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8153135 |
Polysaccharide-polypeptide conjugate
Disclosed is a method of producing a polysaccharide-polypeptide conjugate by reacting a polysaccharide with a polypeptide which contains at least one free amino group, wherein a polysaccharide...
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8080254 |
OB fusion protein compositions and methods
The present invention relates to Fc-OB fusion protein compositions, methods of preparation of such compositions and uses thereof. In particular, the present invention relates to a genetic or...
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7902174 |
Antiviral composition
Chemical compounds, being the alkyl sulfate of sulfated saccharides, particularly, dextrin, dextran, and cyclodextrin, and pharmaceutical compositions containing these compounds. The compounds of...
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7897161 |
External medicine for treating dermatitis
An external medicine for treating dermatitis wherein an adrenocortical steroid is included by a cyclodextrin; and 0.025 to 0.5% by weight of the adrenocortical steroid, 0.2 to 30% by weight of the...
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7879823 |
Topical anti-cancer compositions and methods of use thereof
Described are skin-care compositions containing non denatured soy products and optionally other anti-cancer or anti-aging agents. The compositions can be applied topically to reduce the risk of...
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7871597 |
Polyol and polyether iron oxide complexes as pharmacological and/or MRI contrast agents
Pharmacological compositions, and methods for administration, of the type employing an iron oxide complex with a polyol or polyether. The methods of administration may comprise parenteral...
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7867985 |
Biological lubricant composition and method of applying lubricant composition
Fluid compositions and methods for lubrication of mammalian joints are disclosed, including both natural and artificial fluids. Synovial fluid acts to lubricate the bearing surfaces of bones and...
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7820639 |
Ophthalmic compositions including lubricant, deturgescent agent, and glycosaminoglycan and methods of using the same
Ophthalmic compositions are provided that include a lubricant, a deturgescent agent, a glycosaminoglycan, and water. Methods of using the ophthalmic compositions are also provided.
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7786096 |
Inhibition of antigen presentation with poorly catabolized polymers
Methods to prevent the rejection of immunogenic tissues in an animal by administering a non-immunogenic, poorly catabolized molecule in an amount sufficient to inhibit an immune response are...
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7781400 |
Pharmaceutical compositions comprising dextran with a molecular weight of 1.0-100 KDA and processes for their preparation
A solid or semisolid implant obtainable by providing a liquid composition comprising an aqueous solution of dextran with molecular weight of 1.0-100 kDa and introducing the liquid composition into...
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7776843 |
Therapeutic uses of glucan
The present invention is directed to methods of using glucan compositions, comprising water insoluble microparticulate glucans, in the treatment of bone injuries. The water insoluble...
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7759398 |
Methods for modulating metabolism
The subject invention provides materials and methods for modulating a variety of biological factors to treat biological conditions associated with the factors. In one embodiment of the invention, a...
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7678777 |
Composition for promoting the proliferation of Lactobacillus casei subsp. casei
A composition for promoting bacterial proliferation and selectively proliferating Lactobacillus casei subsp. casei is disclosed, which includes a dextran. A variety of biological activities...
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7659079 |
Transmissible spongiform encephalopathy test reagents and methods
The invention provides improved methods and compositions for selectively binding and/or detecting an aggregating abnormal form of a protein in the presence of non-aggregating normal form of the...
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7659076 |
Binding of pathological forms of prion proteins
Infective aggregating forms of proteins such as PrP, amyloid, and tau are bound selectively in the presence of the normal form protein using a polyionic binding agent such as dextran sulphate or...
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7655639 |
Minimally invasive clinical treatment method for closure of umbilical hernias
The present invention is a minimally invasive clinical method for closing hernias and other abnormal openings existing within the body; and is a unique alternative to conventional surgery and...
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7648968 |
Methods of treating dermal ulcers using glucans
The present invention is directed to methods of using glucan compositions, comprising water insoluble microparticulate glucans, in the treatment of dermal ulcers. The water insoluble...
