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5645816 |
Synthetic polyuronic and hypoosmotic polymer compositions in admixture with proteinaceously bound contrast agents for MRI
Novel contrast media for use in magnetic resonance imaging are described. Such contrast media are comprised of biocompatible polymers either alone or in admixture with one or more contrast agents...
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5631219 |
Method of stimulating hematopoiesis with hemoglobin
The present invention relates to a method for stimulating hematopoiesis in a mammal comprising administration of a therapeutically effective amount of a hemoglobin, including recombinant...
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5614490 |
Administration of low dose hemoglobin to increase perfusion
This invention provides a method to therapeutically increase perfusion in a mammal comprising administering stroma-free hemoglobin at a dose ranging from the least amount effective to increase...
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5604199 |
Method of treating fibrosis in skeletal muscle tissue
A method of treating skeletal muscle fibrosis in mammals. The novel method is effective for reducing the extent of skeletal muscle fibrosis in an individual who suffers from a disorder which...
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5602105 |
Cardiotropic formulation
The invention provides a cardiotropic formulation comprising a cardiac glycoside, a beta-adrenergic receptor stimulant nicotinamide adenine dinucleotide, cytochrome C and inosine for use in...
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5595725 |
Diagnostic media
A diagnostic medium contains at least one physiologically well tolerated complex salt comprising an anion of a complexing acid and one or more central ion or ions of an element with an atomic...
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5593622 |
Preparation of liposomes with peg-bound phospholipid on surface
Agents for inhibiting adsorption of proteins on the liposome surface and liposomes which are agglutination-free by binding said inhibiting agent on the surface are disclosed. The above-mentioned...
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5593658 |
Medical compositions
A biocompatible medical composition including a polymeric carrier, a protective chain linked to the polymeric carrier, and a reporter group linked to the carrier or to the carrier and the...
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5591711 |
L-lysyl-glycyl-L-histidine and therapeutic agent for wound healing containing the same
L-lysyl-glycyl-histidine and metal complexes thereof, for example, L-lysyl-glycyl-L-histidine: copper (II). The L-lysyl-glycyl-L-histidine and salt thereof have a fibroblast proliferation promoting...
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5587371 |
Texaphyrin-oligonucleotide conjugates
Texaphyrins are provided for use as radiation sensitizers. Advantageous properties of texaphyrins for use as a radiation sensitizer include: i) a low redox potential which allows radiation-induced...
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5578564 |
Nickel-free hemoglobin and methods for producing such hemoglobin
According to the present invention removal of nickel from a nickel-containing hemoglobin solution is accomplished by exposing the nickel-containing hemoglobin solution to a chelating agent,...
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5578637 |
Methods of inhibition or killing cancer cells using an endoperoxide
Methods of inhibiting or killing cancer cells are disclosed wherein compounds having an endoperoxide moiety that is reactive with heme are administered under conditions which enhance intracellular...
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5563047 |
Method for crosslinking of haemoglobin
Haemoglobin is crosslinked by means of transglutaminase, whereafter the transglutaminase is inactivated. The crosslinked haemoglobin can be used as a molecular agent for oxygen transportation, as...
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5550183 |
Metal-peptide compositions and methods for stimulating hair growth
There is provided metal-peptide compositions for use as stimulating agents for hair growth in warm-blooded animals. Methods for stimulating the growth of hair in warm-blooded animals are also...
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5545614 |
Controlling nitrogen oxide concentrations to modulate skeletal muscle contraction
A method for inhibiting or relaxing skeletal muscle contractions and for treating disease states resulting from or exacerbated by undesirable skeletal muscle contractions by administering a...
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5543392 |
Digestive tract cell activating agent of EGF and lactoferrin
The present invention provides an activating agent of digestive tract cells, which contains an epidermal growth factor, lactoferrins, a hydrolysate of the lactoferrins, or a mixture thereof. The...
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5534241 |
Amphipathic polychelating compounds and methods of use
An amphipathic polychelating compound including a hydrophilic polymeric moiety having a main backbone and a plurality of reactive side groups, a lipid-soluble anchor linked to the N terminal of the...
