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8183292 |
Chiral cyclic β-amino acids and their derivatives, pharmaceutical compositions containing them and the use of such compounds
The invention relates to chiral cyclic β-amino acids of Formula (I) and their salts formed with pharmaceutically acceptable acids or bases, wherein the main meanings of the substituents are as ...
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8101664 |
Urea foam
Provided, among other things, is a delivery module for a non-greasy, water-based urea composition comprising: an aerosol delivery device; within the aerosol delivery device, the urea composition...
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8013015 |
Small molecule inhibitors of ghrelin O-acyltransferase
Ghrelin O-acyltransferase (GOAT) is inhibited with designed small molecules. Methods comprise contacting the GOAT with an inhibitor and detecting a resultant inhibition.
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7999008 |
Urea compounds that promote desquamation
The invention relates to the use of at least one urea derivative of the following formula (I) in a composition containing a physiologically acceptable medium, as agent intended for stimulating...
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7977385 |
Agents for corneal or intrastromal administration to treat or prevent disorders of the eye
Methods and preparations for treating disorders of the eye and/or causing dissolution of corneal proteoglycans and organized healing of corneal stroma, softening of the cornea for non-surgical...
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7910090 |
Non-irritating compositions
The present invention provides a base composition that allows for the formulation of non-irritating cosmetic and/or dermatological compositions. The base composition includes one or more of...
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7875632 |
Selective serotonin receptor inverse agonists as therapeutics for disease
Disclosed herein are pharmaceutical compositions comprising an inverse serotonin receptor agonist or a serotonin receptor antagonist and an anti-psychotic agent. Disclosed herein are also methods...
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7846469 |
Reversible inhibition of sperm receptor synthesis for contraception
Methods and pharmaceutical compositions are disclosed for reversibly inhibiting sperm receptor activity in animals. Nicarbazin, its derivatives and modifications which retain pharmacological...
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7790749 |
Use of pleuromutilins for the treatment of disorders caused by Helicobacter pylori
A method of preventing or treating diseases mediated by Helicobacter pylori, comprising administering to a subject in need of such treatment an effective amount of pleuromutilin.
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7776363 |
Suppressing microbial growth in pulp and paper
A composition for anti-microbial effect in a water system such as a pulp and paper processing line with an aqueous slurry. The composition comprises a free chlorine-generating biocide comprising a...
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RE41279 |
Acidic aqueous chlorite teat dip with improved visual indicator stability, extended shelf life, sanitizing capacity and tissue protection
The mastitis control teat dip composition having a visible indicator aspect of the invention provides a softening, soothing, smoothing, relaxing property, a rapid initial kill, a useful highly...
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7705016 |
Regulation of food intake by modulation of long-chain fatty acyl-CoA levels in the hypothalamus
Methods of reducing food intake and glucose production in a mammal, or restoring hepatic autoregulation are provided. The methods involve increasing long-chain fatty acyl-Co-A (LC-CoA) levels in...
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7700076 |
Penetrating pharmaceutical foam
The invention relates to an alcohol-free cosmetic or pharmaceutical foam composition comprising water, a hydrophobic solvent, a surface-active agent, a gelling agent, an active component selected...
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7687544 |
Method of using catalpic acid to treat type 2 diabetes and associated disorders
A method of treating and preventing type 2 diabetes and obesity an animal, including mammals and humans, in which a therapeutically effective amount of catalpic acid to the animal is administered...
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RE41109 |
Acidic composition of matter for use to detroy microorganisms
A composition of matter and the method of making that provides a low pH acidic composition that is useful for destroying microorganisms that are undesirable and useful for destroying or reducing...
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7655695 |
Illudin analogs useful as anticancer agents
Acylfulvene analogs, which inhibit tumor growth, especially solid tumor growth, and which have an adequate therapeutic index to be effective for in vivo treatment are provided herein. The compounds...
