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7285574 |
Methods for treating neural cell swelling
A composition comprising a novel Ca 2+ -activated, [ATP] i -sensitive nonspecific cation (NC Ca-ATP ) channel is described. The channel is found in mammalian neural cells and exhibits a different...
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7241756 |
Combinations of dipeptidyl peptidase IV inhibitors and other antidiabetic agents for the treatment of diabetes mellitus
A method for the treatment of diabetes mellitus, especially Type 2 diabetes and conditions associated with diabetes mellitus in a mammal such as a human, which method comprises administering an...
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6992106 |
Anti-tumor composition
The present invention provides composition having as active ingredients a stilbene derivative and a platinum coordination compound which is highly efficacious and highly safe for treating tumors,...
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6951844 |
Phenyl naphthol ligands for thyroid hormone receptor
New thyroid receptor ligands are provided which have the general formula I
wherein R 1 is halogen, trifluoromethyl, substituted or unsubstituted aryl, substituted or unsubstituted C 1-6 ...
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6919310 |
Method of treating the syndrome of coronary heart disease risk factors in humans
The invention provides an improved method of treating a human suffering from one or more conditions included within the Coronary Heart Disease Risk Factor (CHDRF) syndrome. The method includes...
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6911457 |
Diabetes imaging probes
The present invention relates to novel imaging probes and methods for using the probes in diagnostic imaging processes and other imaging processes to determine physiological functions.
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6822001 |
Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents
Combination therapies are provided for the treatment of proliferative disorders which use a pentafluorobenzenesulfonamide of formula I and an antineoplastic agent such as gemcitabine or paclitaxel.
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6794414 |
Method and compositions for treating diseases mediated by transglutaminase activity
Diseases Mediated by transglutaminase, such as Huntington's Disease, spinobulbar atrophy, spinocerebellar ataxia, and dentatorubralpallidoluysian atrophy, as well as inflammatory diseases of the...
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6624117 |
Heat sensitive recording material
A heat sensitive recording material, comprising a) at least one colour forming compound, and b) at least one developer of the formula wherein R 1 is unsubstituted or substituted phenyl,...
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6610746 |
Synergistic effect of a sulfonylurea and/or non-sulfonylurea K&plus ATP channel blocker, and a phosphodiesterase 3 type inhibitor
The present invention provides methods of treating non-insulin dependent diabetes mellitus, insulin resistance, Syndrome X, diabetic neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic...
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6566304 |
Biogenic control and limitation of the reproduction of parasitic earth nematodes in stock culture
The invention relates to use of (a) compounds of phosphorus containing at least partly lipophilic organic radicals together with (b) urea and/or urea derivatives in selected quantity ratios of (a)...
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6511989 |
Acylaminoalkyl-substituted benzenesulfonamide derivatives, their preparation, their use and pharmaceutical preparations comprising them
One embodiment of the present invention relates to acylaminoalkyl-substituted benzenesulfonamide derivatives of the formula (I), in which A, R(1), R(2), X, Y, and Z have the meanings indicated...
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6468963 |
Methods and formulations for reducing toxicity associated with diabetes treatments
Formulations and methods for reducing the unwanted toxicity and complications associated with treatments for diabetes mellitus. The formulations include co-formulations of an anti-diabetic agent...
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6433009 |
Sulfonyl urea derivatives and their use in the control of interleukin-1 activity
A compound of the formula wherein R 1 and R 2 are as defined above, useful in the treatment and condition selected from the group consisting of meningitis and salpingitis, septic shock,...
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6414030 |
Use of benzenesulfonyl(thio)ureas for the treatment and prophylaxis of dysfunctions of the autonomous nervous system and use of benzenesulfonyl(thio)ureas in combination with beta-receptors blockers
Substituted benzenesulfonylureas and -thioureas of the formula I in which R 1 , R 2 , E, X, Y and Z have the meanings described herein, show effects on the autonomous nervous system. The...
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6410573 |
2,5-substituted benzolsulfonylureas and thioureas methods for the production thereof use thereof and pharmaceutical preparations containing the same
Novel 2,5-substituted benzolsulfonyl ureas and thioureas of formula (I) as illustrated in the disclosure. The compounds are useful active ingredients for medicaments. The compounds of formula (I)...
