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8183290 |
Pharmaceutically acceptable propylene glycol solvate of naproxen
The invention relates to pharmaceutical compositions comprising propylene glycol solvates of APIs. In particular a 2:1 complex of naproxen sodium to propylene glycol is disclosed which is a...
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RE43372 |
C16 unsaturated FP-selective prostaglandins analogs
Compounds having the general structure: which are useful for the treatment of a variety of diseases and conditions, such as bone disorders.
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8133477 |
Dispersions of inorganic particulates containing alkoxycrylene
A composition comprising an inorganic particulate material in an amount of about 20 wt % to about 70 wt %, a carrier for the particulate material comprising a compound of formula (I) in an amount...
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8128905 |
Stabilized uncoated particles of reversed liquid crystalline phase materials
Uncoated particles of reversed cubic phase or reversed hexagonal phase material containing an active disposed within are provided. The uncoated particles have an ionic charge that is sufficient to...
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8124629 |
Naphthylacetic acids
The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein X, Q, and R1-R6 are defined in the detailed description and claims. In...
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8114910 |
Acidic composition
A composition is provided which comprises an acidic component, generally fulvic acid, having a molecular weight not exceeding 20,000 Daltons and a low content of the elements aluminum, mercury,...
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8110607 |
Process for producing 1,4-dihydroxy-2-naphthoic acid
A composition containing 1,4-dihydroxy-2-naphthoic acid at a high concentration is obtained by intracellularly and extracellularly producing 1,4-dihydroxy-2-naphthoic acid using a bacterium...
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8101662 |
Treatment of cancer with specific RXR agonists
A method of treating cancer is disclosed comprising administering to a patient in need of such treatment a RXR agonist at a level below the RAR activating threshold and at or above the RXR...
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8093301 |
Anti-allergic agent
The inventors have found that vitamin K3 and vitamin K5 which may be used in pharmaceuticals and foods or ACNQ, DHNA, or the like which can stimulate the growth of bifidobacteria can inhibit...
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8076375 |
Methods of inhibiting poxvirus growth
This disclosure ascribes new functions to derivatives of tetralin, anthraquinone, naphthylamine, tri-amino-pyrimidine, xanthen-3-one, and/or cinnamic acid (including, for example, NSC270718R,...
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8070989 |
Photostabilization of retinoids with alkoxycrylene compounds
The photostabilizing electronic excited state energy—particularly singlet state energy from retinoid compounds—has been found to be readily transferred to (accepted by) α-cyanodiphenylacrylate comp...
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8048918 |
Treatment of hyperproliferative diseases
We describe methods and compositions for treating a patient suffering from a hyperproliferative disorder or photoageing. Our methods involve blocking the activity of a retinol binding protein...
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8044099 |
Synthetic bifunctional molecules containing drug moiety and pharmacokinetic modulating moiety
Bifunctional molecules and methods for their use are provided. The subject bifunctional molecules are conjugates of a drug moiety and a pharmacokinetic modulating moiety, where these two moieties...
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7999007 |
Buffer solutions having selective bactericidal activity against gram negative bacteria and methods of using same
Buffer solutions for pharmaceutical preparations that have bactericidal activity preferentially against gram negative bacteria are provided. The buffers have a pH of greater than about 10 or less...
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7959958 |
Cooling compounds
A cooling composition comprising at least one compound of the Formula I in which R is selected from the group of moieties consisting of (CH2)nCOOR″;(CH2)nCONMe2;(CH2)nOR″; andCHNH2CH3; where n is ...
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7868044 |
Method for the treatment of acne using compositions comprising 0.3% by weight of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid
Dermatological disorders having an inflammatory or proliferative component, notably common acne, are treated with topically applicable pharmaceutical compositions containing about 0.3% by weight of...
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7851510 |
Gossypol derivatives, production method thereof and uses of same
The present invention relates to compounds of general formula (1): in which, independently of each other, R1 and R2 represent: —OH, or—CH2—O—R3, or—CH2—S—R3, or R3, R4, R5 and R6 representing,...
