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7572934 |
Substituted biphenyl GPR40 modulators
The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I:
where the definitions of the variables...
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7560488 |
Methods for treating transthyretin amyloid diseases
Kinetic stabilization of the native state of transthyretin is an effective mechanism for preventing protein misfolding. Because transthyretin misfolding plays an important role in transthyretin...
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7557143 |
Thyroid receptor ligands
Thyroid receptor ligands are provided which have the general formula I
wherein:
R1 is
R2 and R3 are the same or different and are hydrogen, halogen, alkyl of 1 to 4...
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7550507 |
2-(alpha-hydroxypentyl) benzoate and its preparation and use
The invention relates to new synthetic 2-(α-hydroxypentyl) benzoates, their preparation and pharmaceutical compositions containing such salts as active ingredients. The invention also relates to...
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7521463 |
Immunomodulatory compounds
Compounds are described which modulate the tzrosine kinase activity of p56 lck and signal transduction pathways in which this enzyme is involved. The invention also relates to compounds which have...
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7504435 |
Method for stimulating weight loss and/or for lowering triglycerides in patients
Administration of a therapeutically effective amount of 3,5-diiodothyropropionic acid stimulates weight loss in patients, lowers triglyceride levels and reduces risk of death or progression of...
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7485315 |
Compositions comprising a compound of low solubility and a lipophilic amino acid derivative, uses thereof and process for dissolving a compound of low solubility
The invention relates to a process for dissolving at least one compound of low solubility in water, the said process comprising the essential step of mixing the compound of low solubility with at...
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7462644 |
Therapeutic agents
The present invention provides the S enantiomer of a compound of formula I
wherein R 1 represents chloro, trifluoromethyl or trifluoromethoxy, R 2 represents H or fluoro and R 3 represents a...
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7462227 |
Ibuprofen complexes as wood preservatives
Complexes of ibuprofen and copper and/or zinc were solubilized in ammoniacal solution providing preservative solutions that fully penetrate wood. With loss of the ammonia from the wood, the...
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7456218 |
3-(4-benzyloxyphenyl) propanoic acid derivatives
The present invention provides a novel compound represented by the formula (I) wherein each symbol is as defined in the specification, a salt thereof and a prodrug thereof having a superior GPR40...
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7449315 |
Bifunctional energy-reversible acyl-compositions
Energy-reversible acyl conjugates, intermediates, and related compositions are disclosed. In preferred aspects, examples of such compositions include:
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7420083 |
Substituted aryloximes
The present invention relates to substituted aryl oximes and methods of using them.
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7399789 |
Bone targeting compounds for delivering agents to bone for interaction therewith
The present invention relates to compounds of the formula
or pharmaceutically acceptable salts thereof, useful for delivering agents having the capacity to diagnose, treat or prevent bone...
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7390504 |
HDL-boosting combination therapy complexes
A pharmaceutical composition including therapeutically effective amounts of at least one HMG-CoA reductase inhibitor present as a dyhydroxyacid salt and at least one additional therapeutic agent.
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7365085 |
Compounds and methods
Disclosed is a compound having the formula:
pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are...
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7342044 |
Preservative blends containing quaternary ammonium compounds
The present invention provides a biocidal composition comprising a synergistic mixture of certain quaternary ammonium biocides and one or more ketone acids, aromatic carboxylic acids, salts...
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7318930 |
Control methods for boring bark beetles
A composition which causes adult boring bark beetles to discontinue boring, discontinue laying eggs and become disoriented and bore out of the tree or cease boring altogether and die is described....
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7314888 |
Compounds and medicinal use thereof
A compound or a salt thereof having the atom corresponding to N 3 and the two or more atoms selected from N 1 , N 2 , N 4 and N 5 , said atoms constitute the pharmacophore represented by the...
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7309720 |
2-ethoxy-3-phenylpropionic acid derivatives for the treatment of lipid disorders
A compound of formula (I) wherein T represents O, S or NR and wherein R represents a H, a C 1-6 alkyl group or a phenyl C 1-6 alkyl group and pharmaceutically acceptable salts thereof, processes...
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RE39916 |
Compounds that modulate PPAR activity and methods for their preparation
This invention discloses compounds that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the...
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7262217 |
Compositions with anisic acid and glycerides
This invention relates to formulations containing a combination of anisic acid, or a salt thereof, or an ester thereof, and a C 6-14 fatty acid monoglyceride and to the use of such combinations as...
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7262180 |
Compositions and methods for the treatment of inflammatory conditions of mucosae, skin and the eye
The present invention relates to compositions comprising telmesteine, glycyrrhetinic acid, and a proanthocyanidin, as well as methods for using such compositions in the treatment of an inflammatory...
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7232821 |
(2-((2-alkoxy)-phenyl) -cyclopent-1enyl) aromatic carbo and heterocyclic acid and derivatives
Compounds of formula (I) or a pharmaceutically acceptable derivative thereof:
wherein A, R 1 , R 2 , R x , R 8 , R 9 and n are as defined in the specification, a process for the preparation of...
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7220780 |
Naaladase inhibitors for treating retinal disorders and glaucoma
The present invention relates to pharmaceutical compositions and methods for treating a retinal disorder or glaucoma using NAALADase inhibitors.
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7214712 |
Isophthalic acid derivatives as matrix metalloproteinase inhibitors
Selective MMP-13 inhibitors are isophthalic acid derivatives of the formula
wherein:
R 1 , R 2 , and R 3 independently are hydrogen, halo, hydroxy, C 1 –C 6 alkyl, C 1 –C 6 ...