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6291495 |
Method and composition for the treatment of diabetes
This invention is directed to a novel method and composition for the treatment of diabetes mellitus (Type I, Impaired Glucose Tolerance ["IGT"] and Type II). More specifically, this invention...
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6281240 |
Diarylsulfonylureas for use in treating secretory diarrhea
This invention provides methods of treating secretory diarrhea or cystic fibrosis in a mammal which comprises administering to a mammal in need thereof an effective amount of diarylsulfonylurea....
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6174921 |
Antitumor compositions and methods of treatment
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6147115 |
Antitumor compositions and methods of treatment
This invention provides certain sulfonamide compounds, formulations, and a method for treating susceptible neoplasms in mammals using certain sulfonamide compounds.
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6103761 |
Agents acting at cholecystokinin receptors
The invention concerns a series of novel bis-urea derivatives, nonpeptides, which show good binding affinity for the CCK-B receptor. The compounds, compositions containing them, methods of...
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6071910 |
Use of agents to treat eosinophil-associated pathologies
A therapeutic method comprising counteracting or preventing pathologies mediated by IL-5, including those characterized by eosinophil infiltration, degranulation and inflammation, by administering...
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6043284 |
Anti-atherosclerotic diaryl compounds
The present invention is concerned with diaryl compounds of formula (I) and their use in medical therapy, particularly in the prophylaxis or treatment of a clinical condition for which an ACAT...
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5981595 |
Sulfonyl urea and carbamate ACAT inhibitors
A pharmaceutically useful compound which lowers blood cholesterol levels having the formula ##STR1## wherein X is oxygen or --NH--; Ar is phenyl, substituted phenyl, naphthyl or substituted...
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5972973 |
Sulfonylurea-glitazone combinations for diabetes
Combinations of a sulfonylurea antidiabetic agent and a glitazone antidiabetic agent are useful for treating diabetes mellitus and improving glycemic control.
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5965620 |
Methods and compositions for ATP-sensitive K.sup.+ channel inhibition for lowering intraocular pressure
ATP-sensitive K + channel modulating compounds are incorporated into ophthalmically acceptable carriers for administration to the eye in order to affect intraocular pressure. Such formulations...
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5719192 |
Use of terbinafine for the therapeutic treatment of pneumocystosis
A method of use comprising administering terbinafine for the primary and secondary prophylaxis and treatment of Pneumocystis carinii pneumonia, including oral administration of terbinafine at does...
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5677344 |
Method for treating Parkinson's disease employing an ATP-sensitive potassium channel blocker
A method is provided for treatment of Parkinson's disease or controlling movement of a Parkinsonian patient by administering an ATP-sensitive potassium channel blocker, such as a sulfonyl urea,...
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5643853 |
Thiol activation of cytotoxic and auxin-herbicidal agents and root formation stimulation
Thiol compounds are employed in conjunction with compounds which modulate self proliferation, both as to plants and mammals. The thiol compounds find effect in enhancing the effectiveness of auxin...
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5594028 |
Anti-tumor method and compounds
This invention provides certain sulfonamide derivatives, their pharmaceutical formulations, and their use in the treatment of susceptible neoplasms in mammals.
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5565494 |
Antitumor compositions and methods of treatment
This invention provides certain benzenesulfonamide derivatives and methods for using them in the treatment of susceptible neoplasms in mammals. Also provided are certain novel pharmaceutical...
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5476850 |
Amino-substituted benzenesulfonylureas and -thioureas and their use as pharmaceuticals
There are described amino-substituted benzenesulfonylureas and -thioureas of the formula I ##STR1## The compounds I are used for the treatment of cardiac arrhythmias and for the prevention of...
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5451580 |
Method for treating insult to neurons prone to Parkinson's degeneration employing an ATP-sensitive potassium channel blocker
A method is provided for treatment of neuronal insult, such as caused by lack of oxygen, which neurons are prone to Parkinsonian degeneration by administering an ATP-sensitive potassium channel...
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5364850 |
Substituted tyrosyl diamide compounds
The present invention provides substituted tyrosyl diamide compounds of general Formula I: ##STR1## and the pharmaceutically-acceptable salts thereof, which are useful for inducing analgesia in...
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5304575 |
Use of bezafibrate for treating diabetes
Bezafibrate is used for the treatment of normolipidaemic diabetes mellitus type II.
