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6506404 |
Release of ibuprofen from hot melt adhesive compositions through addition of pharmaceutical auxiliaries
Use of auxiliaries to improve the release of ibuprofen from hot melt adhesive compositions.
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6492423 |
Diketoacid-derivatives as inhibitors of polymerases
Diketoacids of Formula (A) are useful as inhibitors of viral polymerases. In particular hepatitis C virus RNA dependent RNA polymerase (HCV RdRp), hepatitis B virus polymerase (HBV pol) and reverse...
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6492424 |
Glucocorticoid and thyroid hormone receptor ligands for the treatment of metabolic disorders
Novel glucocorticoid and thyroid receptor ligands as provided which have the general formula (I): in which R 1 is an aliphatic hydrocarbon, an aromatic hydrocarbon, carboxylic acid or ester...
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6472433 |
Method for treatment of inflammation with R-NSAIDS
This invention relates to the use of enantiomerically pure R-NSAIDs for the treatment of inflammation. Preferably, the R-NSAID used is R-flurbiprofen and is administered in a dose of at least 5...
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6455539 |
Squaric acid derivates
Squaric acid derivatives of formula (1) are described: wherein R 1 is a group Ar 1 Ar 2 Alk- in which Ar 1 is an optionally substituted aromatic or heteroaromatic group; Ar 2 is an optionally...
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6451857 |
Analgesic compositions comprising anti-epileptic compounds and methods of using same
The present invention is directed to novel combinations of one or more anti-epileptic compounds that demonstrate pain alleviating properties, with one or more compounds selected from the group...
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6444699 |
Method for treatment of aging or damage skin
An ascorbic acid-based composition and related method for the treatment of aging or photo-damaged skin is disclosed. The composition includes water and ascorbic acid, at least a portion of which...
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6444665 |
Method for treating pain
The present invention provides a method for treating pain using an atypical antipsychotic compound.
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6429226 |
Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
The invention relates to ophthalmological compositions for topical treatment of glaucoma or ocular hypertension comprising an effective intraocular pressure reducing amount of a prostaglandin...
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6420394 |
Topically applied pharmaceutical formulation
The present invention relates to a novel pharmaceutical formulation for the topical application of drugs, particularly non-steroidal anti-inflammatory drugs (NSAID's), comprising a therapeutically...
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6417159 |
Method of enhancing effect of a neurotrophin with analogues of p75NTR367-379.
The present invention provides methods and compositions for enhancing the effect of a neurotrophin on a cell expressing a neurotrophin receptor. The effect is preferably neurotrophin-mediated...
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6414017 |
Inhibition of hair growth
Mammalian hair growth is reduced by applying to the skin a composition including an inhibitor of an enzyme involved in arachidonic acid metabolism.
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6414026 |
Compounds which interact with the thyroid hormone receptor for the treatment of fibrotic disease
A method of alleviating a fibrotic disease selected from lung fibrosis and liver cirrhosis in a warm blooded animal, which comprises administering an effective amount of at least one compound...
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6410574 |
Fungicidal composition and method for using the same
The present invention relates to a fungicidal composition obtained by mixing a 1,2,3-thiadiazole derivative of general formula (I) useful as a plant disease controller with at least one fungicide...
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6403646 |
Method for the treatment of alpha-1-antitrypsin deficiency and related pathologies
A method for the treatment of alpha-1-antitrypsin deficiency caused by the protease inhibitor type Z mutation by administration of phenylbutyric acid derivatives. Also disclosed are methods for the...
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6403638 |
2,4-pentadienoic acid derivatives having selective activity for retinoid X (RXR) receptors
Compounds having the formulas below, where R is H, lower alkyl, or a pharmaceutically acceptable salt, and where R 1 represents i-propyl, t-butyl or n-butyl groups, have selective RXR retionoid...
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6395785 |
E-2-&lsqb 4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy&rsqb ethanol and pharmaceutical compositions thereof
The present invention relates to E-2-[4-(chloro-1,2-diphenyl-butleny1)phenoxy]ethanol which is useful in lowering serum cholesterol and to pharmaceutical compositions thereof. The invention also...
