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7598292 |
4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs
The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR delta modulators to treat or inhibit the progression...
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7579377 |
Administration of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid for the treatment of dermatological disorders
Dermatological disorders having an inflammatory or proliferative component are treated with pharmaceutical compositions containing on the order of 0.3% by weight of...
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7550488 |
Application methods to rapidly alter disease and injury states using molecular transport of B6
The present invention discloses methods of application employing B5/B6 vitamins in molecular transport creams or gels to deliver B6 in a high dose to bring about therapeutic ways in human or mammal...
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7547716 |
Sulfonamide derivatives
A medicament for enhancing an effect of a cancer therapy based on a mode of action of DNA injury, which comprises as an active ingredient a compound represented by the general formula (I) or a...
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7517910 |
Alkoxyphenylpropanoic acid derivatives
The present invention aims at provision of a novel compound having a GPR40 receptor function modulating action, which is useful as an insulin secretagogue, an agent for the prophylaxis or treatment...
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7511075 |
Therapeutic malonic acid/acetic acid C60 tri-adducts of buckminsterfullerene and methods related thereto
Disclosed and claimed herein are e,e,e malonic acid/acetic acid tri-adducts of buckminsterfullerene of the general formula C 60 R 3 , wherein each R is independently selected from groups of the...
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7468457 |
Ligand inhibitors of the RAR receptors, process for preparing same and therapeutic/cosmetic applications thereof
Novel biaryl compounds having the structural formula (I):
are useful in a variety of pharmaceutical applications, whether human or veterinary, and also in cosmetics.
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7442808 |
Antidiabetic bicyclic compounds
Tricyclic compounds containing a cyclopropyl carboxylic acid or carboxylic acid derivative (e.g. amide) fused to a bicyclic ring, including pharmaceutically acceptable salts and prodrugs thereof,...
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7414042 |
Method and composition for selectively inhibiting melanoma
Compositions and methods are disclosed for treating melanoma wherein a betulinic acid derivative is the active compound in the composition to be administered. The compositions are optionally...
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7374915 |
Process for producing 1,4-dihydroxy-2-naphthoic acid
A composition containing 1,4-dihydroxy-2-naphthoic acid at a high concentration is obtained by intracellularly and extracellularly producing 1,4-dihydroxy-2-naphthoic acid using a bacterium...
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7342046 |
Gossypol co-crystals and the use thereof
This invention relates to compositions comprising co-crystals of (−)-gossypol with a C 1-8 carboxylic acid or C 1-8 sulfonic acid which are useful as inhibitors of Bcl-2 family proteins. The...
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7338977 |
Anti-viral compounds
Compounds of formula I
wherein at least one R 1 is H and the remainder are CH 2 CO 2 K; R 2 is
and L is H are described. The compounds are useful as pharmaceutical compositions in the...
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7332516 |
Geminally di-substituted NSAID derivatives as Aβ42 lowering agents
The present invention encompasses compounds of Formula I (I)
or pharmaceutically acceptable salts thereof, wherein A is the base molecule of a propionic acid or acetic acid NSAID, or a...
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7318930 |
Control methods for boring bark beetles
A composition which causes adult boring bark beetles to discontinue boring, discontinue laying eggs and become disoriented and bore out of the tree or cease boring altogether and die is described....
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7262180 |
Compositions and methods for the treatment of inflammatory conditions of mucosae, skin and the eye
The present invention relates to compositions comprising telmesteine, glycyrrhetinic acid, and a proanthocyanidin, as well as methods for using such compositions in the treatment of an inflammatory...
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7166641 |
Pharmaceutically acceptable salts containing local anesthetic and anti-inflammatory activities and methods for preparing the same
The present invention provides pharmaceutically acceptable salts having local anesthetic and anti-inflammatory activities. The preferred pharmaceutically acceptable salt is a diclofenac salt of...
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7163956 |
Substituted fullerene compositions and their use as antioxidants
This patent discloses a substituted fullerenes, compositions comprising the same, and their use as antioxidants. The substituted fullerenes comprise a fullerene core (Cn) and at least one of: (i)...
