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8183292 Chiral cyclic β-amino acids and their derivatives, pharmaceutical compositions containing them and the use of such compounds  
The invention relates to chiral cyclic β-amino acids of Formula (I) and their salts formed with pharmaceutically acceptable acids or bases, wherein the main meanings of the substituents are as ...
8101664 Urea foam  
Provided, among other things, is a delivery module for a non-greasy, water-based urea composition comprising: an aerosol delivery device; within the aerosol delivery device, the urea composition...
8013015 Small molecule inhibitors of ghrelin O-acyltransferase  
Ghrelin O-acyltransferase (GOAT) is inhibited with designed small molecules. Methods comprise contacting the GOAT with an inhibitor and detecting a resultant inhibition.
7999008 Urea compounds that promote desquamation  
The invention relates to the use of at least one urea derivative of the following formula (I) in a composition containing a physiologically acceptable medium, as agent intended for stimulating...
7977385 Agents for corneal or intrastromal administration to treat or prevent disorders of the eye  
Methods and preparations for treating disorders of the eye and/or causing dissolution of corneal proteoglycans and organized healing of corneal stroma, softening of the cornea for non-surgical...
7910090 Non-irritating compositions  
The present invention provides a base composition that allows for the formulation of non-irritating cosmetic and/or dermatological compositions. The base composition includes one or more of...
7875632 Selective serotonin receptor inverse agonists as therapeutics for disease  
Disclosed herein are pharmaceutical compositions comprising an inverse serotonin receptor agonist or a serotonin receptor antagonist and an anti-psychotic agent. Disclosed herein are also methods...
7846469 Reversible inhibition of sperm receptor synthesis for contraception  
Methods and pharmaceutical compositions are disclosed for reversibly inhibiting sperm receptor activity in animals. Nicarbazin, its derivatives and modifications which retain pharmacological...
7790749 Use of pleuromutilins for the treatment of disorders caused by Helicobacter pylori  
A method of preventing or treating diseases mediated by Helicobacter pylori, comprising administering to a subject in need of such treatment an effective amount of pleuromutilin.
7776363 Suppressing microbial growth in pulp and paper  
A composition for anti-microbial effect in a water system such as a pulp and paper processing line with an aqueous slurry. The composition comprises a free chlorine-generating biocide comprising a...
RE41279 Acidic aqueous chlorite teat dip with improved visual indicator stability, extended shelf life, sanitizing capacity and tissue protection  
The mastitis control teat dip composition having a visible indicator aspect of the invention provides a softening, soothing, smoothing, relaxing property, a rapid initial kill, a useful highly...
7705016 Regulation of food intake by modulation of long-chain fatty acyl-CoA levels in the hypothalamus  
Methods of reducing food intake and glucose production in a mammal, or restoring hepatic autoregulation are provided. The methods involve increasing long-chain fatty acyl-Co-A (LC-CoA) levels in...
7700076 Penetrating pharmaceutical foam  
The invention relates to an alcohol-free cosmetic or pharmaceutical foam composition comprising water, a hydrophobic solvent, a surface-active agent, a gelling agent, an active component selected...
7687544 Method of using catalpic acid to treat type 2 diabetes and associated disorders  
A method of treating and preventing type 2 diabetes and obesity an animal, including mammals and humans, in which a therapeutically effective amount of catalpic acid to the animal is administered...
RE41109 Acidic composition of matter for use to detroy microorganisms  
A composition of matter and the method of making that provides a low pH acidic composition that is useful for destroying microorganisms that are undesirable and useful for destroying or reducing...
7655695 Illudin analogs useful as anticancer agents  
Acylfulvene analogs, which inhibit tumor growth, especially solid tumor growth, and which have an adequate therapeutic index to be effective for in vivo treatment are provided herein. The compounds...
