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8182831 |
Stable and taste masked pharmaceutical dosage form using porous apatite grains
A stable and taste masked pharmaceutical dosage form includes porous apatite grains and a drug entrapped in pores of said grains, wherein said grains have a size of 0.1-1000 μm and said pores of ...
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8183230 |
Antimicrobial preservatives to achieve multi-dose formulation using beta-cyclodextrins for liquid dosage forms
The present invention is directed to pharmaceutical compositions containing a therapeutically effective amount of an Active Pharmaceutical Ingredient (“API”), a pharmaceutically acceptable cyc...
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8158609 |
Use of cyclodextrins as an active ingredient for treating dry AMD and solubilizing drusen
The present invention is directed to the treatment of disorders involving the accumulation of drusen, such as dry age-related macular degeneration and geographic atrophy via administration of...
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8158610 |
Dextrin-containing composition for preventing surgical adhesions
A method of reducing the incidence of post-operative adhesions in or associated with a body cavity, which comprises introducing into the body cavity a composition containing an aqueous solution or...
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8158580 |
Pharmaceutical compositions containing a glycopeptide antibiotic and a cyclodextrin
Disclosed are pharmaceutical compositions containing a cyclodextrin and a therapeutically effective amount of a glycopeptide antibiotic or a salt thereof. Also disclosed are methods of treating a...
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8153613 |
Barrier film-forming germicidal composition for controlling mastitis
A long-lasting persistent, uniform film-forming skin protecting germicidal composition provides a long-lasting persistent barrier film when applied to skin. The compositions have particular utility...
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8119616 |
Formulation of quinazoline based EGFR inhibitors containing a zinc binding moiety
The present invention relates to a composition comprising an inclusion complex of a cyclodextrin and quinazoline containing zinc-binding moiety based derivatives. The cyclodextrin is preferable a...
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8097262 |
Gel type enteral nutrient
An enteral nutrient gel that is excellent at maintaining its solid matter (gel) form in the stomach, does not readily disintegrate or dissolve with a change in pH, is stable in its physical...
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8088744 |
Cholestanol derivative for combined use
The invention provides a cancer chemotherapeutic agent which has fewer side effects and excellent efficacy. The cancer chemotherapeutic agent of the invention includes a cholestanol derivative...
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8071571 |
Orlistat compositions
A pharmaceutical combination or composition containing a lipase inhibitor, preferably orlistat, and a bile acid sequestrant is useful for treating obesity.
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8067433 |
Methods, compositions, and kits for the treatment of ophthalmic disorders
The invention features methods, kits, and compositions for the treatment of ophthalmic disorders. The compositions include a corticosteroid in combination with a non-steroidal...
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8063027 |
Surgical compositions for reducing the incidence of adhesions
A method of preventing or reducing the incidence of post-operative adhesions in or associated with a body cavity, which comprises introducing into the body cavity a composition containing an...
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8044035 |
Pharmaceutical compositions of pyrimidine-2,4,6-triones
A trioxopyrimidine-cyclodextrin complex formed of a trioxopyrimidine derivative or a salt thereof and a water-soluble cyclodextrin derivative has improved solubility.
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8003125 |
Injectable drug delivery systems with cyclodextrin-polymer based hydrogels
A cyclodextrin polymer-based injectable composition comprising cyclodextrin, a polymer which is capable of forming a hydrogel with the cyclodextrin, and a pharmacologically effective amount of at...
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7973022 |
Fluoroquinolone carboxylic acid salt compositions
The invention relates to pharmaceutical compositions that are a solution of a salt formed between a fluoroquinolone and a carboxylic acid, a cyclodextrin, and a pharmaceutically acceptable organic...
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7968116 |
Antitumor agent
A sugar-cholestanol compound which can be readily synthesized and which exhibits a satisfactory antitumor activity. An anticancer agent containing, as an active ingredient, a cholestanol compound...
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7947262 |
Use of fullerenes for the treatment of mast cell and basophil-mediated disease
Mast cell (MC) and peripheral blood basophil (PBB)-associated diseases are treated or prevented, or their symptoms are alleviated by the administration of water soluble fullerenes (buckeyballs) to...