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5234922 |
Use of sulfonylureas and other potassium channel regulators to treat secretory diarrhea
Methods for the treatment of secretory diarrhea comprised of administering to a patient in need thereof, an effective amount of a CFTR chloride channel blocker or a potassium channel opener are...
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5215985 |
Method for treating ischemic insult to neurons employing an ATP-sensitive potassium channel blocker
A method is provided for treatment of neuronal insult, such as caused by lack of oxygen, by administering an ATP-sensitive potassium channel blocker, such as a sulfonyl urea, for example, tolbutamide.
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5116874 |
Anti-tumor method and compounds
This invention provides certain N-[(phenyl)amino]carbonyl-bicyclicsulfonamide sulfonamide derivatives, their pharmaceutical formulations, and their use in the treatment of susceptible neoplasms in...
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5110830 |
Benzenesulfonamides treatment of tumors susceptible to
This invention provides the use of certain benzenesulfonamide derivatives in the treatment of susceptible neoplasms in mammals. Also provided are certain novel benzenesulfonamide derivatives and...
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5091180 |
Protection against rhabdomyolysis-induced nephrotoxicity
The present invention is directed to the in vivo use of compounds which prevent the generation of, effectively scavenge, or detoxify a reactive oxygen metabolite that mediates a toxic effect of...
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5047429 |
Treatment of oedema
A method is described for treating and/or preventing pulmonary oedema in patients comprising administering a suphonylurea compound or a pharmaceutically acceptable salt thereof to patients who...
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4845128 |
N([(4-trifluoromethylphenyl)amino]carbonyl)benzene sulfonamides
This invention provides the use of certain benzenesulfonamide derivatives in the treatment of susceptible neoplasms in mammals. Also provided are certain novel benzenesulfonamide derivatives and...
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4515812 |
Combating fungi with N-sulphenylated ureas
N-Sulphenylated ureas of the formula ##STR1## in which R 1 to R 6 each independently is hydrogen, halogen, nitro, cyano, alkyl, alkoxy, alkylmercapto, trihalogenomethyl-, trihalogenomethoxy or...
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4497822 |
Insecticidal N-benzoyl-N'-phenyl-N'-(R-thio)ureas
Insecticidally active benzoylphenylurea derivatives of the formula: ##STR1## wherein R is haloalkyl, or phenyl optionally substituted by certain substituents and the other symbols have assigned...
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4478822 |
Drug delivery system utilizing thermosetting gels
This invention relates to a unique drug delivery system for delivering drugs to a body cavity. The drug delivery system comprises a medicament and a polymer such that the drug delivery system is a...
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4016291 |
Benzenesulfonyl urea compounds and their therapeutic use
This application is directed to novel sulfonyl urea compounds, their non-toxic pharmaceutically acceptable salts, and to processes for making and using said compound. Exemplary of the sulfonyl...
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3883648 |
Method of making stable granules of N-4-[2-(5-chloro-2-methoxybenzamido)-ethyl]-phenylsulfonyl-N'-cyclohexyl urea and its salts and process for preparing same
A method of making stable granules of N-4-[2-(5-chloro-2-methoxybenzamido)-ethyl]-phenylsulfonyl-N
'-cyclohexyl urea and salts thereof by dissolving or dispersing said materials in a melt of a...
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3860724 |
SUBSTITUTED SULFONYL UREA AND ITS STEREOISOMERS AS HYPOGLYCEMIC AGENTS
A hypoglycemic agent, 1-(p-toluenesulfonyl)-3-(2-hydroxy-3-bornyl)-urea, is prepared, for example, from tosyl ethyl urethane and 3-amino-borneol or 3-amino-isoborneol. One of the isomers, i.e.,...
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3812265 |
FUNGICIDAL N-POLYHALOVINYLTHIO UREAS
Ureas of the formula ##SPC1## In which R is hydrogen, hydrocarbyl radicals of one to 15 carbon atoms which are free of aliphatic unsaturation and have zero to three halogen substituents, X is Cl or...
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3511907 |
ANIMAL FEED COMPONENTS COMPRISING A BIOLOGICALLY ACTIVE SUBSTANCE AND AN AMINOPOLYAMIDE RESIN
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