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7208520 |
Crystals of hydroxynorephedrine derivative
The present invention provides ethyl (−)-2-[4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-meth
ylethyl]amino]ethyl]-2,5-dimethylphenoxy]acetate hydrochloride, crystalline forms thereof and...
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7192601 |
Antimicrobial and sporicidal composition
Germicidal compositions with enhanced activity towards killing microbiological spores and vetgetative cells comprising certain quaternary ammonium compounds (QACs), phenolic compounds, monohydric...
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7169810 |
Guanidine and amidine acid derivatives and analogs and methods of using the same
The present invention releates to certain novel guanidine or amidine acid derivatives and analogs, to a process for preparing such compounds, having the utility in clinical conditions associated...
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7151117 |
Concentrated X-ray contrast media can act as universal antigens and can inhibit or prevent allergic reactions
The present application is directed to the use of X-ray contrast media that act as universal antigens that are labeled herein as “pseudoantigens.” X-ray contrast media have the potential to...
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7132452 |
Topical formulation having effects on alleviating pain/inflammation caused by herpes virus infection
The present invention provides a topical formulation containing NSAID, particularly diclofenac. The topical formulation is particularly useful for alleviating pain/inflammation associated with...
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7122579 |
Eye treatments using synthetic thyroid hormone compositions
The present invention involves the discovery that synthetic thyroid hormones can be used as compositions to reduce intraocular pressure in vivo. Methods of screening synthetic thyroid hormones for...
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7119246 |
Method of treating acne
This invention relates to a method for the treatment of acne that comprises applying a fluid comprising a polyalkylene carbonate over the area affected by acne and penetrating pores within the...
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7094431 |
Method of healing skin wounds in mammals and a composition therefor
This invention pertains to therapeutic antibacterial/antifungal-wound healing compositions comprising a therapeutically effective amount of antibacterial agents and/or antifungal agents and/or...
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7087644 |
Derivatives of dicarboxylic acid having pharmaceutical properties
The invention relates to compounds of formula (I) as well as the salts and stereoisomers thereof
wherein the several variable groups are as defined in the specification and claims....
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7078400 |
20-HETE synthase inhibitor
The present invention relates to an inhibitor for production of 20-hydroxyeicosatetraenoic acid, comprising, as an effective ingredient, specific hydroxyformamidine derivatives or...
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7064124 |
NF-κB inhibitor containing substituted benzoic acid derivative as active ingredient
A NF-κB inhibitor represented by the following formula (I) is provided:
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7060730 |
Rapidly absorbed liquid compositions
The present invention provides a method which provides for a faster absorption of pharmaceutically acceptable amines. The method provides a pharmaceutically acceptable amine in combination with a...
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7048918 |
Insect bait
Disclosed are insect baits for attracting insects such as ants, flies and cockroaches. The baits include amino acids and a sugar. The baits can be combined with an insect toxicant to effectively...
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7030162 |
Treatment of migraine headache
The invention is directed to pharmaceutical compositions useful in the treatment of migraine. The compositions contain metoclopramide and one or more NSAIDs in unit dosage form. By selecting NSAIDs...
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7030133 |
Inhibitors of formation of advanced glycation endproducts (AGEs)
The nonenzymatic glycation and crosslinking of proteins is a part of the aging process with the glycation endproducts and crosslinking of long-lived proteins increasing with age. This process is...
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7029706 |
Composition for the treatment of cutaneous mycosis
The inventions relates to the use of silica in the formulation of antifungal composition for the treatment of cutaneous mycoses, and method to manufacture an antifungal powder with boric acid and...
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7025985 |
Dihydroxyphenyl compounds and glucoside compounds thereof
The present invention is a compound represented by the following formula (1) or (2):
where one of R 1 and R 2 is hydrogen and the other one is hydrogen or glucose residue. The compound is...
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7005451 |
Agent for repelling and inactivating pathogenic organisms of plants
The invention relates to disinfecting agents for combating and inactivating phytopathogenic organisms for use on plants and in their environment. The agents are based on a mixture of anionic,...
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6998144 |
Method of improving sweetness delivery of sucralose
This invention provides a method of improving the sweetness delivery profile of a sucralose-containing ingestible composition, which comprises incorporating therein DHB at a DHB:sucralose weight...
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6995190 |
Method and treatment with ketoprofen solution
A readily water-soluble ingestible form of ketoprofen is provided by the reaction of ketoprofen and any edible weak base to yield a palatable, stable, safe pharmaceutical solution for mass...
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6992109 |
Method for the treatment of incontinence
The instant invention is a method of using certain analogs of glutamic acid and gamma-aminobutyric acid to treat incontinence.
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6992093 |
Method of inhibiting lipofibroblast to myofibroblast transdifferentiation
Methods of inhibiting lipofibroblast to myofibroblast transdifferentiation in a mammal are disclosed comprising administering a PPAR gamma ligand when said mammal is exposed to a hyperoxic condition.
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6991806 |
Pharmaceutical compositions comprising ibuprofen and domperidone
A stable pharmaceutical composition comprising a mixture of (i) an ibuprofen medicament; (ii) a domperidone medicament and (iii) a carrier material characterized in that the carrier material is...
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6984645 |
Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein
Compounds that are dual aP2/k-FABP inhibitors are provided having the formula
wherein A, B, X, Y, R 1 , R 2 and R 3 are as described herein. A method is also provided for treating diabetes...
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6984389 |
Using heat shock proteins to improve the therapeutic benefit of a non-vaccine treatment modality
The present invention relates to methods of improving a treatment outcome comprising administering a heat shock protein (HSP) preparation or an α-2-macroglobulin (α2M) preparation with a...
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