Matches 251 - 300 out of 448 < 1 2 3 4 5 6 7 8 9 >
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5015634 Method of treating tissue damage with inositol triphosphate  
A method of preventing or alleviating tissue or bone damage in mammals is disclosed. The method comprises administering, to a mammal, a tissue damage or a bone damage preventing or alleviating...
5013758 Novel carbacyclins, processes for their preparation and their use as medicinal agents  
(5E)-13,14,18,18,19,19-hexadehydro-3-oxa-6a-carbaprostagland in I 2 derivatives of Formula I ##STR1## wherein R 1 , R 2 , R 3 , R 4 are hydrogen or alkyl of 1-5 carbon atoms, and R 5 is an...
5004752 Novel 9-haloprostaglandins, processes for their preparation, and their use as medicinal agents  
The invention relates to 9-halo-15-cycloalkyl prostaglandin derivatives of Formula I ##STR1## wherein R 1 is hydrogen or methyl, R 2 is fluorine or chlorine, n is 0 or 1, and, if R 1 is...
5001154 Fervescence composition  
This invention provides a fervescence composition containing 15-keto-PHEs separated from any substantial activity such as decrease of blood pressure.
4997823 Anti-infective injectable formulations  
Infection associated with parenteral injections of parenterally suitable compounds, especially of F 2 α prostaglandins, is prevented by novel compositions comprising such compounds, a locally...
4983629 11-haloprostane derivatives, processes for their preparation and their use as medicinal agents  
11-Haloprostane derivatives of general Formula I ##STR1## wherein X is F, Cl or Br, R 1 is the residue CH 2 OH or ##STR2## wherein R 2 means a hydrogen atom, an alkyl, cycloalkyl, aryl,...
4981872 Prostaglandin derivatives, their preparation and their therapeutic use  
Prostaglandin derivatives having an oxo group at specified positions in the α side chain have a variety of physiological effects, notably a strong anti-ulcer activity accompanied by a limited...
4971987 New carbacycline, process for their production and their use as a drug  
The invention also relates to carbacyclin derivatives of general formula I' ##STR1## wherein R 9 is an alkyl group of 1-10 carbon atoms or the group --CC--(CH 2 ) m --R 6 wherein m is 1 to...
4955878 Kit for preventing or treating arterial dysfunction resulting from angioplasty procedures  
A kit for preventing or treating arterial dysfunction resulting from an angioplasty procedure and particularly, in myocardial angioplasty procedures in human beings. The kit provides the materials...
4954524 Carbacylcins, their preparation and use as medicinal agents  
Carbacyclin derivatives of Formula I ##STR1## wherein R 1 is hydrogen or OR 2 , wherein R 2 is hydrogen, alkyl, cycloalkyl, aryl, ##STR2## or a heterocyclic residue; or R 1 is NHR 3 wherein R 3...
4952581 Use of a prostaglandin in combination with an adrenergic blocking agent for reduction of intraocular pressure  
This invention provides a method for treating ocular hypertension or glaucoma in a subject's eye. The method comprises contacting the surface of the eye with an effective intraocular pressure...
4952401 Rodenticide for toxic wick  
A composition and a method of using the same wherein said composition comprises a rodenticide and an additive selected from the group consisting of 1. polyoxyalkylated alkyl phenols; 2....
4937265 Antidiabetic method comprising 7-thiaprostaglandin E.sub.1 or its derivatives  
An antidiabetic composition which comprises a 7-thiaprostaglandin E 1 represented by the formula ##STR1## wherein R 1 is hydrogen atom, a straight-chain or branched-chain alkyl group or one...
4906663 6-fluoroprostaglandins  
A 6-fluoroprostaglandin having the formula: ##STR1## wherein A is a carbonyl group or a hydroxymethylene group, R 1 is a substituted or unsubstituted C 1 -C 10 alkyl group or a substituted or...
4889845 Vehicle for topical application of pharmaceuticals  
A topical pharmaceutical formulation, useful as a vehicle for E-type prostaglandins is described.
4888358 13,14-dihydroprostaglandin C-type derivatives  
Novel 13,14-dihydroprostaglandin derivatives of the formula ##STR1## wherein: m is 1 or 3; R 1 is hydrogen or alkyl; R 2 is hydrogen or lower alkyl; R 3 and R 4 are independently...