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7153886 |
Method for treatment of peripheral inflammation of a loop ileal artificial anus
The present invention provides a novel agent for prophylaxis or treatment of inflammatory bowel diseases for oral administration or intra-intestinal infusion, which comprises as an active...
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7148245 |
Biphenyl derivatives substituted with an aromatic or heteroaromatic radical, and pharmaceutical and cosmetic compositions containing them
Compounds of formula (I):
in which:
Ar represents an aromatic or a heteroaromatic radical optionally substituted, in particular, with an alkyl or a carboxyl group, R 2 and R 3 ...
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7138411 |
Substituted benzopyran derivatives for the treatment of inflammation
A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular...
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7122518 |
Method for preventing or reducing collateral phototoxic damage to neighboring tissues during photodynamic therapy of a target tissue
A method is provided for preventing or reducing the adverse effects of photodynamic therapy such as collateral damage by regulating the localized phototoxicity of an effector photosensitizer...
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7030162 |
Treatment of migraine headache
The invention is directed to pharmaceutical compositions useful in the treatment of migraine. The compositions contain metoclopramide and one or more NSAIDs in unit dosage form. By selecting NSAIDs...
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7026355 |
Use of rhein or diacerhein compounds for the treatment or prevention of vascular diseases
The present invention relates to the use of rhein or diacerhein compounds to treat and prevent vascular diseases that cause obstruction of the vascular system such as blood vessel restenosis and...
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7019034 |
Compositions and methods for reducing serum glucose and triglyceride levels in diabetic mammals
Diabetic mammals are treated with compounds that are significantly more efficacious as agonists of RXR β retinoid receptors than as agonists of RXR α or RXR γ retinoid receptors. The...
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7011854 |
Method for treating a mammal by administration of a compound having the ability to release CO, compounds having the ability to release CO and pharmaceutical compositions thereof
Several classes of in vivo carbon monoxide-releasing compounds are useful for the treatment and/or prevention of diseases, such as chronic inflammatory, e.g., rheumatoid arthritis, and of diseases...
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6992095 |
Stilbene compounds comprising an adamantyl group, compositions and methods thereof
The invention relates to novel stilbene compounds having the general formula (I):
as well as to pharmaceutical compositions for use in human or veterinary medicine, including dermatological,...
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6982097 |
Biocidal compositions and methods of using same
This invention relates to biocidal compositions and methods of using same. Also provided is a process for the manufacturing of a biocidal composition in the form of a tablet and a method of using...
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6951844 |
Phenyl naphthol ligands for thyroid hormone receptor
New thyroid receptor ligands are provided which have the general formula I
wherein R 1 is halogen, trifluoromethyl, substituted or unsubstituted aryl, substituted or unsubstituted C 1-6 ...
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6949250 |
Selective algaecides for control of cyanochloronta
We have now discovered that certain 9,10-anthraquinone derivatives we developed possess potent activity against O. perornata while possessing a sufficiently high level of solubility in water to...
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6943192 |
Treatment regimen for administration of phenylacetylglutamine, phenylacetylisoglutamine, and/or phenylacetate
Herein is disclosed a method of treating neoplastic disease, including cancer, comprising administering a pharmaceutical composition, the pharmaceutical composition comprising a highly concentrated...
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6936636 |
5-[phenyl-tetrahydronaphthalene-2-yl dihydronaphthalen-2-yl and heteroaryl-cyclopropyl]-pentadienoic acid derivatives having serum glucose reducing activity
Compounds of the formula:
where the variables have the meaning defined in the specification are capable of reducing serum glucose levels in diabetic mammals without the undesirable side...
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6936273 |
Liposomal analgesic formulation and use
A liposome formulation containing about 1% diclofenac is an effective topical anti-inflammatory topical treatment for lameness in horses. More particularly it has been discovered that a formulation...
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6911473 |
Detectable agent for wood treatment and method for its detection
The present invention relates to a composition comprising an organic preservative acid and a UV-active indicator substance for preserving wood and for detection of the sufficient preservation of wood.