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7645798 |
N-(2-hydroxyalkanoyl)-N,N′-dialkylureas and a process for their preparation
N-(2-hydroxyalkanoyl)-N,N′-dialkylureas of general formula (1) are described A-X-(A)m (1) where A: m=0 or m=1; when m=0, X=R′″, where R′″ is an aliphatic, cycloaliphatic, arylaliphatic radical, ...
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7572798 |
Combi-molecules having signal transduction inhibitory properties and DNA damaging properties
The present invention relates to a series of new chemical agents that demonstrate anti-tumor activity. More particularly, the present invention relates to molecules, referred to as...
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7456220 |
Immunodulatory compositions and methods of use thereof
The invention relates to immunomodulatory compositions and related methods. The immunomodulatory compositions of a formula disclosed herein are useful for the prevention of sepsis and the treatment...
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7405194 |
Therapeutic agents and methods of use thereof for the treatment of melanoma
The present invention provides angiogenesis inhibitor compounds comprising a MetAP-2 inhibitory core coupled to a peptide, as well as pharmaceutical compositions comprising the angiogenesis...
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7371372 |
Compositions comprising IMPDH inhibitors and uses thereof for treating HCV infection
The present invention relates to optimal compositions useful in treating HCV infections in humans. These compositions comprise alpha-interferon or pegylated alpha-interferon and an IMPDH inhibitor...
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7348307 |
Methionine aminopeptidase-2 inhibitors and methods of use thereof
The present invention provides methods of treating a lymphoma (e.g., a T-cell lymphoma or a B-cell lymphoma) in a subject by administering to the subject a therapeutically effective amount of one...
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7307071 |
RAF-MEK-ERK pathway inhibitors to treat cancer
Materials and methods for treating certain cancers are described, preferably cancers that result from the up-regulation of the RAF-MEK-ERK pathway, and more preferably chronic myelogenous leukemia,...
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7262208 |
Hydroxypropyl amides for the treatment of Alzheimer's disease
The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that...
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7220768 |
Isoxazole-containing thiourea inhibitors useful for treatment of varicella zoster virus
This Invention provides a compound of the Formula: wherein X is R1, R2, R3 and R4 are described in the specification and a pharmaceutical composition comprising the compound used for inhibiting...
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7211602 |
Treatment of neurodegenerative disorders through the modulation of the polyamine pathway
The present invention provides methods and compositions for modulating polyamine pathway activity as a means for ameliorating neurodegenarative disorders. In particular, for ameliorating the...
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7182952 |
Urea and nitrogen based compounds as feeding stimulants/aggregants and masking agents of unpalatable chemicals for subterranean termites
Nitrogen containing compounds are effective as subterranean termite feeding stimulants/aggregants and as masking agents for concealing the presence of other compounds which are repellents to...
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7163703 |
Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds
The invention relates to the use of arsenic compounds to treat a variety of neoplastic diseases. The present invention encompasses the administration to a mammal of arsenic in the form of a salt,...
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7157420 |
Therapeutic agents and methods of use thereof for the modulation of angiogenesis
The present invention provides methods of treating an autoimmune disorder (e.g., lupus erythematosus, multiple sclerosis, myasthenia gravis, vasculitis and diabetes mellitus) in a subject by...
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7074780 |
Substituted phenylcyclohexanecarboxamides and their use
The present invention relates to substituted phenylcyclohexanecarboxamides of the formula (I) to processes for their preparation and to their use in medicaments, in particular for the prevention...
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7067556 |
Compositions containing antimicrobials and urea for the treatment of dermatological disorders and methods for their use
Topical compositions which include urea and an antimicrobial agent, particularly sulfacetamide, are described. Sulfacetamide compositions further including sulfur are also described. Methods for...
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7052683 |
Composition to detoxify formaldehyde in gaseous state, in aqueous solutions, and to protect human cell lines against formaldehyde
A chemical compound is disclosed herein for performing a complex enzymatic neutralization and fixation of formaldehyde, providing a method for instantaneous neutralization of formaldehyde vapors...
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7033838 |
Method for the diagnosis of Helicobacter pylori infection, and a diagnostic kit for performing the method
The method for the diagnosis of Helicobacter pylori infection by the oral administration of defined amounts of 13C-labeled urea and examination for 13C content of blood samples removed at a defined...
