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4534979 |
Polyene compounds useful in the treatment of psoriasis and allergic responses
Polyene compounds represented by the general formulae ##STR1## in which: R and R 1 are each hydrogen or an alkyl group of from 1 to 5 carbon atoms; R 2 is an alkyl group of from 1 to 5 carbon...
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4534980 |
Antiinflammatory and antipyretic cream
Creams for external or topical use comprising ketoprofen as an effective component and crotamiton as an agent for preventing crystalline precipitation of the effective component. The creams possess...
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4533546 |
Antiinflammatory analgesic gelled ointments
An antiinflammatory analgesic gelled ointment comprising a phenylacetic acid type antiinflammatory analgesic agent, a carboxyvinyl polymer in an amount sufficient for gel formation, a water-soluble...
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4514386 |
Cream Preparation
An antiinflammatory cream preparation which comprises an antiinflammatory substance hardly soluble in water in a base composition at a concentration of 0.05 to 1.5% by weight based on the...
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4499299 |
Pharmaceutically active phenylcarboxylic acid derivatives
Compounds which antagonize the slow-reacting substance of anaphylaxis or components thereof, e.g., leukotrienes, in warm blooded animals as well as intermediates and methods for their preparation,...
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4493823 |
Topical cosmetic preparations for the treatment of oily hair and seborrheic skin
This invention relates to topical cosmetic preparations. More particularly, this invention relates to a topical cosmetic preparation for the treatment of oily hair and seborrheic skin which...
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4489080 |
Process for analgesic treatment
An improved process for the management of pain by concommittant administration of narcotic analgesics and flurbiprofen or salt or ester thereof. Process for reducing dosage and dosage forms are...
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4478822 |
Drug delivery system utilizing thermosetting gels
This invention relates to a unique drug delivery system for delivering drugs to a body cavity. The drug delivery system comprises a medicament and a polymer such that the drug delivery system is a...
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4474811 |
Anti-inflammatory ophthalmic solution and process for preparing the same
An anti-inflammatory ophthalmic solution containing (A) 2-(2-fluoro-4-biphenylyl)propionic acid or its ophthalmologically acceptable salt and (B) β-cyclodextrin or γ-cyclodextrin. The ophthalmic...
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4473583 |
Compositions containing certain derivatives of 4-phenyl-4-oxobuten-2-oic acid and methods of treatment using them
Pharmaceutical compositions including compounds of formula (I): ##STR1## in which R 1 represents a hydrogen atom, a hydroxy radical or an alkyl radical containing from 1 to 8 carbon atoms, R 2 ...
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4473584 |
Treatment of Type I Herpes virus with flurbiprofen
A process for treating Herpes Type I virus by the systemic administration or topical application of flurbiprofen (3-fluoro-4-phenylhydratropic acid) or a salt or ester thereof. Dosage forms are...
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4472431 |
Method for treatment of shock
A method for the treatment of shock is disclosed which includes the administration of a therapeutically effective amount of fenoprofen, which may be administered either as a pretreatment or...
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4472376 |
Pharmaceutical insertion compositions and a process for producing the same
A phamaceutical insertion composition comprising a mixture of an aqueous solution of carboxyvinyl polymer with a water-soluble basic compound and a pharmaceutical ingredient, said mixture being a...
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4461912 |
Phenylacetic acid derivatives, their preparation and compositions containing them
Phenylacetic derivatives of formula (I): ##STR1## (wherein R represents a hydrogen atom or a C 1 -C 3 alkyl group and n represents an integer from 1 to 3) and salts and esters thereof have...
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4457942 |
Process for waste nitrogen removal
A method of alleviating the accumulation of waste nitrogen in human beings is disclosed, wherein phenylbutyrate, or even numbered conger thereof, is administered to a patient having such waste...
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4454155 |
Pharmaceutical compositions containing a mono-substituted derivative of 4-phenyl-4-oxobuten-2-oic acid, and methods of using them in treating gastric and gastroduodenal ailments
Pharmaceutical compositions containing a compound of the formula (I): ##STR1## in which R represents a hydrogen atom or an alkyl radical containing from 1 to 8 carbon atoms, R 1 represents a...
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4450292 |
Derivatives of phenyl aliphatic carboxylic acids, and use thereof in treating gastric and gastro-duodenal ailments
A compound of the formula (I) ##STR1## in which the three methoxy radicals are in the 3,4,5, or 2,4,6 or 2,4,5 or 2,3,5 or 2,3,6 positions, in which either A and B together represent a double bond...
