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5385891 |
Polysulfate of β-cyclodextrin derivative and process for preparing the same
Disclosed is a polysulfate of a β-cyclodextrin in which at least one of 7 D-glucose units constituting the β-cyclodextrin is a unit represented by the formula (I-a): ##STR1## wherein R 1 is an...
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5382571 |
Clathrates of peroxyacids, their preparation and their uses
The invention concerns derivatives of peroxyacids consisting of inclusion compounds or clathrates, in a hollow molecule which is capable of behaving as a receiving structure which respect to a...
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5380717 |
Food composite for performing function of large bowel regulation
A food composite performing a function of large bowel regulation and comprising a refined product of pyrodextrin obtained as an active ingredient through a process of decomposing starch or starch...
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5380522 |
Method for treatment of irritable bowel syndrome
A method of treating irritable bowel syndrome, including diarrhea, constipation, and pain aspects thereof, in a human patient, whereby the method involves the step of orally administering to the...
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5380711 |
Methods for delipidation of skin and cerumen removal
The present invention provides delipidating compositions containing essentially oil-free "empty" cyclodextrin compositions. It also provides compositions for use in removal of cerumen from the ear....
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5376645 |
Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
Sulfoalkyl ether cyclodextrin derivatives and their use as solubilizing agents for water insoluble drugs for oral, intranasal, or parenteral administration are disclosed.
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5376632 |
Cyclodextrin based erythropoietin formulation
The present invention relates to a new pharmaceutical composition for parenteral and local administration comprising an aqueous solution of erythropoietin and a β- or γ-cyclodextrin hydroxyalkyl...
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5376641 |
Method for making a steroid water soluble
A complex of branched beta cyclodextrin and steroid is formed by mixing a steroid and a branched beta cyclodextrin together in water for a period of about 4 to 24 hours under ambient conditions....
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5376386 |
Aerosol carriers
Pharmaceutical excipients useful in dry powder inhalents comprise particles having a rugosity (measured by air permeametry) of less than 1.75. The use of these carriers increases the amount of drug...
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5356884 |
Hetero-branched cyclodextrins
A hetero-branched cyclodextrin (CD) having a glucosyl or maltosyl group as the side chain, in which a mannosyl group is α-bonded to the hydroxyl group of the glucosyl group of the side chain; and...
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5344824 |
Method for reducing insulin secretion
A food composite for saving insulin secretion comprising a refined product of pyrodextrin obtained as an active ingredient through a process of decomposing starch or starch hydrolyzate by heating...
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5340580 |
Agglomerated psyllium husk containing edible acid
Agglomerated psyllium husk comprising edible acid uniformly dispersed throughout the agglomerating coating. Preferred are maltodextrin-containing agglomerates of psyllium husk comprising citric...
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5324718 |
Cyclodextrin/drug complexation
The invention provides a method for enhancing the complexation of a cyclodextrin with a lipophilic and/or water-libile drug, comprising combining from about 0.1 to about 70% (weight/volume) of a...
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5324750 |
Compositions and methods for drug delivery and chromatography
Cyclodextrin derivatives and inclusion complexes having increased solubility and stability are provided. Cyclodextrin derivatives include amino and other modified cyclodextrins, and linked...
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5321014 |
Molecular encapsulation and delivery of alkenes alkynes and long chain alkanes, to living mammalian cells
A complex of a cyclodextrin and an alkane, alkene, alkyne, aromatic compound, etc. can be prepared according to the method of the present invention. These complexes can be delivered to prokaryotic...
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5314877 |
Water-soluble pentacyclic triterpene composition and method for producing the same
Disclosed is water-soluble composition made by subjecting pentacyclic triterpene compound belonging to amylin group such as oleanolic acid, ursolic acid and hederagenin to inclusion in...
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5312815 |
Fungicidal (+)-2-(2,4-difluorophenyl)-3-methyl-1-(1H-1,2,4-triazol-1-yl)3-(6-(1H-1, 2,4-triazol-1-yl)pyridazin-3-ylthio) butan-2-ol
(+)-2-(2,4-Difluorophenyl)-3-methyl-1-(1H-1,2,4-triazol-1-yl
)-3-(6-(1H-1,2, 4-triazol-1-yl)pyridazin-3-ylthio)butan-2-ol and a pharmaceutically acceptable salt thereof useful as an antifungal...
