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6280778 |
Process for preparing natural product derivatives from plants in a single step
A process is disclosed, for preparing a derivative of a targeted natural product from plants. The targeted natural product is extracted from the desired part of the plant and the targeted natural...
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6265440 |
Prostaglandins E and anti ulcers containing same
The novel 13,14-dihydro-15-keto prostaglandins E of the invention have remarkable preventive effects against ulcers. Further, the novel 13,14-dihydro-15-keto-prostaglandins E of the invention have...
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6258844 |
Cyclopentane (ene) oic acid, 2-alkenyl derivatives as therapeutic agents
The invention relates to the use of omega chain modified prostaglandins as ocular hypotensive. The derivatives used in accordance with the invention are encompassed by the following structure...
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6239157 |
Inhibition of osteoclastogenesis
A method for inhibiting the differentiation of CD34+ cells into osteoclasts by treating the cells with a peroxisome proliferator-activated receptor-γ agonist.
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6235779 |
Use of cis-Δ4 analogs of prostaglandins as ocular hypotensives
Cis-Δ 4 analogs of prostaglandins and methods of their use in treating glaucoma and ocular hypertension are disclosed.
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6235780 |
ω-cycloalkyl-prostaglandin E1 derivatives
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6235781 |
Prostaglandin product
A pharmaceutical product comprising an aqueous prostaglandin formulation and a polypropylene container are disclosed. Aqueous prostaglandin formulations are more stable in polypropylene containers...
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6232343 |
Ophthalmic preparations
An ophthalmic preparation which exhibits excellent pharmacological effects for various ophthalmic diseases is disclosed. The ophthalmic preparation according to the present invention contains a...
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6232344 |
13-Oxa prostaglandins for the treatment of glaucoma and ocular hypertension
13-Oxa analogs of certain prostaglandins and methods of their use in treating glaucoma and ocular hypertension are disclosed.
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6225347 |
9-halogen-(Z)-prostaglandin derivatives, process for their production and their use as pharmaceutical agents
The invention relates to 9-halogen-(Z) prostane derivatives of formula I ##STR1## in which ##STR2## Z represents the radicals Hal represents a chlorine or fluorine atom in the alpha or beta...
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6225348 |
Method of treating macular degeneration with a prostaglandin derivative
A method of treating age-related macular degeneration in an eye is described, comprising contacting the eye with a therapeutic amount of a prostaglandin F 2 α derivative. The preferred...
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6210343 |
Use of misoprostol or/and misoprostol acid for diagnosis of vascular damage in a subject with erectile dysfunction
A method is provided for diagnosing vascular damage in a subject with erectile dysfunction that includes applying an effective dose of a therapeutic formulation having an excipient and at least one...
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6197801 |
Injectable pharmaceutical composition for treatment and reversal of erectile dysfunction
An injectable pharmaceutical composition for treatment of erectile dysfunction. The composition includes prostaglandin E-1, and optionally further includes levsin and/or additional vasodilators...
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6187756 |
Composition and methods for treatment of neurological disorders and neurodegenerative diseases
It has been discovered that the stimulation of β-adrenergic receptors, which activate cAMP formation, give rise to increased APP and GFAP synthesis in astrocytes. Hence, the in vitro or in vivo...
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6187818 |
Prostaglandins formulation and process
This invention comprises new formulations and methods of preparing a new formulations of prostaglandins and in particular dinoprost tromethamine, where the pH of the formulation is adjusted to...
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6166073 |
Combinations of DP and FP type prostaglandins for lowering IOP
Compositions containing DP-agonist and FP-agonists prostaglandin agonists and methods of their use in treating glaucoma or ocular hypertension are disclosed.
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6160013 |
14-aza prostaglandins for the treatment of glaucoma and ocular hypertension
14-Aza analogs of PGF 2 α, PGD 2 , and PGE 2 and methods of their use in treating glaucoma and ocular hypertension are disclosed.