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6395718 |
Pharmaceutical compositions and methods of inhibiting angiogenesis using naaladase inhibitors
The present disclosure relates to a method of inhibiting angiogenesis comprising administering a N-Acetylated α-Linked Acidic Dipeptidase (NAALADase) inhibitor to a patient in need thereof, and a...
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6391886 |
Oral compositions having improved consumer aesthetics
Oral compositions containing therapeutical agents wherein the undesirable consumer aesthetics associated with these agents are mitigated using coolants and sweeteners.
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6391879 |
Therapeutic anti-fungal nail preparation
A therapeutic solution and application procedure for curing and preventing nail fungus and athlete's foot infections or Onychomycosis comprising a combination of an anti-fungal agent with DMSO in a...
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6384079 |
Compositions comprising 2-hydroxycarboxylic acids and related compounds, and methods for alleviating signs of dermatological aging
Uses of topical compositions comprising a 2-hydroxycarboxylic acid or related compound to alleviate or improve signs of skin, nail and hair changes associated with intrinsic or extrinsic aging are...
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6376531 |
Method of treatment using deuterium compounds
The present invention provides organic deuterium compounds which can be therapeutic compounds to treat manic depression. In particular, the present invention relates to deuterated methionine,...
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6376546 |
Biphenyl-5-alkanoic acid derivatives and use thereof
Compounds represented by general formula I or salts thereof, wherein n is an integer of 2 or 3; R represents a straight-chain or branched saturated alkyl group having 4 or 4 carbon atoms, a...
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6369109 |
Betulinic acid and derivatives thereof useful for the treatment of neuroectodermal tumor
The present invention is, generally, directed to the use of betulinic acid and derivatives thereof for the treatment of neuroectodermal tumors. The present invention is based on the discovery that...
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6362236 |
Inhibition of lipoprotein oxidation
Hydroxylated derivatives of cholesterol lowering agents inhibit the oxidation of lipoproteins, and are thus useful for preventing the progression of atherogenesis and resultant vascular diseases,...
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6362227 |
Methods for the treatment of tinnitus and other disorders using R(−)ketoptofen
Methods of treating neuropathic pain, tinnitus, and related disorders are disclosed. These methods comprise the administration of optically pure R(−)-ketoprofen. Also disclosed are pharmaceutical...
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6362226 |
Modulation of in vivo glutamine and glycine levels in the treatment of autism
A method of treating autism in a patient. The method includes administering to the patient an effective amount of a glutamine level reducing agent, a glycine level reducing agent or combinations...
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6362234 |
Water-soluble prodrugs of propofol for treatment of migrane
This invention provides esters of propofol (2,6-diisopropylphenol). The propofol esters are soluble in water and metabolize rapidly to propofol in the body. The propofol esters are useful as...
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6361792 |
Lipid dispersions and methods of use
Methods for preventing or ameliorating the transient adverse physiological response to particulate dispersions (TAPR response) when these dispersions are administered parenterally to a patient. The...
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6344479 |
Method of preventing retinopathy of prematurity in a neonate
A method is disclosed of preventing retinopathy of prematurity in a prematurely born neonate susceptible to developing retinopathy of prematurity, which comprises the step of parenterally...
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6342525 |
Benzenoid derivatives of 15-hydroxyeicosatetraenoic acid and methods of their use in treating dry eye disorders
Benzenoid HETE derivatives and methods of their use for treating dry eye are disclosed.
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6326397 |
Retinoid antagonists and use thereof
The present invention relates to novel retinoid antagonists of the formula I ##STR1## wherein the dotted bond can be either hydrogenated or form a double bond; and, when the dotted bond forms a...
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6310100 |
Method of treating hypertension
A method for treating hypertension, a cardiac disease, or a cerebrovascular disease comprising administration of ferulic acid or a derivative thereof, to a subject in need of treatment. Therapeutic...
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6306873 |
Substituted β-thiocarboxylic acids
This invention relates to compounds of general formula (I): ##STR1## in which Ar is a group selected from: ##STR2## A1, A2, B, C, D, E, Q1-Q3, R1-R9, Z1 and Z2 are as defined in the disclosure, and...
