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6566326 |
Chemically modified hemoglobin for burn shock resuscitation
Hemoglobin chemically modified to reduce oxygen affinity and prevent dissociation are administered parenterally during resuscitation to patients suffering from burn shock. Such treatment, reduces...
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6565895 |
Bismuth compounds for the treatment and prevention of mucositis
The invention relates to the unexpected discovery that bismuth-containing compounds are effective in the treatment of oral mucositis in a mammal. Thus, the invention relates, in one aspect to a...
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6541449 |
Increasing function of organs having reduced red blood cell flow
The present invention relates to a method of therapeutically, or prophylactically, treating a vertebrate to increase tissue oxygenation, or maintain issue oxygenation, in tissue of a vertebrate...
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6518252 |
Method of treating aquatic animals with an antimicrobial agent and chelating agent
The present invention relates to novel method of reducing microbial infections, especially bacterial infections, of animals, especially of aquatic animals such as fish maintained in tanks or...
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6506725 |
Ultra pure hemoglobin solutions and blood-substitutes
A blood substitute and plasma expander comprising a cross-linked, substantially endotoxin-free hemoglobin solution and process for preparing same. The process comprises fractionating whole blood,...
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6492329 |
Cytokine and hemopoietic factor endogenous production enhancer and methods of use thereof
A method of stimulating endogenous production of cytokines and hemopoietic factors by introducing to a mammalian body in need of stimulation of cytokines or hemopoietic factors or both, an...
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6468964 |
Control of acidic gut syndrome
According to the present invention there is provided a method for the treatment or prophylaxis of acidic gut syndrome resulting from the accumulation of acid and production of endotoxin in the...
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6458758 |
Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
Compositions and processes to alleviate free radical toxicity are disclosed based on the use of nitroxides in association with physiologically compatible macromolecules. In particular,...
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6458762 |
Therapeutic use of hemoglobin for preserving tissue viability and reducing restenosis
Administration of low doses of hemoglobin minimizes damage to the myocardium after blockage and significantly reduces reperfusion injury. Hemoglobin exerts a pharmacological effect by increasing...
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6440690 |
Peptides for the activation of the immune system in humans and animals
The present invention is directed to compositions and methods for the treatment of diseases comprising the administration of compositions comprising one or more peptide(s) having a stimulatory...
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6432917 |
Inhibitor of stem cell proliferation and uses thereof
Disclosed and claimed are methods for the isolation and use of stem cell inhibiting factors for regulating the abnormal stem cell cycle and for accelerating the post-chemotherapy peripheral blood...
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6432918 |
Methods and compositions for optimization of oxygen transport by cell-free systems
Compositions, and methods of use thereof, for use as blood substitute products comprise aqueous mixtures of oxygen-carrying and non-oxygen carrying plasma expanders and methods for the use thereof....
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6416785 |
Molecular probes for targeting of cell density-indicating compounds
A new approach for targeting chemotherapeutics to focal bacterial infections is provided. Such focal infections are characterized by high densities of different bacteria and thus high...
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6372264 |
Method of reducing calcified arterial plaque buildup and cellular malfunction and for balancing ionic calcium
A method for reducing calcified arterial plaque buildup and cellular malfunction with the administration of therapeutically effective dosages of a compounded coordination complex of magnesium. The...
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6368619 |
Hydrophobic preparations of hydrophilic species and process for their preparation
Single phase preparations of hydrophilic species, in particular macromolecular compounds such as proteins or glycoproteins in a hydrophobic solvent such as an oil can be obtained by preparing a...
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6358929 |
Use of a peptide preventing the intolerance reactions of the skin, in particular in cosmetic compositions
Use as additives, in cosmetic compositions, of a peptide containing the sequence Lysine-Proline-Valine, with the aim of preventing or reducing the intolerance reactions linked to a contact...
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6350729 |
Inhibition of nitric oxide-mediated hypotension and septic shock with iron-containing hemoprotein
The invention is directed to a method for the prophylaxis or treatment of an animal for deleterious physiological effects such as systemic hypotension caused by nitric oxide production induced by a...
