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5877215 |
Method of treating neoplastic cells with prostaglandin and radiation treatment or prostaglandin and platinum-based anti-tumor agents
The invention is directed to a method of increasing ionizing radiation's cytotoxic effects on a neoplasm in a subject by increasing the neoplasm's sensitivity to ionizing radiation, comprising...
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5861431 |
Incontinence treatment
The present invention provides a method of treating incontinence in a patient that has a bladder and a urethra. The urethra forms a lumen for draining the bladder. The method comprises the steps of...
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5843999 |
2-phenylazulene derivatives and a manufacturing method of these compounds
A series of new azulene derivatives are disclosed, which are represented by the following formula; ##STR1## wherein: R 1 is hydrogen atom, lower alkoxycarbonyl group, carboxy group, halogen atom,...
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5840328 |
Treatment using arachidonic acid metabolite and particulate formulations
A composition comprises a free arachidonic acid metabolite and endocystosable particles such as phagocytosable or opsonizable particles, or particles binding to phagocytic receptors to serum...
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5817694 |
16-methyl-11,16-dihydroxy-9-oxoprost-2,13-dien-1-oic acid and derivatives
Analogs of the prostaglandin PGE 1 are disclosed. These compounds exhibit uterotonic properties, enhancing the response to PGF 2 α in isolated rat uteri. The compounds also exhibit other...
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5811118 |
Methods of treatment using unilamellar liposomal arachidonic acid metabolite formulations
This invention provides a method of administering an arachidonic acid metabolite, such as prostaglandin E1, to an animal. The metabolite is given to the animal, typically a human, in association...
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5811443 |
Combinations of prostaglandins and clonidine derivatives for the treatment of glaucoma
Combinations of at least one clonidine derivative and at least one prostaglandin are used to treat glaucoma and ocular hypertension without some of the side effects typically associated with...
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5807895 |
Use of prostaglandin E1, E2 or analogs to prevent renal failure induced by medical tests that utilize contrast media agents
A method of preventing renal failure or dysfunction caused by medical tests which utilize contrast media by administering, preferably by intravenous infusion or injection, a prostaglandin selected...
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5807892 |
Use of certain prostaglandin analogues to treat glaucoma and ocular hypertension
Certain prostaglandin analogues are useful in the treatment of glaucoma and ocular hypertension. Also disclosed are ophthalmic, pharmaceutical compositions comprising such prostaglandin analogues.
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5783600 |
Carboxyalkylethers, formulations, and treatment of vascular diseases
Dialkyl ethers lower Lp(a) and triglycerides, and elevate HDL-cholesterol, and are thereby useful for treating vascular diseases and noninsulin-dependent diabetes mellitus.
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5773472 |
Method and means for prevention of cataract
The present invention is related to the use of thiol-binding prostaglandins or prostaglandin-like substances containing alpha beta unsaturated ketone, esp. Prostaglandins of type A or J and...
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5773471 |
Treatment of optic nerve disorder with prostanoic acid compounds
The present invention provides a method for treatment of optic nerve disorder by the administration of a prostanoic acid compound in an amount effective in treatment of optic nerve disorder to a...
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5770230 |
Method for preparing stabilized prostaglandin E1
A stable and lyophilized formulation of prostaglandin E-1 made by the process comprising a) dissolving PGE-1 in a solution of lactose and tertiary butyl alcohol wherein said tertiary butyl alcohol...
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5767154 |
5-trans-prostaglandins of the F series and their use as ocular hypotensives
The invention relates to the use of derivatives of F-type prostaglandins as ocular hypotensives. The PGF derivatives used in accordance with the invention are encompassed by the following structure...
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5760075 |
Method and means for prevention and treatment of secondary cataract
The present invention relates to a method for treatment or prevention of secondary cataract, comprising contacting the surface of the eye with an effective amount of a therapeutically active and...
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5741523 |
Stabilized prostaglandin E1
A stable and lyophilized formulation of prostaglandin E-1 made by the process comprising a) dissolving PGE-1 in a solution of lactose and tertiary butyl alcohol wherein said tertiary butyl alcohol...
