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7560591 Benzamidine derivatives having anti-inflammatory and immunosuppressive activity  
Compounds which can be represented by the general formula (I) indicated below: and in which: A is selected independently from the carboxamide group, the thiocarboxamide group, and the...
7323496 Compounds for treatment of inflammation, diabetes and related disorders  
Novel acyl urea, thiourea, carbamate, thiocarbamate and related compounds are provided which are effective in inhibiting the cytokine-mediated inflammatory response in cultured cells, in...
7265136 Substituted stilbene compounds with vascular damaging activity  
A compound for use in inducing necrosis in vascular tissue of a tumor in an animal. The compound contains a first moiety which is a cis-stilbene moiety and a second moiety which is an inhibitor of...
7262220 Urea- and urethane-substituted acylureas, process for their preparation and their use  
The invention relates to urea- and urethane-substituted acylureas and to their physiologically tolerated salts and physiologically functional derivatives. In particular, the invention relates to...
7186736 NNI for treatment of multi-drug resistant HIV  
The present invention is directed to compounds and methods suitable for the treatment of HIV infection.
7169815 3-methoxybenzyl thiourea derivatives and improved lipid compositions containing same  
1-(3-methoxybenzyl)-3-substituted thiourea antioxidant compounds and improved lipids compositions which are supplemented with amounts of such antioxidant compounds effective for augmenting...
7094807 Substituted aryl thioureas and related compounds; inhibitors of viral replication  
The invention provides compounds and pharmaceutically acceptable salts of Formula I wherein the variables A 1 , A 2 , R 1 , R 2 , V, W, X, Y, and Z are defined herein. Certain compounds of...
6984647 Aminotetralin-derived urea modulators of vanilloid VR1 receptor  
This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to β-aminotetralin-derived ureas that are potent antagonists or agonists of VR1 which are...
6962945 N-aryloxypropanolyl-N′-phenethyl-urea  
The present invention provides N-aryloxypropanolyl-N′-phenethyl-urea derivatives of formula 3, method for their preparation and use thereof as potent appetite suppressants for treatment of...
6924311 Methods for affecting various diseases utilizing LXR compounds  
The present invention relates to methods for elevating high density lipoprotein (HDL) plasma levels, decreasing the absorption of dietary cholesterol in the intestine, decreasing the plasma level...
6838472 Substituted urea retinoid agonists  
The current invention provide novel compounds, methods of treating or preventing emphysema, cancer and dermatological disorders, pharmaceutical compositions suitable for the treatment or prevention...
6620806 Methods and kits for improving vascular health  
The present invention provides methods and kits for improving or maintaining vascular health, including preventing myocardial infarction or stroke; maintaining or improving vascular reactivity;...
6608052 Compounds useful as anti-inflammatory agents  
Disclosed are novel aromatic compounds of the formula(I) wherein G, E, W, Ar, X, Y and Z. The compounds are useful for treating diseases or pathological conditions involving inflammation such as...
6573284 Method of treating melanoma  
Novel pro-drugs and assay reagents are provided which are useful as therapeutic agents especially for delivery and targetting therapeutically active agents to melanoma cells. The pro-drugs and...
6545052 Methods and compositions for inhibiting free radical polymerization in skin and hair  
A method is provided for inhibiting free radical degradation in the skin of a human or nonhuman animal comprising contacting the skin with a skin treatment composition having a concentration of a...
6479458 Targeting the reverse mode of the Na&plus /Ca2&plus exchanger for the treatment of optic neuropathy associated with glaucoma and ischemic optic neuropathy  
A method for preventing retinal ganglion cell depth, associated with glaucoma, in an animal of the mammalian species, including humans, comprising the step of administering to ganglion cells and...
6414030 Use of benzenesulfonyl(thio)ureas for the treatment and prophylaxis of dysfunctions of the autonomous nervous system and use of benzenesulfonyl(thio)ureas in combination with beta-receptors blockers  
Substituted benzenesulfonylureas and -thioureas of the formula I in which R 1 , R 2 , E, X, Y and Z have the meanings described herein, show effects on the autonomous nervous system. The...
