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7557140 |
Carbamic acid compounds comprising a sulfonamide linkage as HDAC inhibitors
This invention pertains to certain active carbamic acid compounds which inhibit HDAC activity and which have the following formula: (I) A is an aryl group; Q 1 is a covalent bond or an aryl leader...
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7534918 |
Histone deacetylase inhibitors
This invention relates to hydroxamic acid derivatives having a sulfonamide linkage, that are inhibitors of histone deacetylase (HDAC), and are useful in the prevention and/or treatment of cellular...
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7504436 |
Bioisosteres of actinonin
The present invention relates to novel bioisosteres of the antibiotic actinonin of the general formula (I). The novel compounds are of particular interest as inhibitors of metalloproteinases.
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7495022 |
α,β-unsaturated hydroxamic acid derivatives and their use as histone deacetylase inhibitors
Disclosed are agents that inhibit histone deacetylase. More specifically, the present invention relates to novel hydroxamic acid derivatives or pharmaceutically acceptable salts thereof for...
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7488754 |
Method for the treatment of polycystic kidney disease
The present invention provides a method for treating, inhibiting the progression of, or eradicating polycystic kidney disease of in a patient in need thereof which comprises providing to said...
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7485750 |
Hydroxamic acid derivatives and the preparation method thereof
The present invention provides hydroxamic acid derivatives represented by the formula, having antioxidation, collagen biosynthesis promotion and skin pore contraction effects, and a method for...
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7456219 |
Polymorphs of suberoylanilide hydroxamic acid
The present invention provides methods of selectively inducing terminal differentiation, cell growth arrest and/or apoptosis of neoplastic cells, and/or inhibiting histone deacetylase (HDAC) by...
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7399787 |
Methods of treating cancer with HDAC inhibitors
The present invention provides methods of treating cancers, chemoprevention, selectively inducing terminal differentiation, cell growth arrest and/or apoptosis of neoplastic cells, and/or...
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7312247 |
Histone deacetylase inhibitors
Histone deacetylase is a metallo-enzyme with zinc at the active site. Compounds having a zinc-binding moiety, such as, for example, a hydroxamic acid group or a carboxylic acid group, can inhibit...
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7282522 |
Hydroxamic acid derivatives and the method for preparing thereof
The present invention provides hydroxamic acid derivatives which have anti-aging efficacy and a method for preparation thereof. It is further provided skin-care external compositions for preventing...
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7282496 |
Allenic aryl sulfonamide hydroxamic acids as matrix metalloproteinase and TACE inhibitors
Compounds of the formula
are useful in treating disease conditions mediated by TNF-α, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis,...
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7271152 |
Compounds and methods for the modulation of CD154
The present invention relates to compounds that are capable of modulating CD154 mobilization and that are useful for stabilizing the thrombotic process and reducing the activation of cells involved...
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7183319 |
Phenylethylamine derivatives and their use in the treatment of melanoma
Novel mono- and dihydroxy phenylethylamine derivatives useful in treating melanoma are provided having the formulae (Ia, Ib or Ic). In the above formulae, R a is hydrogen or —COOR b , R b is...
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7183298 |
Carbamic acid compounds comprising a sulfonamide linkage as HDAC inhibitors
This invention pertains to certain active carbamic acid compounds which inhibit HDAC activity and which have the following formula: (I) A is an aryl group; Q 1 is a covalent bond or an aryl leader...
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7163703 |
Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds
The invention relates to the use of arsenic compounds to treat a variety of neoplastic diseases. The present invention encompasses the administration to a mammal of arsenic in the form of a salt,...
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7067551 |
Deacetylase inhibitors
The present invention provides hydroxamate compounds which are deacetylase inhibitors. The compounds are suitable for pharmaceutical compositions having anti-proliferative properties.
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7053071 |
Induction of apoptosis in cancer cells
The present invention provides compounds that are inducers or inhibitors of apoptosis or apoptosis preceded by cell-cycle arrest. In addition, the present invention provides pharmaceutical...
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6989401 |
Sulfonic acid derivatives of hydroxamic acids and their use as medicinal products
The present invention relates to a novel sulfonic acid derivative of hydroxamic acid or a pharmacologically acceptable salt thereof. More particularly, the present invention relates to a sulfonic...
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6982097 |
Biocidal compositions and methods of using same
This invention relates to biocidal compositions and methods of using same. Also provided is a process for the manufacturing of a biocidal composition in the form of a tablet and a method of using...
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6936639 |
Nitroxyl progenitors in the treatment of heart failure
Administration of an HNO/NO − donating compound, such as Angeli's salt, increases myocardial contractility while concomitantly lowering left ventricular preload in subjects experiencing heart...
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6924308 |
Therapeutic process for inhibiting NF-κB
A therapeutic process is provided for the inhibition of NF-κB in mammals in whose cells NF-κB has been activated by an agency external to said cell.
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6911473 |
Detectable agent for wood treatment and method for its detection
The present invention relates to a composition comprising an organic preservative acid and a UV-active indicator substance for preserving wood and for detection of the sufficient preservation of wood.
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6881727 |
Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same
Compounds having a metalloproteinase inhibitory activity, represented by the formula (I), its optically active isomers, their pharmaceutically acceptable salts, or hydrates thereof.
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6844366 |
Sulfonamide hydroxamates
This invention relates to certain sulfonamide derivatives that are inhibitors of procollagen C-proteinase, pharmaceutical compositions containing them, methods for their use and methods for...
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6809118 |
Methods for therapy of radiation cutaneous syndrome
Compounds of a histone deacetylase inhibitor. The compounds are capable of simultaneously stimulating epithelium regrowth, inhibiting cutaneous fibroblast proliferation, decreasing collagen...
