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7598417 |
Substituted fluoroethyl ureas as alpha 2 adrenergic agents
The present patent application is directed to novel fluoroethyl urea compounds and compositions and their therapeutic use in the treatment of pain and other conditions.
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7572798 |
Combi-molecules having signal transduction inhibitory properties and DNA damaging properties
The present invention relates to a series of new chemical agents that demonstrate anti-tumor activity. More particularly, the present invention relates to molecules, referred to as...
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RE40861 |
Compounds having reversible inhibiting activity of carnitine palmitoyl-transferase
Compounds of formula (I)
wherein the groups are as defined in the description are disclosed.
The compounds of formula (I) are endowed with reversible inhibiting activity of carnitine...
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7456220 |
Immunodulatory compositions and methods of use thereof
The invention relates to immunomodulatory compositions and related methods. The immunomodulatory compositions of a formula disclosed herein are useful for the prevention of sepsis and the treatment...
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7405194 |
Therapeutic agents and methods of use thereof for the treatment of melanoma
The present invention provides angiogenesis inhibitor compounds comprising a MetAP-2 inhibitory core coupled to a peptide, as well as pharmaceutical compositions comprising the angiogenesis...
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7371372 |
Compositions comprising IMPDH inhibitors and uses thereof for treating HCV infection
The present invention relates to optimal compositions useful in treating HCV infections in humans. These compositions comprise alpha-interferon or pegylated alpha-interferon and an IMPDH inhibitor...
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7348307 |
Methionine aminopeptidase-2 inhibitors and methods of use thereof
The present invention provides methods of treating a lymphoma (e.g., a T-cell lymphoma or a B-cell lymphoma) in a subject by administering to the subject a therapeutically effective amount of one...
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7307071 |
RAF-MEK-ERK pathway inhibitors to treat cancer
Materials and methods for treating certain cancers are described, preferably cancers that result from the up-regulation of the RAF-MEK-ERK pathway, and more preferably chronic myelogenous leukemia,...
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7262208 |
Hydroxypropyl amides for the treatment of Alzheimer's disease
The present invention relates to compounds of formula (I):
useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme...
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7220768 |
Isoxazole-containing thiourea inhibitors useful for treatment of varicella zoster virus
This Invention provides a compound of the Formula:
wherein
X is
R 1 , R 2 , R 3 and R 4 are described in the specification and a pharmaceutical composition comprising the...
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7211602 |
Treatment of neurodegenerative disorders through the modulation of the polyamine pathway
The present invention provides methods and compositions for modulating polyamine pathway activity as a means for ameliorating neurodegenarative disorders. In particular, for ameliorating the...
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7182952 |
Urea and nitrogen based compounds as feeding stimulants/aggregants and masking agents of unpalatable chemicals for subterranean termites
Nitrogen containing compounds are effective as subterranean termite feeding stimulants/aggregants and as masking agents for concealing the presence of other compounds which are repellents to...
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7163703 |
Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds
The invention relates to the use of arsenic compounds to treat a variety of neoplastic diseases. The present invention encompasses the administration to a mammal of arsenic in the form of a salt,...
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7157420 |
Therapeutic agents and methods of use thereof for the modulation of angiogenesis
The present invention provides methods of treating an autoimmune disorder (e.g., lupus erythematosus, multiple sclerosis, myasthenia gravis, vasculitis and diabetes mellitus) in a subject by...
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7105482 |
Methionine aminopeptidase-2 inhibitors and methods of use thereof
The present invention provides methods of treating, parasitic infections, thymoma, and lymphoid malignancies in a subject by administering to the subject a therapeutically effective amount of one...
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7074832 |
Compositions containing antimicrobials and urea for the treatment of dermatological disorders and methods for their use
Topical compositions which include urea and an antimicrobial agent, particularly sulfacetamide or metronidazole, are described. Sulfacetamide compositions further including sulfur are also...
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7074780 |
Substituted phenylcyclohexanecarboxamides and their use
The present invention relates to substituted phenylcyclohexanecarboxamides of the formula (I)
to processes for their preparation and to their use in medicaments, in particular for the...