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6908934 |
Therapeutic compounds for treating dyslipidemic conditions
Compounds of Formula I
and the pharmaceutically acceptable salts and esters thereof, wherein Z is selected from the group consisting of:
(a) Formula Ia
and (b) Formula Ib
are...
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6887896 |
7-[(7-Alkoxy)-chrom-3-en-6-yl]-heptatrienoic acid and 7-[(3-alkoxy)-5,6-dihydronaphthalen-2-yl]-heptatrienoic acid derivatives having serum glucose reducing activity
Compounds of the formula
where the variations have the meaning defined in the specification are capable of reducing serum glucose levels in diabetic mammals without the undesirable side...
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6887872 |
Propenecarboxylic acid amidoxime derivatives, a process for the preparation thereof, and pharmaceutical compositions containing the same
The invention refers to novel propenecarboxylic acid amidoxime derivatives furthermore N-oxides and/or geometrical isomers and/or optical isomers and/or pharmaceutically suitable acid addition...
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6884820 |
5,6,7,8-tetrahydronaphthalen-2-yl-7-fluoroalkyl-heptatrienoic acid derivatives having serum glucose reducing activity
Compounds of the formula
where the variables have the meaning defined in the specification are capable of reducing serum glucose levels in diabetic mammals without the undesirable side effect...
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6884819 |
Neuropathy remedies
The present invention provides a neurodegenerative disease therapeutic agent containing as its active ingredient a (15R)-isocarbacycline derivative indicated by the following formula [I] or a...
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6869975 |
Linked biaryl compounds
Compounds, compositions and methods that are useful for the treatment of metabolic disorders, inflammatory diseases and cancer are provided herein. In particular, the invention provides compounds...
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6869967 |
Peroxisome proliferator-activated receptor (PPAR) active vinyl carboxylic acid derivatives
Novel compounds of the general formula (I), the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these...
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6867236 |
Method of preventing of delaying the onset and progression of Alzheimer's disease and related disorders
The present invention relates, in general, to a method of preventing or delaying the onset of Alzheimer's disease and related neurodegenerative disorders. The invention also relates to a method of...
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6844365 |
Substances for use in treating psoriasis
It is disclosed the use of diacerein or a pharmaceutically acceptable derivative thereof for the manufacture of a pharmaceutical composition for the treatment of psoriasis or diseases associated...
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6831101 |
Tricyclic rantes receptor ligands
In various aspects, the invention provides compounds that bind to one or more RANTES receptors for the treatment of chemokine mediated disease states, such as compounds of formula (I):
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6825233 |
Compounds having retinoid-like activity
There are provided compounds represented by the formula I or a nontoxic pharmaceutically acceptable salt, physiologically hydrolyzable ester or solvate thereof, wherein the various substituents...
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6825226 |
Apoptosis inducing adamantyl derivatives and their usage as anti-cancer agents, especially for cervical cancers and dysplasias
The invention relates to the discovery that specific adamantyl or adamantyl group derivatives containing retinoid-related compounds induce apoptosis of cancer cells and therefore may be used for...
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6803386 |
Prostacyclin derivative containing compositions and methods of using the same for the treatment of cancer
The present invention is directed to a pharmaceutical composition containing a cancer-treating effective amount of a class of prostacyclin derivatives, and a pharmaceutically acceptable carrier,...
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6784209 |
Food supplement for increasing lean mass and strength
Food supplement compositions and their methods of use in increasing lean mass and/or muscle size and/or strength in individuals, particularly, athletes is described. The food supplements described...
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6777418 |
Retinoid compounds (I)
The current invention provide novel retinoid compounds and methods for their synthesis, methods of treating or preventing emphysema, cancer and dermatological disorders and pharmaceutical...
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6767920 |
3, 7 or 3 and 7 thia or oxa prostanoic acid derivatives as agents for lowering intraocular pressure
The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective...
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6759396 |
Compositions based on a synergistic mixture of at least one VDR ligand and a retinoid
A novel combination of one or more ligands with VDR receptor selective activity and one or more retinoids selective for RARγ receptors as opposed to RARα receptors is described, as well as the...
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