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7615575 |
Compounds for the treatment of metabolic disorders
Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, artherosclerosis and...
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7605181 |
Method for the treatment of metabolic disorders
Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and...
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7582679 |
Compositions containing solid ibuprofen concentrates and methods of making solid ibuprofen concentrates
The present invention is directed to a solid ibuprofen concentrate composition and method of producing the composition. The solid ibuprofen concentrate contains (a) a solid ibuprofen free acid and...
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7582670 |
Methods of treating an inflammatory-related disease
The invention relates to pharmaceutical compositions and methods of treating inflammatory-related diseases associated with pro-inflammatory cytokine expression and/or reduced expression of...
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7557144 |
Modulation of protein expression using carbocyclic aryl alkenoic acid derivatives
The present invention generally relates to diseases or conditions modulated by undesired protein expression. In one aspect, the methods provide for administration to a mammal, particularly a human,...
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7547727 |
Therapeutic cyclopentane derivatives
Disclosed herein is a compound having a structure
or a pharmaceutically acceptable salt, or a prodrug thereof. Therapeutic methods, compositions, and medicaments related thereto are also...
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7547688 |
Methods for treatment of nocturia
A method for the treatment of nocturia which consists of administering to a mammal in need of such treatment a therapeutically effective amount of a nonsteroidal anti-inflammatory drug consisting...
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7534815 |
Preventive or remedy for hypertension
Provided is a method of treating hypertension, which comprises administering an effective amount of a compound represented by the following formula (1) or (2):
wherein, R 1 and R 2 are the...
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7517911 |
3,4,5-trimethoxy phenyl-based ester compound and preparation method thereof and whitening cosmetic composition containing the same
The present invention relates to ester compounds derived from 3,4,5-trimethoxy phenyl acetate, 3,4,5-trimethoxy cinnamate or 3,4,5-trimethoxy hydrocinnamate that are represented by Formula (I),...
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7517909 |
Amino acids with affinity for the α2δ-protein
This invention relates to certain β-amino acids that bind to the alpha-2-delta (α2δ) subunit of a calcium channel. These compounds and their pharmaceutically acceptable salts are useful in the...
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7514471 |
Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor α (PPAR)
The present invention provides the S enantiomer of a compound of formula (I) wherein n is 1 or 2 as well as pharmaceutically acceptable salts, solvates, crystalline forms and prodrugs thereof, to...
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7504231 |
Method of alleviating chronic pain via peripheral inhibition of neurotransmitter synthesis
A composition having sustained pain-relieving properties such that the composition may be administered to a subject to alleviate chronic pain. The composition includes an effective amount of at...
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7476689 |
Therapeutic compositions for intranasal administration which include KETOROLAC
An analgesic/anti-inflammatory pharmaceutical dosage form which comprises an effective amount of an active ingredient selected from the group consisting of racemic...
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7462227 |
Ibuprofen complexes as wood preservatives
Complexes of ibuprofen and copper and/or zinc were solubilized in ammoniacal solution providing preservative solutions that fully penetrate wood. With loss of the ammonia from the wood, the...
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7456223 |
Treatment of bruxism
A composition and its use for local percutaneous delivery of a drug, in particular a muscle relaxant, more particularly cyclobenzaprine present in an amount of about 1 to about 10% by weight of the...
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7442833 |
Triphenylethylene compounds as selective estrogen receptor modulators
Compounds of formula (I):
with a variety of therapeutic uses, more particularly novel prodrugs that are particularly useful for delivering a parent compound for selective estrogen receptor...
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7420083 |
Substituted aryloximes
The present invention relates to substituted aryl oximes and methods of using them.
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7358245 |
Treatment of gastroesophageal reflux disease
The administration of cannabinoid receptor agonists for inhibition of transient lower esophageal sphincter relaxations, gastroesophageal reflux disease and regurgitation is disclosed.
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7342044 |
Preservative blends containing quaternary ammonium compounds
The present invention provides a biocidal composition comprising a synergistic mixture of certain quaternary ammonium biocides and one or more ketone acids, aromatic carboxylic acids, salts...
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7332516 |
Geminally di-substituted NSAID derivatives as Aβ42 lowering agents
The present invention encompasses compounds of Formula I (I)
or pharmaceutically acceptable salts thereof, wherein A is the base molecule of a propionic acid or acetic acid NSAID, or a...
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7326690 |
Modulation of cell fates and activities by phthalazinediones
Phthalazinediones that function as intracellular redox modulators are useful in treating cells in various disease states where intracellular redox status is impaired. By buffering aberrant redox...
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7323452 |
Method for the accelerated in vivo removal of ethanol
A method for accelerating the process of removing ethanol from the blood through the use of certain additives that accelerate the metabolic oxidation of ethanol, and others which in addition act as...
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7318930 |
Control methods for boring bark beetles
A composition which causes adult boring bark beetles to discontinue boring, discontinue laying eggs and become disoriented and bore out of the tree or cease boring altogether and die is described....
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7314888 |
Compounds and medicinal use thereof
A compound or a salt thereof having the atom corresponding to N 3 and the two or more atoms selected from N 1 , N 2 , N 4 and N 5 , said atoms constitute the pharmacophore represented by the...
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7309720 |
2-ethoxy-3-phenylpropionic acid derivatives for the treatment of lipid disorders
A compound of formula (I) wherein T represents O, S or NR and wherein R represents a H, a C 1-6 alkyl group or a phenyl C 1-6 alkyl group and pharmaceutically acceptable salts thereof, processes...
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7300955 |
Method and materials for treatment of Alzheimer's disease
The invention provides the combined use of an inhibitor of formation or release of β-amyloid and a nitric oxide releaser for the treatment or prevention of Alzheimer's disease.