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7030133 |
Inhibitors of formation of advanced glycation endproducts (AGEs)
The nonenzymatic glycation and crosslinking of proteins is a part of the aging process with the glycation endproducts and crosslinking of long-lived proteins increasing with age. This process is...
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7022737 |
Manipulating nitrosative stress to kill pathologic microbes, pathologic helminths and pathologically proliferating cells or to upregulate nitrosative stress defenses
Mammals are treated for infections or for conditions associated with pathologically proliferating mammalian cell growth by administration of a manipulator of nitrosative stress to selectively kill...
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6986896 |
Method of treating fungal conditions of the skin
Methods of treating fungal conditions and onychomycosis are described which include administration of a safe and effective amount of urea in a topical formulation to an affected area on the skin or...
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6962945 |
N-aryloxypropanolyl-N′-phenethyl-urea
The present invention provides N-aryloxypropanolyl-N′-phenethyl-urea derivatives of formula 3, method for their preparation and use thereof as potent appetite suppressants for treatment of o...
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6960615 |
Carbamide peroxide compositions for the treatment of dermatological disorders and methods for their use
Topical compositions which include urea and carbamide peroxide are described. Compositions having a pH in the acidic range, particularly in the range of about 2.5 to about 9 are also described....
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6846837 |
Topical administration of basic antifungal compositions to treat fungal infections of the nails
Methods and topical pharmaceutical formulations are provided for the treatment of nail fungus (onychomycosis). The invention involves a pharmacologically active antifungal agent, plus a...
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6824769 |
Optimal compositions and methods thereof for treating HCV infections
The present invention relates to optimal compositions useful in treating HCV infections in humans. These compositions comprise alpha-interferon or a derivative thereof and an IMPDH inhibitor,...
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6822001 |
Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents
Combination therapies are provided for the treatment of proliferative disorders which use a pentafluorobenzenesulfonamide of formula I and an antineoplastic agent such as gemcitabine or paclitaxel.
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6797467 |
Compositions and methods for determining interactions of mitochondrial components, and for identifying agents that alter such interactions
Compositions and methods are provided for identifying agents that alter mitochondrial membrane permeability transition. The screening methods generally detect agents that alter the interaction...
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6787567 |
Fungicidal active ingredients combinations
The invention relates to novel fungicidally active compound combinations of (a) methoximinoacetamide derivatives of the general formula (I), in whichR1 represents unsubstituted or fluorine-,...
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6750211 |
Diimino compounds for use as modulators of cell regulation
Compositions, methods of use, isolation and biosynthesis of diimino-piperazine derivatives useful for the modification of sphingolipid metabolism and other biological functions are described. The...
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6673842 |
Method of treating onychomycosis
A method of treating onychomycosis is described which includes administration of an effective amount of urea in a topical formulation to an infected area around a nail of a patient.
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6660284 |
Anthraquinone compounds, manufacturing process, use as pigments and cosmetic composition
The present invention relates to novel compounds corresponding to formula (I) below: The invention also relates to the process for manufacturing them, to their use as pigments and to a cosmetic...
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6596300 |
Animal feed
The present invention includes a method for increasing meat production while reducing fat in ruminant and non-ruminant animals and for increasing egg production in poultry and milk production in...
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6573300 |
Hydroxyurea treatment for spinal muscular atrophy
The invention features a method of modulating SMN exon 7 expression in a subject by administering hydroxyurea to the subject.
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6566304 |
Biogenic control and limitation of the reproduction of parasitic earth nematodes in stock culture
The invention relates to use of (a) compounds of phosphorus containing at least partly lipophilic organic radicals together with (b) urea and/or urea derivatives in selected quantity ratios of (a)...
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6518313 |
Solid sanitizers and cleaner disinfectants
Solid sanitizing compositions have advantages over corresponding liquids and powders. A solid sanitizing product can be contained within a plastic bottle with a label indicating that the contents...
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