Matches 201 - 250 out of 448 < 1 2 3 4 5 6 7 8 9 >
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5468778 Method of lowering intraocular pressure by administering a pharmaceutical composition containing 7-(5-substituted cyclopentyl) and 7-(5-substituted-cyclopentenyl) 5-heptenoic acids and derivatives  
Intraocular pressure is lowered in the eye of a mammal by administration of a pharmaceutical composition containing as active ingredient a compound of the formula ##STR1## where the dotted line...
5466713 Iloprost with action against cerebral malaria  
This invention relates to the use of iloprost for the production of an agent for treating cerebral malaria.
5457130 Eicosapentaenoic acid used to treat cachexia  
The use of the omega-3 polyunsaturated fatty acid eicosapentaenoic acid or EPA, preferably substantially free of any other polyunsaturated fatty acids, is disclosed for making up medical...
5445812 Angiographic adjuvant  
An angiographic adjuvant comprising a fat emulsion containing a compound having prostaglandin E1 activities, and an angiographic method using the adjuvant.
5432174 Treatment of ocular hypertension  
A method for the treatment of ocular hypertension which comprises administering, to a subject in need of such treatment, (a) a β-adrenergic blocker at the enhancement phase of aqueous humor...
5426115 Use of 15-keto-prostaglandin compound for improvement of encephalic function  
A method of treatment for improving encephalic function which comprises administering, to a subject in need of such treatment, a 15-keto-prostaglandin compound in an amount effective for...
5405870 Carbacyclin compounds; pharmaceutical compositions and method of use  
Compounds of formula (Ic): ##STR1## having valuable platelet-aggregation inhibitory activities useful for the prophylaxis and treatment of such diseases as thrombosis and pharmaceutical...
5397797 Treatment of ocular hypertension with an ocular synergistic combination  
A method for treatment of ocular hypertension which comprises ocularly administering, to a subject in need of such treatment, a oculo-hypotensively synergistic combination of (a) a...
5374654 9-substituted carbacyclin derivatives, processes for their preparation, and their use as medicinal agents  
The invention relates to carbacyclin derivatives of Formula I ##STR1## wherein the various substituents are defined herein, including, inter alia, if R 2 is a hydrogen atom, their salts with...
5369128 Method of synchronizing farrowing in swine  
The invention provides a method of synchronizing farrowing in swine comprising the steps of administering an effective amount of a prostaglandin and then administering to the sows an effective...
RE34756 Excretion of potassium ion by prostanoic acid derivatives  
Amethod for inducing decrease in potassium ion concentration in the blood which comprises administering, to a subject having an increased potassium ion concentration in the blood, a prostanoic acid...
5346921 Treatment of inflammation with 15-keto-prostaglandin compounds  
A method of treatment of inflammatory diseases which comprises administering, to a subject in need of such treatment, an anti-inflammatorily effective amount of a 15-keto-prostaglandin compound.
5317032 Prostaglandin cathartic  
The present invention relates to cathartics comprising 15-keto-16-halogen-PGs as an essential ingredient without substantive side-effects; the catharic effect is thought mainly caused by an...
5310759 Methods of protecting and preserving connective and support tissues  
In this invention methods are described by which prostaglandins of the E 1 class and compounds that mimic or induce cyclic adenosine monophosphate are used to block collagenase gene expression by...
5302617 Biochemical treatment with 15-dehydroxy-16-oxoprostaglandin compounds  
A method for treatment of an allergic disease which comprises administering, to a subject in need of such treatment, a 15-dehydroxy-16-oxoprostaglandin compound in an amount effective in treatment...
5270049 2-decarboxyl-2-aminoalkyl-prostaglandins as ocular hypotensives  
The present invention concerns 2-decarboxyl-2-aminoalkyl derivatives of naturally occurring and synthetic prostaglandins, N-substituted derivatives, ester prodrugs and homologues of such compounds...
5260067 Cytotropic heterogeneous molecular lipids (CHML) and process for preparing the same  
A series of cytotropic heterogeneous molecular lipids (CHML) and the method of preparation thereof are disclosed in the invention. CHML provided by this invention is in molecular type, it is an...