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7067556 |
Compositions containing antimicrobials and urea for the treatment of dermatological disorders and methods for their use
Topical compositions which include urea and an antimicrobial agent, particularly sulfacetamide, are described. Sulfacetamide compositions further including sulfur are also described. Methods for...
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7052683 |
Composition to detoxify formaldehyde in gaseous state, in aqueous solutions, and to protect human cell lines against formaldehyde
A chemical compound is disclosed herein for performing a complex enzymatic neutralization and fixation of formaldehyde, providing a method for instantaneous neutralization of formaldehyde vapors...
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7033838 |
Method for the diagnosis of Helicobacter pylori infection, and a diagnostic kit for performing the method
The method for the diagnosis of Helicobacter pylori infection by the oral administration of defined amounts of 13 C-labeled urea and examination for 13 C content of blood samples removed at a...
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7030133 |
Inhibitors of formation of advanced glycation endproducts (AGEs)
The nonenzymatic glycation and crosslinking of proteins is a part of the aging process with the glycation endproducts and crosslinking of long-lived proteins increasing with age. This process is...
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7022737 |
Manipulating nitrosative stress to kill pathologic microbes, pathologic helminths and pathologically proliferating cells or to upregulate nitrosative stress defenses
Mammals are treated for infections or for conditions associated with pathologically proliferating mammalian cell growth by administration of a manipulator of nitrosative stress to selectively kill...
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6986896 |
Method of treating fungal conditions of the skin
Methods of treating fungal conditions and onychomycosis are described which include administration of a safe and effective amount of urea in a topical formulation to an affected area on the skin or...
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6962945 |
N-aryloxypropanolyl-N′-phenethyl-urea
The present invention provides N-aryloxypropanolyl-N′-phenethyl-urea derivatives of formula 3, method for their preparation and use thereof as potent appetite suppressants for treatment of...
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6960615 |
Carbamide peroxide compositions for the treatment of dermatological disorders and methods for their use
Topical compositions which include urea and carbamide peroxide are described. Compositions having a pH in the acidic range, particularly in the range of about 2.5 to about 9 are also described....
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6846837 |
Topical administration of basic antifungal compositions to treat fungal infections of the nails
Methods and topical pharmaceutical formulations are provided for the treatment of nail fungus (onychomycosis). The invention involves a pharmacologically active antifungal agent, plus a...
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6824769 |
Optimal compositions and methods thereof for treating HCV infections
The present invention relates to optimal compositions useful in treating HCV infections in humans. These compositions comprise alpha-interferon or a derivative thereof and an IMPDH inhibitor,...
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6822001 |
Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents
Combination therapies are provided for the treatment of proliferative disorders which use a pentafluorobenzenesulfonamide of formula I and an antineoplastic agent such as gemcitabine or paclitaxel.
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6797467 |
Compositions and methods for determining interactions of mitochondrial components, and for identifying agents that alter such interactions
Compositions and methods are provided for identifying agents that alter mitochondrial membrane permeability transition. The screening methods generally detect agents that alter the interaction...
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6787567 |
Fungicidal active ingredients combinations
The invention relates to novel fungicidally active compound combinations of (a) methoximinoacetamide derivatives of the general formula (I), in which R 1 represents unsubstituted or fluorine-,...
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6750211 |
Diimino compounds for use as modulators of cell regulation
Compositions, methods of use, isolation and biosynthesis of diimino-piperazine derivatives useful for the modification of sphingolipid metabolism and other biological functions are described. The...
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6699510 |
Acidic aqueous chlorite teat dip with improved visual indicator stability, extended shelf life, sanitizing capacity and tissue protection
The mastitis control teat dip composition having a visible indicator aspect of the invention provides a softening, soothing, smoothing, relaxing property, a rapid initial kill, a useful highly...
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6673842 |
Method of treating onychomycosis
A method of treating onychomycosis is described which includes administration of an effective amount of urea in a topical formulation to an infected area around a nail of a patient.
