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5126333 Pharmaceutical compositions having improved dissolution properties  
A pharmaceutical composition comprising a drug and a dehydrated cyclodextrin having improved dissolution properties, and the process for the preparation thereof.
5120720 Preparation of lipophile:hydroxypropylcyclodextrin complexes by a method using co-solubilizers  
The dissolution of lipophilic compounds in aqueous solutions of hydroxypropylcyclodextrins can be accelerated by the addition of co-solubilizers, such as ethanol or ammonia, which again can be...
5118354 Method for making branched cyclodextrins and product produced thereby  
Branched cyclodextrins are made from crystalline cyclodextrin in a fluidized state in an acid environment at a temperature between 110° C. and 170° C.
5116825 Phytosanitary composition, its process for preparation and its use for treating cryptogamic diseases  
Phytosanitary composition, useful particularly for the protection of plants against crypotogamic diseases, characterized in that it contains a source of Cu + + copper ions and at least one...
5114932 Hyperosmolar oxyreplete hemosubstitute  
New blood substitutes are described having osmolarities greater than normal blood. The new blood substitues typically comprise a physiologically acceptable fluid electrolyte solution, a...
5100878 Blocking the effect of teratogens on a fetus  
By administration of sulfated cyclodextrin on a pregnant mother, the effect of a teratogen on a developing fetus is blocked. Blocking the effect of the teratogen reduces congenital defects in a...
5100893 Antipicornaviral pyridazinamines  
Piperidinyl, pyrrolidinyl, azepinyl and piperazinyl pyridazines of formula ##STR1## wherein one or two carbon atoms of the ##STR2## moiety may be substituted with C 1 -4 alkyl, C 1 -4 alkyloxy or...
5096893 Regioselective substitutions in cyclodextrins  
A method for obtaining a desired pattern of substitution of hydroxyalkyl groups on cyclodextrins which comprises controlling the basicity of a reaction mixture comprising epoxide and cyclodextrins...
5096891 Cyclic amp derivative ointments  
An ointment comprising an adenosine 3',5'-cyclic phosphate derivative as an active ingrediment, an ointment base having water-absorbing and drying properties, a saccharide and/or inorganic high...
5095035 Flavor stable zinc acetate compositions for oral absorption  
Thermally, chemically and flavor stable compositions for oral absorption by a human containing zinc acetate with a consumable, sweet pharmaceutical carrier and prepared in the form of a pleasant...
5093127 Preparation of FR115224 substrate for parenteral administration  
A cyclic peptide designated FR115224, administered parenterally in a cyclodextrin carrier, which exhibits antiallergic activity.
5089482 Pharmaceutical compositions for nasal administration containing steroid hormones and dimethyl-β-cyclodextrin  
Pharmaceutical compositions having a formulation and form suitable for nasal administration, and containing 17β-estradiol and/or progesterone. According to the invention, the composition also...
5079237 Inclusion complex of nicardipine or its hydrochloride with beta-cyclodextrin and a sustained release pharmaceutical preparation containing the same  
There is described a new inclusion complex of nicardipine or its hydrochloride with beta-cyclohdextrin, which is prepared by admixing nicardipine or its hydrochloride with beta-cyclodextrin in a...
5079000 Clathrate composition including essential oils and method of using same  
A composition for killing harmful organisms, which contains a clathrate compound composed of one or more natural essential oils and/or derivatives thereof selected from the group consisting of the...
5071838 Treatment of shock by cyclodextrins and their derivatives  
A method for treatment of shock which comprises administering, to a subject in need of such treatment, a cyclodextrin or a derivative thereof in an amount effective in such treatment.
5070081 Inclusion complexes of cyclodextrins by agglomeration  
A combined process is described in which inclusion complexes are formed from guest molecules and cyclodextrins during agglomeration of the cyclodextrins. Sufficient agitation in the presence of a...
5068227 Cyclodextrins as carriers  
Cyclodextrins can be coupled to biorecognition molecules such as antibodies. The cyclodextrins so coupled provide a cavity or complexation zone into which active agents such as labels, drugs and...
5068226 Pharmaceutical preparations containing cyclodextrins and their use in iontophoretic therapies  
Cyclodextrins and especially ionic cyclodextrin derivatives facilitate the iontophoretic delivery of pharmaceutically active agents.