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7612109 |
Water-soluble iron-carbohydrate complexes, production thereof, and medicaments containing said complexes
Water soluble iron carbohydrate complex obtainable from an aqueous solution of iron (III) salt and an aqueous solution of the oxidation product of one or more maltrodextrins using an aqueous...
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7553479 |
Heat stable colloidal iron oxides coated with reduced carbohydrates and uses thereof
Compositions, methods of making the compositions, and methods of using the compositions are provided for an enhanced magnetic resonance imaging agent and a hematinic agent, the agents comprising...
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7553482 |
Use of a phosphate adsorbent to combat vascular diseases
The invention relates to the use of an adsorption material which has been modified with polynuclear metal oxide hydroxides for influencing the calcium level and, in particular, for treating or/and...
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7544656 |
Long acting injectable insulin composition and methods of making and using thereof
A method of lowering blood glucose in a mammal includes injecting a therapeutically effective amount of crystallized dextran microparticles and insulin to the mammal to lower blood glucose of the...
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7538097 |
Inhibition of antigen presentation with poorly catabolized polymers
Methods to prevent the rejection of immunogenic tissues in an animal by administering a non-immunogenic, poorly catabolized molecule in an amount sufficient to inhibit an immune response are...
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7534441 |
Immunogenic LHRH compositions and methods relating thereto
The present invention relates generally to an immunogenic LHRH composition and more particularly to an immunogenic LHRH composition comprising a LHRH C-terminal fragment of at least five amino...
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7427607 |
Drug administration method
A method of administering a drug whereby a fine drug powder can be accurately administered to a target site (in particular, a target site in the body cavity) via fluidization and spraying with a...
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7387796 |
Stable compositions of S-adenosyl-l-methionine with dextran
Stable compositions of S-adenosyl-1-methionine with dextran are described. The compositions according to the invention are stable over time and are valuable for use as active constituents in...
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7348020 |
Invasive medical device, especially for guided tissue regeneration
Biodegradable invasive medical device, in particular for guided tissue regeneration, which device comprises a biodegradable polymer, composed of a thermoplastic and/or thermosetting polymer admixed...
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7309502 |
Pharmaceutical compositions for treating and saving and the method for the preparation thereof
The present invention relates to a pharmaceutical composition and the method for the preparation thereof. The composition comprises 1.5˜6.9% (w/v) of one or more substances selected from sodium ...
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7306802 |
Ophthalmic compositions containing a synergistic combination of three polymers
Ophthalmic compositions suitable for use as artificial tears or as vehicles for ophthalmic drugs are disclosed. The compositions contain a combination of three polymers that have a synergistic...
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7226914 |
Cellulose sulfate and other sulfated polysaccharides to prevent and treat papilloma virus infection and other infections
A method for treating and preventing various infections, including papilloma virus and fungal and parasitic infections is provided. In particular, an effective amount of a sulphated polysaccharide,...
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7196073 |
Imine-forming polysaccharide adjuvants and immunostimulants
The present invention relates to polysaccharide conjugates that comprise: a polysaccharide that binds to surface-receptors present on Antigen Presenting Cells, conjugated to one or more compounds...
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7173008 |
Lyophilized HGF preparations
The invention relates to a lyophilized HGF preparation prepared by lyophilizing an aqueous solution containing HGF, and a lyophilized HGF preparation containing a stabilizer, sodium chloride, a...
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7101862 |
Hemostatic compositions and methods for controlling bleeding
The invention provides hemostatic compositions useful to promote hemostasis at active bleeding wound sites. The hemostatic compositions typically include an article containing cellulose, e.g.,...
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7101863 |
Pharmaceutical compositions with wound healing or anti-complementary activity comprising a dextran derivative
The invention concerns pharmaceutical compositions with wound healing or anti-complementary activity, and their uses, said compositions comprising, (1) at least a dextran derivative of general...
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7091194 |
Method for increasing the production of propionate in the gastrointestinal tract
A method for selectively increasing the production of propionate in the gastro-intestinal tract of a mammal. The method includes the step of enterally administering to the mammal a nutritional...