4883819 Use of A, B and C prostaglandins and derivatives thereof to treat ocular hypertension and glaucoma  
This invention provides a method for treating hypertension or glaucoma in a subject's eye which comprises contacting the surface of the eye with an effective intraocular pressure reducing amount of...
4871772 Process for making a stable pharmaceutical preparation of prostagladin E compounds, and/or 15R forms thereof  
A process for making a stable pharmaceutical preparation of prostaglandin E compounds and/or 15R forms thereof is diclosed. Prostagladin E compounds and 15R forms thereof are know to have useful...
4851432 Therapeutic uses of oligomers of 15-dehydroprostaglandin B.sub.1 and oligomers of derivatives of 15-dehydroprostaglandin B1  
This invention relates to the therapeutic uses of oligomers of 15-dehydroprostaglandin B 1 and oligomers of 16, 16'-dimethyl-15-dehydro PGB 1 and oligomers or other 16 carbon substituted...
4839388 Prostacyclins and pharmaceuticals containing the same  
This invention relates to a novel prostacyclin represented by the formula: ##STR1## [wherein R 1 represents --CO 2 R 5 group or --CONR 6 R 7 group; A is (i) --CHCH--CH 2 CH 2 -- or ...
4839169 Synergistic combination of t-PA and prostacyclin  
A combination of t-PA and a prostaglandin of use in removing or inhibiting the formation of a blood clot in a mammal.
4824857 Use of prostaglandin D.sub.2 -active substances  
Method of treatment of ocular hypertension and glaucoma which comprises administering an effective amount of prostaglandin D 2 -active substance to a subject in need of such treatment.
4822819 Use of trimoprostil and derivatives in glaucoma therapy  
Disclosed is the use of trimoprostil, and its derivatives, such as, 15-acetyl trimoprostil and pharmaceutically acceptable salts and esters thereof in the treatment of glaucoma and ocular...
4822820 Use of tri-methyl PG-F.sub.2 a and derivatives in glaucoma therapy  
Disclosed is the use of Tri-methyl PG-F 2 a, and its derivatives, such as, 15-acetyl Tri-methyl PG-F 2 a and pharmaceutically acceptable esters thereof in the treatment of glaucoma and...
4820732 Method and compositions for reducing dysfunction in angioplasty procedures  
A method for reducing dysfunction in angioplasty procedures and particularly, in myocardial angioplasty procedures in human beings is desired. The method involves the introduction of a selected...
4789685 9-fluoroprostaglandin derivatives, their preparation and use as medicinal agents  
9-fluoroprostane derivatives of Formula I ##STR1## wherein R 1 is CH 2 OH or ##STR2## wherein R 2 is hydrogen, alkyl, cycloalkyl, aryl, or a heterocyclic residue; or R 1 is the residue ##STR3##...
4783480 6-keto-prostaglandin E.sub.1 derivatives  
A 6-keto-prostaglandin E 1 derivative of the formula: ##STR1## (wherein R 1 represents an amino acid or amino alcohol residue, R 2 represents a single bond or an alkylene group of from 1 to 4...
4777184 Prostaglandin derivatives, their preparation and use  
Prostaglandin derivatives, and specifically derivatives of isocarbacyclin, have an optionally substituted methylene group as a substituent on the α-carbon atom of the α-side chain. They have a...
4767787 Sheet-shape adhesive preparation  
A sheet-shape adhesive preparation for promoting tooth-movement in orthodontics comprising a layer of a pharmaceutical composition containing as the active ingredient a prostaglandin (e.g....
4766147 Novel 5-membered cyclic compounds, process for production thereof, and pharmaceutical use thereof  
Novel 5-alkylidene-4-substituted-2-cyclopentenones and 5-(1-hydroxy-aliphatic hydrocarbon)-4-substituted-2-cyclopentenones. These novel cyclopentenones and 5-alkylidene-3-hydroxy-4-substituted...
4751224 Treatment of metastasis  
A method for reducing the incidence of metastasis in tumor victims without treating the primary tumor per se resides in the administration of forskolin or its analogs which are potent inhibitors of...
4749522 Supercritical fluid extraction of animal derived materials  
Supercritical fluids (SCF) are found to be useful in extracting desired materials from animal tissues, cells, and organs. By varying the choice of SCF, experimental conditions, and animal source...
4735902 Stabilized composition containing inositoltriphosphate  
A stabilized composition comprising an organic substrate, such as a pharmaceutical or biological system subject to degradation by oxidation and/or free radicals and a method for production thereof.
