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7186695 |
Treatment of arthritis with arsenoxide compounds
The present invention provides a method of treatment and/or prophylaxis of arthritis in a vertebrate comprising administering to said vertebrate in need of said treatment and/or prophylaxis a...
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7186687 |
Compositions and methods for treatment of Psoriasis
A method for treating psoriasis of the skin of a patient employs topically applying to the affected skin a composition comprising at least one peptide copper complex. In other embodiments, the...
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7172751 |
D-amino acid peptides
The present invention provides compounds of the formula X—R 1 -D-[Dpr, Orn or Lys](A)-R 2 (Z)-D-[Dpr, Orn or Lys](B)—R 3 (Y)—NR 4 R 5 ; or R 1 (X)-D-[Dpr, Orn or Lys](A)-R 2 (Z)-D-[Dpr, Orn...
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7169753 |
Chlorophyll and bacteriochlorophyll esters, their preparation and pharmaceutical compositions comprising them
Novel C-13 2 -COXR 1 , C-17 2 -COXR 2 and C-13 2 -COXR 1 , C-17 2 -COXR 1 derivatives of chlorophyll and bacteriochlorophyll compounds are provided wherein X is O, S or N and R 1 and R 2 , the...
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7160855 |
Enhancement of iron chelation therapy
The present invention provides methods of enhancing the rate of iron release from ferritin. By increasing the amount of iron available for chelation, the invention also provides methods of treating...
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7151084 |
Compound and method of treating neurogenic conditions using non-steroidal anti-inflammatory drug complexes
A complex is provided for the treatment of neurogenic conditions having the formula:
where R 1 is
M is a metal ion Ca(II), Mg(II), Cu(II) or Ni(II); n is an integer 1 or 2; R is BBB...
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7138105 |
Compositions for delivery of therapeutics and other materials, and methods of making and using the same
In part, the present invention is directed to compositions comprising a carrier with a metal binding domain, a metal ion, and an active agent.
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7128923 |
Preserved and stable compositions containing peptide copper complexes and method related thereto
Compositions comprising at least one peptide copper complex and at least one preservative exhibit chemical stability of the peptide copper complex, as well as resistance and/or toxicity to...
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7119065 |
Metal complex-protein composite and oxidation catalyst
We claim a metal complex-protein composite comprising a salen metal complex and an apoprotein having a cavity, wherein the salen metal complex has a structure given by the following formula:
R 1...
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7115267 |
Stimulator of stem cell division
Disclosed and claimed are methods for the isolation and use of stem cell modulating factors for regulating stem cell cycle and for accelerating the post-chemotherapy peripheral blood cell recovery....
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7112563 |
Therapies using hemoproteins
Herein it is shown that hemoproteins (e.g., Ascaris hemoglobin, myoglobin, flavohemoglobins) have NO-consuming and deoxygenase activities. The invention provides a method of reducing the...
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7101846 |
Methods and compositions for optimization of oxygen transport by cell-free systems
Compositions, and methods of use thereof, for use as blood substitute products comprise aqueous mixtures of oxygen-carrying and non-oxygen carrying plasma expanders and methods for the use thereof....
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7097841 |
Ferritin fusion proteins for use in vaccines and other applications
An isolated ferritin fusion protein is provided in which ferritin is fused with a protein or peptide capable of being fused to ferritin without interfering with the polymeric self-assembly of the...
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7094431 |
Method of healing skin wounds in mammals and a composition therefor
This invention pertains to therapeutic antibacterial/antifungal-wound healing compositions comprising a therapeutically effective amount of antibacterial agents and/or antifungal agents and/or...
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7084115 |
Inositol pyrophosphates, and methods of use thereof
The present invention comprises compounds, compositions thereof, and methods capable of delivering modified inositol hexaphospahte (IHP) comprising an internal pyrophosphate ring to the cytoplasm...
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7074759 |
Treatment of case-ready food products with immobilized lactoferrin (Im-LF) and the products so produced
Disclosed is a method for reducing the microbial contamination in products, such as case-ready meat products, including ready-to-eat meat products, subject to microbial contamination, including...