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6660284 |
Anthraquinone compounds, manufacturing process, use as pigments and cosmetic composition
The present invention relates to novel compounds corresponding to formula (I) below: The invention also relates to the process for manufacturing them, to their use as pigments and to a cosmetic...
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6596300 |
Animal feed
The present invention includes a method for increasing meat production while reducing fat in ruminant and non-ruminant animals and for increasing egg production in poultry and milk production in...
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6573300 |
Hydroxyurea treatment for spinal muscular atrophy
The invention features a method of modulating SMN exon 7 expression in a subject by administering hydroxyurea to the subject.
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6566304 |
Biogenic control and limitation of the reproduction of parasitic earth nematodes in stock culture
The invention relates to use of (a) compounds of phosphorus containing at least partly lipophilic organic radicals together with (b) urea and/or urea derivatives in selected quantity ratios of (a)...
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6518313 |
Solid sanitizers and cleaner disinfectants
Solid sanitizing compositions have advantages over corresponding liquids and powders. A solid sanitizing product can be contained within a plastic bottle with a label indicating that the contents...
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6514963 |
Methods for the inhibition of egg production in trematodes
The present invention comprises methods and compositions for use in inhibiting egg production by parasitic trematode worms comprising administering to an individual in need thereof an effective...
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6509353 |
Methods and compositions using terfenadine metabolites in combination with leukotriene inhibitors
Methods and pharmaceutical compositions employing a terfenadine metabolite and a leukotriene inhibitor for the treatment or prevention of inflammation or allergic disorders, such as asthma, or...
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6495602 |
Topical pharmaceutical base with anti-pruritic and/or anti-inflammatory drugs
Disclosed are compositions of a novel astringent and keratolytic topical pharmaceutical base into which drugs can be incorporated such as for example an anti-pruritic drug and/or an...
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6476076 |
Vanilloid analogues containing resinferatoxin pharmacophores as potent vanilloid receptor agonists and analgesics, compositions and uses thereof
The present invention is related to new vanilloid analogues containing resiniferatoxin pharmacophores, pharmaceutical compositions comprising such analogues, and their uses as vanilloid receptor...
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6462071 |
Agents for intravitreal administration to treat or prevent disorders of the eye
Methods and preparations for treating disorders of the eye and/or causing posterior vitreous disconnection or disinsertion. Preparations containing a) urea, b) urea derivatives (e.g., hydroxyurea,...
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6420398 |
Urea derivatives having nitrogen aromatic heterocycle
An object of the present invention is to provide novel urea derivatives which have TNF-α production inhibitory effects and are useful as therapeutic agents for various diseases, particularly as...
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6395189 |
Method for the control of biofilms
A process is provided for both removing and controlling biofilms present in industrial cooling and process waters. The process provides a composition which includes the reaction products of an...
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6369032 |
Method for treating allergies
Use of cathepsin S inhibitors for the treatment of an allergic condition, in particular an atopic allergic condition, more specifically for the treatment of hay fever, asthma, atopic dermatitis or...
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6348464 |
Pyrrolecarbonylimino derivatives as naaladase inhibitors
The present invention relates to pharmaceutical compositions and methods of using pyrrolecarbonylimino derivatives to inhibit N-Acetylated α-Linked Acidic Dipeptidase (NAALADase) enzyme activity,...
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6344476 |
Inhibition of p38 kinase activity by aryl ureas
This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases other than cancer and proteolytic enzyme mediated diseases other than cancer, and pharmaceutical...
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6303656 |
Composition comprising urea, and its uses in the field of cosmetics and/or dermatology
A composition comprising urea and an N-substituted aminosulfonic acid. The composition may be used for the care, treatment and/or protection of human skin, mucous membranes and/or keratin fibers,...
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6255350 |
Stabilized concentrates of water unstable AZA compounds and o/w miniemulsions thereof
This invention relates to a single phase emulsifiable concentrate composition comprising (a) between about 0.05 and about 25 wt. % of a biologically, fungicidally and/or herbicidally active aza...
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