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6306900 |
Enteric coated pharmaceutical compositions
This invention provides a pharmaceutical composition comprising a mycophenolate salt, the composition being adapted to release mycophenolate in the upper part of the intestinal tract.
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6306842 |
Protected forms of a combination of pharmacologically active agents and uses therefor
In accordance with the present invention, there are provided conjugates of a combination of pharmacologically active agents (e.g., NSAIDs and selective COX-2 inhibitors). Invention conjugates...
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6294580 |
Substituted 4-hydroxy-phenylalcanoic acid derivatives with agonist activity to PPAR-gamma
A compound having formula (I), wherein A is selected from the group consisting of: (i) phenyl, wherein said phenyl is optionally substituted by one or more halogen atoms, C 1 -6 alkyl, C 1 -3...
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6291521 |
Anti-portal hypertensive agent
The present invention provides an anti-portal hypertensive agent comprising a 15-keto-prostaglandin compound as an active ingredient.
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6291527 |
Pharmaceutical preparations containing hydrosoluble ketoprofen salts and their application
The new pharmaceutical preparations contain hydrosoluble salts obtained through a reaction between Ketoprofen and Glucosamine and/or Proline and/or Hydroxyproline from 0.01 to 30% of the mass. Such...
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6280778 |
Process for preparing natural product derivatives from plants in a single step
A process is disclosed, for preparing a derivative of a targeted natural product from plants. The targeted natural product is extracted from the desired part of the plant and the targeted natural...
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6265444 |
Ophthalmic composition
An ophthalmic composition containing a divalent salt and a non-steroidal anti-inflammatory agent as a precipitate. The composition reduces or eliminates the risk of stinging and burning the eye...
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6258843 |
4-oxy-3-(aryl)phenyl-arylcarbonyloxy compounds useful as phosphodiesterase inhibitors
(4-oxy-3-(aryl)phenyl)pyridine compounds, in free or acid addition salt form, are useful as pharmaceuticals for treatment and prophylaxis of inflammation, particularly inflammatory or obstructive...
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6255347 |
Methods and compositions comprising R-ibuprofen
The present invention relates generally to the fields of chemotherapeutic treatments. More particularly, it concerns the use of ibuprofen, a non-steroid anti-inflammatory drug, in the treatments of...
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6251945 |
Pharmaceutical mixture comprising a combination of a profen and other active compounds
A pharmaceutical mixture comprising a profen and one or more additional active compounds is described which has a total active compound content of over 85% and contains up to 1%, based on the...
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6242000 |
Composition of S-sodium ibuprofen
The use of S(-)sodium 2-(4-isobutylphenyl)propionate (the sodium salt of S(+)-ibuprofen) in pharmaceutical compositions for the treatment of inflammation, pain and pyrexia is described. Preferred...
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6238703 |
Controlled release oral dosage form of ketoprofen
A controlled release analgesic dosage form comprising: a core comprising an analgesic and binding agent; and a coating comprising an enteric polymer, a water insoluble second polymer and a lubricant.
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6232344 |
13-Oxa prostaglandins for the treatment of glaucoma and ocular hypertension
13-Oxa analogs of certain prostaglandins and methods of their use in treating glaucoma and ocular hypertension are disclosed.
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6228850 |
Antiangiogenic activity of betulinic acid and its derivatives
Use of betulinic acid and/or its derivatives for inhibiting and/or preventing angiogenesis is described. Compositions containing betulinic acid derivatives with or without betulinic acid can be...
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6221391 |
Self-emulsifying ibuprofen solution and soft gelatin capsule for use therewith
This invention relates to a self-emulsifying solution of Ibuprofen suitable for encapsulation into a soft gelatin capsule.
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6221377 |
Administration media for analgesic, anti-inflammatory and anti-pyretic drugs containing nitrous oxide and pharmaceutical compositions containing such media and drugs
Administration mediums comprising solutions of nitrous oxide in water, alcohols, ethers or oils, and optionally including essential fatty acids or C 1 -C 6 alkyl esters thereof enhance the action...
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