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7943662 |
Flavonoid complexes
The invention relates to complexes of certain flavonoid derivatives, of the formula (I), where R1 and R2 are selected from H and OR11, where OR11 stands, independently of one another, for OH,...
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7935685 |
Process for preparation of inclusion compounds between a non-steroidal anti-inflammatory drug and betacyclodextrin by microwave treatment
A process for the preparation of inclusion complexes of a drug (piroxicam or ibuprofen) and a cyclodextrin, characterised in that: a) the drug and cyclodextrin, in the form of finely divided...
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7932238 |
Anti-inflammatory and/or analgesic composition for the intestine comprising branched maltodextrins
The invention concerns a fiber-enriched anti-inflammatory and/or analgesic composition for the intestine, characterized in that it comprises branched maltodextrins having between 15 and 35% of...
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7902174 |
Antiviral composition
Chemical compounds, being the alkyl sulfate of sulfated saccharides, particularly, dextrin, dextran, and cyclodextrin, and pharmaceutical compositions containing these compounds. The compounds of...
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RE42191 |
Methods for the preparation, isolation and purification of epothilone B, and X-ray crystal structures of epothilone B
The present invention relates to improved methods for the production, isolation and purification of epothilone B. These methods include, for example, a fermentation process for the production of...
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7897586 |
Anaesthetic composition
A stable anaesthetic composition is described which is particularly suitable for use in cats and dogs. The composition comprises an aqueous solution of an anaesthetically effective amount of a...
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7893040 |
Cyclodextrin nanotechnology for ophthalmic drug delivery
The invention provides an ophthalmic composition which is an aqueous suspension comprising drug, cyclodextrin and water, the composition having an aqueous phase of from about 0.1% (w/v) to about...
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7887840 |
Pharmaceutical compositions comprising drug and concentration-enhancing polymers
A solubility-improved drug form is combined with a concentration-enhancing polymer in a sufficient amount so that the combination provides substantially enhanced drug concentration in a use...
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7888328 |
Oral formulations of cladribine
Provided are compositions of cladribine and cyclodextrin which are especially suited for the oral administration of cladribine.
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7888334 |
Mitoquinone derivatives used as mitochondrially targeted antioxidants
This invention relates to methods to screen for, identify, select and synthesise amphiphilic mitochondrially targeted antioxidant compounds, and compositions, dosage forms and methods reliant on...
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7888335 |
Mitoquinone derivatives used as mitochondrially targeted antioxidants
This invention relates to pharmaceutically acceptable amphiphilic antioxidant compounds, compositions and dosage forms comprising said compounds, and methods and uses reliant on said compounds. The...
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7879822 |
Stabilized sulforaphane
A method of stabilizing sulforaphane is provided. The method includes contacting sulforaphane, or an analog thereof, and a cyclodextrin to form a complex between the sulforaphane, or analog...
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7879821 |
Method for modulating inflammatory responses by altering plasma lipid levels
A method for treating an immune-related disorder in a patient comprising administering an agent to the patient for altering the patient's plasma concentration of free cholesterol, wherein said...
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7879820 |
Use of a cyclodextrin as pearlescent agent and pearlescent compositions
Use of at least one agent chosen from cyclodextrins and the derivatives thereof as a pearlescent agent, in a composition, for example, a pearlescent cosmetic composition, comprising a...
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7858597 |
Preparation of formulations of angiotensin II AT1 receptors antagonists for the treatment of arterial hypertension, other cardiovascular illnesses and its complications
Preparation of AT1 receptors antagonists formulations using the cyclodextrins, their derivatives and/or biodegradable polymers for the treatment of arterial hypertension, other cardiovascular...
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7851457 |
β-Cyclodextrin derivatives
The invention provides low molecular weight compounds that block the pore formed by protective antigen and inhibit anthrax toxin action. Structures of the compounds are derivatives of...