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5739161 |
Agent for treating hepto.biliary diseases
The object of the present invention is to provide a pharmaceutical composition for treatment of hepato.biliary disease reduced in side effect such as diarrhea, which comprises...
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5721273 |
Use of certain 9-halo-13,14-dihydroprostaglandins to treat glaucoma and ocular hypertension
9-Halo-13,14-dihydroprostaglandins are useful in the treatment of glaucoma and ocular hypertension. Also disclosed are ophthalmic, pharmaceutical compositions comprising such prostaglandins.
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5708031 |
Prostaglandin E2 treatment of impotence
Disclosed are compositions and methods for the treatment of male impotence, wherein erectile dysfunction is alleviated by administering a pharmaceutically acceptable formulation containing...
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5700833 |
Isocarbacyclin derivatives
The present invention provides novel isocarbacyclin derivatives useful for search and study of prostacyclin receptor and as a therapeutic drug for central nervous system diseases, which derivatives...
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5700835 |
3-Oxa-D-prostaglandins for lowering IOP
Compositions containing 3-Oxa-D-prostaglandins and methods of their use in treating glaucoma or ocular hypertension are disclosed.
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5698225 |
Pharmaceutical composition
A pharmaceutical composition including a core of an NSAID selected from diclofenac and piroxicam which core is surrounded by a mantle coating of a prostaglandin, wherein an intermediate coating can...
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5698598 |
EP.sub.2 -receptor agonists as agents for lowering intraocular pressure
The invention relates to the use of EP 2 receptor agonists as potent ocular hypotensives, and are particularly suitable for the management of glaucoma. In particular said compounds are represented...
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5696166 |
Compositions containing hydroxyeicosatetraenoic acid derivatives and methods of use in treating dry eye disorders
Compositions containing a HETE derivative and methods of use for treating dry eye are disclosed.
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5686487 |
Treatment of cataract with 15-keto-prostaglandin compounds
A method for treatment of a cataract which comprises administering, to a subject in need of such treatment, a 15-ketoprostaglandin compound in an amount effective in treatment of cataract.
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5681855 |
PGE.sub.1 emulsion composition kit
The invention concerns a kit for the preparation of an emulsion containing prostaglandin E 1 , a method of preparing the emulsion and a method of preparing the emulsion composition contained in the...
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5665373 |
Pharmaceutical compositions and methods of treatment of the corneal following laser irradiation
Methods for preventing and treating corneal haze resulting from exposure of the eye to laser irradiation are disclosed. The methods include administration of compositions of wound healing...
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5663203 |
Agents containing prostacyclin derivatives for topical application
The invention relates to a dermal application form of prostacyclin derivatives of Formula I ##STR1## wherein R 1 means hydrogen or alkyl of 1-10 carbon atoms, A is a --CH 2 --CH 2 --,...
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5658947 |
Method and composition for selectively inhibiting melanoma using betalinic acid
A composition and method of inhibiting tumor growth and treating malignant melanoma without toxic side effects are disclosed. Betulinic acid or a betulinic acid derivative is the active compound of...
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5656635 |
5-trans-alcohols and their use as ocular hypotensives
The invention relates to the use of alcohol derivatives of F-type prostaglandins as ocular hypotensives. The PGF derivatives used in accordance with the invention are encompassed by the following...
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5654339 |
Use of prostane derivatives of formulate I and II for treatment of chronic polyarthritis
The invention relates to the use of prostane derivatives general formula I ##STR1## in which X 1 is a --CH 2 --CH 2 -- or trans --CHCH--, X 2 is a straight-chain or branched, saturated...
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5624893 |
Pharmaceutical compositions and methods of treatment of the cornea following laser irradiation
Methods for treating the cornea following laser irradiation are disclosed. The methods include administration of compositions of wound healing modulators and pain mediators to the eye. Compositions...
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5610182 |
Pharmaceutical composition for the therapy of cerebral thrombosis
A pharmaceutical composition effective for the therapy of cerebral thrombosis, particularly acute cerebral thrombosis, which is in the form of a fat emulsion containing an isocarbacyclin having a...