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7217705 |
Combination of a CB1 receptor antagonist and of a product which activates dopaminergic neurotransmission in the brain, the pharmaceutical compositions comprising them and their use in the treatment of parkinson's disease
The present invention relates to the combination of one or more CB1 antagonist azetidine derivatives and of one or more products which activate dopaminergic neurotransmission in the brain, to the...
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7214713 |
Antraquinone compositions as anticancer compositions and nutrition supplements and methods of making and using them
A food supplement having prophylactic and-cancer effects, wherein the supplement comprises 20 to 99.99% by weight of a product of biosynthesis by the productive microorganism Penicillium oxalicum...
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7196119 |
Development of new selective estrogen receptor modulators
The present disclosure concerns a new class of selective estrogen receptor modulators (SERMs). The disclosure also includes the identification of a previously unknown membrane associated estrogen...
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7196081 |
Compounds with hydroxycarbonyl-halogenoalkyl side chains
The present invention provides a compound consisting of a moiety and a group chemically bonded to said moiety, wherein said moiety contains a compound having low activity following oral...
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7179841 |
Stabilized ascorbic acid compositions and methods therefor
The present invention relates to ascorbic acid single-phase solution compositions that provide enhanced stability, enhanced solubility and an enhanced photoprotective effect as compared to prior...
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7132452 |
Topical formulation having effects on alleviating pain/inflammation caused by herpes virus infection
The present invention provides a topical formulation containing NSAID, particularly diclofenac. The topical formulation is particularly useful for alleviating pain/inflammation associated with...
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7125910 |
Compounds and compositions for delivering active agents
Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
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7105504 |
Combination of a CB1 receptor antagonist and of a product which activates dopaminergic neurotransmission in the brain, the pharmaceutical compositions comprising them and their use in the treatment of parkinson's disease
The present invention relates to the combination of one or more CB1 antagonist azetidine derivatives and of one or more products which activate dopaminergic neurotransmission in the brain, to the...
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7098195 |
Fluorinated glucosamine analogs useful for modulating post-translational glycosylations on cells
The present invention provides compositions and methods for inhibiting cell migration, e.g., lymphocytes and inflammation. The invention also provides an improved process for preparing fluorinated...
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7091231 |
12-Aryl prostaglandin analogs
Compounds comprising
are disclosed, wherein Y, A, X, R, D, and n are as described.
A compound comprising a prostaglandin EP 2 selective agonist wherein the ω-chain comprises a substituted...
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7030162 |
Treatment of migraine headache
The invention is directed to pharmaceutical compositions useful in the treatment of migraine. The compositions contain metoclopramide and one or more NSAIDs in unit dosage form. By selecting NSAIDs...
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7022736 |
Enzyme inhibitors
Diketoacids of Formula A are useful as inhibitors of viral polymerases. In particular hepatitis C virus RNA dependent RNA polymerase (HCV RdRp), hepatitis B virus polymerase (HBV pol) and reverse...
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6982097 |
Biocidal compositions and methods of using same
This invention relates to biocidal compositions and methods of using same. Also provided is a process for the manufacturing of a biocidal composition in the form of a tablet and a method of using...
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6974835 |
Methods for decreasing cell proliferation based on (3r,4r)-Δ8-tetrahydrocannabinol-11-oic acids
The invention relates to the use of cannabinoid compounds (derivatives of tetrahydrocannabinol) for decreasing cell proliferation in a mammal.
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6972294 |
Compounds, their preparation and use
Disclosed are novel compounds of formula (I)
wherein A 1 , A 2 , Ar, R 5 , R 6 , R 8 , M, Q, Y, Z, k, m and n are as defined in the specification. These compounds are useful in the treatment...
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6943196 |
NF-κB inhibitor comprising phenylmethyl benzoquinone as the active ingredient
An NF-κB inhibitor having as an active ingredient a benzoquinone derivative represented by the general formula (1) wherein R 1 , R 2 , and R 3 are each independently H, alkyl having 1 to 5...
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6924303 |
Analgesic and anti-inflammatory compositions containing COX-2 inhibitors
The present invention is directed to an analgesic composition which consists essentially of a cyclooxygenase-2 inhibitor and a compound selected from the group consisting of non-steroidal...
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6921777 |
Heteroethynylenic compounds and pharmaceutical and cosmetic compositions containing them
The invention relates to novel heteroethynylenic compounds having the general formula (I):
as well as to the use of these compounds in pharmaceutical compositions intended for use in human or...
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6911473 |
Detectable agent for wood treatment and method for its detection
The present invention relates to a composition comprising an organic preservative acid and a UV-active indicator substance for preserving wood and for detection of the sufficient preservation of wood.
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6911466 |
Aβ42 lowering agents
The invention provides a method of preventing, delaying, or reversing the progression of Alzheimer's disease by administering an Aβ 42 lowering agent to a mammal under conditions in which levels...
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6911196 |
Topical medicament for treating nappy rash
A composition and method of treating nappy rash utilizes a combination of Salicylic Acid (0.720/100 g), Boric Acid (5 g/100 g), Tannic Acid (0.575 g/100 g), Zinc oxide (5 g/100 g), Calamine (1.5...
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6900189 |
Analgesic and glucosamine compositions
This invention relates to a composition comprising a glucosamine material and an analgesic compound such as a nonsteroidal anti-inflammatory drug (NSAID) and/or an opioid analgesic and its use for...
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6869967 |
Peroxisome proliferator-activated receptor (PPAR) active vinyl carboxylic acid derivatives
Novel compounds of the general formula (I), the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these...
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6869944 |
Method for treating a patient with neoplasia by treatment with a platinum coordination complex
This invention provides a method for treating a patient with neoplasia by an adjuvant therapy that includes treatment with an antineoplastic platinum coordination complex.
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