6255349 Alph-methylbenzyl-containing thiourea inhibitors of herpes viruses containing a phenylenediamine group  
Compounds having the formula: ##STR1## wherein R 1 -R 5 are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon...
6187799 Inhibition of raf kinase activity using aryl ureas  
Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se.
6034102 Atherosclerosis treatment  
A method of treating atherosclerosis, independent of lipid lowering, in mammals, including humans, in need of treatment by inhibiting progression of an atherogenic lesion or by stabilizing plaque....
5780512 Alkylated (hetero) cyclic compounds  
The invention relates to a compounds selected from these of formula (I): ##STR1## in which: R 1 , R 2 , R 3 and A are as defined in the description, and a medicinal product containing the same...
5773459 Urea- and thiourea-type compounds  
The present invention relates to molecules capable of modulating tyrosine signal transduction to prevent and treat cell proliferative disorders or cell differentiation disorders associated with...
5696138 Urea derivatives and their use  
A compound having the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein X, Z, Y, A, D, E, F, R 1 , R 2 , R 3 , R 4 , R 11 , R 12 have the meanings set forth in the...
5668180 Alkoxyaryl compounds  
A compound selected from those of formula (I): ##STR1## in which A, R, Y, R 1 , R 2 and R 3 are as defined in the description, and a medicinal product containing the same useful for treating a...
5614550 Amide and urea derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses  
Compounds of formula (I) are provided: ##STR1## wherein: R 1 represents an alkyl group; or a group of formula (II), (III), (IV) or (V): ##STR2## and wherein the groups R 2 , R 3 , R 4 and R 5 ...
5534529 Substituted aromatic amides and ureas derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses  
Compounds of formula (I) are provided: ##STR1## wherein: R 1 represents an alkyl group; or a group of formula (II), (III), (IV) or (V): ##STR2## and wherein the groups R 2 , R 3 , R 4 and R 5 ...
5449690 Naphthylethylureas and naphthylethylthioureas  
A compound selected from those of formula (I): ##STR1## in which the meanings of R, R 1 , R 2 and X are as defined in the specification, and medicinal products containing the same which are useful...
5441984 Urea, thiourea and guanidine derivatives  
The present invention provides novel urea, thiourea and guanidine derivatives, pharmaceutical formulations thereof and a method of using same to prevent diabetic complications.
5395853 Anti-atherosclerotic diaryl compounds  
The present invention is concerned with compounds of formula (I) ##STR1## wherein m is 0 or 1; W is hydrogen, a C 1 -16 straight, branched, or cyclic alkyl group, or a C 2 -16 straight,...
5389683 Naphthylethylureas  
A compound selected from those of formula (I): ##STR1## in which the meanings of R, R 1 , R 2 and X are as defined in the specification, and medicinal products containing the same which are in...
5264441 Disubstituted ureas and thioureas derivatives  
The invention provides new ureas and thioureas derivatives of general formula (I) ##STR1## and pharmaceutically acceptable salts thereof, which are useful as therapeutic agents such as for the...
5187197 Phenylthioureas, phenylisothioureas and phenylcarbodiimides, compositions, containing them and their use in the control of pests  
Novel substituted phenyl-thioureas, -isothioureas and -carbodiimides of formula I ##STR1## in which R 1 is C 1 -C 8 alkyl, C 1 -C 8 alkyl mono- or poly-substituted by halogen and/or by C 1 -C...
5153227 Phenylsulfonyl nitromethanes as aldose reductase inhibitors  
The invention concerns novel pharmaceutical compositions for use in the treatment of certain complications of diabetes and galactosemia and which contain a nitromethane derivative (or its non-toxic...
5116848 N-(((2,6-disubstituted)phenyl)-N-diarylalkyl)ureas as antihyperlipidemic and antiatherosclerotic agents  
Certain N-2,6-dialkyl- or N-2,6-dialkoxphenyl-N'-diarylalkylurea compounds are potent inhibitors of the enzyme acyl CoA:cholesterol acyltransferase (ACAT), and are thus useful agents for the...