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4443476 |
Treatment of adult respiratory distress syndrome
A process for treating adult respiratory distress syndrome by the systemic administration of flurbiprofen (3-fluoro-4-phenylhydratropic acid) or a salt or ester thereof. Dosage forms are also...
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4440784 |
Anti-inflammatory, analgesic, and antipyretic pharmaceutical composition
A new anti-inflammatory, analgesic, and antipyretic pharmaceutical composition is disclosed which contains a 3,5-di-tert-butyl-4-hydroxystyrene derivative of the formula: ##STR1## wherein R 1 ...
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4439452 |
Class of analgesics and/or anti-inflammatory agents consisting of inhibitors of breakdown of endogenous enkephalin and/or endorphin, and combinations of said analgesics with antipyretic, anti-inflammatory (aspirin-type) drugs
A new class of analgesics is provided by substances that inhibit breakdown of endogenous substance such as enkephalins and/or endorphins. The analgesic effect of an enkephalin breakdown inhibitor...
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4439450 |
Treatment of the blood-brain barrier with ibuprofen
A process for treating the blood-brain barrier by the systemic administration of ibuprofen (p-isobutylhydratropic acid) or a salt or ester thereof. Dosage forms are also disclosed.
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4439451 |
Treatment of the blood-brain barrier with flurbiprofen
A process for treating the blood-brain barrier by the systemic administration of flurbiprofen (3-fluoro-4-phenylhydratropic acid) or a salt or ester thereof. Dosage forms are also disclosed.
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4436752 |
Treatment of gastric and gastro-duodenal disorders with derivatives of phenyl aliphatic carboxylic acids
Gastric and gastro-duodenal disorders are treated by administering a compound of formula (I) ##STR1## in which A and B together represent a double bond or else A represents a hydrogen atom and B...
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4420483 |
Analgesic and anti-inflammatory compositions comprising ibuprofen and methods of using same
Novel analgesic and anti-inflammatory compositions of matter for use in eliciting an analgesic or anti-inflammatory response, said compositions comprising ibuprofen and caffeine, are disclosed....
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4411754 |
Process for preparing a polymer composition
A polymer composition containing a physiologically active substance which can be released at a controlled rate is prepared by contacting one or more polymerizable monomers with the physiologically...
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4410545 |
Carbonate diester solutions of PGE-type compounds
Stable compositions of PGE-type compounds are achieved by dissolving those compounds in carbonate diester solvents which may contain water up to the solubility limit of the carbonate diester.
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4409239 |
Propylene glycol diester solutions of PGE-type compounds
Stable compositions of PGE and PGE-type compounds are achieved by dissolving these compounds in propylene glycol diesters of short chain fatty acids.
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4407825 |
Novel bis- and poly-disulfides having immunostimulant activity
Compounds of formula R 1 O--(CH 2 ) m --S--S--(CH 2 ) p --S] x S--(CH 2 ) n --OR 2 wherein R 1 and R 2 are, independently, hydrogen, C 1 -5 alkyl or a physiologically-hydrolyzable and...
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4405810 |
7-Aryl-hept-5-ynoic acids and derivatives thereof
7-arylhept-5-ynoic acids and derivatives thereof are anti-allergy and anti-inflammatory agents. As such, they are useful in the treatment of allergy-caused diseases, particularly chronic...
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4402978 |
Gastro-protecting activity of substituted derivatives of 4-phenyl-4-oxo-2-hydroxy-butanoic acid
Diseases and ailments accompanied by gastric and gastroduodenal lesions treated by administering a compound of the formula (I) ##STR1## in which R represents hydrogen or alkyl containing 1 to 5...
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4363815 |
Alpha hydroxyacids, alpha ketoacids and their use in treating skin conditions
Preventive as well as therapeutic treatment to alleviate the symptoms of skin disorders associated with disturbed keratinization or inflammation with one or more alpha or beta hydroxy-acids and...
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4351950 |
Anti-arteriosclerotic agents
Novel substituted arylene compounds and methods for their preparation and use are disclosed. These new compounds are useful as anti-arteriosclerotic agents.
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4348383 |
Dithioether-based cosmetic compositions for the treatment of the oily state of hair and skin
A cosmetic composition for the treatment of the oily appearance of hair and skin so as to reduce or eliminate said oily appearance comprises in a suitable cosmetic vehicle at least one compound of...
