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7381748 |
Compounds and related methods for inhibition of gamma-aminobutyric acid aminotransferase
(1S, 3S)-3-Amino-4-difluoromethylene-1-cyclopentanoic acid illustrates a novel class of compounds as potent irreversible inhibitors of γ-aminobutyric acid aminotransferase (GABA-AT). The...
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7358226 |
Ultrasonic concentration of drug delivery capsules
Methods, compositions and apparatus for localized delivery of compounds are provided. In certain embodiments, radiation force is used to direct carriers to a target site, and additional radiation...
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7318930 |
Control methods for boring bark beetles
A composition which causes adult boring bark beetles to discontinue boring, discontinue laying eggs and become disoriented and bore out of the tree or cease boring altogether and die is described....
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7258850 |
Methods and compositions for treating erectile dysfunction
Methods are provided for increasing libido and/or treating erectile dysfunction in a man. The methods include the administration of a formulation testosterone alone, another fast-acting drug to...
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7241746 |
Method and composition for treating periodontal disease
The present invention is directed to a pharmaceutical composition comprising a therapeutically effective amount of misoprostol and an effective amount of an antibiotic. A suitable antibiotic is...
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7223746 |
Omega cycloalkyl 17-heteroaryl prostaglandin E2 analogs as EP2-receptor agonists
The invention relates to the use of derivatives of E-type prostaglandins as EP 2 agonists, in general, and, in particular as ocular hypotensives. The PGE derivatives used in accordance with the...
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RE39609 |
8-iso-prostaglandins for glaucoma therapy
The present invention relates to the use of 8-iso prostaglandins and their derivatives for decreasing intraocular pressure, for example in the treatment of glaucoma It is based, at least in part,...
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7169580 |
Protein having PGE2 synthase activity and use thereof
A single protein which is the substance of the PGE2 synthesis activity in brain soluble fractions of LPS administered rats has been purified and identified. The protein has an activity of...
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7151094 |
Topical administration of amifostine and related compounds
The present invention is directed to methods of treating or protecting mucosal tissue from damage associated with radiation and/or chemotherapeutic treatment of cancers, by the topical application...
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7132453 |
Method of using prostacyclin to treat respiratory syncytial virus infections
The present invention discloses methods and a kit for treating a respiratory syncytial virus infection. The method comprises providing an infection modulator, and administering a therapeutically...
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7129272 |
Apoptosis inhibitor
Disclosed is a method for treatment of a subject having a disease or condition associated with apoptosis, which comprises administering to the subject an effective amount of a 15-keto-prostaglandin...
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7105571 |
Prostaglandin compositions and methods of treatment for male erectile dysfunction
The invention provides methods and compositions for treating erectile dysfunction. The methods include the step of placing within the fossa navicularis of the patient an effective erection-inducing...
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7064148 |
Chloride channel opener
Disclosed is a novel use of a prostaglandin compound as a chloride channel opener. According to the instant invention, chloride channels in a mammalian subject can be opened by a prostaglandin...
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6992093 |
Method of inhibiting lipofibroblast to myofibroblast transdifferentiation
Methods of inhibiting lipofibroblast to myofibroblast transdifferentiation in a mammal are disclosed comprising administering a PPAR gamma ligand when said mammal is exposed to a hyperoxic condition.
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6982283 |
Method for treating drug-induced constipation
Provided is a method for treating drug-induced constipation comprising a step of administering an effective amount of a 15-keto-prostaglaindin compound to a subject suffering from drug-induced...
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6982097 |
Biocidal compositions and methods of using same
This invention relates to biocidal compositions and methods of using same. Also provided is a process for the manufacturing of a biocidal composition in the form of a tablet and a method of using...
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6956057 |
EP4 agonists as agents for lowering intraocular pressure
The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective...
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6956056 |
Method for providing a cathartic effect
The present invention relates to a novel method for providing a cathartic effect to a patient in need of cathartic induction, which comprises administering to the patient a cathartic-inducing...
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6949526 |
Erectile dysfunction remedies containing prostaglandin derivatives as the active ingredient
Therapeutic agents for erectile dysfunction containing as the active ingredient prostaglandin derivatives of formula (I)
(wherein, R 1 is ethyl or n-2-propenyl.), esters thereof, nontoxic...
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6911473 |
Detectable agent for wood treatment and method for its detection
The present invention relates to a composition comprising an organic preservative acid and a UV-active indicator substance for preserving wood and for detection of the sufficient preservation of wood.
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6897239 |
Use of misoprostol and/or metabolites of misoprostol for treating sexual dysfunction in women
Topical application of a prostaglandin directly to the clitoris is effective for enhancing female sexual desire and responsiveness.
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6875787 |
10,10-dialkyl prostanoic acid derivatives as agents for lowering intraocular pressure
The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective...
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6841574 |
Topical stabilized prostaglandin E compound dosage forms
Compounds of prostaglandin E group (PGE compounds) are stabilized as non-aqueous compositions that include the compound together with a bulking agent that can be a non-aqueous liquid or a solid in...
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6825234 |
Compositions and methods for amelioration of human female sexual dysfunction
The invention provides compositions and methods suitable for ameliorating female sexual dysfunction, and in particular, female sexual arousal disorder. In one embodiment, the invention provides a...
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6825232 |
Use of hydroxyeicosatetraenoic acid compounds to treat ophthalmic inflammatory disorders
The topical use of HETE compounds to treat ophthalmic inflammatory disorders involving cytokines is disclosed.
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6794413 |
Compounds and related methods for inhibition of &ggr -aminobutyric acid aminotransferase
(1S, 3S)-3-Amino-4-difluoromethylene-1-cyclopentanoic acid illustrates a novel class of compounds as potent irreversible inhibitors of γ-aminobutyric acid aminotransferase (GABA-AT). The...