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6156785 |
Method for increasing oxygen tension in the optic nerve and retina
There is disclosed a method for increasing retinal and optic nerve head oxygen tension by application of a composition comprising carbonic anhydrase inhibitors to the eye.
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6156799 |
Method of increasing bone volume using non-naturally-occurring FP selective agonists
The present invention relates to novel methods of increasing bone volume comprising the administration of a non-naturally-occurring selective FP agonist to a subject in need of such treatment. This...
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6150411 |
Use of DHA as a pharmaceutical composition
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6133230 |
Method and pharmaceutical composition for chondrostimulation with a prostaglandin (e.g. misoprostol) and TGF-β, optionally in combination with IGF-1
A pharmaceutical composition comprising a prostaglandin such as misoprostol and TGF-B in amounts sufficient to stimulate production of chondrocyte matrix is disclosed which exhibit therapeutic...
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6127413 |
Ocular depressor
This invention relates to an agent for decreasing ocular tension comprising as an effective ingredient a 4,8-inter-m-phenylene PGI 2 derivative represented by the formula: ##STR1## or a...
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6124353 |
Method of treating ocular hypertension with 8-epi prostaglandins
The present invention provides a method of treating ocular hypertension which comprises applying to the eye an amount sufficient to treat ocular hypertension of a compound of formula (I) ##STR1##...
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6110969 |
Cycloalkyl-prostaglandin E.sub.2 derivatives
A ω-cycloalkyl-prostaglandin E 2 derivatives of the formula (I) ##STR1## wherein R is carboxy or hydroxymethyl; R 1 is oxo, methylene or halogen atom; R 2 is H, OH or C1-4 alkoxy; R 3 is H,...
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6103765 |
Methods for treating male erectile dysfunction
Administration of a pharmaceutical composition comprising: (a) a vasodilator; and (b) a 15-hydroxyprostaglandindehydrogenase inhibitor is effective for the treatment of male erectile...
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6083501 |
Drug for prevention and therapy of diseases caused by fibrinoid formation or thrombus formation in the lung and model animals of the diseases
A drug for prevention and therapy of diseases caused by fibrinoid formation or thrombus formation, as well as a model animal of fibrinoid formation or thrombus formation in the lung is disclosed....
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6048895 |
Aromatic C16-C20 substituted tetrahydro prostaglandins useful as FP agonists
The invention provides novel PGF analogs. In particular, the present invention relates to compounds having a structure according to the following formula: ##STR1## wherein R 1 , R 2 , R 3 , R 4 ,...
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6046244 |
Topical compositions for prostaglandin E.sub.1 delivery
A topical composition of a semi-solid consistency suitable is provided for transdermal application of prostaglandin E 1 . The composition comprises prostaglandin E 1 , a penetration enhancer, a...
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6046240 |
Methods for treating female sexual dysfunction
A method for treating female sexual dysfunction or for female sexual enhancement comprises administering to the vagina a composition comprising a prostanoid compound having a vasodilating effect in...
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6043275 |
3,7-dithiaprostanoic acid derivative
A 3,7-dithiaprostanoic acid derivative of the formula (I) ##STR1## (wherein, R 1 is OH, C1.about.6 alkyloxy, NR 6 R 7 (R 6 , R 7 are H, C1.about.6 alkyl.); R 2 is H, OH; R 3 is single bond,...
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6034133 |
Use of a virucidal hand lotion to prevent the spread of rhinovirus colds
Frequent application of a virucidal hand lotion containing malic acid, citric acid, and a C 1 -6 alcohol will prevent the hand-to-hand transmission of rhinoviruses and reduce the incidence of the...
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6030639 |
Treatment using prostoglandin and particulate formulations
Provided herein is a method of administering a free arachidonic acid metabolite to an animal, the method involving administration of the free metabolite and an endocytosable particle. This method...