7645798 N-(2-hydroxyalkanoyl)-N,N′-dialkylureas and a process for their preparation  
N-(2-hydroxyalkanoyl)-N,N′-dialkylureas of general formula (1) are described A-X-(A)m (1) where A: m=0 or m=1; when m=0, X=R′″, where R′″ is an aliphatic, cycloaliphatic, arylaliphatic radical, ...
7572798 Combi-molecules having signal transduction inhibitory properties and DNA damaging properties  
The present invention relates to a series of new chemical agents that demonstrate anti-tumor activity. More particularly, the present invention relates to molecules, referred to as...
7456220 Immunodulatory compositions and methods of use thereof  
The invention relates to immunomodulatory compositions and related methods. The immunomodulatory compositions of a formula disclosed herein are useful for the prevention of sepsis and the treatment...
7405194 Therapeutic agents and methods of use thereof for the treatment of melanoma  
The present invention provides angiogenesis inhibitor compounds comprising a MetAP-2 inhibitory core coupled to a peptide, as well as pharmaceutical compositions comprising the angiogenesis...
7371372 Compositions comprising IMPDH inhibitors and uses thereof for treating HCV infection  
The present invention relates to optimal compositions useful in treating HCV infections in humans. These compositions comprise alpha-interferon or pegylated alpha-interferon and an IMPDH inhibitor...
7348307 Methionine aminopeptidase-2 inhibitors and methods of use thereof  
The present invention provides methods of treating a lymphoma (e.g., a T-cell lymphoma or a B-cell lymphoma) in a subject by administering to the subject a therapeutically effective amount of one...
7307071 RAF-MEK-ERK pathway inhibitors to treat cancer  
Materials and methods for treating certain cancers are described, preferably cancers that result from the up-regulation of the RAF-MEK-ERK pathway, and more preferably chronic myelogenous leukemia,...
7262208 Hydroxypropyl amides for the treatment of Alzheimer's disease  
The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that...
7220768 Isoxazole-containing thiourea inhibitors useful for treatment of varicella zoster virus  
This Invention provides a compound of the Formula: wherein X is R1, R2, R3 and R4 are described in the specification and a pharmaceutical composition comprising the compound used for inhibiting...
7211602 Treatment of neurodegenerative disorders through the modulation of the polyamine pathway  
The present invention provides methods and compositions for modulating polyamine pathway activity as a means for ameliorating neurodegenarative disorders. In particular, for ameliorating the...
7182952 Urea and nitrogen based compounds as feeding stimulants/aggregants and masking agents of unpalatable chemicals for subterranean termites  
Nitrogen containing compounds are effective as subterranean termite feeding stimulants/aggregants and as masking agents for concealing the presence of other compounds which are repellents to...
7163703 Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds  
The invention relates to the use of arsenic compounds to treat a variety of neoplastic diseases. The present invention encompasses the administration to a mammal of arsenic in the form of a salt,...
7157420 Therapeutic agents and methods of use thereof for the modulation of angiogenesis  
The present invention provides methods of treating an autoimmune disorder (e.g., lupus erythematosus, multiple sclerosis, myasthenia gravis, vasculitis and diabetes mellitus) in a subject by...
7074780 Substituted phenylcyclohexanecarboxamides and their use  
The present invention relates to substituted phenylcyclohexanecarboxamides of the formula (I) to processes for their preparation and to their use in medicaments, in particular for the prevention...
7067556 Compositions containing antimicrobials and urea for the treatment of dermatological disorders and methods for their use  
Topical compositions which include urea and an antimicrobial agent, particularly sulfacetamide, are described. Sulfacetamide compositions further including sulfur are also described. Methods for...
7052683 Composition to detoxify formaldehyde in gaseous state, in aqueous solutions, and to protect human cell lines against formaldehyde  
A chemical compound is disclosed herein for performing a complex enzymatic neutralization and fixation of formaldehyde, providing a method for instantaneous neutralization of formaldehyde vapors...
7033838 Method for the diagnosis of Helicobacter pylori infection, and a diagnostic kit for performing the method  
The method for the diagnosis of Helicobacter pylori infection by the oral administration of defined amounts of 13C-labeled urea and examination for 13C content of blood samples removed at a defined...