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7060677 |
Antimicrobial activity of the first cationic cluster of human lactoferrin
The present invention provides polypeptides related to human lactoferrin protein that have utility in a variety of therapeutic and prophylactic applications, including use as antimicrobial agents....
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7049288 |
Phaseolamin compositions and methods for using the same
The present invention is for compositions containing phaseolamin and a mineral, such as chromium or vanadium or both, where the mineral is bound by a glycoprotein matrix. The present invention is...
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7045503 |
Radiometal-binding peptide analogues
Novel metal binding ligands are disclosed that may be coupled to peptides for use in methods of diagnosis and therapy. Peptides containing the ligands are produced using a method wherein ligand...
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7033999 |
Nitrosated and nitrosylated heme proteins
Nitrosylation of proteins and amino acid groups enables selective regulation of protein function, and also endows the proteins and amino acids with additional smooth muscle relaxant and platelet...
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7005414 |
Synthetic oxygen transport made from cross-linked modified human or porcine haemoglobin with improved properties, method for a preparation thereof from purified material and use thereof
According to the claims, the present invention comprises the preparation of chemically modified, cross-linked hemoglobins with improved functional properties, the cross-linked hemoglobins prepared...
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7001715 |
Purification of red blood cells by separation and diafiltration
Red blood cells are purified by separating whole blood, such as by centrifugation, to form a red blood cell fraction and a liquid fraction. The whole blood can be defibrinated or treated to prevent...
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6992065 |
Sustained release formulations
A composition for sustained release comprises a carrier material containing a non-polymeric, non-water soluble liquid material having a viscosity of at least 5,000 cP at 37° C. that does not...
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6984624 |
Composition containing an iron complexing protein and a precursor of nitrogen monoxide metabolism and/or a chemical donor of nitrogen monoxide and uses thereof
The invention concerns a pharmaceutical composition or a food supplement containing at least an iron complexing protein optionally in the presence of at least an iron salt, and at least a precursor...
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6974794 |
Hemoglobin-antioxidant conjugates
There are provided biocompatible chemical compositions having oxygen transporting capability and comprising oxygen transporting molecules chemically bound to antioxidants, to form compositions...
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6974795 |
Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
The present invention relates to blood products, and more particularly to compositions comprising a modified oxygenated hemoglobin having a high affinity for oxygen and methods for making such...
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6967020 |
Oxygen carrier system, artificial oxygen carrier, and reducing agent
An oxygen carrier system includes an artificial oxygen carrier including hemoglobin vesicles encapsulating hemoglobin and an intermediate electron mediator having a standard electrode potential of...
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6956025 |
Mammalian haemoglobin compatible with blood plasma, cross-linked and conjugated with polyalkylene oxides as artificial medical oxygen carriers, production and use thereof
The invention relates to covalently cross-linked mammalian hemoglobins, to which polyalkylene oxides are covalently linked. Such hemoglobins are surprisingly compatible with proteins of human and...
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6926884 |
GPIb-lipid bond construct and use thereof
The present invention provides a conjugate wherein GP (glycoprotein) Ib and a lipid are bonded via polyalkylene oxide. The present invention also provides a complex (GPIb lipid complex) containing...
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6927206 |
Compositions and methods for treatment of rosacea
A method for treating rosacea of the skin of a patient employs topically applying to the affected skin a composition comprising at least one peptide copper complex. In other embodiments, the...
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6924267 |
Methods and active substances for protecting organs
The present invention comprises a method of protecting organs or tissue susceptible to reperfusion-induced dysfunction after ischemia. The method comprises parenterally administering to a patient a...
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6911427 |
No-modified hemoglobins and uses therefore
S-nitrosohemoglobin (SNO-Hb) can be formed by reaction of Hb with S-nitrosothiol and by other methods described herein which do not result in oxidation of the heme Fe. Other methods can be used...
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6884773 |
Modified hemoglobins, including nitrosylhemoglobins, and uses thereof
Diseases which can be ameliorated by delivery of NO to tissues affected by the disease can be treated by administration of nitrosyl-heme-containing donors of NO, including nitrosylhemoglobin....