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5298496 |
Inclusion complexes of 3-morpholino-sydnonimine or its salts or its tautomer isomer, process for the preparation thereof, and pharmaceutical compositions containing the same
The invention relates to inclusion complexes of 3-morpholino-sydnonimine or its salts or its tautomer isomer, process for the preparation thereof and pharmaceutical compositions containing the...
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5298410 |
Lyophilized formulation of polyethylene oxide modified proteins with increased shelf-life
Disclosed are lyophilized biologically active proteinaceous compositions containing low diol polyalkylene oxide, such as polyethylene glycol, covalently attached to a biologically active...
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5294606 |
Isotonic energy composition and method to use same
This invention relates to an isotonic energy composition including the carbohydrates, fructose and maltodextrin, the electrolytes, zinc, chromium, calcium, potassium, magnesium, sodium, and the...
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5292723 |
Liquid nutritional compositions comprising slowly absorbed glucides
Novel liquid nutritional compositions comprising a lipid fraction, a protein fraction and a specific combination of glucides useful as dietetics and therapeutics.
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5275824 |
Therapeutic compositions with controlled release of medicaments supported on crosslinked polymers and coated with polymer films, and their preparation process
The described therapeutic compositions with controlled release of medicaments comprise a medicament loaded onto particles of a crosslinked non-ionic polymer insoluble but swellable in water, using...
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5273820 |
Separation and purification of cyclodextrins
A method for separating and purifying cyclodextrins is disclosed. This method is also able to sequentially separate alpha, beta and gamma cyclodextrins. The method entails forming a matrix with an...
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5260304 |
Pharmaceutical preparation binding with gastric acid
Granules, possibly pressed into the form of tablets, contain at least one insoluble, complexed or slightly soluble active substance in powder form which can bind or neutralize acids and which does...
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5258370 |
Artificial redox enzymes
Artificial redox enzymes are disclosed wherein one or more redox coenzymes or cofactors are linked to the 2-O, 3-O or 6-O positions of a D-glucopyranose ring of α-, β-, or γ-cyclodextrins. Also...
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5258175 |
Treatment of poisoning and compositions for use therein
A dextrin derivative, in which a proportion of the hydroxyl groups in the dextrin have been replaced by strongly acidic groups, is useful in treatment of poisoning or drug overdose, particularly by...
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5256652 |
Topical compositions and methods for treatment of male impotence
A topical composition which enhances the maintenance of penis erection is disclosed. An effective dosage of a peripheral vasodilator, an absorption enhancer and, optionally, a vasoconstrictor and...
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5254541 |
(Quinolin-2-ylmethoxy)indole/cyclodextrin complex
A complex of cyclodextrin and 3-[N-(p-chlorobenzyl)-3-(t-buthylthio)-5-(quinolin-2-ylmetho
xy)indol-2-yl] -2,2-dimethylpropanoic acid, sodium salt is more soluble in water than the sodium salt...
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5252562 |
Acetohydroxamic compound and complexes pharmaceutical compositions containing them and processes of preparation and use
An acetohydroxamic acid compound of formula I ##STR1## as such or in form of a complex with β-cyclodextrin or hydroxypropyl-β-cyclodextrin specifically inhibits 5-lipoxygenase and is useful in...
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5250520 |
Polysulfate of cyclodextrin derivative and process for preparing the same
A polysulfate of a cyclodextrin in which at least one of 6 to 8 D-glucose units constituting the cyclodextrin has been replaced by a unit represented by Formula(1): ##STR1## wherein R is a group...
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5248667 |
Method of treating psoriasis using synthetic peptide compositions
Peptides previously disclosed as useful for preventing HIV from binding to cell binding sites have now been shown to have thymoleptic qualities and to be useful for tretment of psoriasis in...
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5244881 |
Compositions based on imipyramine
The invention provides new inclusion compounds based on imipramine and cyclodextrin and pharmaceutical compositions which can be administered orally and are based on these new inclusion compounds.
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5236944 |
Compounds, compositions and anti-neoplastic methods
Method of treating neoplasms hosting in mammals by administering a C 1 -4 alkyl [4-[2-(4-C 1 -4 alkylphenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-ylmet
hyl-thio]pheny l]carbamate....
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5231089 |
Method of improving oral bioavailability of carbamazepine
The invention provides a method for improving the oral bioavailability of carbamazepine by administering per os, to a warm-blooded animal in need of carbamazepine therapy, a therapeutically...