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5605931 |
Protective prostaglandins for use in conjunction with chemotherapeutic agents
Prostaglandins of the PGE type can be administered in a therapeutically effective amount to protect tissue from injury resulting from chemotherapeutic agents by administering the PGE-type...
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5601843 |
Pharmaceutical tablet composition
A pharmaceutical composition including a core of an NSAID selected from diclofenac and piroxicam which core is surrounded by a mantle coating of a prostaglandin, wherein an intermediate coating can...
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5599837 |
Treatment for hypertension or glaucoma in eyes
The present invention relates to a 15-deoxyprostaglandin derivative of the formula (I): ##STR1## in which ##STR2## is a 5 membered ring which is selected from a group consisting of ##STR3## R 1 is...
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5589457 |
Process for the synchronization of ovulation
A method for synchronizing ovulation in cattle by sequential injection of hormones is disclosed. A hormone selected from the group consisting of gonadotropin releasing hormone (GnRH), luteinizing...
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5583144 |
Methods for treating erectile impotence
The present invention relates to methods of relieving erectile impotence in a human male. The method comprises administering to the male an erectile impotence relieving amount of piperoxan and the...
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5576351 |
Use of arginine as an immunostimulator
The present invention relates to the treatment of an impaired human immune response or to reduction of the severity of degradation of the human immune response by the administration of arginine or...
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5567732 |
Eicosapentaenoic acid-containing oil and methods for its production
This invention describes a process for producing single cell edible oils containing eicosapentaenoic acid (EPA) from heterotrophic diatoms. The diatoms are cultivated in a fermentor in a nutrient...
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5565492 |
Prostaglandin combinations in glaucoma therapy
Disclosed is the use of combinations of F and E series prostaglandins and their respective derivatives and analogues, as well as pharmaceutically acceptable salts and esters thereof in the...
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5547968 |
Treatment of ocular hypertension with a synergistic combination
A method for treatment of ocular hypertension which comprises ocularly administering, to a subject in need of such treatment, an oculo-hypotensively synergistic combination of (a) a...
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5545671 |
Antimetastically acting agents
The invention relates to an antimetastatically acting agent consisting of Eptaloprost, Cicaprost or combinations of TXA 2 antagonist and prostacyclin derivatives.
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5534547 |
Prostaglandins of the D series, and tranquilizers and soporifics containing the same
The present invention provides novel prostaglandins D, that is, 13,14-dihydro-15-keto-PGDs, whieh have an excellent sedative and sleep-inducing activity, and so they are useful for tranquilizer...
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5523321 |
Prostacyclins, their analogs or prostaglandins and thromboxane antagonists for treatment of thrombotic and thromboembolic syndromes
Combination products containing a prostaglandin (PG), prostacyclin (PC) or a prostacyclin analog (PCA) and a thromboxane receptor antagonist (TXAA) are suitable for joint application to thrombotic...
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5510383 |
Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension
Disclosed is the use of cloprostenol, fluprostenol, and their pharmaceutically acceptable salts and esters for the treatment of glaucoma and ocular hypertension. Also disclosed are ophthalmic...
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5506265 |
Prostacyclin and carbacyclin derivatives as agents for the treatment of multiple sclerosis
This invention relates to the use of prostacyclin and carbacyclin derivatives for the production of an agent for the treatment of multiple sclerosis.
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5491171 |
Pharmaceutical preparation containing prostaglandin compound for rectal or vaginal administration
A pharmaceutical preparation for rectal or vaginal administration, comprising a prostaglandin compound and an alkali metal salt of a fatty acid having 8 to 12 carbon atoms, and a method for...
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5489613 |
Carbacyclin derivatives, process for their preparation and compositions containing them
Compounds of formula (I): ##STR1## have valuable platelet-aggregation inhibitory activities and may be used for the prophylaxis and treatment of such diseases as thrombosis.
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5486540 |
Cyclopentane heptanoic or heptenoic acid, 2-arylalkyl or arylalkenyl and derivatives as therapeutic agents
The present invention provides therapeutic agents comprising cyclopentane heptane or heptenoic acid, 2 arylalkyl or arylalkenyl and derivatives thereof, wherein the carboxylic acid of the parent...
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