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6858583 |
Hemoglobin alpha chain peptide fragments useful for inhibiting stem cell proliferation
Disclosed and claimed are methods for the isolation and use of stem cell inhibiting factors for regulating the abnormal stem cell cycle and for accelerating the post-chemotherapy peripheral blood...
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6855691 |
Methods for producing and using S-nitrosohemoglobins
Nitric oxide (NO) interacts with hemoglobin (Hb) at its metal centers, whereas S-nitrosothiols (RSNOs) can donate the NO group to β93 cysteine residues, thereby shielding the NO functionality from...
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6844317 |
Methods for oxygen transport comprising a high oxygen affinity modified hemoglobin
The present invention relates to blood products, and more particularly to compositions comprising a modified oxygenated hemoglobin having a high affinity for oxygen and methods for making such...
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6818622 |
Selective MMP inhibitors having reduced side-effects
The subject invention pertains to matrix metalloproteinase (MMP) inhibitors that exhibit an IC 50 of below 10 −4 M against MMP and have substantially no activity against non-MMP...
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6812207 |
Hemoglobin mutants that reduce heme loss
The present invention relates to methods of reducing heme loss in hemoglobins to produce stability and improve expression yield of hemoglobins, particularly recombinant hemoglobins. Such methods...
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6790827 |
Bioconjugates and delivery of bioactive agents
The present invention relates to bioconjugates and the delivery of bioactive agents which are preferably targeted for site-specific release in cells, tissues or organs. More particularly, this...
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6784155 |
Inhibitor and stimulator of stem cell proliferation and uses thereof
Disclosed and claimed are methods for the isolation and use of stem cell modulating factors for regulating stem cell cycle and for accelerating the post-chemotherapy peripheral blood cell recovery....
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6773613 |
Method for production of stroma-free hemoglobin
The invention relates to a system and a method of using an automated blood cell separator to prepare a high-quality hemoglobin solution as the raw material for manufacture of hemoglobin-based...
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6743773 |
Method of using lectins for contraception, prophylaxis against diseases transmittable by sexual contact, and therapy of such diseases, and apparatus for administering lectins
In order to prevent conception and/or the spread of sexually transmitted diseases (STD's) one or more lectins capable of binding sperm and/or the pathogenic microorganisms responsible for STD's are...
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6737402 |
Method of preparing fetuin to induce apoptosis
The present invention provides for an improved method of preparing fetuin by using a chelating agent to remove inorganic ions, such as zinc, calcium, and barium, from fetuin. Then, reloading the...
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6726898 |
Local delivery of agents for disruption and inhibition of bacterial biofilm for treatment of periodontal disease
The present invention relates to compositions and methods of treating periodontal disease and related disorders utilizing a sustained, controlled release targeted delivery method to effectively...
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6716814 |
Enhancing solubility of iron amino acid chelates and iron proteinates
A method of enhancing the solubility of iron amino acid chelates and iron proteinates is disclosed. This is accomplished by mixing an effective amount of an organic acid solubilizing agent into...
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6649591 |
Polydithicarbamate-containing non-targeting marcomolecules and the use thereof for therapeutic and diagnostic applications
In accordance with the present invention, there is provided a new class of drugs for therapeutic treatment of such indications as cerebral stroke and other ischemia/reperfusion injury. Thus, in...
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6610654 |
Inhibitor of stem cell proliferation and uses thereof
Disclosed and claimed are methods for the isolation and use of stem cell inhibiting factors for regulating the abnormal stem cell cycle and for accelerating the post-chemotherapy peripheral blood...
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6599878 |
Superoxygenating blood substitutes based on hemoglobin and dihydropyidine compositions
The present invention provides superoxygenating compositions that comprise hemoglobin and guanosine 3′:5′-cyclic monophosphate (cyclic GMP) generating compounds, and methods for treatment of...
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6576221 |
Iron-containing nanoparticles with double coating and their use in diagnosis and therapy
The present invention relates to iron-containing nanoparticles having a modular structure, their production, and their use for diagnostic and therapeutic purposes. The nanoparticles according to...
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6565842 |
Crosslinkable polypeptide compositions
In accordance with the present invention, there are provided rapidly crosslinkable polypeptides which are obtained upon introduction of unsaturated group(s) into the polypeptide via linkage to...
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