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7846427 |
Stabilized interferon liquid formulations
Stabilized liquid pharmaceutical composition comprising an interferon (IFN) or an isoform, mutein, fused protein, functional derivative, active fraction or salt thereof, wherein said formulation is...
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7829550 |
Use of cyclodextrin for treatment and prevention of bronchial inflammatory diseases
The invention provides the use of a cyclodextrin compound for the manufacturing of a medicament for the treatment or prevention of bronchial inflammatory diseases, particularly for asthma.
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7820640 |
Methods for treating hearing loss
In one aspect, the present invention provides otoprotectant compositions useful for ameliorating hearing loss. In some embodiments, the otoprotective compositions comprise at least one glutathione...
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7795207 |
Lipopeptide compositions
The invention relates to a pharmaceutical composition comprising as an active agent a lipopeptide in a physiologically effective dose and a cyclodextrin or a cyclodextrin derivative.
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7786095 |
Amphiphilic macrocyclic derivatives and their analogues
Soluble amphiphilic macrocycle analogues having lipophilic groups attached to one side of the units making up the macrocycle and hydrophilic groups attached to the other side. These amphiphilic...
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7781417 |
Cyclodextrin dimers and derivatives thereof, methods for preparing them and their use, in particular, for the solubilizing pharmacologically active substances
The invention relates to a compound according to the following general formula (I), in which: m represents an integer equal to 5, 6 or 7; n and n1 represent an integer from 1 to 5; the A groups...
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7763282 |
Quaternary compounds comprising propolis as the active substance
The present invention describes a quaternary composition consisting of propolis delivered in a hydrophilic carrier (cyclodextrin and cyclodextrin derivatives) and co ground with the aid of two...
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7749982 |
Complex containing mequitazine, a cyclodextrin and an interaction agent
The present invention relates to a complex that includes mequitazine, a cyclodextrin, and an interaction agent wherein the rate of solubilization in water of complexed mequitazine, measured for a 2...
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7737112 |
Composition for enzyme inhibition
Compositions comprising one or more practically insoluble proteasome inhibitors and a cyclodextrin, particularly a substituted cyclodextrin, substantially increase the solubility of these...
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7737132 |
β-cyclodextrin derivatives as antibacterial agents
The invention provides a new class of antibiotics to which pathogenic bacteria have not been exposed, and thus should not have developed resistance. This new class of antibiotics are derivatives of...
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7732428 |
Surgical compositions and methods of using the same
A method of preventing or reducing the incidence of post-operative adhesions in or associated with a body cavity, which comprises introducing into the body cavity a composition containing an...
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7718695 |
Inclusion compounds of fumagillol derivative or its salt, and pharmaceutical compositions comprising the same
The present invention relates to an inclusion compound of fumagillol derivative or its salt with hydroxypropyl-β-cyclodextrin or sulfobutylether-7-β-cyclodextrin, and pharmaceutical compositions c...
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7709457 |
Methods and compositions for delivery of pharmaceutical agents
Methods and compositions for delivering pharmaceutical agents into cells, in particular urothelial cells of the bladder, are provided. In the methods and compositions of the invention, a...
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7704974 |
Method for the treatment and/or prevention of urinary disorders
The present invention relates to a method for the treatment and/or prevention of urinary disorders, comprising administering an effective amount of an osmotic diuretic agent and an effective amount...
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7700579 |
Process for the preparation of piroxicam: b-cyclodextrin inclusion compounds
The present invention relates to a process for the preparation of inclusion compounds of piroxicam with β-cyclodextrin. More particularly, according to the process of the invention, the aqueous ...
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7683040 |
Intranasal formulation of rotigotine
This invention pertains to a liquid intranasal pharmaceutical formulation comprising a pharmaceutically acceptable acid addition salt of rotigotine and α-cyclodextrin, preferably in the form of a ...
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7678776 |
Inclusion complexes of butylphthalide with cyclodextrin or its derivatives, a process for their preparation and the use thereof
The present invention relates to the inclusion complexes of butylphthalide, which is D, L-mixed or levorotatory, with cyclodextrin or cyclodextrin derivatives, to a process for their preparation...
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