5057502 Composition and topical and systemic treatments of conditions caused by heavy, oily or greasy secretions  
Novel juniper extract materials, having some surfactant properties and other properties, are useful in the thinning of heavy oily, greasy secretions and giving symptom relief in human acne and...
5055288 Vascular magnetic imaging method and agent comprising biodegradeable superparamagnetic metal oxides  
The preparation and isolation of biodegradable superparamagnetic MR imaging contrast agents for the vascular compartment is described. These aggregates are comprised of individual biodegradable...
5043326 Inclusion complex of 7-isopropoxy-isoflavon formed with cyclodextrin, the preparation thereof and pharmaceutical compositions containing these compounds as active ingredients  
The invention relates to the inclusion complexes of 7-isopropoxy-isoflavon formed with cyclodextrin or cyclodextrin derivatives as well as to the pharmaceutical compositions containing these...
5039673 Aminocyclopentyl ethers and their preparation and pharmaceutical formulation  
Compounds are described of the formula (1) ##STR1## where: R 1 is a hydrogen atom or a methyl group; X is cis or trans --CHCH-- or --CH 2 CH 2 --, m is 2, 3 or 4 and n is 1; or X is trans...
5024997 Palatable ibuprofen solutions  
Palatable ibuprofen aqueous base solutions are described which contain dissolved therein ibuprofen and hydroxypropyl beta cyclodextrin, which form an inclusion complex, and sweeteners to mask the...
5019563 Pharmaceutical composition  
Complexes of β-cyclodextrin with various salts of ibuprofen are described in which the molar ratios of ibuprofen to β-cyclodextrin are within the range of from 1:0.20 to 1:0.75. The preferred...
5019562 Growth inhibiting agent and the use thereof  
Pathological or otherwise undesirable cell or tissue growth in mammals, including humans, is inhibited by administering thereto a composition exemplified by (1) a water-soluble cyclodextrin sulfate...
5017566 Redox systems for brain-targeted drug delivery  
Inclusion complexes of hydroxypropyl, hydroxyethyl, glucosyl, maltosyl and maltotriosyl derivatives of β- and γ-cyclodextrin with the reduced, biooxidizable, blood-brain barrier penetrating,...
5010065 Cyclodextrin clathrates of 5-cyanoprostacyclin derivatives and their use as pharmaceutical agents  
The invention relates to cyclodextrin clathrates of 5-cyanoprostacyclin analogs.
5010064 Inclusion complexes of dipyridamole with cyclodextrins  
Inclusion complexes of dipyridamole with beta cyclodextrins in the molar ratio of dipyridamole to cyclodextrin ranging from 1:1 to 1:12 provides higher and more consistent blood concentrations than...
5007966 Cyclodextrin complexing method  
The method employs a ball mill with a charge of cyclodextrin and a guest molecule. The ball mill is operated in a conventional manner for a period between one-half hour to 24 hours. Water can be...
5007967 Separation and purification of branched beta cyclodextrins  
Branched beta cyclodextrins are purified and separated sequentially from solution by passing a solution containing branched beta cyclodextrins through a column containing a matrix on which an...
5002935 Improvements in redox systems for brain-targeted drug delivery  
Inclusion complexes of hydroxypropyl-β-cyclodextrin with the reduced biooxidizable, blood-brain barrier penetrating, lipoidal forms of dihydropyridine⇋pyridinium salt redox systems for...
4992433 Novel pyridazinamine derivatives  
Novel pyridazinamine derivatives having antiviral activity, compositions containing these compounds as active ingredient, and a method of destructing viruses or preventing the growth thereof in...
4985455 External preparations free of discoloration  
External preparations comprising, as active ingredients, kojic acid or a derivative thereof which also contain an ultraviolet absorber, β-cyclodextrin and ethylenediaminetetraacetic acid and have...
4983586 Pharmaceutical formulations for parenteral use  
Aqueous parenteral solutions of drugs which are insoluble or only sparingly soluble in water and/or which are unstable in water, combined with hydroxypropyl-β-cyclodextrin, provide a means for...