5256696 Treatment of cardiac dysfunction with 15-ketoprostaglandin compounds  
A method for treatment of a cardiac dysfunction which comprises administering, to a subject in need of such treatment, a 15-ketoprostaglandin compound in an amount effective in treatment of the...
5254588 Treatment of pulmonary dysfunction with 15-ketoprostaglandin compounds  
A method for treatment of a pulmonary dysfunction which comprises administering, to a subject in need of such treatment, a 15-ketoprostaglandin compound in an amount effective in treatment of the...
5252605 Promotion of wound-healing with 15-keto-prostaglandin compounds  
A method for promoting healing of wound which comprises administering, to a subject in need of such treatment, a wound-healingly effective amount of a 15-ketoprostaglandin compound.
5252602 Effects of misoprostol on allergic responses  
Methods for treating and preventing late-phase allergic reactions with misoprostol in a pharmaceutically acceptable excipient are provided. Tablet forms of misoprostol may be administered at doses...
5238961 PGF 1-alcohols and their use as ocular hypotensives  
The invention relates to the use of alcohol derivatives of F-type prostaglandins as ocular hypotensives. The PGF derivatives used in accordance with the invention are encompassed by the following...
5234954 Treatment of hyperlipidemia with 15-keto-prostaglandin compounds  
A method for treatment of hyperlipemia which comprises administering, to a subject in need of such treatment, a 15-keto-prostaglandin compound in an amount, effective in decreasing lipid...
5234953 Treatment of congestive heart failure  
The present invention is concerned with the use of a compound of formula (I) ##STR1## wherein --W-- is ##STR2## wherein Z is --V(CH 2 ) b CO 2 H where b is 1 or 2 and V is oxygen when b is 1 or...
5221690 Increasing the choroidal blood flow  
A method for increasing the choroidal blood flow which comprises administering to a subject in need of such increasing a 13,14-dihydro-15-keto-20-ethyl-prostaglandin F, a pharmaceutically...
5204371 Pharmaceutically active 9-chloroprostaglandins  
Compounds of the formula ##STR1## wherein the 9-chlorine atom can be in the α-or β-position, A is --CH 2 --CH 2 -- or cis--CHCH--, B is --CH 2 --CH 2 ,--, trans--CHCH--, or...
5194449 Use of prostaglandin F.sub.3α as an ocular hypotensive agent  
The invention relates to a means of reducing or maintaining intraocular pressure, and, more particularly, to a method and composition for reducing or maintaining intraocular pressure involving the...
5192806 Method of preventing penile tissue degenerative change  
The present invention is concerned with the use of TXA 2 receptor antagonists for the preparation of pharmaceutical compositions for the prevention of degenerative changes in penile tissue.
5190964 5-fluorocarbacyclins, their preparation and pharmaceutical use  
5-fluorocarbacyclin derivatives of the Formula I ##STR1## wherein R 1 is CH 2 OH or A is --CH 2 --CH 2 --, trans --CHCH-- or --C.tbd.C--, W is a free or functionally modified...
5185374 Use of 15-ketoprostaglandin E or F compounds for uterine contraction  
A method of inducing uterine contraction which comprises administering, to a subject in need of such contraction, a uterine-contractionally effective amount of a prostanoic acid derivative selected...
5182302 Method for enhancing growth of mammary parenchyma using a prostaglandin  
The growth of milk-producing mammary parenchyma in a mammal can be significantly enhanced by administering to the mammal by intramammary infusion a substance having a mitogenic effect on mammary...
5164415 Treatment of pancreatic disease with 15-keto-prostaglandin compounds  
A method of treatment of pancreatic disease which comprises administering, to a subject in need of such treatment, a 15-keto-prostaglandin compound in an amount effective in treatment of pancreatic...
5162353 Carbacyclins, processes for their preparation, and their use as medicinal agents  
The invention relates to carbacyclin derivatives with general formula I: ##STR1## in which Y 1 stands for the radical --CH 2 --X--(CH 2 ) n --R 1 or the radical ##STR2## n, 1 or 3, R 1 , the...
5157042 3-oxa-5-fluoro-carbacyclins, their preparation and use as medicinal agents  
Carbacyclin derivatives of Formula I ##STR1## wherein R 1 is OR 2 , wherein R 2 is hydrogen, alkyl, cycloalkyl, aryl, ##STR2## or a heterocyclic residue; or R 1 is NHR 3 wherein R 3 is an acid...