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5534542 |
Methods and materials relating to a bi-metallic cross-linking species
Disclosed herein is a bi-metallic cross-linking reagent according to the following formula: ##STR1## where M 1 is a metal ion species capable of forming a complex of coordination number four or...
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5531994 |
Feed additive containing zinc bacitracin
A novel zinc bacitracin--containing animal feed additive, in particulate form, has been discovered having an externally coating with a polymer such as an alkyl cellulose polymer. The novel...
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5521154 |
Imidoester cross-linked hemoglobin compositions
An imidoester, cross-linked hemoglobin composition useful in the transport of oxygen to living cells and being essentially free of any impurities, a P50 of at least 13mm Hg and predominantly in...
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5500353 |
Bacterial surface protein expression
This invention provides a bacterium having an S-layer modified such that the bacterium S-layer protein gene contains one or more in-frame sequences coding for one or more heterologous polypeptides...
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5480866 |
Hemoproteins for inhibition of nitric oxide-mediated hypotension and septic shock
The invention is directed to a method for the prophylaxis or treatment of an animal for deleterious physiological effects such as systemic hypotension caused by nitric oxide production induced by a...
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5478805 |
Fractionation of polyalkylene oxide-conjugated hemoglobin solutions
Hemoglobin-containing solutions containing polyalkyene oxide-conjugated hemoglobin having a molecular weight greater than about 85,000 daltons and a degree of substitution of at least five...
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5474848 |
Paucilamellar lipid vesicles
A new method of producing paucilamellar lipid vesicles has been developed. The vesicles are made of non-phospholipid surfactants. The paucilamellar lipid vesicles have 2-8 lipid bilayers...
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5472938 |
Pharmaceutical depot compositions containing hirudin
The present invention relates to aqueous depot formulations of hirudin, particularly desulphatohirudin, which are very stable. These formulations contain water, hirudin, and calcium, magnesium, or...
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5470876 |
Topical sod for treating hair loss
SOD for treating hair loss is disclosed. The SOD has utility in a topical pharmaceutical formulation for the cosmetic treatment of hair loss and the cosmetic stimulation of hair growth. The SOD...
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5462751 |
Biological and pharmaceutical agents having a nanomeric biodegradable core
A biologically active composition made up of biodegradable core particles which are coated with a layer that is designed to allow attachment of biologically active agents without denaturing them....
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5441737 |
Use of apotransferrin that has bound zinc or copper ions for treatment of toxic effects of endotoxins
Apotransferrin bound to zinc or copper is administered to a patient who has endotoxins present in the patient's bloodstream. The apotransferrin improves the elimination of endotoxins from the...
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5441734 |
Metal-interferon-alpha crystals
The present invention provides for crystalline zinc-interferon alfa-2 (IFN α-2) having a monoclinic morphology. The present invention further provides for crystalline cobalt-IFN α-2, crystalline...
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5439882 |
Blood substitute
An improved blood substitute comprises purified hemoglobin, preferably bovine, cross-linked intramolecularly with periodate-oxidized ATP (o-ATP) and intermolecularly with periodate-oxidized...
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5439883 |
Antihypoxic formulation
The invention relates to cardiology, and provides an antihypoxic formulation, Energostim, including cytochrome C, nicotinamide adenine dinucleotide and inosine. Energostim provides a complete...
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5438041 |
Oxygen carrying multiple emulsions
A process is provided wherein hemoglobin, a fragile material, is formulated into high hemoglobin content water-in-oil-in-water multiple emulsion while maintaining high yields and high oxygen...
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5438051 |
Compositions of porphyrin derivatives
A family of benzochlorins, a family of verdins, a family of porphyrin derivatives and metal complexes thereof are disclosed. The benzochlorins have the formula of FIG. 3 of the attached drawings;...