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4346108 |
Method for preventing adhesion formation
A process for preventing a reducing adhesion formation by the systemic administration of ibuprofen (p-isobutylhydratropic acid) or a salt or ester thereof. Dosage forms are also desirable.
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4338332 |
Fluoro-prostaglandins
16-Fluro-13, 14-dehydro-PG 2 series compounds have been prepared.
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4329361 |
Use of rosmarinic acid in the treatment of inflammations and pharmaceutical products used therein
The present invention is directed to a new process for the treatment of inflammatory diseases and disorders in humans by administering a pharmaceutical preparation containing rosmarinic acid.
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4321275 |
Method of inducing luteolysis using 16-aryloxy-17,18,19,20-tetranor-prostanoic acid derivatives
The disclosure relates to novel 17,18,19,20-tetranor-prostanoic acid derivatives having prostaglandin-type properties, to a method for their manufacture, and also to pharmaceutical or veterinary...
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4310544 |
Hydroxyacetic acid derivatives with anti-arthritic properties
The invention concerns novel 2-[4-(4-chlorophenyl)benzyloxy]acetic acids of the formula: ##STR1## in which R 1 is hydrogen or (1-4C)alkyl, R 2 is phenyl optionally bearing a halogeno substituent,...
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4309421 |
Stabilized parenterally administrable solutions
Solutions of anti-inflammatory acrylacetic and arylpropionic acid derivatives are stabilized by addition of phospholipids. The solutions are suitable for parenteral administration; they are well...
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4304788 |
Hydroxyalkanoic acid derivatives
The invention concerns novel hydroxyalkanoic acid derivatives of the formula: ##STR1## in which A is a straight or branched chain (2-6C)alkylene, R 1 and R 2 are independently hydrogen or (1-6C)...
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4292319 |
Antiphlogistic pharmaceutical compositions and method of use
Pharmaceutical compositions containing a non-steroidal anti-inflammatory compound and 5,11-dihydro-11-[(4-methyl-1-piperazinyl)-acetyl]-6H-pyrido[
2,3-b]-[1,4]be nzodiazepin-6-one or a non-toxic...
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4288453 |
Derivatives of arylalkanoic acids, compositions and use
There are now described some novel alpha-[1-aryl-2,2,2-trifluoroethoxy (or-ethylthio)]alkanoic acids that are useful for reducing triglycerides and cholesterol levels in the blood of animals. The...
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4282252 |
Method of increasing coronary blood flow with ibuprofen
Novel treatments are disclosed for increasing circulating coronary blood flow. These treatments are useful for individuals who are expected to otherwise exhibit symptoms of reduced coronary...
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4254146 |
3-Benzoyl-2-nitrophenylacetic acids, metal salts, amides and esters
3-Benzoyl-2-nitrophenylacetic acids, metal salts, amides and esters are disclosed having the formula: ##STR1## wherein R 1 is hydrogen or lower alkyl; R 2 is OH, OM, O-lower alkyl, NH 2 ,...
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4248892 |
Antifibrotic agent
Compounds of the formula ##STR1## wherein n is equal to zero or 1 and their physiologically acceptable salts are effective for the prophylaxis or treatment of the fibrosis due to excessive collagen...
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4242358 |
Method of treatment of algiae
This invention is concerned with a new method of treatment of algiae which comprises administering to a patient in need of such a treatment a pharmaceutically effective amount of compound selected...
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4239779 |
Use of phenylglyoxylic acids and derivatives thereof in the treatment of ischemic heart disease
The use of phenylglyoxylic acids and derivatives thereof in the treatment of ischemic heart disease and the hyperglycemia of diabetes.
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4232042 |
Di-Carboxylic acid derivatives
The invention relates to novel compounds of general formula I: ##STR1## and salts, esters and amides thereof, in which R 1 and R 2 represent hydrogen, alkyl or alkenyl (1-4 C), R 3 represents...
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4230724 |
Method of treating vascularization of the eye with Flurbiprofen
A method of treating vascularization of the eye as a result of traumatic injury, surgery, such as, corneal transplant, or onset of diabetic retinopathy by topically treating the eye with...
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4219566 |
Phenylglyoxylic acids and derivatives thereof
The use of phenylglyoxylic acids and derivatives thereof in the treatment of ischemic heart disease and the hyperglycemia of diabetes.
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