7030133 Inhibitors of formation of advanced glycation endproducts (AGEs)  
The nonenzymatic glycation and crosslinking of proteins is a part of the aging process with the glycation endproducts and crosslinking of long-lived proteins increasing with age. This process is...
7022737 Manipulating nitrosative stress to kill pathologic microbes, pathologic helminths and pathologically proliferating cells or to upregulate nitrosative stress defenses  
Mammals are treated for infections or for conditions associated with pathologically proliferating mammalian cell growth by administration of a manipulator of nitrosative stress to selectively kill...
6986896 Method of treating fungal conditions of the skin  
Methods of treating fungal conditions and onychomycosis are described which include administration of a safe and effective amount of urea in a topical formulation to an affected area on the skin or...
6962945 N-aryloxypropanolyl-N′-phenethyl-urea  
The present invention provides N-aryloxypropanolyl-N′-phenethyl-urea derivatives of formula 3, method for their preparation and use thereof as potent appetite suppressants for treatment of o...
6960615 Carbamide peroxide compositions for the treatment of dermatological disorders and methods for their use  
Topical compositions which include urea and carbamide peroxide are described. Compositions having a pH in the acidic range, particularly in the range of about 2.5 to about 9 are also described....
6846837 Topical administration of basic antifungal compositions to treat fungal infections of the nails  
Methods and topical pharmaceutical formulations are provided for the treatment of nail fungus (onychomycosis). The invention involves a pharmacologically active antifungal agent, plus a...
6824769 Optimal compositions and methods thereof for treating HCV infections  
The present invention relates to optimal compositions useful in treating HCV infections in humans. These compositions comprise alpha-interferon or a derivative thereof and an IMPDH inhibitor,...
6822001 Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents  
Combination therapies are provided for the treatment of proliferative disorders which use a pentafluorobenzenesulfonamide of formula I and an antineoplastic agent such as gemcitabine or paclitaxel.
6797467 Compositions and methods for determining interactions of mitochondrial components, and for identifying agents that alter such interactions  
Compositions and methods are provided for identifying agents that alter mitochondrial membrane permeability transition. The screening methods generally detect agents that alter the interaction...
6787567 Fungicidal active ingredients combinations  
The invention relates to novel fungicidally active compound combinations of (a) methoximinoacetamide derivatives of the general formula (I), in whichR1 represents unsubstituted or fluorine-,...
6750211 Diimino compounds for use as modulators of cell regulation  
Compositions, methods of use, isolation and biosynthesis of diimino-piperazine derivatives useful for the modification of sphingolipid metabolism and other biological functions are described. The...
6673842 Method of treating onychomycosis  
A method of treating onychomycosis is described which includes administration of an effective amount of urea in a topical formulation to an infected area around a nail of a patient.
6660284 Anthraquinone compounds, manufacturing process, use as pigments and cosmetic composition  
The present invention relates to novel compounds corresponding to formula (I) below: The invention also relates to the process for manufacturing them, to their use as pigments and to a cosmetic...
6596300 Animal feed  
The present invention includes a method for increasing meat production while reducing fat in ruminant and non-ruminant animals and for increasing egg production in poultry and milk production in...
6573300 Hydroxyurea treatment for spinal muscular atrophy  
The invention features a method of modulating SMN exon 7 expression in a subject by administering hydroxyurea to the subject.
6566304 Biogenic control and limitation of the reproduction of parasitic earth nematodes in stock culture  
The invention relates to use of (a) compounds of phosphorus containing at least partly lipophilic organic radicals together with (b) urea and/or urea derivatives in selected quantity ratios of (a)...
6518313 Solid sanitizers and cleaner disinfectants  
Solid sanitizing compositions have advantages over corresponding liquids and powders. A solid sanitizing product can be contained within a plastic bottle with a label indicating that the contents...
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