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5229370 |
Water soluble branched beta cyclodextrin steroid complex
A complex of branched beta cyclodextrin and steroid is formed by mixing a steroid and a branched beta cyclodextrin together in water for a period of about 4 to 24 hours under ambient conditions....
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5227372 |
Method for retaining ophthalmological agents in ocular tissues
A method for retaining ophthalmological agents in ocular tissues is provided comprising complexing an ophthalmological drug or reagent with a sulfated glucan sulfate such as cyclodextrin sulfate...
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5221695 |
Aqueous formulation containing a piperidinylcyclopentylheptenoic acid derivative and beta-cyclodextrin
Aqueous formulations comprising [1R-[1α(Z),2β,3β,5α]]-(+)-7-[5-[[(1,1'-biphenyl)-4-y l]methoxy]-3-hydroxy-2-(1-piperidinyl) cyclopentyl]-4-heptenoic acid or its hydrochloride salt and an...
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5221669 |
Antiviral compositions containing α-cyclodextrin sulfates alone and in combination with other known antiviral agents and glucocorticoids and methods of treating viral infections
The present invention is directed to antiviral compositions containing α-cyclodextrin sulfates alone and in combination with other known antiviral agents and glucocorticoids and methods of...
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5206008 |
Enhancement of immune response
The present invention provides an improved means for regulating the immune response, for ameliorating effects of stress, and for avoiding untoward effects of chemotherapy or exposure to irradiation...
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5206025 |
Porous pharmaceutical form and its preparation
New porous, unitary freeze-dried pharmaceutical form, of homogeneous appearance, consisting of: a) an inclusion compound comprising: one or optionally more active substances, a...
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5206224 |
Treatment of male hormone related diseases by cyclodextrins and their derivatives
A method for treatment of diseases having an etiology based on or accompanied by excess male hormone which comprises administering, to a subject in need of such treatment, a cyclodextrin or a...
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5198430 |
Inclusion complexes with silybinin, their preparation and pharmaceutical compositions containing them
The invention relates to inclusion complexes of Silybinin with a cyclodextrin selected from the group consisting of α-, β- and γ-cyclodextrin and a suitable derivative thereof and to the method...
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5196406 |
Cyclodextrin complex of fumagillin derivative
A complex of a fumagillin derivative represented by the general formula: ##STR1## wherein R 1 is hydrogen; R 2 is halogen, N(O)mR 5 R 6 , N + R 5 R 6 R 7 .X - , S(O)nR 5 or S + R 5 R 6 .X...
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5189149 |
Method for the production of complexes of long chain polyunsaturated fatty acids and their derivatives, with cyclodextrins, and the resulting complexes
A method for the production of a complex formed by a long chain polyunsaturated fatty acid, a salt of it, alkyl ester C 1 -C 3 or glyceride, or a mixture thereof, with a cyclodextrin, and the...
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5182270 |
Stabilizing preparation for thymoxamine
Experiments have been performed which test the stability of thymoxamine in aqueous solution at room temperature and above. It was determined that dimethyl-beta-cyclodextrin slows the hydrolysis...
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5180716 |
Cyclodextrin complexes for neuraxial administration of drugs
A method of delivering a drug to a patient, comprising administering said drug to the neuraxis of said patient in the form of a complex between said drug and a cyclodextrin, the cyclodextrin...
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5173481 |
Preparation of specifically substituted cyclodextrins
A process for producing monosubstituted alpha-, beta-, and gamma-cyclodextrins includes the step of condensing an excess of a cyclodextrin with an epoxide under alkaline conditions. A process for...
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5164379 |
Sucralfate/cyclodextrin complexes
Complexes of sucralfate with alpha cyclodextrin, beta cyclodextrin, gamma cyclodextrin or 2-hydroxypropyl beta cyclodextrin are disclosed. Also disclosed are a process for producing complexes and...
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5164380 |
Process for preparing piroxicam/cyclodextrin complexes, the products obtained and their pharmaceutical compositions
A process for preparing complexes of piroxicam with cyclodextrins in which the two components in the powder state are premixed and then co-ground in a high energy mill in the presence of steam. The...
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5135919 |
Method and a pharmaceutical composition for the inhibition of angiogenesis
Fumagillin and its salts have an angiogenesis inhibiting activity and are useful for prophylaxis and treatment of diseases induced by abnormally stimulated neovascularization. The invention also...
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