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6031001 |
Use of prostaglandins
Methods for topical treatment of psoriasis are disclosed comprising applying to the skin a composition comprising an effective amount of a therapeutically active and physiologically acceptable...
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6031002 |
Method for enhancing female sexual response and a composition therefor
A method for enhancing female sexual response in which topically administered to the clitoris of the female subject and the surrounding tissue is a pharmaceutically-acceptable composition whose...
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6025396 |
Stable prostaglandin E1-containing injectable composition
The present invention relates to a stable injectable composition containing prostaglandin E 1 . More specifically, the present invention relates to a stable injectable composition which is prepared...
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6022897 |
Selective modulators of peroxisome proliferator activated receptor-gamma, and methods for the use thereof
In accordance with the present invention, there are provided a class of compounds which are capable of selectively modulating processes mediated by peroxisome proliferator activated receptor-gamma...
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6011062 |
Storage-stable prostaglandin compositions
The use of polyethoxylated castor oils in prostaglandin compositions enhances the prostaglandin's chemical stability.
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5990168 |
Methods and compositions for the treatment of ataxia telangiectasia
Embodiments of the invention include formulations for the treatment of (AT) ataxia telangiectasia patient and asymptomatic AT heterozygous carriers. The subject formulations comprise one or more...
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5985920 |
Difluoroprostaglandin derivatives and their use
A fluorine-containing prostaglandin derivative of the formula (1) (or a salt thereof) and a medicine containing it, particularly, a preventive or therapeutic medicine for an eye disease: ##STR1##...
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5981594 |
Method of treatment for diabetic neuropathy
A method of treatment for diabetic neuropathy using combined administration of a formulation including as an active ingredient a prostaglandin I derivative, especially a prostaglandin I 2 ...
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5977171 |
Sustained release emulsions
Ophthalmic methods and compositions are disclosed where particles of the dispersed phase of emulsions are themselves dispersed and stably maintained in physical separation by lightly crosslinked,...
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5962528 |
Prostaglandin E.sub.2 /F.sub.2α combination for treating impotence
Disclosed herein is method of treating and a composition for treating erectile dysfunction in a male patient by administering to the patient a unit dose of a formulation comprising an erectile...
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5958379 |
Pharmaceutical composition
A pharmaceutical composition containing at least one systemically and/or locally effective, topically applicable active substance, preferably selected from the group consisting of local...
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5952378 |
Methods and means for drug administration
Method and means for delivery of drugs to the optic nerve head and the region surrounding it which comprises contacting the surface of the eye with an effective amount of a drug for treatment of...
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5942545 |
Composition and method for treating penile erectile dysfunction
A composition for the topical transdermal administration to the penis is based on prostaglandin E 1 . The composition is non-irritating and effective for relieving erectile impotence or other...
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5935939 |
Stabilized dispersions of misoprostol
The present invention provides for stabilization of misoprostol in solid dispersions using amorphous excipients or excipients which have been converted to an amorphous state such as hydroxypropyl...
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5925375 |
Therapeutic use of multilamellar liposomal prostaglandin formulations
This invention provides a multilamellar liposome containing an arachidonic acid metabolite, two or more lipid-containing bilayers and two or more aqueous compartments containing a...
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5905091 |
Enhancement of skin pigmentation by prostaglandins
A composition comprising a carrier and prostaglandin effective in stimulating synthesis of melanin in a human melanocyte thereby enhancing pigmentation of the human skin and optionally comprising a...
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5900433 |
Vascular treatment method and apparatus
This invention relates to the method of use of a congener of an endothelium-derived bioactive composition of matter, which comprises administering said congener percutaneously to a site proximately...
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5882678 |
Interdigitation-fusion liposomes containing arachidonic acid metabolites
This invention provides an interdigitation-fusion liposome comprising an arachidonic acid metabolite, a lipid bilayer comprising a lipid and an aqueous compartment comprising a release-inhibiting...
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