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6340667 |
Reptilian-derived peptides for the treatment of microbial infections
The present invention provides compositions useful as antimicrobial agents which include reptilian hemoglobin, the α and β chains of hemoglobin free of heme, fragments of said proteins or...
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6337314 |
Mammalian-derived peptides for the treatment of microbial infections
The present invention provides compositions useful as antimicrobial agents which include mammalian hemoglobin, the α and β chains of hemoglobin free of heme, fragments of the α and β chains...
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6323175 |
Compositions and methods utilizing nitroxides to avoid oxygen toxicity, particularly in stabilized, polymerized, conjugated, or encapsulated hemoglobin used as a red cell substitute
Compositions and processes to alleviate oxygen toxicity are disclosed based on the addition of nitroxides to physio-logically compatible macromolecules. In particular, hemoglobin-based red cell...
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6255278 |
Composition containing pooled transferrins as an active principle for the induction of immune tolerance against antigens
A method for controlling immune reactions to a foreign tissue or a foreign cell in a recipient host mammal to enhance tolerance of the recipient host mammal towards a grafted foreign tissue or a...
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6242417 |
Stabilized compositions containing hemoglobin
The present invention relates to a hemoglobin compositions stabilized against the formation of aggregates. The present invention further relates to methods of making such hemoglobin compositions.
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6203822 |
Gallium-containing compounds for the treatment of infections caused by intracellular pathogens and pathogens causing chronic pulmonary infection
This invention relates to the use of gallium-containing compounds, to inhibit intracellular pathogens including pathogens that are members of the genus Mycobacteria, Legionella, Histoplasma, and...
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6197745 |
Methods for producing nitrosated hemoglobins and therapeutic uses therefor
S-nitrosothiols (RSNOs) can donate the NO group to the β93 cysteine residues of hemoglobin (Hb) without inactivating the heme. S-nitrosylation of Hb is under the allosteric control of oxygen and...
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6187744 |
Methods and compositions for regulating the intravascular flow and oxygenating activity of hemoglobin in a human or animal subject
Methods for time-regulated prophylaxis or treatment of animals or humans for limited circulatory oxygen delivery induced by the inhibitory effects of a plasma-borne hemoglobin-based material on...
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6180598 |
Covalently modified hemoglobin having low temperature-dependent oxygen-binding function
The present invention provides various covalently modified hemoglobin compositions, each having a low temperature-dependent oxygen-binding function. The present invention also provides methods for...
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6172039 |
Expression of recombinant hemoglobin and hemoglobin variants in yeast
The invention is directed to a substantially pure mammalian globin chain or heme-binding fragment thereof. The invention is further directed to recombinant DNA vectors capable of expressing at...
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6172040 |
Immobilized lactoferrin antimicrobial agents and the use thereof
Disclosed is a method for treating products, such as meat products, with immobilized lactoferrin to reduce microbial contamination. The lactoferrin is immobilized on a naturally occurring...
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6153172 |
Reflective microspheres for ultrasonic imaging
The present invention provides a method of contrast enhanced ultrasonic diagnostic imaging comprising administering to a subject a contrast enhancing amount of spheres or particles comprising a...
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6139882 |
Method of producing iron-whey-proteolysate complex
A carbonate- and/or bicarbonate-iron-whey-proteolysate complex includes 1 to 1,000 atoms of iron and one or more molecules of carbonate and/or bicarbonate per one molecule of whey-protein as...
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6124258 |
Iron-casein complex and process for preparing the same
Iron-casein complexes and methods for preparation thereof without iron characteristic astringent taste even by heat sterilization and having high iron supplying effect. The iron-casein complexes...
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6117838 |
Use of hemoglobin in the treatment of hypotension
A method of treating a mammal suffering from hypotension by administering intermolecularly- or intramolecularly-crosslinked stroma-free hemoglobin to the mammal.
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6114303 |
Hemoglobin therapy in hemodialysis
Low doses of stroma-free diaspirin cross-linked hemoglobin are administered to patients undergoing hemodialysis, to achieve hemostabilization and avoid hypotensive episodes in susceptible patients....