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7084112 |
Activated polyethylene glycol compounds
Novel arylisothiocyanate compounds are described that are useful for activating alcohol-containing macromolecules, for example polyethyleneglycols and cellulose, for covalent linkage to...
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7056901 |
Microgel particles for the delivery of bioactive materials
Novel microgels, microparticles and related polymeric materials capable of delivering bioactive materials to cells for use as vaccines or therapeutic agents. The materials are made using a...
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7053069 |
Pharmaceutical compositions and methods of using C-21 modified epothilone derivatives
Pharmaceutical compositions containing C-21 modified epothilone derivatives, methods for their preparation and dosing regimen for administration of these epothilone compounds are provided. The...
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7045510 |
Methods for prevention and treatment of mastitis
A method of preventing or treating mastitis in a mammal, involving administering to the mammal a therapeutically effective amount of diethylaminoethyl-dextran (DEAE-dextran) or dextran.
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7041655 |
Capillary membrane stabilization and reduction of tissue injury through use of IV biodegradable macromolecules with antioxidants and/or other chemicals
In accordance with the invention there is provided a method of treating a human subject to prevent leakage of serum proteins from capillary endothelial junctions during a period of increased...
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7005426 |
Folic acid-polysaccharide complex, its preparation method and pharmaceutical composition containing the same as active component
The present invention relates to folic acid-polysaccharide complexs and method of preparation thereof, more particularly relates to folic acid-Dextran complexs, method of preparation thereof,...
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6998393 |
Aquespheres, their preparation and uses thereof
This invention provides method for sustained release delivery of structurally delicate agents such as proteins and peptides. Using a unique emulsion system (Stable polymer aqueous-aqueous...
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6977249 |
Process for producing an iron-dextran compound, iron-dextran compound produced according to said process, pharmaceutical composition for prophylaxis or treatment of iron-deficiency and use of said compound for the preparation of parenterally administrable pharmaceutical composition
In a process for producing an iron-dextran compound for use in parenteral treatment of iron-deficiency in humans or animals a stable compound of desired relatively low molecular weight is obtained...
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6946443 |
Biomaterial based on an insolubilized dextran derivative and a growth factor
The invention concerns a biologically active material essentially comprising at least an insolubilized dextran derivative of general formula DMCaBbSUcSd and at least a growth factor having an...
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6939668 |
Compositions and methods for treatment of lung transplants
Methods and compositions for pre-treatment of lung transplants to reduce susceptibility to post-operative B. cepacia infection are provided. The methods and compositions employ saccharides,...
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6919088 |
Water-soluble stable salts of petroselinic acid
Stable water-soluble salts of petroselinic acid with dextran useful as active constituents in pharmaceutical as well as cosmeceutical applications are described.
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6838450 |
Drug complex
A drug complex characterized in that a residue of a drug compound such as antineoplastic agents and a carboxy(C1-4)alkyldextran polyalcohol obtained by treating a dextran under conditions that...
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6828307 |
Low molecular weight sulphated polysaccharide to obtain a medicine with antithrombotic activity
The invention concerns the use of a sulphated polysaccharide capable of being obtained by radical depolymerization of a raw fucan derived from Pheophyceae, said polysaccharide having a molar mass...
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6821959 |
Antibiotic-natural polysaccharide polymer adducts
Antibiotic-natural polysaccharides polymer adducts based on non-covalent and non-ionic bonds, with an improved profile of activity compared with the corresponding antibiotic.
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6821958 |
Antiviral composition
Chemical compounds, being the alkyl sulfate of sulfated saccharides, particularly, dextrin, and cyclodextrin, and pharmaceutical compositions containing these compounds. The compounds of the...
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6818624 |
Therapeutic agent for a cancer and method of screening the same, and health-care auxillary food
A therapeutic agent for a cancer comprising a therapeutically effective amount of an active ingredient, wherein the therapeutic agent is used referring to an ability of acting on NK cell antigen...
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