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7838558 |
Administration of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid for the treatment of dermatological disorders
Dermatological disorders having an inflammatory or proliferative component are treated with pharmaceutical compositions containing on the order of 0.3% by weight of...
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7834060 |
Administration of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphtoic acid for the treatment of dermatological disorders
Dermatological disorders having an inflammatory or proliferative component are treated with pharmaceutical compositions containing on the order of 0.3% by weight of...
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7834061 |
Process for producing 1,4-dihydroxy-2-naphthoic acid
A composition containing 1,4-dihydroxy-2-naphthoic acid at a high concentration is obtained by intracellularly and extracellularly producing 1,4-dihydroxy-2-naphthoic acid using a bacterium...
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7795305 |
CDDO-compounds and combination therapies thereof
CDDO-compounds in combination with other chemotherapeutic agents induce and potentiate cytotoxicity and apoptosis in cancer cell. One class of chemotherapeutic agents include retinoids. Cancer...
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7795311 |
Methods and compositions for the management of soil-borne fungal diseases
Improved methods and compositions for protecting plants or seeds from soil-borne fungal diseases. The composition may include a triterpenoid isolated from Glycyrrhiza glabra and a polymer. The...
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7781479 |
Heteroaryl derivatives
A compound of the following formula (1), or its prodrug or pharmaceutically acceptable salt thereof, being useful as a diabetic medicine or preventive, or blood sugar regulator, or therapeutic...
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7754767 |
Method for treatment of premature ejaculation in humans
The present invention belongs to the fields of pharmacology, medicine and medicinal chemistry, and provides methods and compositions for treating sexual dysfunction; more particularly, the...
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7737181 |
Pharmaceutical compositions comprising 0.3% by weight of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid for the treatment of dermatological disorders
Dermatological disorders having an inflammatory or proliferative component, notably common acne, are treated with topically applicable pharmaceutical compositions containing about 0.3% by weight of...
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7714017 |
Carboxylic acid peri-substituted bicyclics for occlusive artery disease
Peri-substituted, fused bicyclic ring carboxylic acids useful for the treatment or prophylaxis of a prostaglandin-mediated disease or condition are disclosed. The compounds are of the general...
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7691828 |
Compositions for ameliorating fecal properties
Provided is a fecal condition improving composition containing (a) a compound selected from the group consisting of caffeic acid, chlorogenic acid and ferulic acid, esters thereof, and...
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7687526 |
Benzo-fused compounds for use in treating metabolic disorders
The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables and A...
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7666914 |
Topical preparation and method for transdermal delivery and localization of therapeutic agents
Disclosed herein is a preparation for topically delivering and localizing therapeutic agents, comprising: a vasoconstrictor for retarding vascular dispersion of a therapeutic agent; and a...
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7655699 |
Compounds having selective activity for retinoid X receptors, and means for modulation of processes mediated by retinoid X receptors
Compounds, compositions, and methods for modulating processes mediated by Retinoid X Receptors using retinoid-like compounds which have activity selective for members of the subclass of Retinoid X...
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7645779 |
Linked biaryl compounds
Compounds, compositions and methods that are useful for the treatment of metabolic disorders, inflammatory diseases and cancer are provided herein. In particular, the invention provides compounds...
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7642288 |
Topical application of adapalene for the long-term treatment of acne vulgaris
Administration of adapalene in a topical medicament to a patient so as to sustain its biological response in the treatment of acne vulgaris, wherein the administration pattern of the topical...
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7579377 |
Administration of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid for the treatment of dermatological disorders
Dermatological disorders having an inflammatory or proliferative component are treated with pharmaceutical compositions containing on the order of 0.3% by weight of...
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7550488 |
Application methods to rapidly alter disease and injury states using molecular transport of B6
The present invention discloses methods of application employing B5/B6 vitamins in molecular transport creams or gels to deliver B6 in a high dose to bring about therapeutic ways in human or mammal...