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6770675 |
Compositions and methods for reducing ocular hypertension
An improved ophthalmic composition, including docosanoid active agents, which is especially useful in lowering intraocular pressure associated with glaucoma. Improvements in IOP reduction efficacy,...
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6756407 |
Method and compositions for the treatment or amelioration of female sexual dysfunction
The present invention provide a method of treating sexual dysfunction in a female, including the vasculogenic symptoms of delayed vaginal engorgement, diminished vaginal lubrication, pain or...
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6756033 |
Method for delivering benzindene prostaglandins by inhalation
A method of delivering benzindene prostaglandins to a patient by inhalation is discussed. A benzindene prostaglandin known as UT-15 has unexpectedly superior results when administered by inhalation...
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6747063 |
Combination therapy for treatment of erectile dysfunction
In the field of treatment of erectile dysfunction there is disclosed a novel therapy in which the actions of an agent or agents, produce a combination of effects to induce effective erection (and...
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6723748 |
Use of cloprostenol and fluprostenol analogues to treat glaucoma and ocular hypertension
Disclosed is the use of cloprostenol and fluprostenol analogues in combination with carbonic anhydrase inhibitors for the treatment of glaucoma and ocular hypertension and ophthalmic compositions...
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6716876 |
Cyclopentane(ENE)heptenoic or heptanoic acids and derivatives thereof useful as therapeutic agents
The invention relates to 7-[5-hydroxy-2-(hydroxyhydrocarbyl or heteroatom-substituted hydroxy hydrocarbyl)-3-hydroxy-cyclopentyl(enyl)] heptanoic or heptenoic acids and derivatives of said acids,...
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6710081 |
Erection insufficiency remedies
Therapeutic agents for erectile dysfunction containing as the active ingredient prostaglandin derivatives of formula (I) (wherein symbols have the same meanings as described in the description),...
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6703423 |
Inhibition of TNFα-initiated neutrophil response
The impact of lipoxin A 4 (LXA 4 ) and aspirin-triggered-lipoxins (ATL) was investigated in tumor necrosis factor (TNFα)-initiated neutrophil (PMN) responses in vitro and in vivo using...
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6693135 |
Prostaglandin compositions and methods of treatment for male erectile dysfunction
The invention provides methods of treating erectile dysfunction comprising the step of placing within the fossa navicularis of the patient an effective erection-inducing amount of a prostaglandin E...
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6686388 |
Regulators of the hedgehog pathway, compositions and uses related thereto
The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function...
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6680339 |
15-fluoro prostaglandins as ocular hypotensives
15-fluoro substituted analogs of PGF 2α and methods of their use in treating glaucoma and ocular hypertension are disclosed.
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6680337 |
Cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents
The present invention provides cyclopentane heptanoic acid, 2 heteroaryl alkyl or alkenyl derivatives which may be substituted in the 1-position with hydroxyl, alkyloxy, amino and amido groups,...
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6673841 |
Alprostadil alkyl ester-containing composition for external application
The present invention relates to a composition of topical preparation containing alprostadil alkyl ester, and more particularly, comprising an alprostadil alkyl ester, an oily vehicle, a skin...
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6656969 |
Methods and compositions for inhibiting the proliferation of prostate cancer cells
The invention provides for methods of monitoring the proliferation of cultured prostate cancer cells in the presence of omega-3 fatty acids, methods of treating an individual with prostate cancer...
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6649655 |
11β-fluoro 15β-hydroxy PGF2α analogs as FP receptor antagonists
Methods and compositions for the antagonism of FP receptor-mediated biological responses are disclosed.
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6649653 |
15-fluoro prostaglandins as ocular hypotensives
15-Fluoro substituted analogs of PGF 2α and methods of their use in treating glaucoma and ocular hypertension are disclosed.
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6646008 |
Treatment of disease states which result from neoplastic cell proliferation using PPAR-&ggr activators and compositions useful therefor
In accordance with the present invention, it has been discovered that PPARγ is expressed consistently in tissues associated with each of a variety of disease states which result from neoplastic...
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6646001 |
Use of non-steroidal anti-inflammatory agents in combination with prostaglandin FP receptor agonists to treat glaucoma and ocular hypertension
Disclosed are methods and compositions for the treatment of glaucoma and ocular hypertension, comprising the administration of a prostaglandin FP receptor agonist and a prostaglandin synthesis...
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6642274 |
Methods and compositions for preventing and treating prostate disorders
The present invention relates to methods, compositions, devices and kits for the prevention and treatment of prostate disorders in mammals, including, but not limited to, benign prostatic...
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6632419 |
Increasing libido in humans via acute testosterone administration
The libido of adult human female patients is increased by the bolus delivery of a testosterone which is preferably dihydrotestosterone. The formulation is preferably aerosolized and inhaled into a...
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6610719 |
Use of prostaglandin (PGE2) receptor a (EP4) selective agonists for the treatment of acute and chronic renal failure
This invention is directed to methods and compositions of treating acute or chronic renal failure or dysfunction, or conditions caused thereby, comprising administering prostaglandin agonists,...
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6602487 |
Methods and tests for producing and for inhibiting coronary artery vasospasms
Methods for producing coronary vasospasms and for inhibiting coronary vasospasms are disclosed. Both in vivo and in vitro methods are disclosed. The methods are useful as tests for determining the...
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6596765 |
Treatment of ocular hypertension and glaucoma
15-keto latanoprost and other 15-keto prostaglandin analogs are used as ocularly applied intraocular pressure reducing agents.
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6593369 |
Methods, compositions, and kits for enhancing female sexual desire and responsiveness
Topical application of a prostaglandin directly to the clitoris is effective for enhancing female sexual desire and responsiveness.
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