4983636 Composition and method of treating selected malignant conditions  
As a result of research work and investigations relating to the effect of benzaldehyde on cell membranes, it was found that benzaldehyde has high activity in the treatment of selected malignant...
4968673 Use of a thromboxane receptor antagonist in renal diseases and dysfunction  
The use is described of [1R-[1α(Z),2β,3β,5α]]-(+)-7-[5-[[(1,1'-biphenyl)-4-y l]methoxy]-3-hydroxy-2-(1-piperidinyl)cyclopentyl]-4-hepteno ic acid or a physiologically acceptable salt, solvate...
4960762 Chiral two-phase system and method for resolution of racemic mixtures and separation of diastereomers  
A chiral two-phase system for resolution of racemic mixtures, or for separation of diastereomers, is disclosed. The system comprises two immiscible liquid phases and one or more enantioselectively...
4956351 Antiviral pharmaceutical compositions containing cyclodextrins  
An antiviral composition for adminisitration to a mammal, in particular, intranasally, for the treatment of the common cold by control of common rhinoviruses. The composition is an inclusion...
4952565 Inclusion complex of ibuproxam with beta-cyclodextrin, a process for preparing the same and a pharmaceutical preparation containing the same  
A new inclusion complex of ibuproxam with beta-cyclodextrin is described, which is prepared by adding ibuproxam to a boiling aqueous solution of beta-cyclodextrin, stirring the reaction mixture at...
4935407 Thermochemiluminescent cyclodextrin complexes  
Thermochemiluminescent complexes of an adamanthylideneadamantane 1,2-dioxetane and a cyclodextrin are non-volatile at the temperatures used to excite the thermochemiluminescence. The complexes can...
4929577 Transparent wound dressings in sheet form  
A transparent gel composition is provided for dressing of skin wounds. The dressing is in the form of a sheet comprising dextrin and a water-swellable, cross-linked polymer selected from...
4923853 Process for enhancing the activity of plant protecting agents by using cyclodextrin  
The invention relates to fungicidal plant protecting composition comprising 3-90% by weight of a fungicidal active ingredient in admixture with 1-90% by weight of cyclodextrin and optionally with...
4904306 Separation and purification of gamma cyclodextrin  
Gamma cyclodextrin is separated and purified by a process that first precipitates the gamma cyclodextrin from solution using a gamma cyclodextrin complexant followed by a step of removing the...
4898852 Cyclopolgalcturonic acid composition and treatment  
Novel Cyclopolyglycuronic acid compounds which are useful in the treatment of symptom relief in human disease including acne, blackheads and other facial lesions.
4891361 Method of minimizing erythema and elastosis  
Drugs containing, as an effective ingredient, kojic acid or kojic acid/β-cyclodextrin inclusion complex are effective in preventing elastosis in an animal test using Spraguex-Dawley rats. The...
4889634 Dialysate solution containing hydroxypropyl-beta-cyclodextrin and method of using same  
A dialysate solution suitable for peritoneal dialysis and containing hydroxypropyl-beta-cyclodextrin is disclosed.
4886788 Cyclodextrin clathrates of carbacyclin derivatives and their use as medicinal agents  
Cyclodextrin clathrates of carbacyclin analogs of general Formula I ##STR1## wherein R 1 is hydrogen, alkyl or alkenyl of up to 10 carbon atoms, A is a --CH 2 CH 2 --, trans--CHCH--, or...
4883785 Complex of anti-fungal agent and cyclodextrin and method  
An anti-fungal complex formed of a polyene anti-fungal agent, such as amphotericin B, and cyclodextrin, preferably γ-cyclodextrin, is provided. The complex which includes amphoterin B has improved...
4877774 Administration of steroid hormones  
Crystalline complexes of steroid hormones with gamma-cyclodextrin are prepared by mixing the components together. Tablets can be formed from the complexes, which can be administered by contact with...
4877778 Method of enhancing lipophile transport using cyclodextrin derivatives  
Levels of cholesterol, vitamin A, triglycerides, and other lipophiles in the human circulation can be manipulated by intravenous infusion of cyclodextrin-type compounds. The cyclodextrin-type...
Matches 351 - 400 out of 475 < 1 2 3 4 5 6 7 8 9 10 >