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5428007 |
Genetically engineered low oxygen affinity mutants of human hemoglobin
Peptides encoded by a substantially pure polynucleotide coding for an alpha and/or beta human globin, the globin when part of a hemoglobin molecule conferring lower oxygen affinity than normal...
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5414014 |
Methods for efficacious removal of attached, sucking antropods from human dermis
The present invention provides methods of using compositions containing local anesthetic compounds for facilitating the removal of sucking arthropods from the skin of a mammal; for reducing...
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5411730 |
Magnetic microparticles
Superparamagnetic particles are provided for medical applications including hyperthermia techniques, localized heating and tissue-specific release of therapeutic agents, and magnetic resonance...
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5409893 |
Ruthenium(III) complexes as antineoplastic agents
The invention concerns a coordination complexes with R 111 as central metal attached to a heterocyclic ligand in the apical position trans to a sulfoxide and their pharmaceutical compositions...
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5403576 |
Iodo-phenylated chelates for magnetic resonance imaging
Hybrid agents for enhancing in vivo diagnostic imaging of body organs and tissues, and methods of preparing and using the same.
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5389611 |
Lactoferrin hydrolyzate for use as an antibacterial agent and as a tyrosinase inhibition agent
Lactoferrin hydrolyzates, having a decomposition rate between 6%-20% as measured by formol titration, for use as an antibacterial agent, and which have remarkably more potent activity than...
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5368840 |
Natural polymers as contrast media for magnetic resonance imaging
Novel contrast media for use in magnetic resonance imaging are described. Such contrast media are comprised of biocompatible polymers either alone or in admixture with one or more contrast agents...
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5352476 |
Nutrient composition containing non-phosphorylated peptides from case in based material
Non-phosphorylated peptides and phosphopeptides useful as alimentary products or medicaments are produced by proteolytic enzyme hydrolysis of a casein-based material. Membrane ultrafiltration is...
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5334408 |
Nutrient composition containing non-phosphorylated peptides from casin-based material
Non-phosphorylated peptides and phosphopeptides useful as alimentary products or medicaments are produced. A hydrolyzate containing non-phosphorylated peptides and phosphopeptides is prepared by...
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5324503 |
Iodo-phenylated chelates for x-ray contrast
Hybrid agents for enhancing in vivo diagnostic imaging of body organs and tissues, and methods of preparing and using the same.
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5322836 |
Bioactive agents, compositions and materials comprising said bioactive agents
Bioactive agents, having growth-promoting activity upon Bifidobacteria, consisting of one or more lactoferrin-compounds selected from the group consisting of bovine lactoferrin, bovine...
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5314679 |
Vascular magnetic resonance imaging agent comprising nanoparticles
The preparation and isolation of biodegradable superparamagnetic MR imaging contrast agents for the vascular compartment is described. These aggregates are comprised of individual biodegradable...
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5281579 |
Purified virus-free hemoglobin solutions and method for making same
An aqueous solution of cross-linked hemoglobin free of active virus and having a P50 under physiologic conditions of at least 26 mm. Hg. are disclosed.
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5281578 |
Gallium compounds
Gallium(III) complexes of general formula I, ##STR1## in which X=O 2 CR 2 , halogen, NO 3 or -OA, R 1 =H, alkyl, alkoxy, halogen, NO 2 or amino, R 2 =alkyl, alkoxy or aryl, each of R 3 , R 4 ,...
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5268165 |
Polymer-deferoxamine-ferric iron adducts for use in magnetic resonance imaging
Compositions comprising a covalently bounded adduct of deferoxamine, ferric iron and polymer for image enhancement in magnetic resonance (MR) imaging are provided. A pharmaceutical composition...
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5258367 |
Uteroferrin and rose proteins for stimulating hematopoietic cells
Method of using uteroferrin and rose for stimulating proliferation of hematopoietic cells.
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5240909 |
Use of lactoferrin for treatment of toxic effects of endotoxins
Animal species are treated either intravenously or by tube directly to the gut with a solution containing a lactoferrin bound to a metal ion, the metal ion content being at least 0.1 mg per gram of...
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