5139491 2-decarboxyl-2-alkoxyalkyl prostaglandins as ocular hypotensives  
The present invention relates to 2-decarboxyl-2-alkoxyalkyl prostaglandins that are potent ocular hypotentives, and are particularly suitable for the management of glaucoma. Said...
5126372 Excretion of nonprotein nitrogen into the intestine by prostanoic acid derivatives  
A method for improvement of excretion of nonprotein nitrogen into the intestines which comprises administering, to a subject in need of such improvement, a prostanoic acid derivative in an amount...
5124352 Fat emulsions containing isocarbacyclin  
The fat emulsions containing the prostaglandin I 2 's expressed by the following formula (I): ##STR1## where X represents an oxygen atom to a methine group, Y is a carbon atom, Z represents a...
5124343 Carbacyclins, process for the preparation thereof, and use thereof as medicinal agents  
The invention relates to carbacyclins of general Formula I ##STR1## wherein R 1 is the residue CH 2 OH or ##STR2## with R 2 meaning a hydrogen atom, an alkyl, cycloalkyl, aryl residue, a...
5122603 Purified insulin mediators and purification process for same  
A method for purifying two distinct insulin mediators to substantial homogeneity, and relative purity values above 80%, comprises adsorption on first anion exchange resin and subsequently on a...
5120719 Conjugate of prostaglandin and polysaccharide  
A conjugate formed by the covalent bonding of a prostaglandin or a similar compound thereto and a polysaccharide. The prostaglandin is selected from prostaglandin E1, prostaglandin E2,...
5116869 2-substituted-2-cyclopentenones  
2-Substituted-2-cyclopentenones represented by the formula (I): ##STR1## wherein A is a hydroxyl group or ##STR2## and B is a hydrogen atom or A and B are bonded together to form one bonding arm; ...
5109021 Prostaglandin analogues, process for their preparation and pharmaceutical compositions containing them  
The present invention relates to novel isomers of PGAs, PGDs, PGEs, PGFs, 6-keto-PGE 1 s, 6-keto-PGF 1 s, PGI 2 s, 6,9α-nitrilo-PGI 1 s and 6,9α-methano-PGI 2 s, having a specific steric...
5100917 Novel A-nor-steroid-3-carboxylic acid derivatives  
The present invention relates to novel A-nor-steroid-3-carboxylic acid derivatives and to their use as inhibitors of mammalian 5α-reductase.
5096927 Treatment of hepatobiliary disease with 15-keto-prostaglandin compounds  
A method for treatment of a hepatobiliary disease which comprises administering, to a subject in need of such treatment, a 15-ketoprostaglandin compound in an amount effective in treatment of the...
5091417 Preventive and therapeutic agent for hepatitis  
A preventive and therapeutic agent for hepatitis, comprising a fat emulsion containing a compound having prostaglandin E 1 activities.
5049582 Prostacyclin derivatives with cytoprotective effect on liver, pancreas and kidney  
The invention relates to an agent for cytoprotection in the liver, in the pancreas and in the kidney, characterized in that it contains prostacyclin derivatives of Formula I ##STR1## wherein R 1 ...
5028628 Methods of treating pulmonary hypertension  
The present invention is concerned with methods for the treatment and diagnosis of pulmonary hypertension which comprise the administration of an effective amount of a compound of formula (I)...
5023273 6-oxoprostaglandin E derivatives, process for their production and their pharmaceutical use  
The invention relates to 6-oxo-prostaglandin E 1 derivatives of formula I, ##STR1## in which R 1 means the radical COOR 2 with R 2 meaning a hydrogen atom, C 1 -C 10 alkyl, a C 5 -C 6 ...
5023248 Method of treating diabetes with inositol triphosphate  
A method of treating diabetes or complications of diabetes is disclosed. In this method a pharmaceutically effective amount of at least one isomer of inositol triphosphate is administered to a...
5019566 Method of treating inflammation with inositol triphosphate  
A method of reducing the negative effect of cadmium or aluminum ion or free-radicals in body tissues and a method of preventing or alleviating certain diseases and conditions by administering to a...
Matches 201 - 250 out of 448 < 1 2 3 4 5 6 7 8 9 >