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7547716 |
Sulfonamide derivatives
A medicament for enhancing an effect of a cancer therapy based on a mode of action of DNA injury, which comprises as an active ingredient a compound represented by the general formula (I) or a...
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7517910 |
Alkoxyphenylpropanoic acid derivatives
The present invention aims at provision of a novel compound having a GPR40 receptor function modulating action, which is useful as an insulin secretagogue, an agent for the prophylaxis or treatment...
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7511075 |
Therapeutic malonic acid/acetic acid C60 tri-adducts of buckminsterfullerene and methods related thereto
Disclosed and claimed herein are e,e,e malonic acid/acetic acid tri-adducts of buckminsterfullerene of the general formula C60R3, wherein each R is independently selected from groups of the formula...
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7414042 |
Method and composition for selectively inhibiting melanoma
Compositions and methods are disclosed for treating melanoma wherein a betulinic acid derivative is the active compound in the composition to be administered. The compositions are optionally...
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7342046 |
Gossypol co-crystals and the use thereof
This invention relates to compositions comprising co-crystals of (−)-gossypol with a C1-8 carboxylic acid or C1-8 sulfonic acid which are useful as inhibitors of Bcl-2 family proteins. The i...
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7338977 |
Anti-viral compounds
Compounds of formula I wherein at least one R1 is H and the remainder are CH2CO2K; R2 is and L is H are described. The compounds are useful as pharmaceutical compositions in the treatment of AIDS.
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7332516 |
Geminally di-substituted NSAID derivatives as Aβ42 lowering agents
The present invention encompasses compounds of Formula I (I) or pharmaceutically acceptable salts thereof, wherein A is the base molecule of a propionic acid or acetic acid NSAID, or a derivative...
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7318930 |
Control methods for boring bark beetles
A composition which causes adult boring bark beetles to discontinue boring, discontinue laying eggs and become disoriented and bore out of the tree or cease boring altogether and die is described....
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7262180 |
Compositions and methods for the treatment of inflammatory conditions of mucosae, skin and the eye
The present invention relates to compositions comprising telmesteine, glycyrrhetinic acid, and a proanthocyanidin, as well as methods for using such compositions in the treatment of an inflammatory...
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7166641 |
Pharmaceutically acceptable salts containing local anesthetic and anti-inflammatory activities and methods for preparing the same
The present invention provides pharmaceutically acceptable salts having local anesthetic and anti-inflammatory activities. The preferred pharmaceutically acceptable salt is a diclofenac salt of...
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7163956 |
Substituted fullerene compositions and their use as antioxidants
This patent discloses a substituted fullerenes, compositions comprising the same, and their use as antioxidants. The substituted fullerenes comprise a fullerene core (Cn) and at least one of: (i)...
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7153886 |
Method for treatment of peripheral inflammation of a loop ileal artificial anus
The present invention provides a novel agent for prophylaxis or treatment of inflammatory bowel diseases for oral administration or intra-intestinal infusion, which comprises as an active...
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7148245 |
Biphenyl derivatives substituted with an aromatic or heteroaromatic radical, and pharmaceutical and cosmetic compositions containing them
Compounds of formula (I): in which: Ar represents an aromatic or a heteroaromatic radical optionally substituted, in particular, with an alkyl or a carboxyl group,R2 and R3 represent, in...
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7138411 |
Substituted benzopyran derivatives for the treatment of inflammation
A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular...
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7122518 |
Method for preventing or reducing collateral phototoxic damage to neighboring tissues during photodynamic therapy of a target tissue
A method is provided for preventing or reducing the adverse effects of photodynamic therapy such as collateral damage by regulating the localized phototoxicity of an effector photosensitizer...
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7030162 |
Treatment of migraine headache
The invention is directed to pharmaceutical compositions useful in the treatment of migraine. The compositions contain metoclopramide and one or more NSAIDs in unit dosage form. By selecting NSAIDs...
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