4734424 Bicycloheptane substituted diamide and its congener prostaglandin analogs  
Bicycloheptane substituted amide prostaglandin analogs are provided having the structural formula ##STR1## wherein m is 0 to 4; A is --CHCH-- or --CH 2 --CH 2 --; n is 1 to 5; Q is...
4732914 Prostacyclin analogs  
Prostacyclin (PGI 2 ) analogs having a 6a-carba feature, for example a compound of the formula ##STR1## said analogs having pharmacological activity. Processes for preparing them and the...
4711895 4-hydroxy-2-cyclopentenone, process for production thereof, pharmaceutical composition comprising it  
A 4-hydroxy-2-cyclopentenone represented by the following formula (I) ##STR1## wherein X represents a hydrogen or halogen atom, A represents a hydrogen atom and B represents a hydroxyl group, or A...
4708963 Novel carbacyclins, their preparation and use  
Carbacyclin derivatives of Formula I ##STR1## wherein R 1 is OR 2 , wherein R 2 is hydrogen, alkyl, cycloalkyl, aryl, a heterocyclic residue, or NHR 3 , wherein R 3 is an acid residue or...
4707495 Peptic ulcer treatment method  
A method of treating peptic ulcer disease by topical application of a prostaglandin analog is described.
4699920 9-halo-2-prostaglandin derivatives, processes for the preparation thereof and use thereof as medicinal agents  
The invention relates to 9-halo-Δ 2 -prostane derivatives of general Formula I ##STR1## wherein Hal is a fluorine or chlorine atom in the α- or β-position, R 1 is the residue OR 2 with R 2...
4698363 Prostacyclin analogues  
Prostaglandin analogues of the formula: ##STR1## (wherein R 1 represents a hydrogen atom or an aliphatic or alicyclic hydrocarbon radical, Y 1 represents a carbonyl or hydroxymethylene group, A 1...
4687762 Water soluble drug complex and method for production of same  
The invention provides a method of producing a water-soluble complex comprising a water-insoluble drug and a phospholipid, comprising the steps of (1) dissolving a water-insoluble drug and a...
4686103 Method of managing cattle breeding herds  
Cattle breeding herds are managed for accelerated time-controlled calving, using groups of cows predicted to calve within a period of 10 days, 1000 to 10,000 units of purified porcine relaxin are...
4684633 Phospholipid-emulsified prostaglandin composition  
A prostaglandin emulsion composition comprising a prostaglandin emulsified with a phosphatidylethanolamine-free phospholipid, the composition being suitable for intravenous administration.
4680307 Carbacyclin analogs  
A compound of the formula: ##STR1## wherein X 1 is a free or an esterified carboxyl group, or a group of the formula: ##STR2## (R a and R b are each independently a hydrogen atom, a C 1 -C 4 ...
4680312 Stable prostaglandin E gels utilizing colloidal silicon dioxide as a gel-forming agent  
The present invention provides an improved class of stable gels of prostaglandin E compounds prepared from solutions of prostaglandin E compounds in a pharmaceutically acceptable, stabilizing...
4680288 Sulfur-containing 6-ketoprostaglandins  
Sulfur-containing 6-ketoprostaglandins of the formula I ##STR1## in which D is a bond, alkylene having 1-3 C atoms, cis-alkenylene having 2-5 C atoms or alkinylene having 2-5 C atoms, R 1 is H,...
4649156 6-nitroprostaglandin derivatives  
The present invention provides a novel 6-nitroprostaglandin derivatives of the formula (I) ##STR1## wherein A, n, R 1 , R 2 , R 3 , R 4 and R 5 are as defined in claim 1. The 6-nitroprostaglandin...
4647585 Bicycloheptane substituted ethers  
Bicycloheptane substituted ether prostaglandin analogs are provided having the structural formula ##STR1## wherein X is O or ##STR2## and including all stereoisomers thereof. The compounds are...
4621100 Treatment of osteoporosis with prostaglandins  
The present invention provides a novel method for treating osteoporoses, joint and dental diseases and increasing the rate of bone healing by orally administering certain prostaglandins. Further...
4599353 Use of eicosanoids and their derivatives for treatment of ocular hypertension and glaucoma  
Ocular hypertension and glaucoma can be effectively controlled in primates through topical application of an effective amount of an eicosanoid or an eicosanoid derivative to the surface of an...
Matches 251 - 300 out of 448 < 1 2 3 4 5 6 7 8 9 >