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6790834 |
Cytostatic agents
Compounds of formula I are disclosed wherein R 4 is an ester or thioester group, and R, R 1 , R 2 , and R 3 are as defined in the specification are inhibitors of rapidly dividing tumor cells.
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6770644 |
Hydroxamic acid derivatives, process for the production thereof and drug containing the same as the active ingredient
Hydroxamic acid derivatives of the formula (I) (wherein all the symbols have the same meaning as defined in the specification.), non-toxic salt thereof or prodrugs thereof. The compounds of the...
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6759432 |
Medical use of matrix metalloproteinase inhibitors for inhibiting tissue contraction
The use of an MMP inhibitor, especially a collagenase inhibitor, in the manufacture of a medicament for the treatment of a natural or artificial tissue comprising extracellular matrix components to...
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6716878 |
Antimicrobial agents
Compounds of formula (I) are antibacterial agents: wherein Z represents a radical of formula —N(OH)CH(═O) or of formula —C(═O)NH(OH), and R 1 -R 4 are as defined in the specification. A...
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6716844 |
Aromatic sulfonyl alpha-hydroxy hydroxamic acid compounds
An aromatic sulfonyl aipha-hydroxy hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed, as is a treatment process that comprises administering a...
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6696449 |
Sulfonyl aryl hydroxamates and their use as matrix metalloprotease inhibitors
This invention is directed to sulfonyl aromatic hydroxamic acid compounds and salts thereof that, inter alia, inhibit matrix metalloprotease (MMP) activity and/or aggrecanase activity. In some...
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6689771 |
Amide derivatives as inhibitors of matrix metalloproteinases, TNF-α, and aggrecanase
The present application describes novel amides and derivatives thereof of formula I: or pharmaceutically acceptable salt forms thereof, wherein these compounds are useful as inhibitors of matrix...
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6610729 |
Hydroxamic acid derivatives and medicinal utilization thereof
The present invention relates to a hydroxamic acid derivative of the formula (I) wherein each symbol is as defined in the specification, a pharmacologically acceptable salt thereof, a...
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6608112 |
Use of metalloproteinase inhibitors in the treatment and prevention of pulmonary emphysema
The invention provides a use of a metalloproteinase inhibitor for the preparation of a pharmaceutical composition for treating human pulmonary emphysema which comprises admixing the...
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6569895 |
Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
Tetrahydrofurans, tetrahydrothiophenes, pyrrolidines and cyclopentanes are disclosed that reduce the chemotaxis and respiratory burst leading to the formation of damaging oxygen radicals of...
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6566384 |
Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity
Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity.
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6545051 |
Antibacterial hydroxamic acid derivatives
A method for the treatment of bacterial infections in humans and non-human mammals, which comprises administering to a subject suffering such infection an antibacterial effective dose of a compound...
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6511990 |
Class of cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof
The present invention provides the compound having the formula: wherein each of R 1 and R 2 is, substituted or unsubstituted, aryl, cycloalkyl, cycloalkylamino, naphtha, pyridineamino,...
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6509380 |
Method of treating iron overload with acetaminophen
The present invention relates to methods of controlling iron overload in a patient in need thereof. The present invention particularly relates to methods of treating hemochromatosis and other...
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6506764 |
Hydroxamic and carboxylic acid derivatives
Compounds of the formula B—X—(CH 2 ) m —CR 1 R 2 —(CH 2 ) n —CO—Y (I) have therapeutic utility as inhibitors of metalloproteinases etc.
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6503947 |
Method of treating cytotoxic damage
The invention features methods of treating cytotoxic damage in a subject comprising administering to the subject a substance which is a complement inhibitor, free radical scavenger, or both, to...
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6495597 |
Cytostatic agents
Compounds of formula (I) wherein R 4 is an ester or thioester group and R, R 1 , R 2 and R 3 are as defined in the specification, inhibit proliferation of tumor cells.
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6492422 |
Tricyclic sulfonamides and their derivatives as inhibitors of matrix metalloproteinases
Tricyclic sulfonamide compounds and derivatives are described as well as methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix...
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6476027 |
N-hydroxy 4-sulfonyl butanamide compounds
An N-hydroxy sulfonyl butanamide compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a contemplated N-hydroxy...
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6403647 |
Pulsed administration of compositions for the treatment of blood disorders
The invention relates to novel compositions and to methods for the pulsed administration of compositions to a patient or to cells in vitro for the treatment of human blood disorders. Compositions...
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6344485 |
Method for treating glaucoma
Methods of using prostaglandin agonists for the reduction of intraocular pressure, and accordingly glaucoma.
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6344457 |
Amino acid derivatives inhibiting extracellular matrix metalloproteinase and TNF alpha release
The invention concerns compounds of general formula (X) in which Y represents in particular —CONHOH, R 1 represents in particular a C 1 -C 5 alkyl group, AA represents an amino acid, or an...
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6329373 |
Metalloproteinase inhibitors
A compound of formula (I) ##STR1## wherein X is a --CONHOH group and the R groups are defined in the claims. The compounds are inhibitors of matrix metalloproteinases involved in tissue degradation...
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6326516 |
Acetylenic β-sulfonamido and phosphinic acid amide hydroxamic acid TACE inhibitors
The invention discloses hydroxamide acids of the formula: ##STR1## which are useful in treating disease conditions mediated by TNF-α, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS,...
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6326014 |
Use of oxamate derivatives as depigmenting agents
The invention relates to the use of oxamate derivatives in a composition, as agents for depigmenting and/or bleaching human skin, head hair and/or other hairs. The invention also relates to a...
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