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6103690 |
Prevention or inhibition of pathogenic syndromes caused by nitric oxide overproduction using iron-containing hemoprotein
The invention is directed to a method for the prophylaxis or treatment of an animal for deleterious physiological effects such as systemic hypotension caused by nitric oxide production induced by a...
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6090779 |
Use of hemoglobin to treat septic shock
Therapeutic treatment of septic shock comprises administering to an animal stroma-free hemoglobin, typically at a dose ranging from the least amount effective to increase perfusion, up to a dosage...
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6083909 |
Haemoglobin-hydroxyethyl starch conjugates as oxygen carriers
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6046170 |
Therapeutic use of hemoglobin to treat head injury
A method for treating head injury in a mammal is provided. The method comprises administering to a mammal having a head injury an effective amount of a hemoglobin preparation. A preferred...
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6046161 |
Use of hemoglobin in the treatment of cardiogenic shock
A method for increasing perfusion in a mammal suffering from cardiogenic shock by administering a perfusion-increasing effective amount of intermolecularly- or intramolecularly-crosslinked...
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6030611 |
Therapeutic SOD compositions and uses thereof
Improved methods for production of recombinant human superoxide dismutase and analogs thereof have been developed. Such superoxide dismutase or analogs may be used to catalyze the reduction of...
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6022850 |
Use of hemoglobin in the treatment of stroke
A method for increasing perfusion in a mammal suffering from stroke by admninistering a perfusion-increasing effective amount of intermolecularly- or intramolecularly-crosslinked stroma-free...
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6022849 |
Mutant recombinant hemoglobins containing heme pocket mutations
This invention relates to recombinant hemoglobins containing mutations in or near the heme pocket of the hemoglobin molecule. This invention particularly relates to recombinant hemoglobins that...
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6020308 |
Methods for improving therapeutic effectiveness of treatment of vascularization disorders
The present invention is directed to the use of an inhibitor of NO activity, such as a nitric oxide scavenger or an NO synthase inhibitor, as as an adjunct to treatment of inappropriate tissue...
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6017888 |
Stimulation of hair growth by peptide copper complexes
Peptide-copper complexes are disclosed which stimulate the growth of hair on warm-blooded animals. In one aspect of this invention, the peptide-copper complexes are dipeptides or tripeptides...
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6017943 |
Hemoglobin crosslinkers
The present invention provides a class of compounds having the formula: Y--R--CH 2 --CH 2 --[O--CH 2 --CH 2 ] n --R'--Y' wherein n is an integer from about 5 to about 200; R is carbamate,...
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6013623 |
Use of heme-peptides to prevent or retard disease associated with oxidative stress
This invention provides a method for treating a condition associated with oxidative stress in a subject which comprises administering to the subject an amount of a heme-peptide effective to treat...
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6008190 |
Cobalt Schiff base compounds
The invention relates to novel cobalt compounds, having a general structure ##STR1## wherein Co is either Co(II) or Co(III), and each of the R groups is selected from the group consisting of...
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5998361 |
Polymerized hemoglobin
Stroma-free hemoglobin intermolecularly cross-linked, i.e., polymerized, so as to transform stroma-free hemoglobin into a physiologically competent oxygen carrier which is retained in vivo for...
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5997912 |
Method for inhibiting growth of P. aeruginosa using gallium-containing compounds
This invention relates to methods for using gallium-containing compounds to inhibit the growth of pathogenic P. aeruginosa in a mammal infected with the pathogen.
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5981475 |
Treatment for sensitive teeth
An oral composition for the treatment of dentinal hypersensitivity containing a dentinal hypersensitivity reducing or relieving amount of an active compound selected from casein, a component of...
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5976500 |
Gel particle contrast media for magnetic resonance imaging
A contrast medium useful for diagnostic imaging is provided. The contrast medium comprises gel particles, preferably of less than about 90μ in mean diameter, the gel particles comprising at least...
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