritis with arsenoxide compounds
The present invention provides a method of treatment and/or prophylaxis of arthritis in a vertebrate comprising administering to said vertebrate in need of said treatment and/or prophylaxis a...
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7186687 |
Compositions and methods for treatment of Psoriasis
A method for treating psoriasis of the skin of a patient employs topically applying to the affected skin a composition comprising at least one peptide copper complex. In other embodiments, the...
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7179789 |
Compositions and methods for treatment of rosacea
A method for treating rosacea of the skin of a patient employs topically applying to the affected skin a composition comprising at least one peptide copper complex. In other embodiments, the...
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7172751 |
D-amino acid peptides
The present invention provides compounds of the formula X—R 1 -D-[Dpr, Orn or Lys](A)-R 2 (Z)-D-[Dpr, Orn or Lys](B)—R 3 (Y)—NR 4 R 5 ; or R 1 (X)-D-[Dpr, Orn or Lys](A)-R 2 (Z)-D-[Dpr, Orn...
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7169753 |
Chlorophyll and bacteriochlorophyll esters, their preparation and pharmaceutical compositions comprising them
Novel C-13 2 -COXR 1 , C-17 2 -COXR 2 and C-13 2 -COXR 1 , C-17 2 -COXR 1 derivatives of chlorophyll and bacteriochlorophyll compounds are provided wherein X is O, S or N and R 1 and R 2 , the...
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7169412 |
Methods for production of the oxidized glutathione composite with cis-diamminedichloroplatinum and pharmaceutical compositions based thereof regulating metabolism, proliferation, differentiation and apoptotic mechanisms for normal and transformed cells
The present invention relates to a composite for the treatment of a variety of medical conditions, the composite comprising an oxidized glutathione-based compound, which has a disulfide bond, and a...
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7160855 |
Enhancement of iron chelation therapy
The present invention provides methods of enhancing the rate of iron release from ferritin. By increasing the amount of iron available for chelation, the invention also provides methods of treating...
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7151084 |
Compound and method of treating neurogenic conditions using non-steroidal anti-inflammatory drug complexes
A complex is provided for the treatment of neurogenic conditions having the formula:
where R 1 is
M is a metal ion Ca(II), Mg(II), Cu(II) or Ni(II); n is an integer 1 or 2; R is BBB...
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7138105 |
Compositions for delivery of therapeutics and other materials, and methods of making and using the same
In part, the present invention is directed to compositions comprising a carrier with a metal binding domain, a metal ion, and an active agent.
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7128923 |
Preserved and stable compositions containing peptide copper complexes and method related thereto
Compositions comprising at least one peptide copper complex and at least one preservative exhibit chemical stability of the peptide copper complex, as well as resistance and/or toxicity to...
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7119065 |
Metal complex-protein composite and oxidation catalyst
We claim a metal complex-protein composite comprising a salen metal complex and an apoprotein having a cavity, wherein the salen metal complex has a structure given by the following formula:
R 1...
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7115267 |
Stimulator of stem cell division
Disclosed and claimed are methods for the isolation and use of stem cell modulating factors for regulating stem cell cycle and for accelerating the post-chemotherapy peripheral blood cell recovery....
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7112563 |
Therapies using hemoproteins
Herein it is shown that hemoproteins (e.g., Ascaris hemoglobin, myoglobin, flavohemoglobins) have NO-consuming and deoxygenase activities. The invention provides a method of reducing the...
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7101846 |
Methods and compositions for optimization of oxygen transport by cell-free systems
Compositions, and methods of use thereof, for use as blood substitute products comprise aqueous mixtures of oxygen-carrying and non-oxygen carrying plasma expanders and methods for the use thereof....
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7097841 |
Ferritin fusion proteins for use in vaccines and other applications
An isolated ferritin fusion protein is provided in which ferritin is fused with a protein or peptide capable of being fused to ferritin without interfering with the polymeric self-assembly of the...
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7094431 |
Method of healing skin wounds in mammals and a composition therefor
This invention pertains to therapeutic antibacterial/antifungal-wound healing compositions comprising a therapeutically effective amount of antibacterial agents and/or antifungal agents and/or...
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7084115 |
Inositol pyrophosphates, and methods of use thereof
The present invention comprises compounds, compositions thereof, and methods capable of delivering modified inositol hexaphospahte (IHP) comprising an internal pyrophosphate ring to the cytoplasm...
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7074759 |
Treatment of case-ready food products with immobilized lactoferrin (Im-LF) and the products so produced
Disclosed is a method for reducing the microbial contamination in products, such as case-ready meat products, including ready-to-eat meat products, subject to microbial contamination, including...
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7060677 |
Antimicrobial activity of the first cationic cluster of human lactoferrin
The present invention provides polypeptides related to human lactoferrin protein that have utility in a variety of therapeutic and prophylactic applications, including use as antimicrobial agents....
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7049288 |
Phaseolamin compositions and methods for using the same
The present invention is for compositions containing phaseolamin and a mineral, such as chromium or vanadium or both, where the mineral is bound by a glycoprotein matrix. The present invention is...
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7045503 |
Radiometal-binding peptide analogues
Novel metal binding ligands are disclosed that may be coupled to peptides for use in methods of diagnosis and therapy. Peptides containing the ligands are produced using a method wherein ligand...
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