5106873 ACAT inhibitors  
This invention relates to novel compounds which are ACAT inhibitors rendering them useful in lowering blood cholesterol levels. The compounds contain two urea or thiourea, amide, or amine moieties...
5063247 Diphenylurea derivatives  
Novel diphenylurea derivatives represented by the following formula (I): ##STR1## wherein R 1 is an alkyl group of 5 to 18 carbon atoms, each of R 2 and R 3 is independently an alkyl group of 1...
5015644 Antihyperlipidemic and antiatherosclerotic urea and carbamate compounds  
Certain substituted urea, thiourea, carbamate, and thiocarbamate compounds are potent inhibitors of the enzyme acyl-CoA: cholesterol acyltransferase and are thus useful agents for inhibiting the...
4977170 Isoprenoidamine compounds which are useful antiulcer agents  
Novel isoprenoidamine compounds (I) which show antiulcer activity are provided. ##STR1##
4920135 Insecticidal ureas and thioureas  
Certain organic compounds derived from urea or thiourea having insecticidal activity and methods of their preparation are disclosed. The compounds according to the invention have been found to...
4857556 Substituted benzylcycloalkenylurea derivatives  
Substituted benzylcycloalkenylurea derivatives of the formula (I) ##STR1## wherein X represents a halogen atom or a lower alkyl group, Y represents an oxygen atom or a sulfur atom, R 1 ...
4752615 Fungicidal aniline derivatives  
A compound of the formula: ##STR1## useful as a fungicidal agent against phytopathogenic fungi, particularly their strains resistant to benzimidazole, thiophanate and/or cyclic imide fungicides.
4731385 Insecticidal and fungicidal composition for agricultural and horticultural use  
An insecticidal and fungicidal composition comprising (1) An insecticidally effective amount of a nitromethylene derivative of the formula ##STR1## in which X is a lower alkyl group, a lower alkoxy...
4564638 Fungicidal novel N-benzyl-N-(2-norbornyl)-ureas  
Fungicidally active novel benzylurea derivatives of the formula ##STR1## in which R 1 is a halogen atom or a lower alkyl group, X is an oxygen or sulfur atom, and R 2 is an alkyl group, a...
4405644 Medicaments for the treatment of disorders of lipometabolism and their use  
The invention relates primarily to pharmaceutical compositions and medicaments containing a compound of Formula (I), infra as the active ingredient. Also included in the invention are methods for...
4387105 Methods of treating atherosclerosis with dialkylureas and dialkylthioureas  
Method of treating atherosclerosis with dialkylureas and dialkylthioureas, compositions thereof and processes for their preparation.
4366164 Amine derivatives  
The invention provides compounds of general formula ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof, in which Y and Z, which may be the same or different, each...
4216228 Combating fungi with N-benzyl-N-cycloalkyl-ureas  
N-Benzyl-N-cycloalkyl-ureas of the formula ##STR1## in which R 1 represents cycloalkyl with 5-8 carbon atoms in the ring, which may be optionally substituted by alkyl with 1-8 carbon atoms, R 2...
4194008 N-aryl-N'-(cyclo)-alkyl-thioureas and their use as agents for combating animal pests and plant pests  
N-Aryl-N'-(cyclo)-alkyl-thioureas of the formula ##STR1## in which R 1 represents alkyl-(C 1 -C 6 ) or cycloalkyl-(C 3 -C 7 ), R 2 represents alkyl-(C 2 -C 6 ) or cycloalkyl-(C 3 -C 7 ), ...
4127673 Combating fungi with new N-4-halobenzyl-N-cycloalkyl-N'-phenylureas and thioureas  
N-4-halobenzyl-N-cycloalkyl-N'-phenylureas and thioureas of the formula ##STR1## in which R is cycloalkyl or methyl-cycloalkyl, X is halogen, and Y is oxygen or sulfur, Which possess...
4097605 Alkyl thiourea miticides  
Miticidally active compounds, which are defined by the following generic formula ##STR1## wherein R and R 1 in general are selected from the group consisting of benzhydryl,...
Matches 1 - 50 out of 77 1 2 >